ATE98879T1 - Osteoinduktive kollagenzusammensetzung zur bekaempfung von knochendefekten. - Google Patents

Osteoinduktive kollagenzusammensetzung zur bekaempfung von knochendefekten.

Info

Publication number
ATE98879T1
ATE98879T1 AT88308793T AT88308793T ATE98879T1 AT E98879 T1 ATE98879 T1 AT E98879T1 AT 88308793 T AT88308793 T AT 88308793T AT 88308793 T AT88308793 T AT 88308793T AT E98879 T1 ATE98879 T1 AT E98879T1
Authority
AT
Austria
Prior art keywords
collagen
osteoinductional
bone defects
collagen composition
implants
Prior art date
Application number
AT88308793T
Other languages
English (en)
Inventor
George Chu
Ranga Nathan
Saeid Seyedin
Original Assignee
Collagen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Collagen Corp filed Critical Collagen Corp
Application granted granted Critical
Publication of ATE98879T1 publication Critical patent/ATE98879T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/92—Method or apparatus for preparing or treating prosthetic
    • Y10S623/923—Bone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Composite Materials (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT88308793T 1987-09-25 1988-09-22 Osteoinduktive kollagenzusammensetzung zur bekaempfung von knochendefekten. ATE98879T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/100,990 US4888366A (en) 1984-10-24 1987-09-25 Inductive collagen-based bone repair preparations
EP88308793A EP0309241B1 (de) 1987-09-25 1988-09-22 Osteoinduktive Kollagenzusammensetzung zur Bekämpfung von Knochendefekten

Publications (1)

Publication Number Publication Date
ATE98879T1 true ATE98879T1 (de) 1994-01-15

Family

ID=22282569

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88308793T ATE98879T1 (de) 1987-09-25 1988-09-22 Osteoinduktive kollagenzusammensetzung zur bekaempfung von knochendefekten.

Country Status (8)

