ATE97916T1 - Cyclosporine. - Google Patents

Cyclosporine.

Info

Publication number: ATE97916T1
Authority: AT; Austria
Prior art keywords: amino; group; methylamino; mercapto; acid residue
Prior art date: 1987-07-22

Application number

AT88306697T

Other languages

English (en)

Inventor

Ian James Galpin

Original Assignee

British Tech Group

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-22

Filing date

1988-07-21

Publication date

1993-12-15

1988-07-21 Application filed by British Tech Group filed Critical British Tech Group

1993-12-15 Application granted granted Critical

1993-12-15 Publication of ATE97916T1 publication Critical patent/ATE97916T1/de

Links

108010036941 Cyclosporins Proteins 0.000 title abstract 3
229930182912 cyclosporin Natural products 0.000 title abstract 3
-1 amino, methylamino, mercapto Chemical class 0.000 abstract 5
125000000539 amino acid group Chemical group 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
125000002015 acyclic group Chemical group 0.000 abstract 3
125000001931 aliphatic group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
IADUEWIQBXOCDZ-UHFFFAOYSA-N azetidine-2-carboxylic acid Chemical compound OC(=O)C1CCN1 IADUEWIQBXOCDZ-UHFFFAOYSA-N 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
229940125721 immunosuppressive agent Drugs 0.000 abstract 1
239000003018 immunosuppressive agent Substances 0.000 abstract 1
HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
HXEACLLIILLPRG-UHFFFAOYSA-N pipecolic acid Chemical compound OC(=O)C1CCCCN1 HXEACLLIILLPRG-UHFFFAOYSA-N 0.000 abstract 1
FBVVGPMIPAZFAW-WCCKRBBISA-N pyrrolidine-2-carboxylic acid;(2s)-pyrrolidine-2-carboxylic acid Chemical compound OC(=O)C1CCCN1.OC(=O)[C@@H]1CCCN1 FBVVGPMIPAZFAW-WCCKRBBISA-N 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
125000003396 thiol group Chemical group [H]S* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Rheumatology (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Communicable Diseases (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT88306697T 1987-07-22 1988-07-21 Cyclosporine. ATE97916T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878717300A GB8717300D0 (en)	1987-07-22	1987-07-22	Cyclosporins
EP88306697A EP0300785B1 (de)	1987-07-22	1988-07-21	Cyclosporine

Publications (1)

Publication Number	Publication Date
ATE97916T1 true ATE97916T1 (de)	1993-12-15

Family

ID=10621087

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88306697T ATE97916T1 (de)	1987-07-22	1988-07-21	Cyclosporine.

Country Status (6)

Country	Link
US (1)	US5079341A (de)
EP (1)	EP0300785B1 (de)
JP (1)	JPH01151600A (de)
AT (1)	ATE97916T1 (de)
DE (1)	DE3885959T2 (de)
GB (2)	GB8717300D0 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH679119A5 (de) *	1988-05-13	1991-12-31	Sandoz Ag
GB8916901D0 (en)	1989-07-24	1989-09-06	Sandoz Ltd	Improvements in or relating to organic compounds
FI111730B (fi) *	1990-11-02	2003-09-15	Novartis Ag	Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi
US5362629A (en) *	1991-08-05	1994-11-08	President And Fellows Of Harvard College	Detection of immunosuppressants
GB9204466D0 (en) *	1992-03-02	1992-04-15	Sandoz Ltd	Improvements in or relating to organic compounds
WO1993017701A1 (en) *	1992-03-12	1993-09-16	The Administrators Of The Tulane Educational Fund	Endothelin receptor-binding peptides
EP0572688B1 (de) *	1992-05-30	1997-05-07	Predrag Dr.Sc. Sikiric	BPC-Peptide, deren Herstellung und Verwendung
US5709797A (en) *	1996-06-05	1998-01-20	Poli Industria Chimica S.P.A.	Method of isolating cyclosporins
RU2170741C2 (ru) *	1996-08-16	2001-07-20	Новартис Аг	Способ получения циклоспорина
AU750245B2 (en)	1997-10-08	2002-07-11	Aurinia Phamaceuticals Inc.	Deuterated cyclosporine analogs and their use as immunomodulating agents
US20030220234A1 (en)	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
WO2000046239A1 (fr) *	1999-02-05	2000-08-10	Debiopharm S.A.	Derives de cyclosporine et procede de preparation desdits derives
US6995139B2 (en) *	2001-04-20	2006-02-07	Debiopharm S.A.	Cyclic undecapeptide pro-drugs and uses thereof
MXPA04003625A (es) *	2001-10-19	2004-12-02	Sotechnika Inc	Sintesis de analogos de ciclosporina.
US7538084B2 (en)	2003-03-17	2009-05-26	Amr Technology, Inc.	Cyclosporins
JP2008514701A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキン類似体およびそれらの薬学的使用
JP2008514702A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	新規シクロスポリン類似体およびそれらの薬学的使用
JP2008515886A (ja)	2004-10-06	2008-05-15	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
KR20110111321A (ko)	2009-01-30	2011-10-10	이난타 파마슈티칼스, 인코포레이티드	Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체
US8481483B2 (en)	2009-02-19	2013-07-09	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
US8349312B2 (en)	2009-07-09	2013-01-08	Enanta Pharmaceuticals, Inc.	Proline substituted cyclosporin analogues
US8685917B2 (en)	2009-07-09	2014-04-01	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
US8367053B2 (en)	2009-07-09	2013-02-05	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues
US8623814B2 (en)	2010-02-23	2014-01-07	Enanta Pharmaceuticals, Inc.	Antiviral agents
BR112013014890B1 (pt)	2010-12-15	2023-10-24	Contravir Pharmaceuticals, Inc	Composto análogo de moléculas pertencentes à família ciclosporina, composição farmacêutica compreendendo o mesmo, uso terapêutico ou profilático do referido composto e processos para a preparação dos mesmos
WO2012145427A1 (en)	2011-04-18	2012-10-26	The Trustees Of Columbia University In The City Of New York	Methods to treat cancer using cyclosporine and cyclosporine derivatives
WO2014085623A1 (en)	2012-11-28	2014-06-05	Enanta Pharmaceuticals, Inc.	Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
JP2016538317A (ja)	2013-08-26	2016-12-08	エナンタファーマシューティカルズインコーポレイテッド	Ｃ型肝炎を防止または治療するための新規シクロスポリン類似体
US9669095B2 (en)	2014-11-03	2017-06-06	Enanta Pharmaceuticals, Inc.	Cyclosporin analogues for preventing or treating hepatitis C infection

