ATE92767T1 - Auf tocopherol basierte arzneimittelsysteme. - Google Patents

Auf tocopherol basierte arzneimittelsysteme.

Info

Publication number: ATE92767T1
Authority: AT; Austria
Prior art keywords: composition; stabilizer; organic acid; acid derivative; based drug
Prior art date: 1987-10-19

Application number

AT88909942T

Other languages

English (en)

Inventor

Andrew S Janoff

Lawrence Boni

Lois E Bolcsak

Sharma R Minchey

Steven J Weiss

Original Assignee

Liposome Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-19

Filing date

1988-10-19

Publication date

1993-08-15

1988-10-19 Application filed by Liposome Co Inc filed Critical Liposome Co Inc

1993-08-15 Application granted granted Critical

1993-08-15 Publication of ATE92767T1 publication Critical patent/ATE92767T1/de

Links

229940079593 drug Drugs 0.000 title abstract 3
239000003814 drug Substances 0.000 title abstract 3
GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title 1
229960001295 tocopherol Drugs 0.000 title 1
229930003799 tocopherol Natural products 0.000 title 1
235000010384 tocopherol Nutrition 0.000 title 1
239000011732 tocopherol Substances 0.000 title 1
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 title 1
239000000203 mixture Substances 0.000 abstract 3
-1 organic acid derivative of alpha tocopherol Chemical class 0.000 abstract 2
239000003381 stabilizer Substances 0.000 abstract 2
QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 abstract 1
QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
239000012867 bioactive agent Substances 0.000 abstract 1
239000003599 detergent Substances 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
239000002502 liposome Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229960001416 pilocarpine Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Dispersion Chemistry (AREA)
Biophysics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

AT88909942T 1987-10-19 1988-10-19 Auf tocopherol basierte arzneimittelsysteme. ATE92767T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US11026187A	1987-10-19	1987-10-19
EP88909942A EP0382779B1 (de)	1987-10-19	1988-10-19	Auf tocopherol basierte arzneimittelsysteme
PCT/US1988/003752 WO1989003689A1 (en)	1987-10-19	1988-10-19	Tocopherol-based pharmaceutical systems

Publications (1)

Publication Number	Publication Date
ATE92767T1 true ATE92767T1 (de)	1993-08-15

Family

ID=22332058

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88909942T ATE92767T1 (de)	1987-10-19	1988-10-19	Auf tocopherol basierte arzneimittelsysteme.

Country Status (6)

Country	Link
EP (1)	EP0382779B1 (de)
JP (1)	JP2921792B2 (de)
AT (1)	ATE92767T1 (de)
CA (1)	CA1333360C (de)
DE (1)	DE3883246T2 (de)
WO (1)	WO1989003689A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2657526B1 (fr) *	1990-01-31	1994-10-28	Lvmh Rech	Utilisation d'un phosphate d'alpha-tocopherol, ou de l'un de ses derives, pour la preparation de compositions cosmetiques, dermatologiques, ou pharmaceutiques; compositions ainsi obtenues.
US5179122A (en) *	1991-02-11	1993-01-12	Eastman Kodak Company	Nutritional supplement containing vitamin e
FR2679904A1 (fr) *	1991-08-01	1993-02-05	Lvmh Rech	Utilisation d'un phosphate de tocopherol, ou de l'un de ses derives, pour la preparation de compositions cosmetiques, ou pharmaceutiques et compositions ainsi obtenues.
JP2811036B2 (ja) *	1992-05-26	1998-10-15	参天製薬株式会社	ビタミンｅ点眼剤
CN1129400A (zh) *	1994-05-06	1996-08-21	阿尔康实验室公司	维生素e生育酚衍生物在眼科组合物中的应用
GB9409778D0 (en)	1994-05-16	1994-07-06	Dumex Ltd As	Compositions
GB9514878D0 (en) *	1995-07-20	1995-09-20	Danbiosyst Uk	Vitamin E as a solubilizer for drugs contained in lipid vehicles
GB2317562B (en) *	1995-07-20	1999-08-18	Danbiosyst Uk	Lipid vehicle drug delivery composition containing vitamin E
US6458373B1 (en)	1997-01-07	2002-10-01	Sonus Pharmaceuticals, Inc.	Emulsion vehicle for poorly soluble drugs
US7030155B2 (en)	1998-06-05	2006-04-18	Sonus Pharmaceuticals, Inc.	Emulsion vehicle for poorly soluble drugs
JP5246182B2 (ja) *	2010-02-24	2013-07-24	ライオン株式会社	点眼剤、防腐剤及び防腐力向上剤
JP6122646B2 (ja) *	2013-01-23	2017-04-26	昭和電工株式会社	皮膚外用剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3608075A (en) *	1969-07-28	1971-09-21	American Home Prod	Compositions and methods of treating the menopausal syndrome
JPS5659710A (en) *	1979-10-22	1981-05-23	Eisai Co Ltd	Preventive and remedy for psoriasis
US4861580A (en) *	1985-10-15	1989-08-29	The Liposome Company, Inc.	Composition using salt form of organic acid derivative of alpha-tocopheral
JPS6295134A (ja) *	1985-10-21	1987-05-01	Nippon Saafuakutanto Kogyo Kk	リポソ−ムの製造法
AU596581B2 (en) *	1986-04-15	1990-05-10	Sansho Seiyaku Co., Ltd.	Topical agents for inhibiting the melanin generation

1988
- 1988-10-19 JP JP63509168A patent/JP2921792B2/ja not_active Expired - Fee Related
- 1988-10-19 DE DE88909942T patent/DE3883246T2/de not_active Expired - Fee Related
- 1988-10-19 CA CA000580562A patent/CA1333360C/en not_active Expired - Fee Related
- 1988-10-19 EP EP88909942A patent/EP0382779B1/de not_active Expired - Lifetime
- 1988-10-19 WO PCT/US1988/003752 patent/WO1989003689A1/en not_active Ceased
- 1988-10-19 AT AT88909942T patent/ATE92767T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2921792B2 (ja)	1999-07-19
CA1333360C (en)	1994-12-06
EP0382779A4 (en)	1991-01-09
WO1989003689A1 (en)	1989-05-05
JPH03500651A (ja)	1991-02-14
DE3883246T2 (de)	1993-12-02
EP0382779A1 (de)	1990-08-22
EP0382779B1 (de)	1993-08-11
DE3883246D1 (de)	1993-09-16

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Legal Events

Date	Code	Title	Description
1994-04-15	UEP	Publication of translation of european patent specification
2006-07-15	REN	Ceased due to non-payment of the annual fee