ATE92043T1 - Pyrrolidin-derivate und ihre pharmazeutische verwendung. - Google Patents

Pyrrolidin-derivate und ihre pharmazeutische verwendung.

Info

Publication number
ATE92043T1
ATE92043T1 AT90102102T AT90102102T ATE92043T1 AT E92043 T1 ATE92043 T1 AT E92043T1 AT 90102102 T AT90102102 T AT 90102102T AT 90102102 T AT90102102 T AT 90102102T AT E92043 T1 ATE92043 T1 AT E92043T1
Authority
AT
Austria
Prior art keywords
pharmaceutical use
substituent
pyrrolidine derivatives
heteroaryl
phenyl
Prior art date
Application number
AT90102102T
Other languages
German (de)
English (en)
Inventor
Motosuke Yamanaka
Tomonori Hoshiko
Shinji Suda
Naoki Yoneda
Nobuyuki Mori
Mitsumasa Shino
Hiroki Ishihara
Mamoru Saito
Toshiyuki Matsuoka
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1254349A external-priority patent/JP2928288B2/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ATE92043T1 publication Critical patent/ATE92043T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT90102102T 1989-02-03 1990-02-02 Pyrrolidin-derivate und ihre pharmazeutische verwendung. ATE92043T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2526289 1989-02-03
JP1254349A JP2928288B2 (ja) 1989-09-29 1989-09-29 ピロリジン誘導体

Publications (1)

Publication Number Publication Date
ATE92043T1 true ATE92043T1 (de) 1993-08-15

Family

ID=26362859

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90102102T ATE92043T1 (de) 1989-02-03 1990-02-02 Pyrrolidin-derivate und ihre pharmazeutische verwendung.

Country Status (15)

Country Link
US (1) US5444083A (fr)
EP (1) EP0381235B1 (fr)
KR (1) KR920003892B1 (fr)
CN (1) CN1044652A (fr)
AT (1) ATE92043T1 (fr)
CA (1) CA2009162A1 (fr)
DE (1) DE69002338T2 (fr)
DK (1) DK0381235T3 (fr)
ES (1) ES2058620T3 (fr)
FI (1) FI900353A7 (fr)
HU (1) HUT53867A (fr)
NO (1) NO173988C (fr)
NZ (1) NZ232334A (fr)
PT (1) PT93045A (fr)
RU (1) RU2024506C1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0476156B1 (fr) * 1990-04-06 1996-08-07 Eisai Co., Ltd. Preparation buccale solide contenant un compose de catechol
DK0641320T3 (da) * 1991-04-17 2001-08-20 Upjohn Co Substituerede (S)-3-phenylpiperidinderivater, deres fremstilling og deres anvendelse som dopaminautoreceptorantagonister
US5665754A (en) * 1993-09-20 1997-09-09 Glaxo Wellcome Inc. Substituted pyrrolidines
DK0813525T3 (da) * 1995-03-10 2004-02-16 Berlex Lab Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter
US6294561B1 (en) * 1999-12-23 2001-09-25 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
US6514226B1 (en) * 2000-02-10 2003-02-04 Chf Solutions, Inc. Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney
EP1265861A2 (fr) * 2000-03-16 2002-12-18 Inflazyme Pharmaceuticals, Ltd. Inhibiteurs benzyles de pde4
DE10257356A1 (de) * 2002-12-09 2004-06-24 Bayer Ag Fluorhaltige Aromaten
EP2155671B8 (fr) * 2007-06-05 2018-02-21 Integrative Research Laboratories Sweden AB Phénylpyrrolidines disubstituées en tant que modulateurs de la neurotransmission catécholaminergique corticale
CN103012175A (zh) * 2012-12-21 2013-04-03 东南大学 抗肿瘤含氮取代基姜黄素类似物、其盐及制备方法
CN118084757B (zh) * 2023-10-10 2025-09-16 广东药科大学 2个内酰胺类物质及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2852526A (en) * 1955-05-03 1958-09-16 Schering Corp Substituted pyrrolidines
AT232503B (de) * 1962-03-05 1964-03-25 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen 3-Phenyl-pyrrolidinen und deren Salzen
FR2460929A1 (fr) * 1979-07-06 1981-01-30 Roussel Uclaf Nouveaux derives de l'a-phenyl 2-pyrrolidinemethanol et leur sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FI822585A7 (fi) * 1981-07-22 1983-01-23 Syntex Inc Sydän-verisuonisysteemiä säätäviä ja antihypertensiivisiä substituoituja pyrrolidiineja.

Also Published As

Publication number Publication date
DE69002338T2 (de) 1993-12-16
DK0381235T3 (da) 1993-10-04
NO900417L (no) 1990-08-06
FI900353A7 (fi) 1990-08-04
NO900417D0 (no) 1990-01-30
NO173988B (no) 1993-11-22
KR900012903A (ko) 1990-09-03
FI900353A0 (fi) 1990-01-23
NO173988C (no) 1994-03-02
EP0381235B1 (fr) 1993-07-28
ES2058620T3 (es) 1994-11-01
HUT53867A (en) 1990-12-28
AU619943B2 (en) 1992-02-06
EP0381235A2 (fr) 1990-08-08
NZ232334A (en) 1991-06-25
RU2024506C1 (ru) 1994-12-15
PT93045A (pt) 1990-08-31
CA2009162A1 (fr) 1990-08-03
EP0381235A3 (fr) 1991-04-03
DE69002338D1 (de) 1993-09-02
HU900654D0 (en) 1990-04-28
US5444083A (en) 1995-08-22
AU4901390A (en) 1990-11-01
KR920003892B1 (ko) 1992-05-18
CN1044652A (zh) 1990-08-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee