ATE421577T1 - Entkoppelte anabole und katabole stoffwechselwege in wirtszellen - Google Patents

Entkoppelte anabole und katabole stoffwechselwege in wirtszellen

Info

Publication number: ATE421577T1
Authority: AT; Austria
Prior art keywords: host cells; uncoupled; anabolic; nucleic acid; metabolic pathways
Prior art date: 2001-04-04

Application number

AT02763934T

Other languages

English (en)

Inventor

Timothy Dodge

Fernando Valle

Original Assignee

Genencor Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-04

Filing date

2002-04-04

Publication date

2009-02-15

2002-04-04 Application filed by Genencor Int filed Critical Genencor Int

2009-02-15 Application granted granted Critical

2009-02-15 Publication of ATE421577T1 publication Critical patent/ATE421577T1/de

Links

230000001195 anabolic effect Effects 0.000 title 1
230000001925 catabolic effect Effects 0.000 title 1
230000037353 metabolic pathway Effects 0.000 title 1
150000007523 nucleic acids Chemical class 0.000 abstract 3
102000039446 nucleic acids Human genes 0.000 abstract 3
108020004707 nucleic acids Proteins 0.000 abstract 3
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
230000002255 enzymatic effect Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
230000004048 modification Effects 0.000 abstract 2
238000012986 modification Methods 0.000 abstract 2
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 abstract 1
108010021582 Glucokinase Proteins 0.000 abstract 1
102000030595 Glucokinase Human genes 0.000 abstract 1
108010021382 Gluconokinase Proteins 0.000 abstract 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
229960005070 ascorbic acid Drugs 0.000 abstract 1
235000010323 ascorbic acid Nutrition 0.000 abstract 1
239000011668 ascorbic acid Substances 0.000 abstract 1
230000006652 catabolic pathway Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/58—Aldonic, ketoaldonic or saccharic acids
- C12P7/60—2-Ketogulonic acid

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT02763934T 2001-04-04 2002-04-04 Entkoppelte anabole und katabole stoffwechselwege in wirtszellen ATE421577T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28161801P	2001-04-04	2001-04-04
US28225901P	2001-04-05	2001-04-05

Publications (1)

Publication Number	Publication Date
ATE421577T1 true ATE421577T1 (de)	2009-02-15

Family

ID=26960977

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT08020730T ATE513036T1 (de)	2001-04-04	2002-04-04	Entkoppelte anabole und katabole stoffwechselwege in wirtszellen
AT02763934T ATE421577T1 (de)	2001-04-04	2002-04-04	Entkoppelte anabole und katabole stoffwechselwege in wirtszellen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT08020730T ATE513036T1 (de)	2001-04-04	2002-04-04	Entkoppelte anabole und katabole stoffwechselwege in wirtszellen

Country Status (9)

Country	Link
US (2)	US7241587B2 (de)
EP (2)	EP1373480B1 (de)
JP (2)	JP4430869B2 (de)
AT (2)	ATE513036T1 (de)
AU (1)	AU2002338340A1 (de)
CA (1)	CA2443145C (de)
DE (1)	DE60230971D1 (de)
DK (1)	DK1373480T3 (de)
WO (1)	WO2002081631A2 (de)

