ATE92323T1 - Verwendung eines thromboxan-a2-rezeptorantagonist zur herstellung eines arzeneimittels zur behandlung pulmonarer hypertonie, die durch protamin-induzierte neutralisation von heparin verursacht wird. - Google Patents

Verwendung eines thromboxan-a2-rezeptorantagonist zur herstellung eines arzeneimittels zur behandlung pulmonarer hypertonie, die durch protamin-induzierte neutralisation von heparin verursacht wird.

Info

Publication number: ATE92323T1
Authority: AT; Austria
Prior art keywords: protamine; heparin; receptor antagonist; pulmonary hypertension; thromboxan
Prior art date: 1988-04-11

Application number

AT89303511T

Other languages

English (en)

Inventor

Martin L Ogletree

Gary J Grover

William A Schumacher

Lawrence T Friedhoff

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-11

Filing date

1989-04-10

Publication date

1993-08-15

1989-04-10 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1993-08-15 Application granted granted Critical

1993-08-15 Publication of ATE92323T1 publication Critical patent/ATE92323T1/de

Links

HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 2
229960002897 heparin Drugs 0.000 title abstract 2
229920000669 heparin Polymers 0.000 title abstract 2
208000002815 pulmonary hypertension Diseases 0.000 title abstract 2
239000000670 adrenergic alpha-2 receptor antagonist Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000006386 neutralization reaction Methods 0.000 title 1
206010067484 Adverse reaction Diseases 0.000 abstract 1
102000007327 Protamines Human genes 0.000 abstract 1
108010007568 Protamines Proteins 0.000 abstract 1
229940123987 Thromboxane A2 receptor antagonist Drugs 0.000 abstract 1
230000006838 adverse reaction Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229940048914 protamine Drugs 0.000 abstract 1
239000003769 thromboxane A2 receptor blocking agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)

AT89303511T 1988-04-11 1989-04-10 Verwendung eines thromboxan-a2-rezeptorantagonist zur herstellung eines arzeneimittels zur behandlung pulmonarer hypertonie, die durch protamin-induzierte neutralisation von heparin verursacht wird. ATE92323T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/179,694 US5066480A (en)	1988-04-11	1988-04-11	Method of preventing or reducing adverse reactions to protamine using a thromboxane a2 receptor antagonist
EP89303511A EP0337697B1 (de)	1988-04-11	1989-04-10	Verwendung eines Thromboxan-A2-Rezeptorantagonist zur Herstellung eines Arzeneimittels zur Behandlung pulmonarer Hypertonie, die durch Protamin-induzierte Neutralisation von Heparin verursacht wird.

Publications (1)

Publication Number	Publication Date
ATE92323T1 true ATE92323T1 (de)	1993-08-15

Family

ID=22657593

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89303511T ATE92323T1 (de)	1988-04-11	1989-04-10	Verwendung eines thromboxan-a2-rezeptorantagonist zur herstellung eines arzeneimittels zur behandlung pulmonarer hypertonie, die durch protamin-induzierte neutralisation von heparin verursacht wird.

Country Status (12)

