ATE91721T1 - Verfahren zur herstellung von ibuprofen. - Google Patents

Verfahren zur herstellung von ibuprofen.

Info

Publication number: ATE91721T1
Authority: AT; Austria
Prior art keywords: ibuprofen; manufacture; ester; stereoselectively; hydrolyse
Prior art date: 1987-07-01

Application number

AT88201365T

Other languages

English (en)

Inventor

Mauro Attilio Bertola

Smet Marie Jose De

Arthur Friedrich Marx

Gareth Thomas Phillips

Original Assignee

Gist Brocades Nv

Shell Int Research

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-01

Filing date

1988-06-30

Publication date

1993-08-15

1988-06-30 Application filed by Gist Brocades Nv, Shell Int Research filed Critical Gist Brocades Nv

1993-08-15 Application granted granted Critical

1993-08-15 Publication of ATE91721T1 publication Critical patent/ATE91721T1/de

Links

HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title abstract 4
229960001680 ibuprofen Drugs 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
150000002148 esters Chemical class 0.000 abstract 2
244000005700 microbiome Species 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/823—Acetobacter
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/882—Staphylococcus

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Analytical Chemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT88201365T 1987-07-01 1988-06-30 Verfahren zur herstellung von ibuprofen. ATE91721T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878715476A GB8715476D0 (en)	1987-07-01	1987-07-01	Preparation of ibuprofen
EP88201365A EP0299558B1 (de)	1987-07-01	1988-06-30	Verfahren zur Herstellung von Ibuprofen

Publications (1)

Publication Number	Publication Date
ATE91721T1 true ATE91721T1 (de)	1993-08-15

Family

ID=10619903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88201365T ATE91721T1 (de)	1987-07-01	1988-06-30	Verfahren zur herstellung von ibuprofen.

Country Status (8)

Country	Link
US (1)	US5108917A (de)
EP (1)	EP0299558B1 (de)
JP (1)	JP2793812B2 (de)
AT (1)	ATE91721T1 (de)
DE (1)	DE3882453T2 (de)
ES (1)	ES2059492T3 (de)
GB (1)	GB8715476D0 (de)
IE (1)	IE61906B1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100204837B1 (ko) *	1989-04-28	1999-06-15	기스트 브로카데스 나암로제 베노오트하프	카르복실 에스테라제의 안정화
DE3919029A1 (de) *	1989-06-10	1990-12-13	Hoechst Ag	Verfahren zur enzymatischen spaltung von 2-arylpropionsaeure-vinylester
DE69225009T2 (de) *	1991-01-10	1998-11-19	Sumitomo Chemical Co	Eine asymmetrisch aktive Esterase kodierendes Gen
IT1247533B (it) *	1991-04-26	1994-12-17	Mini Ricerca Scient Tecnolog	Processo per la separazione degli isomeri ottici di acidi carbossilici alfa-sostitutivi
US5273895A (en) *	1992-10-26	1993-12-28	Sepracor, Inc.	Enantioselective production of chiral carboxylic acids
US5457051A (en) *	1993-03-09	1995-10-10	Sepracor, Inc.	Enantioselective hydrolysis of ketoprofen esters by beauveria bassiana and enzymes derived therefrom
US5580783A (en) *	1994-10-12	1996-12-03	E. I. Du Pont De Nemours And Company	Enzymatic process for the preparation of chiral α-tertiary carboxylic acid esters
US5843765A (en) *	1997-01-31	1998-12-01	National Research Council Of Canada	Streptomyces microorganism useful for the preparation of (R)-baclofen from the racemic mixture
DE19716713A1 (de) *	1997-04-21	1998-10-22	Paz Arzneimittelentwicklung	Arzneimittel, enthaltend Ibuprofenthioester als Hemmer der Nf-kappaB abhängigen Bildung von Mediatoren von Entzündung und Schmerz
US7358254B2 (en) *	2001-07-13	2008-04-15	Bristol-Myers Squibb Company	Method for treating atherosclerosis employing an aP2 inhibitor and combination
US6844574B1 (en)	1999-03-12	2005-01-18	Sumitomo Chemical Company, Limited	III-V compound semiconductor
JP4192331B2 (ja) *	1999-04-16	2008-12-10	住友化学株式会社	光学活性２−オキソビシクロ［３．１．０］ヘキサン−６−カルボン酸誘導体の製造方法
US6365399B1 (en)	1999-08-09	2002-04-02	Sumitomo Chemical Company, Limited	Process for producing carboxylic acid isomer using Nocardia diaphanozonaria or Saccharopolyspora hirsuta
CA2501239A1 (en) *	2002-10-07	2004-04-22	Encore Pharmaceuticals, Inc.	R-nsaid esters and their use
US7599463B2 (en) *	2002-11-21	2009-10-06	Cole Philip L	Remote sensing device to detect materials of varying atomic numbers
DE10352511A1 (de) *	2003-11-07	2005-06-16	Ernst-Moritz-Arndt-Universität Greifswald	Verwendung von MRP4-Inhibitoren zur Behandlung und/oder Prophylaxe kardiovaskulärer Erkrankungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1201408B (it) *	1985-03-22	1989-02-02	Montedison Spa	Processo per la preparazione biotecnologica di acidi alfa-arilalcanoici otticamente attivi
US4668628A (en) *	1985-04-01	1987-05-26	Stauffer Chemical Company	Resolution of racemic mixtures of aliphatic acid esters
GB8600245D0 (en) *	1986-01-07	1986-02-12	Shell Int Research	Preparation of 2-arylpropionic acids

