ATE92476T1 - Kondensierte pyridazin-verbindungen und deren verwendung als arzneimittel. - Google Patents
Kondensierte pyridazin-verbindungen und deren verwendung als arzneimittel.Info
- Publication number
- ATE92476T1 ATE92476T1 AT88909359T AT88909359T ATE92476T1 AT E92476 T1 ATE92476 T1 AT E92476T1 AT 88909359 T AT88909359 T AT 88909359T AT 88909359 T AT88909359 T AT 88909359T AT E92476 T1 ATE92476 T1 AT E92476T1
- Authority
- AT
- Austria
- Prior art keywords
- different
- same
- action
- leucocytes
- alkyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical class C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 206010057249 Phagocytosis Diseases 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 230000008782 phagocytosis Effects 0.000 abstract 2
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 2
- 206010061598 Immunodeficiency Diseases 0.000 abstract 1
- 208000029462 Immunodeficiency disease Diseases 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxy, nitro, amino Chemical group 0.000 abstract 1
- 230000007813 immunodeficiency Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 150000004892 pyridazines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/36—Benzo-cinnolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27809987 | 1987-11-02 | ||
| JP24829588 | 1988-09-30 | ||
| EP88909359A EP0351435B1 (de) | 1987-11-02 | 1988-10-29 | Kondensierte pyridazin-verbindungen und deren verwendung als arzneimittel |
| PCT/JP1988/001109 WO1989004306A1 (fr) | 1987-11-02 | 1988-10-29 | Composes de pyridazine fusionnes et leurs utilisations medicales |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE92476T1 true ATE92476T1 (de) | 1993-08-15 |
Family
ID=26538701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88909359T ATE92476T1 (de) | 1987-11-02 | 1988-10-29 | Kondensierte pyridazin-verbindungen und deren verwendung als arzneimittel. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5045541A (de) |
| EP (1) | EP0351435B1 (de) |
| JP (1) | JP2623784B2 (de) |
| AT (1) | ATE92476T1 (de) |
| DE (1) | DE3882982T2 (de) |
| WO (1) | WO1989004306A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5339890A (en) * | 1993-02-08 | 1994-08-23 | Climate Master, Inc. | Ground source heat pump system comprising modular subterranean heat exchange units with concentric conduits |
| US20100210590A1 (en) * | 1995-09-27 | 2010-08-19 | Northwestern University | Compositions and treatments for seizure-related disorders |
| HU225162B1 (en) * | 1995-11-06 | 2006-07-28 | Ortho Mcneil Pharm Inc | 1-[arylsulphonyl or aryl(thio)carbonyl]-pyridazin derivatives, process for producing them, pharmaceutical compositions containing them and their use |
| GB9610893D0 (en) * | 1996-05-24 | 1996-07-31 | Astra Pharma Prod | Pharmaceutically useful compounds |
| US5723666A (en) * | 1996-06-21 | 1998-03-03 | Allergan | Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
| CA2263586A1 (en) * | 1996-09-05 | 1998-03-12 | Eifion Phillips | Novel aryl-pyridazines |
| US20030176437A1 (en) * | 2001-08-31 | 2003-09-18 | D.M. Watterson | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death |
| ATE523199T1 (de) * | 2004-11-02 | 2011-09-15 | Univ Northwestern | Pyridazinverbindungen und verfahren |
| BRPI0517947A (pt) | 2004-11-02 | 2008-10-21 | Univ Northwestern | composto de piridazina, composições e métodos |
| US20100168120A1 (en) * | 2006-04-28 | 2010-07-01 | Neuromedix Inc. | Salts of pyridazine compounds |
| CA2650711A1 (en) * | 2006-04-28 | 2007-11-08 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
| JP2009535344A (ja) | 2006-04-28 | 2009-10-01 | ノースウェスタン ユニバーシティ | 神経炎症性疾患の処置のためのピリダジン化合物を含む処方物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4602019A (en) * | 1983-04-22 | 1986-07-22 | Warner-Lambert Company | Indeno[1,2-c]pyridazin-3-one derivatives useful as cardiotonic and antihypertensive agents |
| GB2164643B (en) * | 1984-07-27 | 1988-11-02 | Boehringer Biochemia Srl | Tricyclic dihydropyridazinones and pharmaceutical compositions containing them |
| JPH06763B2 (ja) * | 1984-08-28 | 1994-01-05 | 吉富製薬株式会社 | ベンゾ〔ｈ〕シンノリン誘導体 |
| AU578496B2 (en) * | 1984-11-01 | 1988-10-27 | Smith Kline & French Laboratories Limited | Tricyclic heterocyclic compounds |
| JPH0633277B2 (ja) * | 1986-01-10 | 1994-05-02 | 吉富製薬株式会社 | ベンゾチオピラノ〔４，３−ｃ〕ピリダジン化合物 |
| EP0281045B1 (de) * | 1987-03-02 | 1991-12-27 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzothiepino[5,4-c]pyridazin-Verbindungen und ihre pharmazeutischen Wirkungen |
| JP2531687B2 (ja) * | 1987-07-01 | 1996-09-04 | 吉富製薬株式会社 | ベンズオキセピノ〔５，４−ｃ〕ピリダジン化合物 |
| JPH06147468A (ja) * | 1992-11-16 | 1994-05-27 | Sanden Corp | 気化式燃焼装置の制御方法 |
| JPH06156169A (ja) * | 1992-11-18 | 1994-06-03 | Mitsubishi Motors Corp | キャブオーバトラックのフロントグリル |
-
1988
- 1988-10-29 AT AT88909359T patent/ATE92476T1/de active
- 1988-10-29 DE DE88909359T patent/DE3882982T2/de not_active Expired - Fee Related
- 1988-10-29 WO PCT/JP1988/001109 patent/WO1989004306A1/ja not_active Ceased
- 1988-10-29 US US07/391,603 patent/US5045541A/en not_active Expired - Fee Related
- 1988-10-29 EP EP88909359A patent/EP0351435B1/de not_active Expired - Lifetime
- 1988-10-31 JP JP63275666A patent/JP2623784B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0351435B1 (de) | 1993-08-04 |
| EP0351435A4 (de) | 1990-02-26 |
| US5045541A (en) | 1991-09-03 |
| JP2623784B2 (ja) | 1997-06-25 |
| DE3882982D1 (de) | 1993-09-09 |
| EP0351435A1 (de) | 1990-01-24 |
| JPH02167269A (ja) | 1990-06-27 |
| WO1989004306A1 (fr) | 1989-05-18 |
| DE3882982T2 (de) | 1993-11-25 |
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