ATE63742T1 - Chinazolinon-derivate. - Google Patents

Chinazolinon-derivate.

Info

Publication number
ATE63742T1
ATE63742T1 AT88311461T AT88311461T ATE63742T1 AT E63742 T1 ATE63742 T1 AT E63742T1 AT 88311461 T AT88311461 T AT 88311461T AT 88311461 T AT88311461 T AT 88311461T AT E63742 T1 ATE63742 T1 AT E63742T1
Authority
AT
Austria
Prior art keywords
hydrogen
4alkyl
different
same
nar
Prior art date
Application number
AT88311461T
Other languages
English (en)
Inventor
Robert John Ife
Thomas Henry Brown
Colin Andrew Leach
Original Assignee
Smithkline Beecham Intercredit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878728336A external-priority patent/GB8728336D0/en
Priority claimed from GB888820184A external-priority patent/GB8820184D0/en
Application filed by Smithkline Beecham Intercredit filed Critical Smithkline Beecham Intercredit
Application granted granted Critical
Publication of ATE63742T1 publication Critical patent/ATE63742T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Chemically Coating (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT88311461T 1987-12-03 1988-12-02 Chinazolinon-derivate. ATE63742T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878728336A GB8728336D0 (en) 1987-12-03 1987-12-03 Compounds
GB888820184A GB8820184D0 (en) 1988-08-25 1988-08-25 Compounds
EP88311461A EP0322133B1 (de) 1987-12-03 1988-12-02 Chinazolinon-Derivate

Publications (1)

Publication Number Publication Date
ATE63742T1 true ATE63742T1 (de) 1991-06-15

Family

ID=26293140

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88311461T ATE63742T1 (de) 1987-12-03 1988-12-02 Chinazolinon-derivate.

Country Status (16)