Country	Link
US (1)	US5066480A (de)
EP (1)	EP0337697B1 (de)
JP (1)	JPH0296537A (de)
AT (1)	ATE92323T1 (de)
AU (1)	AU624370B2 (de)
CA (1)	CA1336953C (de)
DE (1)	DE68907976T2 (de)
DK (1)	DK170989A (de)
HU (1)	HU206261B (de)
IE (1)	IE63735B1 (de)
NZ (1)	NZ228491A (de)
ZA (1)	ZA892412B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH07507769A (ja) *	1992-03-20	1995-08-31	コアー・セラピュティックス・インコーポレーテッド	Ｘ因子のグリコシル化媒介による阻害
US7356737B2 (en) *	2004-10-29	2008-04-08	International Business Machines Corporation	System, method and storage medium for testing a memory module
AU2015258805B2 (en)	2014-05-16	2018-05-10	Cumberland Pharmaceuticals, Inc.	Compositions and methods of treating cardiac fibrosis with ifetroban
US12161632B2 (en)	2014-05-16	2024-12-10	Cumberland Pharmaceuticals Inc.	Compositions and methods of treating cardiac fibrosis with ifetroban
JP7033454B2 (ja)	2015-06-30	2022-03-10	カンバーランドファーマシューティカルズ，インコーポレーテッド	Ａｅｒｄ／喘息におけるトロンボキサン受容体拮抗薬
CN115624549A (zh)	2016-05-11	2023-01-20	坎伯兰医药品股份有限公司	用血栓烷-a2受体拮抗剂治疗肌营养不良的组合物和方法
KR102687556B1 (ko)	2017-11-29	2024-07-22	반더빌트유니버시티	종양 전이를 억제하는 방법
US11494695B2 (en)	2019-09-27	2022-11-08	Google Llc	Training neural networks to generate structured embeddings

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2809377A1 (de) *	1978-03-04	1979-09-13	Boehringer Mannheim Gmbh	Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3000377A1 (de) *	1980-01-07	1981-07-09	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
ZA827529B (en) *	1981-11-09	1983-09-28	Squibb & Sons Inc	7-oxabicycloheptane and 7-oxabicycloheptene compounds
US4416896A (en) *	1982-05-17	1983-11-22	E. R. Squibb & Sons, Inc.	7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease
EP0153858A3 (de) *	1984-02-29	1985-12-11	The Upjohn Company	Therapeutische Anwendung von Protaglandinen
US4663336A (en) *	1985-07-01	1987-05-05	E. R. Squibb & Sons, Inc.	7-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the treatment of thrombotic disease

1988
- 1988-04-11 US US07/179,694 patent/US5066480A/en not_active Expired - Lifetime
1989
- 1989-03-29 NZ NZ228491A patent/NZ228491A/en unknown
- 1989-03-31 ZA ZA892412A patent/ZA892412B/xx unknown
- 1989-04-04 IE IE106189A patent/IE63735B1/en not_active IP Right Cessation
- 1989-04-10 DE DE89303511T patent/DE68907976T2/de not_active Expired - Fee Related
- 1989-04-10 DK DK170989A patent/DK170989A/da not_active Application Discontinuation
- 1989-04-10 HU HU891710A patent/HU206261B/hu not_active IP Right Cessation
- 1989-04-10 AT AT89303511T patent/ATE92323T1/de not_active IP Right Cessation
- 1989-04-10 EP EP89303511A patent/EP0337697B1/de not_active Expired - Lifetime
- 1989-04-11 JP JP1092793A patent/JPH0296537A/ja active Pending
- 1989-04-11 CA CA000596348A patent/CA1336953C/en not_active Expired - Fee Related
- 1989-04-11 AU AU32691/89A patent/AU624370B2/en not_active Ceased

Also Published As

Publication number	Publication date
JPH0296537A (ja)	1990-04-09
AU3269189A (en)	1989-10-12
IE891061L (en)	1989-10-11
DK170989D0 (da)	1989-04-10
HUT52372A (en)	1990-07-28
EP0337697B1 (de)	1993-08-04
CA1336953C (en)	1995-09-12
EP0337697A3 (en)	1990-08-16
AU624370B2 (en)	1992-06-11
DK170989A (da)	1989-10-12
ZA892412B (en)	1990-01-31
US5066480A (en)	1991-11-19
NZ228491A (en)	1997-03-24
DE68907976T2 (de)	1994-03-31
IE63735B1 (en)	1995-06-14
DE68907976D1 (de)	1993-09-09
EP0337697A2 (de)	1989-10-18
HU206261B (en)	1992-10-28

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Legal Events

Date	Code	Title	Description
1994-03-15	UEP	Publication of translation of european patent specification
2006-01-15	REN	Ceased due to non-payment of the annual fee