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2455859C2 (de) *	1973-12-06	1983-12-15	Sandoz-Patent-GmbH, 7850 Lörrach	Das Antibiotikum Cyclosporin A (S 7481/F-1), seine Herstellung und Verwendung
CH614931A5 (de) *	1975-11-04	1979-12-28	Sandoz Ag
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds
DE2819094A1 (de) *	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
DE2907460A1 (de) *	1978-03-07	1979-09-13	Sandoz Ag	Neue resorbierbare galenische kompositionen
SE448386B (sv) *	1978-10-18	1987-02-16	Sandoz Ag	Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
IE54936B1 (en) *	1980-02-14	1990-03-28	Sandoz Ltd	A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
US4649047A (en) *	1985-03-19	1987-03-10	University Of Georgia Research Foundation, Inc.	Ophthalmic treatment by topical administration of cyclosporin

1987
- 1987-07-22 GB GB878717300A patent/GB8717300D0/en active Pending
1988
- 1988-07-21 US US07/222,211 patent/US5079341A/en not_active Expired - Fee Related
- 1988-07-21 AT AT88306697T patent/ATE97916T1/de not_active IP Right Cessation
- 1988-07-21 DE DE88306697T patent/DE3885959T2/de not_active Expired - Fee Related
- 1988-07-21 GB GB8817434A patent/GB2208294B/en not_active Expired - Lifetime
- 1988-07-21 EP EP88306697A patent/EP0300785B1/de not_active Expired - Lifetime
- 1988-07-22 JP JP63184461A patent/JPH01151600A/ja active Pending

Also Published As

Publication number	Publication date
JPH01151600A (ja)	1989-06-14
GB2208294A (en)	1989-03-22
GB2208294B (en)	1991-04-24
GB8817434D0 (en)	1988-08-24
DE3885959T2 (de)	1994-03-24
GB8717300D0 (en)	1987-08-26
EP0300785A2 (de)	1989-01-25
EP0300785B1 (de)	1993-12-01
US5079341A (en)	1992-01-07
DE3885959D1 (de)	1994-01-13
EP0300785A3 (en)	1990-05-23

Legal Events

Date	Code	Title	Description
1994-08-15	UEP	Publication of translation of european patent specification
1996-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE97916T1 (de)	1993-12-15	Cyclosporine.
GB2207433B (en)	1990-10-10	Acyclic cyclosporins
AU7929491A (en)	1992-01-02	New 4-aminobutyric acid compunds process for the preparation thereof and pharmaceutical preparations containing them
DE69021176D1 (de)	1995-08-31	Polypeptid und Verfahren zu dessen Herstellung.
DE3880922D1 (de)	1993-06-17	Faktor viii-analog, verfahren zu dessen herstellung und dieses enthaltende zusammensetzung.
TW274541B (de)	1996-04-21
CA2086404A1 (en)	1993-07-01	Triazolopyrimidine derivatives
TW256832B (de)	1995-09-11
ATE73790T1 (de)	1992-04-15	Amino 5,6,7,8tetrahydronaphtho(2,3b>furanderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
NO302072B1 (no)	1998-01-19	Azabicyklo-arylacetylen- og -arylenyn-oksimer som cholinerge midler og preparater inneholdende slike
EP0696585A4 (de)	1996-03-27
AU579869B2 (en)	1988-12-15	4-amino-8-alkylthio-2-piperazino-pyrimido ``5,4-d`` pyrimidines
IE890175L (en)	1989-07-21	Aminoacid glycerides.
AU626095B2 (en)	1992-07-23	Hydroxyalkane carboxylic acid derivatives, their production and use
PH24709A (en)	1990-10-01	Allylmercaptoacetylsydnonimines and pharmaceutical compositions thereof
AU5176093A (en)	1994-04-26	Oleaginous compositions
DE69116383D1 (de)	1996-02-22	Hexapeptidderivate von teicoplanin und verfahren zu deren herstellung