Country Link
EP (1) EP0322133B1 (de)
JP (1) JPH02502462A (de)
KR (1) KR900700465A (de)
CN (1) CN1033380A (de)
AT (1) ATE63742T1 (de)
DE (1) DE3862928D1 (de)
ES (1) ES2032024T3 (de)
FI (1) FI893632A7 (de)
GR (1) GR3002113T3 (de)
HU (1) HU203325B (de)
IL (1) IL88507A (de)
NZ (1) NZ227125A (de)
PH (1) PH25508A (de)
PT (1) PT89110B (de)
WO (1) WO1989005297A1 (de)
ZW (1) ZW16588A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411963A (en) * 1988-01-29 1995-05-02 Dowelanco Quinazoline derivatives
US5114939A (en) * 1988-01-29 1992-05-19 Dowelanco Substituted quinolines and cinnolines as fungicides
IL89027A (en) * 1988-01-29 1993-01-31 Lilly Co Eli Quinazoline derivatives, process for their preparation and fungicidal, insecticidal and miticidal compositions containing them
IL89029A (en) * 1988-01-29 1993-01-31 Lilly Co Eli Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them
IL89028A0 (en) * 1988-01-29 1989-08-15 Lilly Co Eli Quinoline,quinazoline and cinnoline derivatives
CA2011086A1 (en) * 1989-03-17 1990-09-17 Karl-Heinz Geiss 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom
IE63502B1 (en) * 1989-04-21 1995-05-03 Zeneca Ltd Aminopyrimidine derivatives useful for treating cardiovascular disorders
CA2015981A1 (en) * 1989-05-10 1990-11-10 Thomas H. Brown Compounds
GB9008818D0 (en) * 1990-04-19 1990-06-13 Ici Plc Amine derivatives
GB9012592D0 (en) * 1990-06-06 1990-07-25 Smithkline Beecham Intercredit Compounds
GB9022644D0 (en) * 1990-10-18 1990-11-28 Ici Plc Heterocyclic compounds
EP0556310B1 (de) * 1990-11-06 1995-07-05 Pfizer Inc. Chinazolinderivate um die antitumorwirkung zu verbessern
JPH06500117A (ja) * 1991-02-20 1994-01-06 フアイザー・インコーポレイテツド 抗腫瘍活性を増強させる２，４−ジアミノキナゾリン誘導体
JP2657760B2 (ja) * 1992-07-15 1997-09-24 小野薬品工業株式会社 ４−アミノキナゾリン誘導体およびそれを含有する医薬品
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
CA2148260A1 (en) * 1993-09-10 1995-03-16 Yasutaka Takase Quinazoline cpompounds
TW334434B (en) * 1995-05-16 1998-06-21 Kanebo Ltd Novel quinazoline compound and anti-tumor agent
AU2769897A (en) * 1996-05-07 1997-11-26 Basf Aktiengesellschaft Imidazoquinazolines, agents containing them and their use to combat fungi and animal pests
IN188411B (de) * 1997-03-27 2002-09-21 Yuhan Corp
GB9708917D0 (en) 1997-05-01 1997-06-25 Pfizer Ltd Compounds useful in therapy
GB9711650D0 (en) * 1997-06-05 1997-07-30 Pfizer Ltd Compounds useful in therapy
AU2960599A (en) * 1998-03-30 1999-10-18 Akira Karasawa Quinazoline derivatives
WO2003055866A1 (en) * 2001-12-21 2003-07-10 Bayer Pharmaceuticals Corporation Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
RS63204A (sr) 2002-01-17 2006-10-27 Neurogen Corporation Supstituisani analozi hinazolin-4-ilamina kao modulatori kapsaicina
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
CN1984660B (zh) * 2003-07-03 2010-12-15 美瑞德生物工程公司 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉
US7329664B2 (en) 2003-07-16 2008-02-12 Neurogen Corporation Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
EP1833482A4 (de) * 2005-01-03 2011-02-16 Myriad Genetics Inc Verbindungen und ihre therapeutische verwendung
JP2008526776A (ja) * 2005-01-03 2008-07-24 ミリアド ジェネティクス， インコーポレイテッド 脳癌の治療の方法
US8252806B2 (en) 2005-03-14 2012-08-28 Neurosearch A/S Potassium channel modulating agents and their medical use
WO2006105056A2 (en) * 2005-03-28 2006-10-05 Fmc Corporation Insecticidal 2,4-diaminoquinazolines and related derivatives
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
AU2007278986B2 (en) 2006-07-25 2010-09-16 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI
CA2691932A1 (en) * 2007-06-27 2008-12-31 Summit Corporation Plc Use of compounds for preparing anti-tuberculosis agents
PL3097102T3 (pl) * 2015-03-04 2018-04-30 Gilead Sciences Inc Związki 4,6-diamino-pirydo[3,2-d]pirymidyny modulujące działanie receptora toll-podobnego
KR102268448B1 (ko) 2016-09-02 2021-06-22 길리애드 사이언시즈, 인코포레이티드 톨 유사 수용체 조정제 화합물
ES2826748T3 (es) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
CN106518849B (zh) * 2016-10-27 2019-08-16 上海人类基因组研究中心 喹唑啉类化合物及其制备方法和用途
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
MX2024002852A (es) * 2021-09-07 2024-08-30 Gismo Therapeutics Inc Compuestos y composiciones farmaceuticas que comprenden inhibidores de las interacciones del peptido amiloide con los glicosaminoglicanos, metodos de tratamiento y uso de los mismos.
WO2024101336A1 (ja) * 2022-11-07 2024-05-16 国立大学法人京都大学 含窒素複素環化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE958197C (de) * 1952-04-18 1957-02-14 Dr Siegfried Skraup Verfahren zur Herstellung von 2, 4-Diaminochinazolin
GB806772A (en) * 1956-03-29 1958-12-31 Wellcome Found Diaminoquinazolines and method of preparing
CH457460A (fr) * 1966-06-20 1968-06-15 Parke Davis & Co Procédé de préparation de quinazolines
US3635979A (en) * 1969-09-29 1972-01-18 Pfizer Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines
GB1390014A (en) * 1971-05-07 1975-04-09 Koninklijke Pharma Fab Nv Process for the preparation of carbocyclic fused pyrimidine derivatives
US3956495A (en) * 1973-10-30 1976-05-11 Eli Lilly And Company 2,4-Diaminoquinazolines as antithrombotic agents
US4098788A (en) * 1977-06-20 1978-07-04 Bristol-Myers Company Process for preparing quinazolines
US4287341A (en) * 1979-11-01 1981-09-01 Pfizer Inc. Alkoxy-substituted-6-chloro-quinazoline-2,4-diones

Also Published As

Publication number Publication date
ES2032024T3 (es) 1993-01-01
FI893632A0 (fi) 1989-07-31
CN1033380A (zh) 1989-06-14
NZ227125A (en) 1990-09-26
HU203325B (en) 1991-07-29
KR900700465A (ko) 1990-08-13
PT89110A (pt) 1988-12-01
PT89110B (pt) 1993-03-31
EP0322133A1 (de) 1989-06-28
EP0322133B1 (de) 1991-05-22
ZW16588A1 (en) 1989-06-21
IL88507A (en) 1993-02-21
DE3862928D1 (de) 1991-06-27
JPH02502462A (ja) 1990-08-09
GR3002113T3 (en) 1992-12-30
WO1989005297A1 (en) 1989-06-15
FI893632A7 (fi) 1989-07-31
PH25508A (en) 1991-07-24
HUT50322A (en) 1990-01-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee