DK84693A - Tetracycliske forbindelser - Google Patents

Tetracycliske forbindelser

Info

Publication number: DK84693A
Authority: DK; Denmark
Prior art keywords: lower alkyl; chem; formula; independently hydrogen; alpha
Prior art date: 1987-04-13

Application number

DK084693A

Other languages

English (en)

Other versions

DK84693D0 (da

Inventor

Robin D Clark

Original Assignee

Syntax Usa Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-13

Filing date

1993-07-15

Publication date

1993-07-15

1993-07-15 Application filed by Syntax Usa Inc filed Critical Syntax Usa Inc

1993-07-15 Publication of DK84693D0 publication Critical patent/DK84693D0/da

1993-07-15 Publication of DK84693A publication Critical patent/DK84693A/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
-1 methylenedioxy Chemical group 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Obesity (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Child & Adolescent Psychology (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Anesthesiology (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Compounds Of Unknown Constitution (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK084693A 1987-04-13 1993-07-15 Tetracycliske forbindelser DK84693A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/037,320 US4791108A (en)	1987-04-13	1987-04-13	Sulfonyl-decahydro-8H-isoquino[2,1-G][1,6]-naphthyridines and related compounds useful as α2 -blockers

Publications (2)

Publication Number	Publication Date
DK84693D0 DK84693D0 (da)	1993-07-15
DK84693A true DK84693A (da)	1993-07-15

Family

ID=21893706

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK199388A DK171106B1 (da)	1987-04-13	1988-04-12	Sulfonyldecahydro-8H-isoquino-[2,1-g][1,6]-naphthyridiner, anvendelse af disse forbindelser ved fremstilling af et medikament, fremgangsmåde til fremstilling af disse forbindelser, farmaceutisk præparat indeholdende disse forbindelser og farmaceutisk præparat til brug ved behandling af en alfa2-blokker, samt fremgangsmåde til fremstilling af et farmaceutisk præparat
DK084693A DK84693A (da)	1987-04-13	1993-07-15	Tetracycliske forbindelser

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK199388A DK171106B1 (da)	1987-04-13	1988-04-12	Sulfonyldecahydro-8H-isoquino-[2,1-g][1,6]-naphthyridiner, anvendelse af disse forbindelser ved fremstilling af et medikament, fremgangsmåde til fremstilling af disse forbindelser, farmaceutisk præparat indeholdende disse forbindelser og farmaceutisk præparat til brug ved behandling af en alfa2-blokker, samt fremgangsmåde til fremstilling af et farmaceutisk præparat

Country Status (20)

Country	Link
US (1)	US4791108A (da)
EP (1)	EP0288196B1 (da)
JP (1)	JP2527784B2 (da)
KR (1)	KR960007864B1 (da)
AT (1)	ATE92066T1 (da)
AU (1)	AU613610B2 (da)
CA (1)	CA1331459C (da)
DE (1)	DE3882571T2 (da)
DK (2)	DK171106B1 (da)
ES (1)	ES2058264T3 (da)
FI (1)	FI88162C (da)
HU (2)	HU199469B (da)
IE (1)	IE60624B1 (da)
IL (1)	IL86039A (da)
MX (1)	MX11083A (da)
NO (1)	NO170805C (da)
NZ (1)	NZ224221A (da)
PH (1)	PH25961A (da)
PT (1)	PT87219B (da)
ZA (1)	ZA882562B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4960891A (en) *	1987-04-13	1990-10-02	Syntex (U.S.A.) Inc.	Process for the preparation of decahydro-8H-isoquino[2,1-g][1,6]naphthyridine derivatives
US4886798A (en) *	1987-04-13	1989-12-12	Syntex (U.S.A.) Inc.	Optical isomers of sulfonyldecahydro-8H-isoquino-(2,1-G)(1,6) naphthyridines and related compounds useful as α2 -blockers
US4956365A (en) *	1987-04-13	1990-09-11	Syntex (U.S.A.) Inc.	Decahydro-8H-isoquino(2,1-g)(1,6)naphthyridine derivatives and related compounds
GB9012469D0 (en) *	1990-06-05	1990-07-25	Glaxo Group Ltd	Medicaments
US5231181A (en) *	1991-03-21	1993-07-27	Syntex (U.S.A.) Inc.	Process for the preparation of (8as,12as,13as)-decahydroisoquino ((2,1-g) (1,6)-naphthyridin-8-one derivatives
AU655998B2 (en) *	1991-07-17	1995-01-19	Syntex (U.S.A.) Inc.	Decahydro-8H-isoquino(2,1-g) (1,6) naphthyridine and decahydrobenzo(a) pyrrolo(2,3-e) quinolizine derivatives
US5229387A (en) *	1991-09-20	1993-07-20	Syntex (U.S.A.) Inc.	Decahydro-8H-isoquino[2,1-g][1,6]naphthyridine and decahydrobenzo[a]pyrrolo [2,3-e]quinolizine derivatives
WO2003074469A1 (de) *	2002-03-04	2003-09-12	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue zimtsäuresalze, verfahren zu deren herstellung und deren verwendung als arzneimittel
CN103387583B (zh) *	2012-05-09	2018-04-13	中国科学院上海药物研究所	二芳基并[a,g]喹嗪类化合物、其制备方法、药物组合物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3953598A (en) *	1972-09-08	1976-04-27	The Upjohn Company	Compounds, compositions and methods of use
GB1513824A (en) *	1975-05-22	1978-06-14	Wyeth John & Brother Ltd	1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative
US4353911A (en) *	1979-07-20	1982-10-12	Andre Buzas	Indolo(2,3-a)quinolizidines, useful in increasing femoral and vertebral blood flow
CH645653A5 (de) *	1980-08-01	1984-10-15	Ciba Geigy Ag	Quaternaere, copolymere, hochmolekulare ammoniumsalze auf acrylbasis, deren herstellung und verwendung als aktive komponente in kosmetischen mitteln.
US4454139A (en) *	1980-08-28	1984-06-12	John Wyeth & Brother, Limited	α2 -Adrenoceptor antagonistic benzoquinolizines
GB8302499D0 (en) *	1983-01-29	1983-03-02	Wyeth John & Brother Ltd	Benzoquinolizines
US4690928A (en) *	1984-02-02	1987-09-01	Merck & Co., Inc.	Substituted hexahydro arylquinolizines as α2 blockers
US4673680A (en) *	1985-09-18	1987-06-16	Pendleton Robert G	α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility

1987
- 1987-04-13 US US07/037,320 patent/US4791108A/en not_active Expired - Fee Related
1988
- 1988-04-12 AU AU14502/88A patent/AU613610B2/en not_active Ceased
- 1988-04-12 ES ES88303271T patent/ES2058264T3/es not_active Expired - Lifetime
- 1988-04-12 PH PH36784A patent/PH25961A/en unknown
- 1988-04-12 IE IE109788A patent/IE60624B1/en not_active IP Right Cessation
- 1988-04-12 PT PT87219A patent/PT87219B/pt not_active IP Right Cessation
- 1988-04-12 HU HU881816A patent/HU199469B/hu not_active IP Right Cessation
- 1988-04-12 IL IL86039A patent/IL86039A/xx not_active IP Right Cessation
- 1988-04-12 NO NO881574A patent/NO170805C/no unknown
- 1988-04-12 AT AT88303271T patent/ATE92066T1/de not_active IP Right Cessation
- 1988-04-12 DK DK199388A patent/DK171106B1/da not_active IP Right Cessation
- 1988-04-12 NZ NZ224221A patent/NZ224221A/xx unknown
- 1988-04-12 KR KR1019880004144A patent/KR960007864B1/ko not_active Expired - Fee Related
- 1988-04-12 ZA ZA882562A patent/ZA882562B/xx unknown
- 1988-04-12 CA CA000563919A patent/CA1331459C/en not_active Expired - Fee Related
- 1988-04-12 MX MX1108388A patent/MX11083A/es unknown
- 1988-04-12 JP JP63090154A patent/JP2527784B2/ja not_active Expired - Lifetime
- 1988-04-12 DE DE88303271T patent/DE3882571T2/de not_active Expired - Fee Related
- 1988-04-12 FI FI881687A patent/FI88162C/fi not_active IP Right Cessation
- 1988-04-12 EP EP88303271A patent/EP0288196B1/en not_active Expired - Lifetime
1993
- 1993-07-15 DK DK084693A patent/DK84693A/da not_active Application Discontinuation
1994
- 1994-07-01 HU HU94P/P00005P patent/HU210349A9/hu unknown

