ATE94557T1 - Markierte nukleinsaeuren. - Google Patents

Markierte nukleinsaeuren.

Info

Publication number
ATE94557T1
ATE94557T1 AT86306305T AT86306305T ATE94557T1 AT E94557 T1 ATE94557 T1 AT E94557T1 AT 86306305 T AT86306305 T AT 86306305T AT 86306305 T AT86306305 T AT 86306305T AT E94557 T1 ATE94557 T1 AT E94557T1
Authority
AT
Austria
Prior art keywords
nucleic acids
labeled nucleic
labeled
polynucleotides
isotopically labeled
Prior art date
Application number
AT86306305T
Other languages
English (en)
Inventor
Graham A Mock
Michael J Powell
Michael J Septak
Original Assignee
Amoco Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amoco Corp filed Critical Amoco Corp
Application granted granted Critical
Publication of ATE94557T1 publication Critical patent/ATE94557T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT86306305T 1985-08-15 1986-08-15 Markierte nukleinsaeuren. ATE94557T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76603885A 1985-08-15 1985-08-15
EP86306305A EP0212951B1 (de) 1985-08-15 1986-08-15 Markierte Nukleinsäuren

Publications (1)

Publication Number Publication Date
ATE94557T1 true ATE94557T1 (de) 1993-10-15

Family

ID=25075208

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86306305T ATE94557T1 (de) 1985-08-15 1986-08-15 Markierte nukleinsaeuren.

Country Status (4)

Country Link
EP (1) EP0212951B1 (de)
JP (1) JP2509574B2 (de)
AT (1) ATE94557T1 (de)
DE (1) DE3689019T2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0082636B2 (de) * 1981-12-11 2006-10-18 The Welsh National School of Medicine Lumineszierende Markierungssubstanzen und -verfahren
US4948882A (en) * 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
US4957858A (en) * 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
JPS6261969A (ja) * 1985-09-06 1987-03-18 アモコ・コーポレーション アクリジニウムエステルの合成法
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
SE454781B (sv) * 1986-10-17 1988-05-30 Wallac Oy Hybridiseringsforfarande for detektion av polynukleotidsekvens
US5639604A (en) * 1987-09-21 1997-06-17 Gen-Probe Incorporated Homogeneous protection assay
WO1989002476A1 (en) * 1987-09-21 1989-03-23 Ml Technology Ventures, L.P. Homogeneous protection assay
JP3012244B2 (ja) * 1987-09-21 2000-02-21 ジェン―プローブ インコーポレイテッド ヌクレオチドプローブ用非ヌクレオチド連結試薬
US5283174A (en) * 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US6004745A (en) * 1987-09-21 1999-12-21 Gen-Probe Incorporated Hybridization protection assay
PT88665B (pt) * 1987-10-05 1992-12-31 Ml Tecnology Ventures Lp Metodo para a marcacao com ester de acridinio e purificacao de sondas nucleotidicas
AU619223B2 (en) * 1987-10-05 1992-01-23 Gen-Probe Incorporated Acridinium ester labelling and purification of nucleotide probes
US5185439A (en) * 1987-10-05 1993-02-09 Gen-Probe Incorporated Acridinium ester labelling and purification of nucleotide probes
NL8703075A (nl) * 1987-12-18 1989-07-17 Nederlanden Staat Acridiniumverbindingen als chemiluminescentie-merkstof.
DE3804243A1 (de) * 1988-02-11 1989-08-24 Max Planck Gesellschaft Teils einzel- und teils doppelstraengige nukleinsaeuresonde und verfahren zu ihrer herstellung
US4962045A (en) * 1988-05-02 1990-10-09 The Perkin-Elmer Corporation Time-resolved fluorimetric detection of lanthanide labeled nucleotides
SE8802574D0 (sv) * 1988-07-08 1988-07-08 Wallac Oy Oligonucleotide hybridization probes and means for the synthesis of the most preferred probes
IL91673A0 (en) * 1988-09-20 1990-04-29 Us Health Method for tagging an oligodeoxynucleotide
US5082780A (en) * 1989-09-12 1992-01-21 Eastman Kodak Company Oligonucleotide-enzyme conjugate that can be used as a probe in hybridization assays and polymerase chain reaction procedures
DE69033546T2 (de) * 1989-10-13 2000-09-21 Zeneca Ltd., London Sonden
GB8927365D0 (en) * 1989-12-04 1990-01-31 Ici Plc Reagent
JPH04121239U (ja) * 1991-02-16 1992-10-29 武内プレス工業株式会社 通 箱
EP0602524A1 (de) * 1992-12-15 1994-06-22 Hoechst Aktiengesellschaft Chemilumineszenzmarkierte Gensonden und ihre Verwendung in Gensondentesten
GB2282222A (en) * 1993-09-09 1995-03-29 Univ Nottingham Detecting genetic material using labelled DNA
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
DE19534122A1 (de) * 1995-09-14 1997-03-20 Behringwerke Ag Homogener Gensondentest mit einem gegen das Label gerichteten Rezeptor
JP2000514799A (ja) * 1996-07-03 2000-11-07 プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ オリゴヌクレオチドリンカーおよび固定化および結合オリゴヌクレオチドを用いる技術
EP0941314A1 (de) 1996-08-02 1999-09-15 Bio Merieux Verfahren zur amplifizierung von zielnukleinsäuresequenzen
AU9110698A (en) * 1997-08-21 1999-03-08 Capricorn Products, Inc. Peroxide-based chemiluminescent assays and chemiluminescent compounds used ther ein
CA2357793A1 (fr) 1999-01-05 2000-07-13 Bio Merieux Compose fonctionnalise, polynucleotide eventuellement marque et procede de detection d'un acide nucleique cible
BRPI0415771A (pt) 2003-10-23 2006-12-26 Illumigen Biosciences Inc detecção de mutações em um gene associado à resistência a infecção viral, oas1

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1461877A (en) * 1974-02-12 1977-01-19 Wellcome Found Assay method utilizing chemiluminescence
CA1205028A (en) * 1981-07-01 1986-05-27 Jerald C. Hinshaw Fluorescent chelates and labeled specific binding reagents prepared therefrom
EP0082636B2 (de) * 1981-12-11 2006-10-18 The Welsh National School of Medicine Lumineszierende Markierungssubstanzen und -verfahren
CA1223831A (en) * 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
SE454115B (sv) * 1982-09-13 1988-03-28 Wallac Oy Homogenfasanalys med lantanidkelat som merksubstans
WO1984001394A1 (fr) * 1982-09-30 1984-04-12 Iro Ab Dispositif de stockage, debitage et mesure de fil
US4547569A (en) * 1982-11-24 1985-10-15 The United States Of America As Represented By The Department Of Health And Human Services Intercalating agents specifying nucleotides
FR2540122B1 (fr) * 1983-01-27 1985-11-29 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
AU596068B2 (en) * 1983-02-22 1990-04-26 Syngene, Inc. Defined sequence single strand oligonucleotides incorporating reporter groups, process for the chemical synthesis thereof, and nucleosides useful in such synthesis

Also Published As

Publication number Publication date
EP0212951B1 (de) 1993-09-15
EP0212951A2 (de) 1987-03-04
EP0212951A3 (en) 1988-05-04
DE3689019D1 (de) 1993-10-21
DE3689019T2 (de) 1994-05-05
JPS6239598A (ja) 1987-02-20
JP2509574B2 (ja) 1996-06-19

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