1987
- 1987-07-01 GB GB878715476A patent/GB8715476D0/en active Pending
1988
- 1988-06-28 US US07/212,591 patent/US5108917A/en not_active Expired - Fee Related
- 1988-06-30 AT AT88201365T patent/ATE91721T1/de not_active IP Right Cessation
- 1988-06-30 ES ES88201365T patent/ES2059492T3/es not_active Expired - Lifetime
- 1988-06-30 DE DE88201365T patent/DE3882453T2/de not_active Expired - Fee Related
- 1988-06-30 IE IE198188A patent/IE61906B1/en not_active IP Right Cessation
- 1988-06-30 EP EP88201365A patent/EP0299558B1/de not_active Expired - Lifetime
- 1988-07-01 JP JP63164816A patent/JP2793812B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US5108917A (en)	1992-04-28
DE3882453T2 (de)	1993-11-18
JPS6486898A (en)	1989-03-31
GB8715476D0 (en)	1987-08-05
DE3882453D1 (de)	1993-08-26
IE61906B1 (en)	1994-11-30
ES2059492T3 (es)	1994-11-16
IE881981L (en)	1989-01-01
EP0299558A1 (de)	1989-01-18
EP0299558B1 (de)	1993-07-21
JP2793812B2 (ja)	1998-09-03

Legal Events

Date	Code	Title
1994-02-15	UEP	Publication of translation of european patent specification
2000-02-15	EEIH	Change in the person of patent owner
2003-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE91721T1 (de)	1993-08-15	Verfahren zur herstellung von ibuprofen.
DE69016590D1 (de)	1995-03-16	Verfahren zur Herstellung von Acrylsäure.
DE3874209D1 (de)	1992-10-08	Verfahren zur herstellung von acrylsaeure.
DE3769115D1 (de)	1991-05-08	Verfahren zur herstellung von estern.
DE3672270D1 (de)	1990-08-02	Verfahren zur herstellung von fettsaeureestern.
DE69224124D1 (de)	1998-02-26	Verfahren zur Herstellung von Dihomo-Gamma-Linolensäure und das in dieser enthaltende Lipid
DE68913714D1 (de)	1994-04-14	Verfahren zur Herstellung von ungesättigter Carbonsäure oder ihrem Ester.
DE3885151D1 (de)	1993-12-02	Methode zur Herstellung von Methacrylatestern.
ATE87664T1 (de)	1993-04-15	Verfahren zur herstellung von optisch aktiven 2- arylpropionsaeuren.
DE69011880D1 (de)	1994-10-06	Verfahren zur Herstellung von L-Aminosäuren durch Fermentation.
DE69220746D1 (de)	1997-08-14	Verfahren zur Herstellung einer mehrfach ungesättigten Fettsäure des Omega 9 Typs
DE3752086D1 (de)	1997-08-14	Verfahren zur Herstellung von optisch-aktiven Cyclopropancarbonsäure
DE3866766D1 (de)	1992-01-23	Verfahren zur herstellung von methacrylsaeureestern.
DE3889084D1 (de)	1994-05-19	Verfahren zur Herstellung von Polyol-Fettsäureester.
DE69427955D1 (de)	2001-09-20	Verfahren zur Herstellung von 2,2-Difluorketensilylacetalen und alpha,alpha-Difluor-beta -Silyloxy-1,3-Dioxolan-4-Propansäureestern
DE58907182D1 (de)	1994-04-14	Verfahren zur Herstellung von 6-Aminocapronsäureestern.
ATE111898T1 (de)	1994-10-15	Verfahren zur herstellung von chinoloncarbonsäuren.
DE3874260D1 (de)	1992-10-08	Verfahren zur herstellung von estern ungesaettigter alkohole.
DE59007810D1 (de)	1995-01-12	Verfahren zur enzymatischen Spaltung von 2-Arylpropionsäurevinylestern.
DE3862624D1 (de)	1991-06-06	Verfahren zur herstellung von pentensaeurealkylestern.
DE58902114D1 (de)	1992-10-01	Verfahren zur herstellung von hydroxicarbonsaeureestern.
DE3866783D1 (de)	1992-01-23	Verfahren zur herstellung von estern.
DE68909305D1 (de)	1993-10-28	Verfahren zur Herstellung von Carbonsäureestern.
DE3861154D1 (de)	1991-01-10	Verfahren zur herstellung von tetrahydropyran-4-carbonsaeureestern.
DE3751347D1 (de)	1995-07-20	Verfahren zur Herstellung von HNS II.