ATE96658T1 - Verfahren zum mikronisieren schwerloeslicher arzneistoffe. - Google Patents

Verfahren zum mikronisieren schwerloeslicher arzneistoffe.

Info

Publication number
ATE96658T1
ATE96658T1 AT90114858T AT90114858T ATE96658T1 AT E96658 T1 ATE96658 T1 AT E96658T1 AT 90114858 T AT90114858 T AT 90114858T AT 90114858 T AT90114858 T AT 90114858T AT E96658 T1 ATE96658 T1 AT E96658T1
Authority
AT
Austria
Prior art keywords
micronizing
medicinal substances
partly soluble
soluble medicinal
drug
Prior art date
Application number
AT90114858T
Other languages
English (en)
Inventor
Masayoshi Samejima
Kazuo Noda
Masao Kobayashi
Takashi Osawa
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Application granted granted Critical
Publication of ATE96658T1 publication Critical patent/ATE96658T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
AT90114858T 1989-08-04 1990-08-02 Verfahren zum mikronisieren schwerloeslicher arzneistoffe. ATE96658T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1204132A JP2642486B2 (ja) 1989-08-04 1989-08-04 難溶性薬物の超微粒子化法
EP90114858A EP0411629B1 (de) 1989-08-04 1990-08-02 Verfahren zum Mikronisieren schwerlöslicher Arzneistoffe

Publications (1)

Publication Number Publication Date
ATE96658T1 true ATE96658T1 (de) 1993-11-15

Family

ID=16485367

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90114858T ATE96658T1 (de) 1989-08-04 1990-08-02 Verfahren zum mikronisieren schwerloeslicher arzneistoffe.

Country Status (9)

Country Link
US (1) US5202129A (de)
EP (1) EP0411629B1 (de)
JP (1) JP2642486B2 (de)
KR (1) KR0126465B1 (de)
AT (1) ATE96658T1 (de)
CA (1) CA2022465C (de)
DE (1) DE69004372T2 (de)
DK (1) DK0411629T3 (de)
ES (1) ES2062221T3 (de)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
FR2684298B1 (fr) * 1991-12-03 1994-03-11 Rhone Poulenc Rorer Sa Nouvelles compositions pharmaceutiques solides a base de derives de lapiperidine substitues en 1,4.
US5302400A (en) * 1992-06-22 1994-04-12 Digestive Care Inc. Preparation of gastric acid-resistant microspheres containing digestive enzymes and buffered-bile acids
US7336788B1 (en) * 1992-12-09 2008-02-26 Discovery Communicatoins Inc. Electronic book secure communication with home subsystem
JP3254219B2 (ja) * 1993-01-19 2002-02-04 ワーナー−ランバート・コンパニー 安定な経口用のｃｉ−９８１製剤およびその製法
US20070117862A1 (en) * 1993-02-22 2007-05-24 Desai Neil P Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US20010003739A1 (en) * 1993-06-24 2001-06-14 Astrazeneca Ab Systemic administration of a therapeutic preparation
TW402506B (en) * 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
US6632456B1 (en) 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
US5747445A (en) * 1993-06-24 1998-05-05 Astra Aktiebolag Therapeutic preparation for inhalation
IS1796B (is) * 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
US6794357B1 (en) 1993-06-24 2004-09-21 Astrazeneca Ab Compositions for inhalation
US5830853A (en) * 1994-06-23 1998-11-03 Astra Aktiebolag Systemic administration of a therapeutic preparation
US7865567B1 (en) 1993-12-02 2011-01-04 Discovery Patent Holdings, Llc Virtual on-demand electronic book
US6165976A (en) * 1994-06-23 2000-12-26 Astra Aktiebolag Therapeutic preparation for inhalation
CA2172807C (en) * 1994-08-01 1999-10-12 Keith S. Lienhop Tastemasked liquid pharmaceutical delivery system
US5618845A (en) 1994-10-06 1997-04-08 Cephalon, Inc. Acetamide derivative having defined particle size
SE9404468D0 (sv) * 1994-12-22 1994-12-22 Astra Ab Powder formulations
EP1283035A3 (de) * 1994-12-22 2003-03-19 AstraZeneca AB Parathyroidhormon enthaltende therapeutische Zubereitung zur Inhalation
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
EE9700138A (et) 1994-12-22 1997-12-15 Astra Aktiebolag Aerosoolravimvormid
US5503723A (en) * 1995-02-08 1996-04-02 Eastman Kodak Company Isolation of ultra small particles
US6458811B1 (en) * 1996-03-26 2002-10-01 Eli Lilly And Company Benzothiophenes formulations containing same and methods
US5750104A (en) * 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
PT1023050E (pt) * 1997-06-27 2013-12-04 Abraxis Bioscience Llc Novas formulações de agentes farmacológicos, métodos para a sua preparação e métodos para a sua utilização
ZA991922B (en) 1998-03-11 1999-09-13 Smithkline Beecham Corp Novel compositions of eprosartan.
US6197347B1 (en) 1998-06-29 2001-03-06 Andrx Pharmaceuticals, Inc. Oral dosage for the controlled release of analgesic
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
US6432448B1 (en) * 1999-02-08 2002-08-13 Fmc Corporation Edible coating composition
EG23951A (en) * 1999-03-25 2008-01-29 Otsuka Pharma Co Ltd Cilostazol preparation
US6787531B1 (en) * 1999-08-31 2004-09-07 Schering Ag Pharmaceutical composition for use as a contraceptive
US6500462B1 (en) * 1999-10-29 2002-12-31 Fmc Corporation Edible MCC/PGA coating composition
US8771740B2 (en) 1999-12-20 2014-07-08 Nicholas J. Kerkhof Process for producing nanoparticles by spray drying
EP1239844B1 (de) 1999-12-20 2005-06-08 Nicholas J. Kerkhof Verfahren zur herstellung von nanometer partikeln durch fliessbett- sprühtrocknung
WO2002013823A1 (en) * 2000-08-14 2002-02-21 Teva Pharmaceutical Industries Ltd. Micronized torsemide
US6932861B2 (en) * 2000-11-28 2005-08-23 Fmc Corporation Edible PGA coating composition
BR0115585A (pt) 2000-11-28 2005-12-13 Fmc Corp Composições de revestimento de pronta liberação, endurecìvel, comestìvel, seca e, úmida, forma de dosagem sólida, e, método para revestir uma forma de dosagem sólida farmacêutica ou veterinária, confeito, semente, ração animal, fertilizante, comprimido de pesticida ou alimento
US6544552B2 (en) 2001-01-11 2003-04-08 Particle And Coating Technologies, Inc. Method of producing porous tablets with improved dissolution properties
AU2002244247B2 (en) 2001-03-01 2007-12-13 Harbor Biosciences, Inc. Use of certain steroids for treatment of blood cell deficiencies
DE60205491T2 (de) * 2001-06-29 2006-06-01 Eurand Pharmaceuticals Ltd. Verfahren zur arzneimittelaktivierung mittels schwingmühle
WO2007064311A1 (en) * 2001-07-10 2007-06-07 Teva Pharmaceutical Industries Ltd. Micronized mirtazapine
CA2456806C (en) 2001-08-08 2011-10-18 Brown University Research Foundation Methods for micronization of hydrophobic drugs
US7217426B1 (en) 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
US7033602B1 (en) 2002-06-21 2006-04-25 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of coating implantable medical devices
US7794743B2 (en) * 2002-06-21 2010-09-14 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of making the same
US6994867B1 (en) 2002-06-21 2006-02-07 Advanced Cardiovascular Systems, Inc. Biocompatible carrier containing L-arginine
US7011842B1 (en) 2002-06-21 2006-03-14 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of making the same
US7070798B1 (en) 2002-06-21 2006-07-04 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine
US7056523B1 (en) 2002-06-21 2006-06-06 Advanced Cardiovascular Systems, Inc. Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine
US8506617B1 (en) 2002-06-21 2013-08-13 Advanced Cardiovascular Systems, Inc. Micronized peptide coated stent
US20040048931A1 (en) * 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
US7094256B1 (en) 2002-12-16 2006-08-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical device containing polycationic peptides
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US20040146537A1 (en) * 2003-01-28 2004-07-29 Ramachandran Radhakrishnan Oily wax matrix suspension formulation comprising pharmacologically active agents
MXPA05008088A (es) * 2003-02-24 2005-09-21 Mallinckrodt Inc Proceso mejorado para preparar benzhidril tioacetamida.
US20040253308A1 (en) * 2003-04-29 2004-12-16 Barr Laboratories, Inc. Surface-treated modafinil particles
EP1646369B1 (de) * 2003-07-11 2019-04-10 F.Hoffmann-La Roche Ag Saquinavir-mesylat orale dosierform
MXPA06000524A (es) * 2003-07-18 2006-08-11 Santarus Inc Formulacion farmaceutica y metodo para tratar desordenes gastrointestinales provocados por acido.
CN1878602A (zh) * 2003-11-28 2006-12-13 三菱化学株式会社 有机化合物微粒的制造方法
EP1701698B1 (de) * 2004-01-08 2008-01-16 Wyeth a Corporation of the State of Delaware Direkt komprimierbare pharmazeutische zusammensetzung für die orale verabreichung von cci-779
EP2471536A1 (de) 2004-09-29 2012-07-04 Harbor BioSciences, Inc. Steroidanaloga sowie charakterisierungs- und behandlungsverfahren
ES2231043B2 (es) * 2004-10-29 2005-10-01 Laboratorios Cinfa, S.A. Composicion farmaceutica de ebastina de liberacion inmediata y su proceso de fabricacion.
JP4754211B2 (ja) * 2004-12-28 2011-08-24 ライオン株式会社 粒状医薬組成物及びその製造方法
EP1830824B1 (de) * 2004-12-31 2016-01-13 Iceutica Pty Ltd. Nanoteilchen-zusammensetzung und verfahren zu ihrer synthese
PT1920786E (pt) 2005-07-25 2011-12-28 Otsuka Pharma Co Ltd Preparação oral para avaliar a capacidade metabólica da pirimidina
EP1912621B1 (de) * 2005-08-02 2019-09-11 Drossapharm AG Pharmazeutische zusammensetzung enthaltend indometacin und/oder acemetacin
US20070092576A1 (en) * 2005-10-20 2007-04-26 Adolor Corporation Compositions containing opioid antagonists
EP1978933A2 (de) * 2005-12-15 2008-10-15 Acusphere, Inc. Verfahren zur herstellung von pharmazeutischen formulierungen auf teilchenbasis zur oralen verabreichung
CA2631493A1 (en) * 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
MX2008011418A (es) * 2006-03-06 2008-09-22 Teva Pharma Composiciones de ezetimibe.
JP2007314529A (ja) * 2006-04-28 2007-12-06 Lion Corp 造粒粒子、錠剤、及び造粒粒子の製造方法
NZ705763A (en) * 2006-06-30 2016-10-28 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
AU2013273795C1 (en) * 2006-06-30 2016-08-18 Iceutica Pty Ltd Method for the Preparation of Biologically Active Compounds in Nanoparticle Form
AU2016203251B2 (en) * 2006-06-30 2017-11-16 Iceutica Pty Ltd Methods for the Preparation of Biologically Active Compounds in Nanoparticle Form
AU2012203877B2 (en) * 2006-06-30 2013-10-10 Iceutica Pty Ltd Methods For The Preparation Of Biologically Active Compounds In Nanoparticulate Form
AU2007264418B2 (en) * 2006-06-30 2012-05-03 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
US20080181966A1 (en) * 2006-10-18 2008-07-31 Cephalon, Inc. Modafinil pharmaceutical compositions
NZ597109A (en) * 2007-03-29 2013-01-25 Daiichi Sankyo Co Ltd Tablet composition having favorable dissolution property useful as an anticoagulant
