ATE92935T1 - Serinproteaseinhibitoren und isolierungsverfahren dazu. - Google Patents

Serinproteaseinhibitoren und isolierungsverfahren dazu.

Info

Publication number: ATE92935T1
Authority: AT; Austria
Prior art keywords: serine protease; protease inhibitor; inhibitor; ability; inhibit
Prior art date: 1984-12-06

Application number

AT86900423T

Other languages

English (en)

Inventor

Robert C Thompson

Kjell Ohlsson

Original Assignee

Synergen Biolog Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-06

Filing date

1985-12-04

Publication date

1993-08-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27102098&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE92935(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-12-04 Application filed by Synergen Biolog Inc filed Critical Synergen Biolog Inc

1993-08-15 Application granted granted Critical

1993-08-15 Publication of ATE92935T1 publication Critical patent/ATE92935T1/de

Links

239000003112 inhibitor Substances 0.000 title abstract 3
238000002955 isolation Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
MTCFGRXMJLQNBG-UHFFFAOYSA-N serine Chemical compound OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 title 2
241000208465 Proteaceae Species 0.000 title 1
241001522306 Serinus serinus Species 0.000 title 1
235000019419 proteases Nutrition 0.000 title 1
101710102218 Serine protease inhibitor Proteins 0.000 abstract 6
239000003001 serine protease inhibitor Substances 0.000 abstract 6
229940122055 Serine protease inhibitor Drugs 0.000 abstract 5
238000004925 denaturation Methods 0.000 abstract 2
230000036425 denaturation Effects 0.000 abstract 2
LKDMKWNDBAVNQZ-UHFFFAOYSA-N 4-[[1-[[1-[2-[[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(=O)NC=1C=CC(=CC=1)[N+]([O-])=O)CC1=CC=CC=C1 LKDMKWNDBAVNQZ-UHFFFAOYSA-N 0.000 abstract 1
102000004173 Cathepsin G Human genes 0.000 abstract 1
108090000617 Cathepsin G Proteins 0.000 abstract 1
102000016387 Pancreatic elastase Human genes 0.000 abstract 1
108010067372 Pancreatic elastase Proteins 0.000 abstract 1
102000035195 Peptidases Human genes 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
102000004142 Trypsin Human genes 0.000 abstract 1
108090000631 Trypsin Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000002779 inactivation Effects 0.000 abstract 1
230000003993 interaction Effects 0.000 abstract 1
230000001590 oxidative effect Effects 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
239000012588 trypsin Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Detergent Compositions (AREA)
Enzymes And Modification Thereof (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

AT86900423T 1984-12-06 1985-12-04 Serinproteaseinhibitoren und isolierungsverfahren dazu. ATE92935T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US67882384A	1984-12-06	1984-12-06
US80347185A	1985-12-02	1985-12-02
EP86900423A EP0205555B2 (de)	1984-12-06	1985-12-04	Serinproteaseinhibitoren und isolierungsverfahren dazu
PCT/US1985/002384 WO1986003497A1 (en)	1984-12-06	1985-12-04	Serine protease inhibitors and methods for isolation of same

Publications (1)

Publication Number	Publication Date
ATE92935T1 true ATE92935T1 (de)	1993-08-15

Family

ID=27102098

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86900423T ATE92935T1 (de)	1984-12-06	1985-12-04	Serinproteaseinhibitoren und isolierungsverfahren dazu.

Country Status (5)