Country Link
US (1) US4888366A (de)
EP (1) EP0309241B1 (de)
JP (1) JPH01158964A (de)
AT (1) ATE98879T1 (de)
AU (1) AU618756B2 (de)
CA (1) CA1335177C (de)
DE (1) DE3886493T2 (de)
ES (1) ES2060656T3 (de)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246457A (en) * 1985-03-28 1993-09-21 Collagen Corporation Xenogeneic collagen/mineral preparations in bone repair
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5447966A (en) * 1988-07-19 1995-09-05 United States Surgical Corporation Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin
US5573771A (en) * 1988-08-19 1996-11-12 Osteomedical Limited Medicinal bone mineral products
US5108436A (en) * 1988-09-29 1992-04-28 Collagen Corporation Implant fixation
US5258029A (en) * 1988-09-29 1993-11-02 Collagen Corporation Method for improving implant fixation
US5207710A (en) * 1988-09-29 1993-05-04 Collagen Corporation Method for improving implant fixation
US5264214A (en) * 1988-11-21 1993-11-23 Collagen Corporation Composition for bone repair
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5819748A (en) * 1988-11-30 1998-10-13 Ed Geistlich Sohne Ag Fur Chemische Industrie Implant for use in bone surgery
WO1991001720A1 (en) * 1989-08-07 1991-02-21 Herman Wade Schlameus Composition and method of promoting hard tissue healing
ES2118723T3 (es) * 1989-10-17 1998-10-01 Stryker Corp Dispositivos osteogenicos.
US5236456A (en) * 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5425769A (en) * 1990-04-23 1995-06-20 Snyders, Jr.; Robert V. Composition of material for osseous repair
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
CA2363965C (en) * 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
NZ241979A (en) * 1991-03-20 1996-01-26 Merck & Co Inc Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker
US5563124A (en) * 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
US5290763A (en) * 1991-04-22 1994-03-01 Intermedics Orthopedics/Denver, Inc. Osteoinductive protein mixtures and purification processes
US5693615A (en) * 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
US5356629A (en) * 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5320844A (en) * 1992-03-12 1994-06-14 Liu Sung Tsuen Composite materials for hard tissue replacement
US5531791A (en) * 1993-07-23 1996-07-02 Bioscience Consultants Composition for repair of defects in osseous tissues, method of making, and prosthesis
DE4425776C2 (de) * 1994-07-13 2002-08-29 Britta Hofmann Verfahren zur Herstellung eines verbesserten Kollagentransplantats mit aufgelockerter Struktur
US5782919A (en) * 1995-03-27 1998-07-21 Sdgi Holdings, Inc. Interbody fusion device and method for restoration of normal spinal anatomy
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US6902584B2 (en) 1995-10-16 2005-06-07 Depuy Spine, Inc. Bone grafting matrix
US5776193A (en) * 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
WO1998030252A1 (en) * 1997-01-09 1998-07-16 Cohesion Technologies, Inc. Methods and apparatuses for making swellable uniformly shaped devices from polymeric materials
US6679918B1 (en) 1997-02-13 2004-01-20 Centerpulse Biologics Inc. Implantable putty material
US20030032586A1 (en) * 1997-05-15 2003-02-13 David C. Rueger Compositions for morphogen-induced osteogenesis
US5972368A (en) * 1997-06-11 1999-10-26 Sdgi Holdings, Inc. Bone graft composites and spacers
EP0896825B1 (de) 1997-08-14 2002-07-17 Sulzer Innotec Ag Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren
US20040081704A1 (en) * 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US6383519B1 (en) * 1999-01-26 2002-05-07 Vita Special Purpose Corporation Inorganic shaped bodies and methods for their production and use
ES2209820T3 (es) * 1999-02-04 2004-07-01 Sdgi Holdings, Inc. Composiciones esponjosas osteogenicas altamente mineralizadas, y usos de las mismas.
CA2362046A1 (en) * 1999-02-04 2000-08-10 Sdgi Holdings, Inc. Osteogenic paste compositions and uses thereof
US6458162B1 (en) * 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
US7323193B2 (en) 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US20020115742A1 (en) * 2001-02-22 2002-08-22 Trieu Hai H. Bioactive nanocomposites and methods for their use
CA2433038A1 (en) 2001-10-12 2003-04-17 Osteotech, Inc. Bone graft compositions with improved growth factor stability
US6752938B2 (en) * 2001-10-13 2004-06-22 Invigor Biotechnology Co., Ltd. Method of preparing microsphere composite of collagen and bioceramic powder
TW200400062A (en) 2002-04-03 2004-01-01 Mathys Medizinaltechnik Ag Kneadable, pliable bone replacement material
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
KR20060031808A (ko) 2003-06-11 2006-04-13 오스테오테크, 인코포레이티드 뼈 임플란트 및 그의 제조 방법
US8328876B2 (en) 2003-12-31 2012-12-11 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
US7189263B2 (en) 2004-02-03 2007-03-13 Vita Special Purpose Corporation Biocompatible bone graft material
WO2006083260A2 (en) 2004-04-28 2006-08-10 Angiotech Biomaterials Corporation Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US7348802B2 (en) * 2004-06-15 2008-03-25 Stmicroelectronics Pvt. Ltd. Differential receiver
US9220595B2 (en) 2004-06-23 2015-12-29 Orthovita, Inc. Shapeable bone graft substitute and instruments for delivery thereof
US7722895B1 (en) * 2004-09-20 2010-05-25 Warsaw Orthopedic, Inc. Osteogenic implants with combined implant materials, and materials and methods for same
DE102005016443A1 (de) * 2004-11-23 2006-05-24 Ossacur Ag Bioresorbierbares und mineralisiertes Material zur Füllung von Knochendefekten
US7857853B2 (en) * 2005-04-29 2010-12-28 Sdgi Holdings, Inc Synthetic loadbearing collagen-mineral composites useful for spinal implants, and methods of manufacture
US8506646B2 (en) * 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
CN101365499A (zh) 2005-11-01 2009-02-11 骨骼技术股份有限公司 骨基质组合物和方法
WO2007056671A1 (en) 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
AU2007265379B9 (en) 2006-06-29 2014-05-29 Orthovita, Inc. Bioactive bone graft substitute
US20080177330A1 (en) * 2006-10-24 2008-07-24 Ralph James D Self-locking screws for medical implants
US7381224B1 (en) * 2006-12-08 2008-06-03 Collagen Matrix, Inc. Bone implant composite
US7544212B2 (en) 2006-12-08 2009-06-09 Collagen Matrix, Inc. Bone implant composite
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
CA2945295C (en) 2007-06-15 2020-01-14 Warsaw Orthopedic, Inc. Method of treating tissue
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
CA2690457C (en) 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
US9492278B2 (en) 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system
CA2702499A1 (en) 2007-10-19 2009-04-23 Osteotech, Inc. Demineralized bone matrix compositions and methods
US9149563B2 (en) * 2007-11-06 2015-10-06 The University Of Connecticut Calcium phosphate/structural protein composites and method of preparation thereof
US8084095B2 (en) * 2007-11-06 2011-12-27 The University Of Connecticut Ceramic/structural protein composites and method of preparation thereof
US9510885B2 (en) 2007-11-16 2016-12-06 Osseon Llc Steerable and curvable cavity creation system
US20090131867A1 (en) 2007-11-16 2009-05-21 Liu Y King Steerable vertebroplasty system with cavity creation element
US20090131886A1 (en) 2007-11-16 2009-05-21 Liu Y King Steerable vertebroplasty system
JP2012506733A (ja) 2008-10-24 2012-03-22 ウォーソー・オーソペディック・インコーポレーテッド 骨形成を促進するための組成物および方法
WO2010093959A2 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery systems, tools, and methods of use
US20100226959A1 (en) * 2009-03-04 2010-09-09 Warsaw Orthopedic, Inc. Matrix that prolongs growth factor release
US20100298832A1 (en) 2009-05-20 2010-11-25 Osseon Therapeutics, Inc. Steerable curvable vertebroplasty drill
CN106618669B (zh) 2010-04-29 2019-11-12 Dfine有限公司 用于治疗椎骨骨折的系统
AU2011329054B2 (en) 2010-11-15 2015-05-28 Zimmer Orthobiologics, Inc. Bone void fillers
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
EP2529764A1 (de) 2011-05-31 2012-12-05 Curasan AG Biologisch degradierbares kompositmaterial
US9078832B2 (en) 2012-03-22 2015-07-14 The University Of Connecticut Biomimetic scaffold for bone regeneration
US20130345826A1 (en) 2012-06-22 2013-12-26 Collagen Matrix, Inc. Implants for Bone and Cartilage Repair
US9539363B2 (en) 2014-04-24 2017-01-10 Warsaw Orthopedic, Inc. Collagen matrix
JP5900692B1 (ja) * 2015-09-08 2016-04-06 東洋紡株式会社 多孔質複合体および骨再生材料
US10512709B2 (en) 2015-09-08 2019-12-24 Toyobo Co., Ltd. Porous composite and bone regeneration material
JP5900691B1 (ja) * 2015-09-08 2016-04-06 東洋紡株式会社 多孔質複合体および骨再生材料
CN109862834B (zh) 2016-10-27 2022-05-24 Dfine有限公司 具有接合剂递送通道的可弯曲的骨凿
WO2018098433A1 (en) 2016-11-28 2018-05-31 Dfine, Inc. Tumor ablation devices and related methods
US10463380B2 (en) 2016-12-09 2019-11-05 Dfine, Inc. Medical devices for treating hard tissues and related methods
WO2018129180A1 (en) 2017-01-06 2018-07-12 Dfine, Inc. Osteotome with a distal portion for simultaneous advancement and articulation
US11510723B2 (en) 2018-11-08 2022-11-29 Dfine, Inc. Tumor ablation device and related systems and methods
US11986229B2 (en) 2019-09-18 2024-05-21 Merit Medical Systems, Inc. Osteotome with inflatable portion and multiwire articulation
US11883302B2 (en) 2021-11-22 2024-01-30 Warsaw Orthopedic, Inc. Spinal implant having a compressible insert

