ATE92066T1 - Sulfonyldecahydro-8h-isochino(2,1g>(1,6>naphthyridine, optische isomere davon und verwandte verbindungen. - Google Patents

Sulfonyldecahydro-8h-isochino(2,1g>(1,6>naphthyridine, optische isomere davon und verwandte verbindungen.

Info

Publication number: ATE92066T1
Authority: AT; Austria
Prior art keywords: lower alkyl; sulfonyldecahydro; isochino; naphthyridine; optical isomers
Prior art date: 1987-04-13

Application number

AT88303271T

Other languages

English (en)

Inventor

Robin D Clark

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-13

Filing date

1988-04-12

Publication date

1993-08-15

1988-04-12 Application filed by Syntex Inc filed Critical Syntex Inc

1993-08-15 Application granted granted Critical

1993-08-15 Publication of ATE92066T1 publication Critical patent/ATE92066T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Obesity (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Child & Adolescent Psychology (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Anesthesiology (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Compounds Of Unknown Constitution (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT88303271T 1987-04-13 1988-04-12 Sulfonyldecahydro-8h-isochino(2,1g>(1,6>naphthyridine, optische isomere davon und verwandte verbindungen. ATE92066T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/037,320 US4791108A (en)	1987-04-13	1987-04-13	Sulfonyl-decahydro-8H-isoquino[2,1-G][1,6]-naphthyridines and related compounds useful as α2 -blockers
EP88303271A EP0288196B1 (de)	1987-04-13	1988-04-12	Sulfonyldecahydro-8H-isochino[2,1-g][1,6]naphthyridine, optische Isomere davon und verwandte Verbindungen

Publications (1)

Publication Number	Publication Date
ATE92066T1 true ATE92066T1 (de)	1993-08-15

Family

ID=21893706

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88303271T ATE92066T1 (de)	1987-04-13	1988-04-12	Sulfonyldecahydro-8h-isochino(2,1g>(1,6>naphthyridine, optische isomere davon und verwandte verbindungen.

Country Status (20)

Country	Link
US (1)	US4791108A (de)
EP (1)	EP0288196B1 (de)
JP (1)	JP2527784B2 (de)
KR (1)	KR960007864B1 (de)
AT (1)	ATE92066T1 (de)
AU (1)	AU613610B2 (de)
CA (1)	CA1331459C (de)
DE (1)	DE3882571T2 (de)
DK (2)	DK171106B1 (de)
ES (1)	ES2058264T3 (de)
FI (1)	FI88162C (de)
HU (2)	HU199469B (de)
IE (1)	IE60624B1 (de)
IL (1)	IL86039A (de)
MX (1)	MX11083A (de)
NO (1)	NO170805C (de)
NZ (1)	NZ224221A (de)
PH (1)	PH25961A (de)
PT (1)	PT87219B (de)
ZA (1)	ZA882562B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4960891A (en) *	1987-04-13	1990-10-02	Syntex (U.S.A.) Inc.	Process for the preparation of decahydro-8H-isoquino[2,1-g][1,6]naphthyridine derivatives
US4886798A (en) *	1987-04-13	1989-12-12	Syntex (U.S.A.) Inc.	Optical isomers of sulfonyldecahydro-8H-isoquino-(2,1-G)(1,6) naphthyridines and related compounds useful as α2 -blockers
US4956365A (en) *	1987-04-13	1990-09-11	Syntex (U.S.A.) Inc.	Decahydro-8H-isoquino(2,1-g)(1,6)naphthyridine derivatives and related compounds
GB9012469D0 (en) *	1990-06-05	1990-07-25	Glaxo Group Ltd	Medicaments
US5231181A (en) *	1991-03-21	1993-07-27	Syntex (U.S.A.) Inc.	Process for the preparation of (8as,12as,13as)-decahydroisoquino ((2,1-g) (1,6)-naphthyridin-8-one derivatives
AU655998B2 (en) *	1991-07-17	1995-01-19	Syntex (U.S.A.) Inc.	Decahydro-8H-isoquino(2,1-g) (1,6) naphthyridine and decahydrobenzo(a) pyrrolo(2,3-e) quinolizine derivatives
US5229387A (en) *	1991-09-20	1993-07-20	Syntex (U.S.A.) Inc.	Decahydro-8H-isoquino[2,1-g][1,6]naphthyridine and decahydrobenzo[a]pyrrolo [2,3-e]quinolizine derivatives
WO2003074469A1 (de) *	2002-03-04	2003-09-12	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue zimtsäuresalze, verfahren zu deren herstellung und deren verwendung als arzneimittel
CN103387583B (zh) *	2012-05-09	2018-04-13	中国科学院上海药物研究所	二芳基并[a,g]喹嗪类化合物、其制备方法、药物组合物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3953598A (en) *	1972-09-08	1976-04-27	The Upjohn Company	Compounds, compositions and methods of use
GB1513824A (en) *	1975-05-22	1978-06-14	Wyeth John & Brother Ltd	1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative
US4353911A (en) *	1979-07-20	1982-10-12	Andre Buzas	Indolo(2,3-a)quinolizidines, useful in increasing femoral and vertebral blood flow
CH645653A5 (de) *	1980-08-01	1984-10-15	Ciba Geigy Ag	Quaternaere, copolymere, hochmolekulare ammoniumsalze auf acrylbasis, deren herstellung und verwendung als aktive komponente in kosmetischen mitteln.
US4454139A (en) *	1980-08-28	1984-06-12	John Wyeth & Brother, Limited	α2 -Adrenoceptor antagonistic benzoquinolizines
GB8302499D0 (en) *	1983-01-29	1983-03-02	Wyeth John & Brother Ltd	Benzoquinolizines
US4690928A (en) *	1984-02-02	1987-09-01	Merck & Co., Inc.	Substituted hexahydro arylquinolizines as α2 blockers
US4673680A (en) *	1985-09-18	1987-06-16	Pendleton Robert G	α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility

1987
- 1987-04-13 US US07/037,320 patent/US4791108A/en not_active Expired - Fee Related
1988
- 1988-04-12 AU AU14502/88A patent/AU613610B2/en not_active Ceased
- 1988-04-12 ES ES88303271T patent/ES2058264T3/es not_active Expired - Lifetime
- 1988-04-12 PH PH36784A patent/PH25961A/en unknown
- 1988-04-12 IE IE109788A patent/IE60624B1/en not_active IP Right Cessation
- 1988-04-12 PT PT87219A patent/PT87219B/pt not_active IP Right Cessation
- 1988-04-12 HU HU881816A patent/HU199469B/hu not_active IP Right Cessation
- 1988-04-12 IL IL86039A patent/IL86039A/xx not_active IP Right Cessation
- 1988-04-12 NO NO881574A patent/NO170805C/no unknown
- 1988-04-12 AT AT88303271T patent/ATE92066T1/de not_active IP Right Cessation
- 1988-04-12 DK DK199388A patent/DK171106B1/da not_active IP Right Cessation
- 1988-04-12 NZ NZ224221A patent/NZ224221A/xx unknown
- 1988-04-12 KR KR1019880004144A patent/KR960007864B1/ko not_active Expired - Fee Related
- 1988-04-12 ZA ZA882562A patent/ZA882562B/xx unknown
- 1988-04-12 CA CA000563919A patent/CA1331459C/en not_active Expired - Fee Related
- 1988-04-12 MX MX1108388A patent/MX11083A/es unknown
- 1988-04-12 JP JP63090154A patent/JP2527784B2/ja not_active Expired - Lifetime
- 1988-04-12 DE DE88303271T patent/DE3882571T2/de not_active Expired - Fee Related
- 1988-04-12 FI FI881687A patent/FI88162C/fi not_active IP Right Cessation
- 1988-04-12 EP EP88303271A patent/EP0288196B1/de not_active Expired - Lifetime
1993
- 1993-07-15 DK DK084693A patent/DK84693A/da not_active Application Discontinuation
1994
- 1994-07-01 HU HU94P/P00005P patent/HU210349A9/hu unknown

