ATE93272T1 - Expression von protein c. - Google Patents

Expression von protein c.

Info

Publication number
ATE93272T1
ATE93272T1 AT86304970T AT86304970T ATE93272T1 AT E93272 T1 ATE93272 T1 AT E93272T1 AT 86304970 T AT86304970 T AT 86304970T AT 86304970 T AT86304970 T AT 86304970T AT E93272 T1 ATE93272 T1 AT E93272T1
Authority
AT
Austria
Prior art keywords
protein
nucleotide sequence
disclosed
mammalian host
biological activity
Prior art date
Application number
AT86304970T
Other languages
English (en)
Inventor
Mark J Murray
Kathleen L Berkner
Donald C Foster
Earl W Davie
Original Assignee
Zymogenetics Inc
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27115147&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE93272(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/766,109 external-priority patent/US4968626A/en
Application filed by Zymogenetics Inc, Univ Washington filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of ATE93272T1 publication Critical patent/ATE93272T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT86304970T 1985-06-27 1986-06-26 Expression von protein c. ATE93272T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74960085A 1985-06-27 1985-06-27
US06/766,109 US4968626A (en) 1985-08-15 1985-08-15 DNA sequence coding for protein C
EP86304970A EP0215548B2 (de) 1985-06-27 1986-06-26 Expression von Protein C

Publications (1)

Publication Number Publication Date
ATE93272T1 true ATE93272T1 (de) 1993-09-15

Family

ID=27115147

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86304970T ATE93272T1 (de) 1985-06-27 1986-06-26 Expression von protein c.

Country Status (7)

Country Link
EP (1) EP0215548B2 (de)
JP (2) JP2614848B2 (de)
AT (1) ATE93272T1 (de)
CA (1) CA1341228C (de)
DE (1) DE3688900T3 (de)
DK (1) DK175574B1 (de)
NO (1) NO305660B1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959318A (en) * 1985-06-27 1990-09-25 Zymogenetics, Inc. Expression of protein C
US5550036A (en) * 1986-04-09 1996-08-27 Eli Lilly And Company Method for co-amplification of human protein C genes in human cells
USH1148H (en) 1987-04-17 1993-03-02 Method of separating activated human protein C
PT87688B (pt) * 1987-06-12 1992-09-30 Hoechst Japan Processo para a preparacao de proteina hibrida c
US5084274A (en) * 1987-11-17 1992-01-28 Scripps Clinic And Research Foundation Inhibition of arterial thrombotic occlusion or thromboembolism
US4992373A (en) * 1987-12-04 1991-02-12 Eli Lilly And Company Vectors and compounds for direct expression of activated human protein C
US5196322A (en) * 1987-12-28 1993-03-23 Eli Lilly And Company Vectors and compounds for expression of zymogen forms of human protein C
JP2728240B2 (ja) * 1988-07-26 1998-03-18 ヘキスト薬品工業株式会社 ヒトプロテインｃ変異体及びその製造方法
CA1332049C (en) * 1988-10-07 1994-09-20 Eli Lilly And Company Eukaryotic expression
DK0485504T3 (da) * 1989-08-11 1994-04-18 Zymogenetics Inc Fremgangsmåde til fremstilling af aktiveret protein C ved celledyrkning
JP2774156B2 (ja) * 1989-09-05 1998-07-09 帝人株式会社 ヒトプロテインｃおよび／または活性化ヒトプロテインｃ様活性を有する蛋白
JP2774163B2 (ja) * 1989-11-14 1998-07-09 帝人株式会社 ヒトプロテインｃ様活性を有する蛋白
ES2113878T3 (es) * 1989-12-29 1998-05-16 Zymogenetics Inc Proteina c hibrida.
US5358932A (en) * 1989-12-29 1994-10-25 Zymogenetics, Inc. Hybrid protein C
IL97311A0 (en) * 1990-02-23 1992-05-25 Lilly Co Eli Vectors and compounds for expression of glycosylation mutants of human protein c
US5270178A (en) * 1990-02-23 1993-12-14 Eli Lilly And Company Vectors and compounds for expression of zymogen forms of human protein C
AT402263B (de) 1991-06-20 1997-03-25 Immuno Ag Pharmazeutische präparation enthaltend eine thrombolytisch wirkende substanz
EP0592692B1 (de) * 1992-05-01 1997-07-02 Teijin Limited Fed-batch-Verfahren für Proteine sekretierende Zellen
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
US5561053A (en) * 1994-08-05 1996-10-01 Genentech, Inc. Method for selecting high-expressing host cells
EP1237917A2 (de) * 1999-11-19 2002-09-11 Eli Lilly And Company Derivate aus protein c
BRPI0611376A2 (pt) * 2005-05-24 2010-08-31 Avestha Gengraine Tech Pvt Ltd processo para a producão de proteìna c ativada humana para o tratamento de sepsia
WO2014064580A1 (en) 2012-10-23 2014-05-01 Koninklijke Philips N.V. Stress-measuring system

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8327860D0 (en) * 1983-10-18 1983-11-16 Fujisawa Pharmaceutical Co Monoclonal antiprotein c antibody
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C

Also Published As

Publication number Publication date
EP0215548B1 (de) 1993-08-18
JPS62111690A (ja) 1987-05-22
DE3688900D1 (de) 1993-09-23
JPH09107976A (ja) 1997-04-28
DE3688900T2 (de) 1993-12-09
CA1341228C (en) 2001-05-15
JP2614848B2 (ja) 1997-05-28
NO862601D0 (no) 1986-06-27
NO305660B1 (no) 1999-07-05
EP0215548B2 (de) 1998-01-07
DK308586D0 (da) 1986-06-27
DK308586A (da) 1986-12-28
DE3688900T3 (de) 1998-06-10
EP0215548A1 (de) 1987-03-25
NO862601L (no) 1986-12-29
DK175574B1 (da) 2004-12-13
JP2688407B2 (ja) 1997-12-10

Similar Documents

Publication Publication Date Title
NO874495D0 (no) Ekspresjon av protein c.
ATE93272T1 (de) Expression von protein c.
ATE391175T1 (de) Multidrug resistenz gen
FR2716459B1 (fr) Système hôte-vecteur utilisable en thérapie génique.
DE69828193D1 (de) Hyaluronan synthase gen und seine verwendung
KR880014110A (ko) 인체 프로아포지방단백질 a-i의 발현
ATE88501T1 (de) Rekombinante dns-expressionsvektoren.
GR860984B (en) Expression of factor vii and ix activities in mammalian cells
FI870261A0 (fi) Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
EP0835661A3 (de) Menslisches Interferon-Beta 2A zur Verwendung als Arzneimittel
ES2078243T3 (es) Mejoras en o relativas a la expresion eucariotica.
EP0336383A3 (de) Menschliches rekombinantes Lymphotoxin
EP0302838A3 (en) Cloning of the gene coding the isoamylase enzyme and its use in the production of said enzyme
AU6560886A (en) DNA sequence containing the DNA sequence coding for human tissue plasminogen activator originating from human normal cells, recombinant DNA incorporating the DNA sequence, host cells transformed with the recombinant DNA, and process for producing human tissue plasminogen activator by use of the host cells
ATE181115T1 (de) Stabilisierung von messenger-rns in tierischen zellen
ATA435083A (de) Das polypeptid interleukin-2 kodierendes gen, rekombinante, dieses gen enthaltende dna, diese rekombinante dna aufweisende zellinien und verfahren zur herstellung von interleukin-2 unter verwendung der genannten zellen
ATE111527T1 (de) Herstellung und verwendung einer dna zur erhöhung der ausbeute bei der expression von rekombinanten genen.
WO1991009951A3 (en) Recombinant protein c with truncated light chain
EP0211662A3 (de) Nod-D zugehörende Gene von Rhizobium japonicum 191
ES2005189A6 (en) Nucleotide sequences from RESA antigen of Plasmodium falciparum
NO179453C (no) Fremgangsmåte for fremstilling av terapeutisk aktivt amphiregulin, vertscelle som produserer proteinet, rekombinant vektor inneholdt i vertscellen, samt nukleotidsekvens som koder for proteiner med amphiregulinaktivitet

Legal Events

Date Code Title Description
EELA Cancelled due to lapse of time