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US717072A (en) 1901-05-08 1902-12-30 John Burry Magnetotherapeutic apparatus.
US816268A (en) 1905-03-30 1906-03-27 Otto W Steindorf Tripod for cameras.
US848443A (en) 1906-07-12 1907-03-26 Frederick Conrath Lamp-jack.
US4097935A (en) 1976-07-21 1978-07-04 Sterling Drug Inc. Hydroxylapatite ceramic
US4455256A (en) 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4314380A (en) 1980-09-26 1982-02-09 Koken Co., Ltd. Artificial bone
US4430760A (en) 1981-12-18 1984-02-14 Collagen Corporation Nonstress-bearing implantable bone prosthesis
US4394370A (en) * 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4440750A (en) * 1982-02-12 1984-04-03 Collagen Corporation Osteogenic composition and method
US4485097A (en) 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
JPS60126217A (ja) * 1983-12-14 1985-07-05 Sumitomo Chem Co Ltd 長期徐放性製剤
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
JPS60253455A (ja) * 1984-05-28 1985-12-14 京セラ株式会社 骨形成因子を含有する生体材料とその製造方法
US4627982A (en) 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
US4563350A (en) 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
CA1260391A (en) * 1985-03-28 1989-09-26 Karl A. Piez Xenogeneic collagen/mineral preparations in bone repair
JPH0662679B2 (ja) * 1985-06-21 1994-08-17 新田ゼラチン株式会社 組織親和性コラ−ゲンとその製法
JPH0759522B2 (ja) * 1985-12-27 1995-06-28 住友製薬株式会社 徐放性製剤の製造法
CA1294876C (en) * 1986-04-22 1992-01-28 Karl A. Piez Marrow/collagen/mineral matrix for bone defect repair
US4865602A (en) * 1986-11-06 1989-09-12 Collagen Corporation Gamma irradiation of collagen/mineral mixtures