Also Published As

Publication number	Publication date
IE60624B1 (en)	1994-07-27
DK199388D0 (da)	1988-04-12
PH25961A (en)	1992-01-13
US4791108A (en)	1988-12-13
NO881574D0 (no)	1988-04-12
PT87219B (pt)	1992-12-31
EP0288196B1 (de)	1993-07-28
FI881687A7 (fi)	1988-10-14
DK84693D0 (da)	1993-07-15
HUT47107A (en)	1989-01-30
JP2527784B2 (ja)	1996-08-28
DK171106B1 (da)	1996-06-10
KR960007864B1 (ko)	1996-06-13
FI88162C (fi)	1993-04-13
IL86039A (en)	1993-05-13
FI881687A0 (fi)	1988-04-12
DE3882571D1 (de)	1993-09-02
DE3882571T2 (de)	1994-01-20
AU1450288A (en)	1988-10-13
NO170805B (no)	1992-08-31
ZA882562B (en)	1989-12-27
IL86039A0 (en)	1988-09-30
MX11083A (es)	1993-04-01
ES2058264T3 (es)	1994-11-01
EP0288196A1 (de)	1988-10-26
NO881574L (no)	1988-10-14
NO170805C (no)	1992-12-09
PT87219A (pt)	1988-05-01
CA1331459C (en)	1994-08-16
JPS63277679A (ja)	1988-11-15
HU199469B (en)	1990-02-28
KR880012601A (ko)	1988-11-28
IE881097L (en)	1988-10-13
DK199388A (da)	1988-10-14
NZ224221A (en)	1990-07-26
AU613610B2 (en)	1991-08-08
HU210349A9 (en)	1995-03-28
FI88162B (fi)	1992-12-31
DK84693A (da)	1993-07-15

Legal Events

Date	Code	Title	Description
1994-03-15	UEP	Publication of translation of european patent specification
1998-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE214393T1 (de)	2002-03-15	Bis(3,4-dialkylbenzyliden)sorbitolacetale und diese enthaltende zusammensetzungen
FI102965B1 (fi)	1999-03-31	Kondensoituneet heterosykliset yhdisteet, niiden valmistus ja käyttö
NO895273D0 (no)	1989-12-27	Plantebeskyttende forbindelser, deres fremstilling og anvendelse.
NO1999015I1 (no)	1999-07-08	Imiquimod
ATE93232T1 (de)	1993-09-15	Bis(methylendioxy)biphenyl-verbindungen.
DE3882571D1 (de)	1993-09-02	Sulfonyldecahydro-8h-isochino(2,1-g)(1,6)naphthyridine, optische isomere davon und verwandte verbindungen.
GR3002051T3 (en)	1992-12-30	3-oxadiazolyl and 3-carboxylic-acid beta-carboline derivatives, their preparation and their use as medicaments
GR3007460T3 (de)	1993-07-30
FI862909A0 (fi)	1986-07-10	Foerfarande foer framstaellning av nya indolkarboxamidderivat och deras salter.
ES2065994T3 (es)	1995-03-01	Beta-dicetonas substituidas.
NO875357L (no)	1988-06-23	Kjemiske sammensetninger og deres bruk som brennstoffadditiver.
GR3020488T3 (en)	1996-10-31	Benzo(b)thiophene-2-carboxamides for the treatment of disorders of the central nervous system
SE8901060D0 (sv)	1989-03-28	New compounds
DE69005318D1 (de)	1994-02-03	1,8-Benzonaphthyridinderivate, ihre Herstellung und diese enthaltende Zusammensetzungen.
DK0481742T3 (da)	1997-12-29	Piperazinderivater
GR3008034T3 (de)	1993-09-30
FI883507A0 (fi)	1988-07-26	Naftotiazepinderivat och deras framstaellning.
SE8701524D0 (sv)	1987-04-10	Nya sulfonamider och deras framstellningsforfarande
DE3160719D1 (en)	1983-09-08	Benzothiopyrano(2,3-c) pyridines and their acid addition salts, their preparation, their use as medicaments and compositions containing them