NO976085D0 - Difenylmetylen-piperidin-derivater - Google Patents

Difenylmetylen-piperidin-derivater

Info

Publication number: NO976085D0
Authority: NO; Norway
Prior art keywords: piperidine derivatives; diphenylmethylene piperidine; group; diphenylmethylene; medicine
Prior art date: 1996-12-26

Application number

NO976085A

Other languages

English (en)

Other versions

NO976085L (no

NO317060B1 (no

Inventor

Eiichi Shirasawa

Masaaki Kageyama

Tadashi Nakajima

Takashi Nakano

Nobuaki Mori

Hideshi Sasakura

Yasushi Matsumura

Yoshitomi Morizawa

Original Assignee

Asahi Glass Co Ltd

Santen Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-26

Filing date

1997-12-23

Publication date

1997-12-23

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27301396&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO976085(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-12-23 Application filed by Asahi Glass Co Ltd, Santen Pharmaceutical Co Ltd filed Critical Asahi Glass Co Ltd

1997-12-23 Publication of NO976085D0 publication Critical patent/NO976085D0/no

1998-06-29 Publication of NO976085L publication Critical patent/NO976085L/no

2004-08-02 Publication of NO317060B1 publication Critical patent/NO317060B1/no

Links

ZFDDWBKSMIWSBN-UHFFFAOYSA-N 2-benzhydrylidenepiperidine Chemical class N1CCCCC1=C(C=1C=CC=CC=1)C1=CC=CC=C1 ZFDDWBKSMIWSBN-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
208000030533 eye disease Diseases 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
230000003449 preventive effect Effects 0.000 abstract 1
150000003180 prostaglandins Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO19976085A 1996-12-26 1997-12-23 Fluor-holdig prostaglandinderivat, anvendelse derav samt medisiner inneholdende derivatet NO317060B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP34861496		1996-12-26
JP7405497		1997-03-26
JP17247797		1997-06-27

Publications (3)

Publication Number	Publication Date
NO976085D0 true NO976085D0 (no)	1997-12-23
NO976085L NO976085L (no)	1998-06-29
NO317060B1 NO317060B1 (no)	2004-08-02

Family

ID=27301396

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO19976085A NO317060B1 (no)	1996-12-26	1997-12-23	Fluor-holdig prostaglandinderivat, anvendelse derav samt medisiner inneholdende derivatet
NO2009006C NO2009006I2 (no)	1996-12-26	2009-03-06	isopropyl(5Z)-7{(1R, 2R, 3R, 5S)-2-[(IE)-3,3-difluor-4-fenoksybut-l-enyl]-3,5-dihydroksycyklopentyl}hept-5-enoat eller 16-fenoksy-15-deoksy-15,15-difluor-17,18,19,20-tetranorprostaglandin F2a isopropyl ester

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO2009006C NO2009006I2 (no)	1996-12-26	2009-03-06	isopropyl(5Z)-7{(1R, 2R, 3R, 5S)-2-[(IE)-3,3-difluor-4-fenoksybut-l-enyl]-3,5-dihydroksycyklopentyl}hept-5-enoat eller 16-fenoksy-15-deoksy-15,15-difluor-17,18,19,20-tetranorprostaglandin F2a isopropyl ester

Country Status (16)

Country	Link
US (2)	US5886035A (no)
EP (1)	EP0850926B1 (no)
JP (2)	JP3480549B2 (no)
KR (1)	KR100526282B1 (no)
CN (1)	CN1108289C (no)
AT (1)	ATE225770T1 (no)
CA (1)	CA2225761C (no)
DE (2)	DE122008000050I2 (no)
DK (1)	DK0850926T3 (no)
ES (1)	ES2187719T3 (no)
FR (1)	FR11C0020I2 (no)
LU (1)	LU91943I2 (no)
NL (1)	NL300407I2 (no)
NO (2)	NO317060B1 (no)
PT (1)	PT850926E (no)
TW (1)	TW536534B (no)

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EP0930296B2 (en) *	1996-09-17	2005-11-02	Asahi Glass Company Ltd.	Fluorinated prostaglandin derivatives and medicines
US6225348B1 (en)	1998-08-20	2001-05-01	Alfred W. Paulsen	Method of treating macular degeneration with a prostaglandin derivative
IL143477A (en)	2001-05-31	2009-07-20	Finetech Pharmaceutical Ltd	Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives
IL134241A (en)	2000-01-27	2006-06-11	Finetech Pharmaceutical Ltd	Process for the preparation of latanoprost
AU2001228836A1 (en) *	2000-01-28	2001-08-07	Santen Pharmaceutical Co., Ltd.	Novel difluoroprostaglandin derivative
PT1321144E (pt) *	2000-09-13	2011-03-10	Santen Pharmaceutical Co Ltd	Colírio
EP1532981B1 (en) *	2002-08-23	2007-09-26	Santen Pharmaceutical Co., Ltd.	Stable eye drops containing latanoprost as the active ingredient
CA2498233C (en) *	2002-09-09	2012-08-14	Santen Pharmaceutical Co., Ltd.	Clear ophthalmic solution comprising latanoprost as active ingredient
US20060199863A1 (en) *	2003-07-31	2006-09-07	Santen Pharmaceutical Co., Ltd.	Product containing prostaglandin
CN102497368A (zh) *	2003-12-08	2012-06-13	高通股份有限公司	具有改进链路同步的高数据速率接口
CA2590277C (en) *	2004-12-09	2014-07-08	Santen Pharmaceutical Co., Ltd.	Product containing prostaglandin having fluorine atom in its molecule
JP4753178B2 (ja) *	2004-12-24	2011-08-24	参天製薬株式会社	プロスタグランジンＦ２α誘導体含有製品
JP5100025B2 (ja) *	2005-03-31	2012-12-19	旭硝子株式会社	プロスタグランジンＦ２α誘導体を有効成分として含む網膜神経細胞保護剤
CN102293774A (zh) *	2005-03-31	2011-12-28	旭硝子株式会社	前列腺素F2α衍生物的应用
EP1870099A4 (en)	2005-04-13	2008-07-16	Ube Industries	PROTECTION AGAINST RETINAL NERVOUS CELLS WITH INDAZOLE DERIVATIVE AS ACTIVE SUBSTANCE
JP2009500315A (ja) *	2005-06-29	2009-01-08	ファイザー・インク	フルオロプロスタグランジンのニトロ誘導体
CA2637797C (en) *	2006-02-07	2015-03-17	R-Tech Ueno, Ltd.	Method for preparing prostaglandin derivative
WO2007111806A2 (en) *	2006-03-23	2007-10-04	Massachusetts Eye And Ear Infirmary	Cyclopentane heptanoic acid compounds for reducing body fat
FR2918891B1 (fr) *	2007-07-20	2009-09-25	Thea Sa Lab	Solution ophtalmique a base de prostaglandines sans conservateur
EP2127638A1 (en)	2008-05-30	2009-12-02	Santen Pharmaceutical Co., Ltd	Method and composition for treating ocular hypertension and glaucoma
WO2010027040A1 (ja) *	2008-09-04	2010-03-11	参天製薬株式会社	１５，１５－ジフルオロプロスタグランジンＦ2α誘導体を有効成分として含有する毛髪成長促進剤
US20110293549A1 (en)	2009-02-03	2011-12-01	Athena Cosmetics, Inc.	Composition, method and kit for enhancing hair