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EP1704241A2 (de) *	2003-12-18	2006-09-27	Basf Aktiengesellschaft	Verfahren zur fermentativen herstellung einer feinchemikalie
CN101292026B (zh) *	2005-09-09	2013-04-24	帝斯曼知识产权资产管理有限公司	新颖的基因gms 08
US8222223B2 (en) *	2005-09-20	2012-07-17	Battelle Memorial Institute	Method of treating biocells
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AT505263B1 (de) *	2007-06-01	2009-08-15	Vogelbusch Gmbh	Verfahren zum herstellen von ascorbinsäure
AU2008334945C1 (en) *	2007-12-13	2013-09-05	Danisco Us Inc.	Compositions and methods for producing isoprene
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MX318543B (es) *	2008-07-02	2014-03-18	Danisco Us Inc	Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros.
ZA201102111B (en) *	2008-09-15	2013-10-30	Danisco Us Inc	Reduction of carbon dioxide emission during isoprene production by fermentation
CA2737158A1 (en)	2008-09-15	2010-03-18	Danisco Us Inc.	Increased isoprene production using the archaeal lower mevalonate pathway
EP2337845A1 (de) *	2008-09-15	2011-06-29	Danisco US Inc.	Erhöhte isoprenproduktion mittels mevalonatkinase und isoprensynthase
SG169641A1 (en)	2008-09-15	2011-04-29	Danisco Us Inc	Systems using cell culture for production of isoprene
CA2737195A1 (en)	2008-09-15	2010-03-18	The Goodyear Tire & Rubber Company	Conversion of prenyl derivatives to isoprene
SG172806A1 (en)	2008-12-30	2011-08-29	Danisco Us Inc	Methods of producing isoprene and a co-product
WO2010092924A1 (ja) *	2009-02-10	2010-08-19	国立大学法人宮崎大学	ペントース資化性エタノール生産組換え大腸菌及びこれを用いるエタノールの製造方法
AU2010238770A1 (en) *	2009-04-23	2011-11-03	Danisco Us Inc.	Three-dimensional structure of isoprene synthase and its use thereof for generating variants
TWI434921B (zh) *	2009-06-17	2014-04-21	Danisco Us Inc	從生物異戊二烯組合物製造燃料成分之方法及系統
TWI427149B (zh) *	2009-06-17	2014-02-21	Danisco Us Inc	使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
CN103025688A (zh)	2010-06-17	2013-04-03	丹尼斯科美国公司	包含异戊二烯衍生物的燃料组合物
SG10201504733XA (en) *	2010-07-12	2015-07-30	Univ Gent	Metabolically engineered organisms for the production of added value bio-products
CA2816306A1 (en)	2010-10-27	2012-05-03	Danisco Us Inc.	Isoprene synthase variants for improved production of isoprene
US8288137B2 (en) *	2010-11-15	2012-10-16	E I Du Pont De Nemours And Company	Recombinant Escherichia coli having enhanced acetyl-coenzyme a synthetase activity for producing glyerol and glycerol-derived products
US8691541B2 (en)	2010-12-22	2014-04-08	Danisco Us Inc.	Biological production of pentose sugars using recombinant cells
BR112013018316A2 (pt)	2010-12-22	2018-09-11	Danisco Us Inc	composições e métodos para produção aprimorada de isopreno usando dois tipos de enzimas ispg
US9163263B2 (en)	2012-05-02	2015-10-20	The Goodyear Tire & Rubber Company	Identification of isoprene synthase variants with improved properties for the production of isoprene