Also Published As

Publication number	Publication date
IE60624B1 (en)	1994-07-27
DK199388D0 (da)	1988-04-12
PH25961A (en)	1992-01-13
US4791108A (en)	1988-12-13
NO881574D0 (no)	1988-04-12
PT87219B (pt)	1992-12-31
EP0288196B1 (en)	1993-07-28
FI881687A7 (fi)	1988-10-14
DK84693D0 (da)	1993-07-15
HUT47107A (en)	1989-01-30
JP2527784B2 (ja)	1996-08-28
DK171106B1 (da)	1996-06-10
KR960007864B1 (ko)	1996-06-13
FI88162C (fi)	1993-04-13
IL86039A (en)	1993-05-13
FI881687A0 (fi)	1988-04-12
ATE92066T1 (de)	1993-08-15
DE3882571D1 (de)	1993-09-02
DE3882571T2 (de)	1994-01-20
AU1450288A (en)	1988-10-13
NO170805B (no)	1992-08-31
ZA882562B (en)	1989-12-27
IL86039A0 (en)	1988-09-30
MX11083A (es)	1993-04-01
ES2058264T3 (es)	1994-11-01
EP0288196A1 (en)	1988-10-26
NO881574L (no)	1988-10-14
NO170805C (no)	1992-12-09
PT87219A (pt)	1988-05-01
CA1331459C (en)	1994-08-16
JPS63277679A (ja)	1988-11-15
HU199469B (en)	1990-02-28
KR880012601A (ko)	1988-11-28
IE881097L (en)	1988-10-13
DK199388A (da)	1988-10-14
NZ224221A (en)	1990-07-26
AU613610B2 (en)	1991-08-08
HU210349A9 (en)	1995-03-28
FI88162B (fi)	1992-12-31

Legal Events

Date	Code	Title	Description
1993-07-15	A0	Application filed
1997-12-22	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
IL69912A0 (en)	1984-01-31	Substituted 1-hydroxyethyl-triazolyl derivatives,their preparation and their use as plant protection agents
ATE61374T1 (de)	1991-03-15	Diaminoandrostanderivate.
ATE93232T1 (de)	1993-09-15	Bis(methylendioxy)biphenyl-verbindungen.
DK84693D0 (da)	1993-07-15	Tetracycliske forbindelser
FI834730A0 (fi)	1983-12-22	1-karboxialkanoylperhydro-indol-2-karboxylsyror och deras derivat
EP0288969A3 (en)	1990-05-23	Antiulcer composition
ZA858418B (en)	1986-07-30	5-alkyl-1-phenyl-2-piperazinoalkylpyrazoline-3-one compounds and methods for the preparation thereof,intermediates for use in the preparation of said compounds and medicaments containing said compounds
PH23489A (en)	1989-08-16	Novel (4.2.0) bicyclooctane derivatives with valuable therapeutic properties
MX9204194A (es)	1993-08-01	Los compuestos de 1,2,4-oxadiazolil-fenoxialquilisoxazolas y su uso como agentes antivirales
ATE98961T1 (de)	1994-01-15	1,8-benzonaphthyridinderivate und ihre herstellung.
ATE115572T1 (de)	1994-12-15	N-2-chlorbenzyl-2-oxo- und n-2-chlorbenzyl-2,2,- dioxo-1,2,3-oxathiazolidinderivate, ihre herstellung und ihre verwendung in der synthese von thieno(3,2-c>pyridinderivaten.
DE69005318D1 (de)	1994-02-03	1,8-Benzonaphthyridinderivate, ihre Herstellung und diese enthaltende Zusammensetzungen.
GR3020488T3 (en)	1996-10-31	Benzo(b)thiophene-2-carboxamides for the treatment of disorders of the central nervous system
EP0364254A3 (en)	1991-08-14	Decahydro-8H-isoquino[2,1-g][1,6]naphthyridine derivatives and related compounds
FI883507A0 (fi)	1988-07-26	Naftotiazepinderivat och deras framstaellning.
GB2071093B (en)	1984-01-18	Benzothiopyrano(2,3-c)pyridines
ES2015297B3 (es)	1990-08-16	Herbicidas de fenilurea.
IL66333A0 (en)	1982-11-30	Substituted phenyl-cyclopropane-carboxylic acid esters,their preparation and their use as pesticides