TWI405590B (zh) 2007-04-06 2013-08-21 活效製藥股份有限公司 微粉碎化有機化合物粒子之製法
US20080262078A1 (en) * 2007-04-20 2008-10-23 Namdeo Alok B Pharmaceutical Compositions
JP2009091298A (ja) * 2007-10-10 2009-04-30 Asuka Corporation:Kk 皮膚改善化粧料
MX2010008707A (es) * 2008-02-06 2011-03-25 Wockhardt Ltd Composiciones farmaceuticas de entacapona comicronizada con alcoholes de azucar.
EP2252284B1 (de) * 2008-02-06 2011-05-25 Wockhardt Research Centre Pharmazeutische zusammensetzungen von entacapon, levodopa und carbidopa mit verbesserter bioverfügbarkeit
US20170105966A1 (en) * 2008-02-28 2017-04-20 Roger Imboden Pharmaceutical composition containing indometacin and/or acemetacin
JP5149673B2 (ja) * 2008-04-03 2013-02-20 有限会社不動権現 こんにゃく粉製造方法
DK2273994T3 (en) 2008-04-03 2016-02-01 Neurmedix Inc PHARMACEUTICAL FORMS OF A MEDICINE
US20100016450A1 (en) * 2008-07-21 2010-01-21 Otonomy, Inc. Controlled release delivery devices for the treatment of otic disorders
DE102008037025C5 (de) * 2008-08-08 2016-07-07 Jesalis Pharma Gmbh Verfahren zur Herstellung kristalliner Wirkstoff-Mikropartikel bzw. einer Wirkstoffpartikel-Festkörperform
EP2345426B1 (de) * 2008-09-19 2014-03-05 Activus Pharma Co., Ltd. Organische pulvrige verbindung für medizinische verwendung, herstellungsverfahren dafür und suspension daraus
EP2168573A1 (de) * 2008-09-30 2010-03-31 LEK Pharmaceuticals D.D. Zubereitungen enthaltend Ezetimib
JP5898613B2 (ja) * 2009-04-24 2016-04-06 イシューティカ ピーティーワイ リミテッド 生物学的活性物質の溶解プロファイルを改善するための方法
US20120160944A1 (en) * 2009-04-24 2012-06-28 Aaron Dodd Method for the production of commercial nanoparticle and micro particle powders
CN102438594A (zh) 2009-04-24 2012-05-02 伊休蒂卡有限公司 吲哚美辛的新剂型
EA201171284A1 (ru) * 2009-04-24 2012-05-30 Айсьютика Пти Лтд. Новая технология изготовления напроксена
MX360019B (es) * 2009-04-24 2018-10-15 Iceutica Pty Ltd Una formulación novedosa de metaxalona.
KR101580656B1 (ko) 2009-04-24 2015-12-30 아이슈티카 피티와이 리미티드 디클로페낙의 신규 제형
SG10201607849TA (en) * 2009-04-24 2016-11-29 Iceutica Pty Ltd Production of encapsulated nanoparticles at commercial scale
CN102573912B (zh) 2009-09-30 2014-01-01 三仪股份有限公司 难溶性物质的水溶性改善方法
JP5390014B2 (ja) 2010-03-19 2014-01-15 第一三共株式会社 抗凝固剤の溶出改善方法
US8828445B2 (en) 2010-03-22 2014-09-09 Bio-Synectics Inc. Method for preparing nano-particles utilizing a saccharide anti-coagulant
CN102408756B (zh) * 2011-08-05 2013-06-19 中国人民解放军第四军医大学 DiI 显微颗粒简易制作及其标记神经元的方法
ES2673182T3 (es) 2011-08-10 2018-06-20 Daiichi Sankyo Company, Limited Composición farmacéutica que contiene un derivado de diamina
KR101794032B1 (ko) 2011-09-21 2017-11-07 (주)바이오시네틱스 나노입자 제조방법
JP5909796B2 (ja) 2012-03-02 2016-04-27 株式会社サンギ 難溶性物質の水溶解性改善方法
CA2882528A1 (en) 2012-08-20 2014-02-27 Otsuka Pharmaceutical Co., Ltd. Method for measuring carbohydrate metabolism ability, and composition for use in said method
KR20210014204A (ko) 2013-03-15 2021-02-08 오츠카 세이야쿠 가부시키가이샤 지방산 연소에 의한 인슐린 저항성의 측정 방법, 및 그에 사용하는 조성물
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
WO2017209216A1 (ja) * 2016-05-31 2017-12-07 協和発酵キリン株式会社 難溶性薬物の微粒子を含有する医薬組成物の製造方法
EP3453384B1 (de) 2017-09-07 2020-05-27 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmazeutische tablette enhaltend bilastin
EP3470062B1 (de) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmazeutische tablettenzusammensetzung mit bilastin polymorph form 3 und magnesiumaluminometasilikat
JP7421542B2 (ja) * 2019-03-06 2024-01-24 株式会社 伊藤園 植物含有組成物の製造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA952431A (en) * 1970-09-28 1974-08-06 Frank M. Bardani Controlled release medicament
FR2162245A1 (en) * 1971-12-06 1973-07-20 Sobio Lab Micronized l-dopa - with increased bioavailability
FR2257266B1 (de) * 1974-01-10 1977-07-01 Pasteur Institut
DE2401037C2 (de) * 1974-01-10 1978-03-30 Eric G. 7000 Stuttgart Doubleday Rohrstück für Reinigungsmaschinen, insbesondere für Staub- oder Flüssigkeitssauggeräte
JPS5132718A (en) * 1974-09-13 1976-03-19 Yoshinobu Nakai Nanyoseiyakuhin no yoshutsusokudochosetsuho
JPS59101423A (ja) * 1982-12-02 1984-06-12 Takada Seiyaku Kk 新規なニフエジピン固形製剤
US4753800A (en) * 1985-10-04 1988-06-28 Warner-Lambert Company Medicament adsorbates and their preparation
JPH0215026A (ja) * 1988-07-01 1990-01-18 Takada Seiyaku Kk 新規なプロブコール固形製剤
HU200926B (en) * 1988-10-28 1990-09-28 Egyt Gyogyszervegyeszeti Gyar Pharmaceutical composition comprising piroxicam and lactose for use in making tablets or capsules