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2002
- 2002-04-04 WO PCT/US2002/010575 patent/WO2002081631A2/en not_active Ceased
- 2002-04-04 CA CA2443145A patent/CA2443145C/en not_active Expired - Fee Related
- 2002-04-04 JP JP2002579995A patent/JP4430869B2/ja not_active Expired - Fee Related
- 2002-04-04 DK DK02763934T patent/DK1373480T3/da active
- 2002-04-04 AT AT08020730T patent/ATE513036T1/de not_active IP Right Cessation
- 2002-04-04 AU AU2002338340A patent/AU2002338340A1/en not_active Abandoned
- 2002-04-04 EP EP02763934A patent/EP1373480B1/de not_active Expired - Lifetime
- 2002-04-04 DE DE60230971T patent/DE60230971D1/de not_active Expired - Lifetime
- 2002-04-04 AT AT02763934T patent/ATE421577T1/de not_active IP Right Cessation
- 2002-04-04 EP EP08020730A patent/EP2055773B1/de not_active Expired - Lifetime
- 2002-04-04 US US10/117,283 patent/US7241587B2/en not_active Expired - Fee Related
2006
- 2006-11-13 US US11/598,375 patent/US7407780B2/en not_active Expired - Fee Related
2009
- 2009-10-30 JP JP2009250085A patent/JP5328038B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP4430869B2 (ja)	2010-03-10
EP1373480A4 (de)	2005-02-02
JP5328038B2 (ja)	2013-10-30
US20030073200A1 (en)	2003-04-17
EP2055773A1 (de)	2009-05-06
AU2002338340A1 (en)	2002-10-21
ATE513036T1 (de)	2011-07-15
EP1373480A2 (de)	2004-01-02
US7241587B2 (en)	2007-07-10
DK1373480T3 (da)	2009-05-11
US7407780B2 (en)	2008-08-05
JP2005503769A (ja)	2005-02-10
WO2002081631A3 (en)	2002-11-28
EP2055773B1 (de)	2011-06-15
CA2443145A1 (en)	2002-10-17
EP1373480B1 (de)	2009-01-21
JP2010057499A (ja)	2010-03-18
DE60230971D1 (de)	2009-03-12
CA2443145C (en)	2013-01-22
WO2002081631A2 (en)	2002-10-17
US20070059811A1 (en)	2007-03-15

Legal Events

Date	Code	Title	Description
2009-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE513036T1 (de)	2011-07-15	Entkoppelte anabole und katabole stoffwechselwege in wirtszellen
DK1383903T3 (da)	2009-03-23	Fremgangsmåder til fremstilling af askorbinsyre-intermediater i vært-celler
ATE471370T1 (de)	2010-07-15	Varianten von beta-glukosidasen
EP1516053A4 (de)	2006-07-12	Xylanasen, diese codierende nukleinsäuren sowie verfahren zur herstellung und verwendung davon
NZ595499A (en)	2013-05-31	Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
AU2001242299A1 (en)	2001-09-24	Fungal transcriptional activator useful in methods for producing polypeptides
ATE491788T1 (de)	2011-01-15	Proteasevarianten
WO2005033094A3 (de)	2005-11-24	Verfahren zur herstellung von 3-methylamino-1-(thien-2-yl)-propan-1-ol
WO2005058945A3 (de)	2005-10-20	Genvarianten die für proteine aus dem stoffwechselweg von feinchemikalien kodieren
DE60330579D1 (de)	2010-01-28	Mikrobielle trypsinvarianten mit chymotrypsinaktivität und diese codierende nukleinsäuren
DK1136559T3 (da)	2010-08-02	Nukleotidsekvenser, der koder for dapC-genet, og fremgangsmåde til fremstilling af L-lysin
DE60043509D1 (de)	2010-01-21	Biosynthese von Polyketidsynthase-Substrate
EP1699469A4 (de)	2007-01-24	Rekombinanter faktor viii mit erhöhter spezifischer aktivität
TW200621284A (en)	2006-07-01	Polypeptides having antimicrobial activity and polynucleotides encoding same
TW200502253A (en)	2005-01-16	Antimicrobial polypeptides
DK1226236T3 (da)	2006-06-19	Polypeptider, der har glucanotransferase-aktivitet, og nucleinsyrer, som koder disse
NZ592147A (en)	2012-10-26	Delta-8 desaturase genes, enzymes encoded thereby and uses thereof
EP1551976A4 (de)	2007-06-27	Neue n-acetylgalactosamin-transferasen und diese codierende nukleinsäuren
TW200621285A (en)	2006-07-01	Polypeptides having antimicrobial activity and polyncleotides encoding same
EA200700287A1 (ru)	2007-08-31	Улучшенные ферменты
DK1472347T3 (da)	2011-04-04	Forbedret proteinekspression i Bacillus Subtilis
WO1999035274A3 (en)	1999-09-16	Nucleic acids encoding thermostable pullulanases
WO2000031241A3 (en)	2001-04-12	Polypeptides having choline oxidase activity and nucleic acids encoding same