ES2132399T3 - Composicion estimulante del crecimiento de osteoblastos que contiene pdgf y vitamina d. - Google Patents

Composicion estimulante del crecimiento de osteoblastos que contiene pdgf y vitamina d.

Info

Publication number
ES2132399T3
ES2132399T3 ES94911725T ES94911725T ES2132399T3 ES 2132399 T3 ES2132399 T3 ES 2132399T3 ES 94911725 T ES94911725 T ES 94911725T ES 94911725 T ES94911725 T ES 94911725T ES 2132399 T3 ES2132399 T3 ES 2132399T3
Authority
ES
Spain
Prior art keywords
vitamin
osteoblastos
growth
stimulating composition
growth containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94911725T
Other languages
English (en)
Inventor
Emma E Moore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of ES2132399T3 publication Critical patent/ES2132399T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SE PRESENTAN METODOS Y COMPOSICIONES PARA ESTIMULAR EL CRECIMIENTO DE OSTEOBLASTOS. SE APLICA UNA COMPOSICION QUE CONTIENEN UN FACTOR DE CRECIMIENTO DERIVADO DE LAS PLAQUETAS Y VITAMINA D A LOS OSTEOBLASTOS EN UNA CANTIDAD SUFICIENTE COMO PARA ESTIMULAR SU CRECIMIENTO. LOS METODOS SE PUEDEN UTILIZAR PARA POTENCIAR EL CRECIMIENTO DE OSTEOBLASTOS IN VIVO O PARA POTENCIAR LA CURACION DE DEFECTOS EN LOS HUESOS IN VIVO.
ES94911725T 1993-03-29 1994-03-29 Composicion estimulante del crecimiento de osteoblastos que contiene pdgf y vitamina d. Expired - Lifetime ES2132399T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3832593A 1993-03-29 1993-03-29

Publications (1)

Publication Number Publication Date
ES2132399T3 true ES2132399T3 (es) 1999-08-16

Family

ID=21899306

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94911725T Expired - Lifetime ES2132399T3 (es) 1993-03-29 1994-03-29 Composicion estimulante del crecimiento de osteoblastos que contiene pdgf y vitamina d.

Country Status (14)

Country Link
US (1) US5533836A (es)
EP (1) EP0691849B1 (es)
JP (1) JP3699111B2 (es)
KR (1) KR960701648A (es)
CN (1) CN1104257C (es)
AT (1) ATE180674T1 (es)
AU (1) AU681879B2 (es)
CA (1) CA2159449C (es)
DE (1) DE69418865T2 (es)
DK (1) DK0691849T3 (es)
ES (1) ES2132399T3 (es)
GR (1) GR3030402T3 (es)
RU (1) RU2140282C1 (es)
WO (1) WO1994022463A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700289A (en) * 1995-10-20 1997-12-23 North Shore University Hospital Research Corporation Tissue-engineered bone repair using cultured periosteal cells
WO1997048694A1 (en) * 1996-06-20 1997-12-24 Board Of Regents, The University Of Texas System Compounds and methods for providing pharmacologically active preparations and uses thereof
US20030129194A1 (en) * 1997-02-13 2003-07-10 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
US6042855A (en) * 1997-06-27 2000-03-28 United States Of America (Usda) Use of vitamin D, its metabolites and analogs to improve tenderness of meat and meat products
EP1043963A4 (en) * 1997-12-31 2001-02-07 Depuy Orthopaedics Inc OSTEOPONTIN-BASED COMPOSITION TO INCREASE BONE FORMATION
US6551355B1 (en) 1998-08-14 2003-04-22 Cambridge Scientific, Inc. Tissue transplant coated with biocompatible biodegradable polymer
US6663870B2 (en) * 1998-12-07 2003-12-16 Zymogenetics, Inc. Methods for promoting growth of bone using zvegf3
US6468543B1 (en) 1999-05-03 2002-10-22 Zymogenetics, Inc. Methods for promoting growth of bone using ZVEGF4
WO2001032197A2 (en) * 1999-11-02 2001-05-10 Eli Lilly And Company Methods of using lp8, a pdgf-related protein, to treat musculoskeletal disorders
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
WO2007061889A2 (en) * 2005-11-17 2007-05-31 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
EP1991282B1 (en) 2006-02-09 2013-06-19 BioMimetic Therapeutics, LLC Compositions and methods for treating bone
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
CA2656278C (en) 2006-06-30 2016-02-09 Biomimetic Therapeutics, Inc. Compositions and methods for treating rotator cuff injuries
US8106008B2 (en) 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
ES2422259T3 (es) * 2008-02-07 2013-09-10 Biomimetic Therapeutics Inc Composiciones para la osteogénesis por distracción
BE1018748A3 (fr) * 2008-05-07 2011-08-02 Bone Therapeutics Sa Nouvelles cellules souches mesenchymateuses et cellules osteogeniques .
EP2327427A4 (en) * 2008-08-19 2014-01-22 Univ Osaka CELL PREPARATION FOR BONE WEAVER AGENCY
KR20110067035A (ko) 2008-09-09 2011-06-20 바이오미메틱 세라퓨틱스, 인크. 건 및 인대 손상의 치료를 위한 혈소판-유래 성장 인자 조성물 및 방법
CN107080834A (zh) 2010-02-22 2017-08-22 生物模拟治疗有限责任公司 用于治疗腱病的血小板衍生生长因子组合物和方法
EP2823787B1 (en) * 2012-02-01 2019-01-09 Organ Technologies, Inc. Dental implant and method for producing same
MX2017004520A (es) 2014-10-14 2018-03-15 Lynch Samuel Composiciones para tratar heridas.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4264512A (en) * 1975-09-29 1981-04-28 The Regents Of The University Of California 3-Deoxy-1α-hydroxy- and 3-deoxy-1α,25-dihydroxycholecalciferol and processes for the preparation thereof
US4350687A (en) * 1980-02-10 1982-09-21 Research Corporation Platelet derived cell growth factor
CA1322714C (en) * 1986-11-14 1993-10-05 Harry N. Antoniades Wound healing and bone regeneration
DE3785758T2 (de) * 1986-11-14 1993-08-05 Harvard College Wundheilung und knochenregeneration.
US5124316A (en) * 1986-11-14 1992-06-23 President And Fellows Of Harvard College Method for periodontal regeneration
US4833125A (en) * 1986-12-05 1989-05-23 The General Hospital Corporation Method of increasing bone mass
IL84911A (en) * 1987-12-22 1993-04-04 Yissum Res Dev Co Processes for the preparation of collagen products, and pharmaceutical compositions containing the same
US5254538A (en) * 1989-10-04 1993-10-19 Trustees Of Boston University Method of treating periodontal disease
US5149691A (en) * 1991-03-12 1992-09-22 Creative Biomolecules, Inc. Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
CA2110410C (en) * 1991-06-05 1997-04-15 The Procter & Gamble Company Therapeutic compositions for osteoinduction
US5129691A (en) * 1991-08-20 1992-07-14 Mcfarlen Jonn Gate latch control device