Also Published As

Publication number Publication date
JPH01158964A (ja) 1989-06-22
ES2060656T3 (es) 1994-12-01
DE3886493D1 (de) 1994-02-03
JPH0553139B2 (de) 1993-08-09
AU2275188A (en) 1989-04-06
AU618756B2 (en) 1992-01-09
EP0309241B1 (de) 1993-12-22
CA1335177C (en) 1995-04-11
EP0309241A2 (de) 1989-03-29
EP0309241A3 (en) 1989-09-06
US4888366A (en) 1989-12-19
DE3886493T2 (de) 1994-04-14

Similar Documents

Publication Publication Date Title
DE3886493D1 (de) Osteoinduktive Kollagenzusammensetzung zur Bekämpfung von Knochendefekten.
HUT47977A (en) Polipeptides, process for their production and process for production of medical compositions containing such active substances
DE69028535D1 (de) Herstellung des vaskulären endothelialen zellwachstumsfaktors
TW427905B (en) Aqueous pharmaceutical composition of nerve growth factor
ATE70277T1 (de) Teilweise gereinigter knocheninduzierender faktor zur anwendung in der orteogenese.
DE3869577D1 (de) Injizierbare zusammensetzung zur wiederherstellung von knochen.
ATE341T1 (de) Implantierbare knochenersatzwerkstoffe auf der basis von calciumphosphat-keramik in einem matrix-material und verfahren zu deren herstellung.
AU7783587A (en) Novel osteoinductive compositions
ES2164691T3 (es) Formulacion de insulina.
IE76140B1 (en) Implant material
HUT62599A (en) Process for producing bile acid derivatives and pharmaceutical compositions comprising same
ES2087165T3 (es) Uso de acido nervonico y de acidos grasos de cadenas largas en el tratamiento de las alteraciones provocadas por la desmielinizacion.
ES2132399T3 (es) Composicion estimulante del crecimiento de osteoblastos que contiene pdgf y vitamina d.
ATE64537T1 (de) Mark-/kollagen-/mineralmatrix zur bekaempfung von knochendefekten.
ES2080132T3 (es) Procedimiento para la insolubilizacion y la aglomeracion de cenizas volantes de incineracion.
ATE160588T1 (de) Aus bakteriellen proteinen bestehender extrakt, verfahren zur dessen herstellung und diesen extrakt enthaltende pharmazeutische zusammensetzung
ES2012128A6 (es) Metodo de tratar plantas con acidos organicos que contienen azufre.
SE8803583D0 (sv) Pharmaceutical composition
ATE47274T1 (de) Tierstreu sowie verfahren zur herstellung derselben.
DE69014769D1 (de) Verfahren zur Herstellung von Torfkugeln, welche in biologischen Filtern verwandt werden.
FR2619313B1 (fr) Nouvelles compositions d'elements mineraux et/ou oligoelements et leur procede de preparation
HUT47375A (en) Fungicide compositions containing /2-cyano-2-oximino-acetyl/-aminoacid derivatives as active components and process for producing the active components
EP0165074A3 (en) Absorbent polymer material and its preparation
DE3270983D1 (en) Process for preparing a mixture of bee pollen having an improved resorption capacity, and a hyposensibilizing mixture of bee pollen
Suh Biodegradable Inorganic-Organic Composite Artiticial Bone Substitue-Part2. Collagen purification and its physical and biological properties