Country	Link
EP (1)	EP0205555B2 (de)
AT (1)	ATE92935T1 (de)
AU (1)	AU591474B2 (de)
DE (1)	DE3587526T3 (de)
WO (1)	WO1986003497A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6291662B1 (en)	1984-12-05	2001-09-18	Amgen Inc.	Recombinant methods for production of serine protease inhibitors and DNA sequences
US5871956A (en) *	1984-12-06	1999-02-16	Amgen Inc.	Recombinant methods for production of serine inhibitors and DNA sequences useful for same
US6132990A (en) *	1984-12-06	2000-10-17	Amgen Boulder Inc.	Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same
US5900400A (en) *	1984-12-06	1999-05-04	Amgen Inc.	Serine protease inhibitor analogs
DE3600571A1 (de) *	1986-01-10	1987-08-06	Gruenenthal Gmbh	Dna-sequenzen, die fuer proteine mit der biologischen aktivitaet der husi-typi-inhibitoren codieren, gentechnologische verfahren zur herstellung dieser proteine und diese proteine enthaltende arzneimittel
EP0238473A3 (de) *	1986-03-18	1989-06-07	Monsanto Company	Serinprotease-Hemmungsstoffe
DE3841873A1 (de) *	1988-12-13	1990-06-21	Gruenenthal Gmbh	Neue serinprotease-inhibitor-proteine, diese enthaltende arzneimittel, dna-sequenzen, die fuer diese proteine codieren und verfahren zur herstellung dieser proteine, arzneimittel und dna-sequenzen
JPH0739329B2 (ja) *	1989-03-13	1995-05-01	味の素株式会社	植物の開花を制御する方法及び植物の開花制御剤
FR2647677B1 (fr) *	1989-05-31	1991-09-27	Roussel Uclaf	Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines
DE69129747T2 (de) *	1990-09-05	1998-11-12	Southern Cross Biotech Pty. Ltd., Toorak, Victoria	In lösung bringen von proteinen in aktiver form
US6869925B1 (en) *	1992-09-09	2005-03-22	Amgen Inc.	Inhibition of retrovirus infection
US6017880A (en) *	1994-03-09	2000-01-25	Amgen Inc.	Inhibition of retrovirus infection
PL316444A1 (en) *	1994-03-23	1997-01-20	Tokyo Tanabe Co	Novel agent against viral diseases of respiratory tracts
US5633227A (en) *	1994-09-12	1997-05-27	Miles, Inc.	Secretory leukocyte protease inhibitor as an inhibitor of tryptase
EP0834556A1 (de) *	1996-09-25	1998-04-08	Academisch Ziekenhuis Leiden	Verfahren zur Zellkultivierung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE668563A (de) *	1964-09-22	1965-12-16
AU577259B2 (en) *	1982-08-13	1988-09-22	Zymogenetics Inc.	Glycolytic promters for regulated protein expression protease inhibitor
AU560584B2 (en) *	1983-07-28	1987-04-09	Bayer Aktiengesellschaft	Homologues of aprotinin
JPS60186290A (ja) *	1983-08-10	1985-09-21	チモ−ジエネテイツクス　インコ−ポレ−テツド	アルフア−１−アンチトリプシンを細菌に表現させる方法
US4711848A (en) *	1984-03-14	1987-12-08	Zymogenetics, Inc.	Site specific mutagenesis in alpha-1-antitrypsin
AU590238B2 (en) *	1984-12-06	1989-11-02	Amgen, Inc.	Recombinant methods for production of serine protease inhibitors and dna sequences useful for same

1985
- 1985-12-04 DE DE3587526T patent/DE3587526T3/de not_active Expired - Lifetime
- 1985-12-04 AU AU52328/86A patent/AU591474B2/en not_active Expired
- 1985-12-04 WO PCT/US1985/002384 patent/WO1986003497A1/en not_active Ceased
- 1985-12-04 AT AT86900423T patent/ATE92935T1/de not_active IP Right Cessation
- 1985-12-04 EP EP86900423A patent/EP0205555B2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0205555B1 (de)	1993-08-11
WO1986003497A1 (en)	1986-06-19
DE3587526T2 (de)	1993-11-25
DE3587526D1 (de)	1993-09-16
EP0205555A4 (de)	1987-11-09
EP0205555A1 (de)	1986-12-30
AU591474B2 (en)	1989-12-07
EP0205555B2 (de)	2002-04-10
AU5232886A (en)	1986-07-01
DE3587526T3 (de)	2002-08-08

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Legal Events

Date	Code	Title	Description
1994-02-15	UEP	Publication of translation of european patent specification
1997-06-15	EEIH	Change in the person of patent owner
2001-07-15	EEIH	Change in the person of patent owner
2003-03-15	UEP	Publication of translation of european patent specification	Ref document number: 0205555 Country of ref document: EP
2006-03-15	EELA	Cancelled due to lapse of time