Also Published As

Publication number Publication date
DE69418865D1 (de) 1999-07-08
RU2140282C1 (ru) 1999-10-27
DK0691849T3 (da) 1999-12-13
ATE180674T1 (de) 1999-06-15
CA2159449A1 (en) 1994-10-13
GR3030402T3 (en) 1999-09-30
AU6417194A (en) 1994-10-24
JPH08508499A (ja) 1996-09-10
DE69418865T2 (de) 2000-02-17
WO1994022463A1 (en) 1994-10-13
KR960701648A (ko) 1996-03-28
CN1121693A (zh) 1996-05-01
EP0691849B1 (en) 1999-06-02
US5533836A (en) 1996-07-09
CA2159449C (en) 1999-09-14
JP3699111B2 (ja) 2005-09-28
AU681879B2 (en) 1997-09-11
CN1104257C (zh) 2003-04-02
EP0691849A1 (en) 1996-01-17

Similar Documents

Publication Publication Date Title
DK0691849T3 (da) Osteoblastvækststimulerende præparat indeholdende PDGF og vitamin D
DE69028535D1 (de) Herstellung des vaskulären endothelialen zellwachstumsfaktors
ES2007625A6 (es) Un procedimiento para la produccion de una proteina para huesos y cartilagos.
LV10180A (lv) Farmaceitiska kompozicija
DE69429450D1 (de) Die verwendung von angiotensin iii und seiner analoge für die gewebeheilung
EP0339607A3 (en) Composition for repair of cartilage and bone and method for their preparation as skeletal tissue implant
SE9901973L (sv) Implantat för applicering i ben och förfarande och användning vid sådant implantat
DE69727158D1 (de) Pharmazeutische zusammensetzungen enthaltend eine mischung von selbstvernetzter und nichtselbstvernetzter hyaluronsäure zur behandlung von arthropathien
EP0441639A3 (en) Instrument for the application of controlled mechanical loads to tissues in sterile culture
DE69435096D1 (de) Zusammensetzung zur in vivo erzeugung von therapeutischen produkten
PL349028A1 (en) Cancer treatment composition and method using natural plant essential oils
ATE135208T1 (de) Verwendung von nervonsäure und langkettiger fettsäuren zur behandlung demyelinisierender erkrankungen
DE59209679D1 (de) Implantat zur elektrischen Impulsbeaufschlagung von lebendem Gewebe
FI971536A0 (fi) Keratinosyytti-kasvutekijän analogeja
ATE103815T1 (de) Verwendung von thrombospondin zur beschleunigung der wundheilung.
ATE67094T1 (de) Knochenzement.
ES2150902T3 (es) Procedimientos para potenciar la cicatrizacion de heridas y la reparacion de tejidos.
DE69010294D1 (de) Verwendung von Antiprogestomimetika zur Stimulierung des Eisprungs.
Schliephake et al. Experimental transplantation of hydroxylapatite-bone composite grafts
DE69133387D1 (de) Verwendung von Neotrehalose zur Herstellung eines Medikaments zur Energiesupplementierung bei einem lebenden Organismus
EP0347932A3 (en) Treatment of conditions requiring enhanced oxygen availability to mammalian tissues
DE69816808D1 (de) Somatostatin agoniste zur reduzierung von körpergewicht
PT862453E (pt) Composicoes contendo uma proteina morfogenetica do osso e um factor de crescimento dos fibroblastos e metodos para a inducao de cardiogenese
BR8800979A (pt) Composicao reguladora do crescimento de plantas e utilizacao
ATE283024T1 (de) Arachidonsäure-bindendes isoliertes heteromer und seine kosmetische oder pharmazeutische anwendung

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 691849

Country of ref document: ES