BR112013002584A2 (pt)	2010-08-02	2016-06-07	Pharma Patent Holding Inc	composição, processo de kit para aperfeiçoamento de cabelo
CA2824317C (en)	2011-01-19	2014-12-16	Terakine Therapeutics, Inc.	Uses of certain f-series prostaglandin analogs for treating diabetes and dyslipidemia
TW201906614A (zh)	2011-02-04	2019-02-16	日商興和股份有限公司	青光眼或高眼壓症之預防或治療用之點眼藥
US8426471B1 (en)	2011-12-19	2013-04-23	Topokine Therapeutics, Inc.	Methods and compositions for reducing body fat and adipocytes
US20150011755A1 (en) *	2012-02-07	2015-01-08	Dr. Reddys Laboratories Limited	Amine salts of prostaglandin analogs
WO2013180229A1 (ja)	2012-05-30	2013-12-05	旭硝子株式会社	育毛用組成物
SG11201600237YA (en)	2012-11-21	2016-02-26	Topokine Therapeutics Inc	Methods and compositions for locally increasing body fat
NO2753788T3 (no)	2013-05-10	2018-06-16
US9820993B2 (en)	2013-05-15	2017-11-21	Topokine Therapeutics, Inc.	Methods and compositions for topical delivery of prostaglandins to subcutaneous fat
CN103570549B (zh) *	2013-10-11	2016-01-27	天泽恩源（天津）制药有限公司	一种合成他氟前列素的方法
CN103804195B (zh) *	2014-01-26	2016-06-15	天泽恩源（天津）制药有限公司	一种合成他氟前列素的方法
CN103819436A (zh) *	2014-02-21	2014-05-28	天泽恩源（天津）医药技术有限公司	(3aR,4R,5R,6aS)-4-((E)-3,3-二氟-4-苯氧基丁-1-烯-1-基)-2-氧代六氢-2H-环戊烷[b]呋喃-5-基苯甲酸酯的一种晶型及相应晶体的制备方法
WO2015200425A1 (en)	2014-06-27	2015-12-30	Topokine Therapeutics, Inc.	Topical dosage regimen
KR20160116402A (ko)	2015-03-30	2016-10-10	연성정밀화학(주)	타플루프로스트의 제조방법
KR20180058758A (ko)	2015-09-22	2018-06-01	그레이버그 비젼, 인크.	안구 장애의 치료를 위한 화합물 및 조성물
CN107226790A (zh) *	2016-03-25	2017-10-03	苏州朗科生物技术有限公司	一种高纯度他氟前列素及其类似化合物的制备方法及中间体化合物
GR1009040B (el)	2016-04-19	2017-05-19	Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων	Φαρμακευτικο οφθαλμικο σκευασμα ελευθερο συντηρητικου
WO2018033854A1 (en)	2016-08-15	2018-02-22	Santen Pharmaceutical Co., Ltd.	Ophthalmic composition and a method for treating ocular hypertension and glaucoma
CN108299192A (zh) *	2017-01-10	2018-07-20	江苏恒瑞医药股份有限公司	一种他氟前列素酸的金属盐化合物结晶形式及其制备方法
CN106986766B (zh) *	2017-05-08	2021-01-12	扬子江药业集团有限公司	他氟前列素的制备方法
CN112457277B (zh) *	2020-12-16	2022-06-28	西安国康瑞金制药有限公司	一种他氟前列腺素的制备方法
CN112832150B (zh) *	2021-01-27	2022-06-24	中交第三公路工程局有限公司	一种涵洞通道等立面垂直凿毛装置
CN112851510B (zh) *	2021-01-27	2022-07-19	Ａｇｃ株式会社	他氟前列素的纯化方法
CN116120268A (zh) *	2023-03-06	2023-05-16	南京华威医药科技集团有限公司	一种他氟前列素中间体杂质及其制备方法
CN116425707A (zh) *	2023-03-31	2023-07-14	南京华威医药科技集团有限公司	一种他氟前列素中间体异构体杂质及其制备方法
CN117024324A (zh) *	2023-08-03	2023-11-10	南京华威医药科技集团有限公司	一种他氟前列素对映异构体的制备方法

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EP0930296B2 (en) *	1996-09-17	2005-11-02	Asahi Glass Company Ltd.	Fluorinated prostaglandin derivatives and medicines
CA2269855A1 (en) *	1996-11-12	1998-05-22	Alcon Laboratories, Inc.	15-fluoro prostaglandins as ocular hypotensives

1997
- 1997-12-12 JP JP34334397A patent/JP3480549B2/ja not_active Expired - Lifetime
- 1997-12-17 TW TW086119094A patent/TW536534B/zh not_active IP Right Cessation
- 1997-12-18 US US08/993,017 patent/US5886035A/en not_active Expired - Lifetime
- 1997-12-22 DE DE122008000050C patent/DE122008000050I2/de active Active
- 1997-12-22 ES ES97122702T patent/ES2187719T3/es not_active Expired - Lifetime
- 1997-12-22 AT AT97122702T patent/ATE225770T1/de active
- 1997-12-22 DE DE69716226T patent/DE69716226T2/de not_active Expired - Lifetime
- 1997-12-22 PT PT97122702T patent/PT850926E/pt unknown
- 1997-12-22 EP EP97122702A patent/EP0850926B1/en not_active Expired - Lifetime
- 1997-12-22 DK DK97122702T patent/DK0850926T3/da active
- 1997-12-23 NO NO19976085A patent/NO317060B1/no not_active IP Right Cessation
- 1997-12-23 CA CA002225761A patent/CA2225761C/en not_active Expired - Lifetime
- 1997-12-26 CN CN97126331A patent/CN1108289C/zh not_active Expired - Lifetime
- 1997-12-26 KR KR1019970074620A patent/KR100526282B1/ko not_active Expired - Lifetime
1998
- 1998-08-03 US US09/127,804 patent/US5985920A/en not_active Expired - Lifetime
2003
- 2003-07-31 JP JP2003284134A patent/JP3994074B2/ja not_active Expired - Lifetime
2009
- 2009-03-06 NO NO2009006C patent/NO2009006I2/no not_active IP Right Cessation
- 2009-09-02 NL NL300407C patent/NL300407I2/nl unknown
2011
- 2011-06-21 FR FR11C0020C patent/FR11C0020I2/fr active Active
2012
- 2012-02-15 LU LU91943C patent/LU91943I2/fr unknown

Also Published As

Publication number	Publication date
LU91943I2 (fr)	2012-04-16
FR11C0020I1 (no)	2011-07-29
PT850926E (pt)	2003-02-28
ES2187719T3 (es)	2003-06-16
TW536534B (en)	2003-06-11
NL300407I2 (nl)	2010-03-01
NO2009006I1 (no)	2009-03-16
FR11C0020I2 (fr)	2012-03-16
JP3480549B2 (ja)	2003-12-22
US5985920A (en)	1999-11-16
DE122008000050I2 (de)	2011-06-16
EP0850926A2 (en)	1998-07-01
DE69716226D1 (de)	2002-11-14
NO976085L (no)	1998-06-29
NL300407I1 (nl)	2009-11-02
EP0850926B1 (en)	2002-10-09
KR100526282B1 (ko)	2006-05-17
JP3994074B2 (ja)	2007-10-17
NO317060B1 (no)	2004-08-02
CN1187486A (zh)	1998-07-15
CA2225761C (en)	2009-04-21
DE122008000050I1 (de)	2009-01-29
NO2009006I2 (no)	2012-03-05
CN1108289C (zh)	2003-05-14
US5886035A (en)	1999-03-23
DE69716226T2 (de)	2003-06-05
EP0850926A3 (en)	1999-06-16
JP2004002462A (ja)	2004-01-08
CA2225761A1 (en)	1998-06-26
ATE225770T1 (de)	2002-10-15
KR19980064718A (ko)	1998-10-07
DK0850926T3 (da)	2003-02-17
JPH1171344A (ja)	1999-03-16

Legal Events

Date

Code

Title

Description

2012-03-05

SPCG

Granted supplementary protection certificate

Free format text: PRODUCT NAME: TAFLOTAN OEYEDRAPER; NAT. REG. NO/DATE: 07-4894 20081009; FIRST REG. NO/DATE: DK , 43230 20080430

Spc suppl protection certif: 2009006

Filing date: 20090306

Extension date: 20221223

2018-01-08

MK1K

Patent expired

2018-10-01

SPCS

Change of name or address of the owner of a supplementary protection certificate

Owner name: SANTEN PHARMACEUTICAL CO LTD, JP