Also Published As

Publication number Publication date
EP0411629B1 (de) 1993-11-03
KR910004183A (ko) 1991-03-28
JPH0366613A (ja) 1991-03-22
DE69004372D1 (de) 1993-12-09
EP0411629A3 (en) 1991-05-08
JP2642486B2 (ja) 1997-08-20
CA2022465A1 (en) 1991-02-05
US5202129A (en) 1993-04-13
EP0411629A2 (de) 1991-02-06
DK0411629T3 (da) 1993-12-13
KR0126465B1 (ko) 1997-12-24
ES2062221T3 (es) 1994-12-16
DE69004372T2 (de) 1994-04-21
CA2022465C (en) 1998-04-21

Similar Documents

Publication Publication Date Title
ATE96658T1 (de) Verfahren zum mikronisieren schwerloeslicher arzneistoffe.
ATE119393T1 (de) Verwendung eines opiatantagonisten zur herstellung eines transdermal zu verabreichenden arzneimittels sowie eine vorrichtung zur transdermalen verabreichung.
PT86819A (pt) Process for the preparation of novel insulin derivatives and of pharmaceutical compositions containing the same
PT84786A (en) Process for the preparation of pharmaceutical formulations of acid labile substances for oral use
ZA888734B (en) Stabilized medicinal substances,a process for the preparation thereof,and stable medicinal formulations
IE861813L (en) New Polysaccharide Esters and their Salts
HUT54999A (en) Process for producing imidazolyl-alkenic acids and pharmaceutical compositions containing them as active components
HUT47552A (en) Process for producing 10-dihydro-10-deoxo-11-aza-erythronolid a derivatives and pharmaceutical compositions containing them as active components
YU215090A (sr) Formulacija u obliku pilule za kontrolisano oslobađanje
HUT48247A (en) Process for producing aza-bicyclo-octyl-ether derivatives and pharmaceutical compositions containing them as active components
EP0404283A3 (de) 11-Beta-aryl-4-estrene, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
NZ225242A (en) Pad printing process for manufacturing a pharmaceutical presentation and/or dosage form for active ingredients of drugs
HUT51620A (en) Process for producing multicyclic pyrimidine derivatives and pharmaceutical preparations containing these compounds as active substance
BR9304431A (pt) Medicamento processo para sua preparaçao e aplicaçao de uma mistura
DZ1390A1 (fr) Procédé de préparation de dérivés d'acides benzocycloalcényl dihydroxy alcanoïque et de médicaments les contenant.
WO1987004926A3 (en) Method of modifying the lipid structure of cell membranes and pharmaceutical compositions for use therein
DK330787D0 (da) Stabiliseret farmaceutisk sammensaetning
PT86874A (pt) Process for the preparation of cromona by products and of pharmaceutical compounds containing them
PT87301A (pt) Process for the preparation of 1,3-dioxanes by products and of pharmaceutical compounds containing them
HUT48119A (en) Process for producing pharmaceutical compositions against addiction to nicotine and comprising 2-pyrimidinyl-1-piperazine derivatives
HU903492D0 (en) Process for producing new pyrido-benzo-indole derivatives and pharmaceutical preparatives containing these compounds as active substance
EA199800179A1 (ru) Способ изготовления твердых лекарственных форм, содежащих лекарства в очень малых дозах
PT84405B (pt) Processo para a preparacao de composicoes farmaceuticas contendo 2-alcoxi-n-(1-azabiciclo {2.2.2} octil-3-benzamida-n-oxidos apropriadas para controlar a emese provocada por drogas anti-cancro
ATE89744T1 (de) Pharmazeutische zusammensetzung.
HU904062D0 (en) Process for producing substituted 3-amino-sydnonimines and pharmaceutical preparations containing these compounds as active substance

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee