ATE99318T1 - 4-substituierte-anthracyclinone und anthracyclin- glycoside und verfahren zu ihrer herstellung. - Google Patents

4-substituierte-anthracyclinone und anthracyclin- glycoside und verfahren zu ihrer herstellung.

Info

Publication number: ATE99318T1
Authority: AT; Austria
Prior art keywords: group; substituted; production; anthracycline glycosides; anthracyclinones
Prior art date: 1988-10-25

Application number

AT89118648T

Other languages

English (en)

Inventor

Walter Cabri

Bernardinis Silvia De

Franco Francalanci

Sergio Penco

Original Assignee

Erba Carlo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-25

Filing date

1989-10-06

Publication date

1994-01-15

1989-10-06 Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa

1994-01-15 Application granted granted Critical

1994-01-15 Publication of ATE99318T1 publication Critical patent/ATE99318T1/de

Links

229940045799 anthracyclines and related substance Drugs 0.000 title abstract 2
229930182470 glycoside Natural products 0.000 title abstract 2
150000002338 glycosides Chemical class 0.000 title abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000004185 ester group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004665 trialkylsilyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT89118648T 1988-10-25 1989-10-06 4-substituierte-anthracyclinone und anthracyclin- glycoside und verfahren zu ihrer herstellung. ATE99318T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB888824947A GB8824947D0 (en)	1988-10-25	1988-10-25	New 4-substituted anthracyclinones & process for preparing them
EP89118648A EP0366973B1 (de)	1988-10-25	1989-10-06	4-Substituierte-Anthracyclinone und Anthracyclin-Glycoside und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number	Publication Date
ATE99318T1 true ATE99318T1 (de)	1994-01-15

Family

ID=10645743

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89118648T ATE99318T1 (de)	1988-10-25	1989-10-06	4-substituierte-anthracyclinone und anthracyclin- glycoside und verfahren zu ihrer herstellung.

Country Status (18)

Country	Link
US (1)	US5587495A (de)
EP (1)	EP0366973B1 (de)
JP (1)	JPH04501414A (de)
KR (1)	KR900701812A (de)
AT (1)	ATE99318T1 (de)
AU (1)	AU624444B2 (de)
DE (1)	DE68911855T2 (de)
DK (1)	DK168597B1 (de)
ES (1)	ES2061871T3 (de)
FI (1)	FI93364C (de)
GB (1)	GB8824947D0 (de)
HU (1)	HU207733B (de)
IE (1)	IE64161B1 (de)
IL (1)	IL92052A (de)
NZ (1)	NZ231052A (de)
PT (1)	PT92080B (de)
WO (1)	WO1990004601A1 (de)
ZA (1)	ZA898052B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8803301D0 (en) *	1988-02-12	1988-03-09	Erba Carlo Spa	Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) *	1988-04-11	1988-05-11	Erba Carlo Spa	Process for preparing 4-demethoxydauno-mycinone
NL9001834A (nl) *	1990-08-16	1992-03-16	Pharmachemie Bv	Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten.
CN100379749C (zh) *	2003-05-21	2008-04-09	獀洛克斯股份有限公司	4-r-取代的4-去甲氧基柔红霉素的制备方法
US7053191B2 (en)	2003-05-21	2006-05-30	Solux Corporation	Method of preparing 4-R-substituted 4-demethoxydaunorubicin
US8802830B2 (en) *	2005-12-20	2014-08-12	Solux Corporation	Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) *	2008-01-08	2013-01-22	Solux Corporation	Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en)	2011-04-29	2014-09-30	Synbias Pharma Ag	Method of producing 4-demethoxydaunorubicin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1500421A (en) *	1975-01-22	1978-02-08	Farmaceutici Italia	Optically active anthracyclinones
US4116981A (en) *	1977-05-02	1978-09-26	Yuh-Geng Tsay	5,12-epoxy-naphthacene-6,11-dione derivatives
AU567978B2 (en) *	1983-10-19	1987-12-10	Anti-Cancer Council Of Victoria	Carminomycinone precursors and analogues and derivatives thereof.
IT1177014B (it) *	1983-10-19	1987-08-26	Univ Melbourne	Composti organici che comprendono antracicline e antraciclinoni

1988
- 1988-10-25 GB GB888824947A patent/GB8824947D0/en active Pending
1989
- 1989-10-06 ES ES89118648T patent/ES2061871T3/es not_active Expired - Lifetime
- 1989-10-06 DE DE89118648T patent/DE68911855T2/de not_active Expired - Fee Related
- 1989-10-06 EP EP89118648A patent/EP0366973B1/de not_active Expired - Lifetime
- 1989-10-06 AT AT89118648T patent/ATE99318T1/de not_active IP Right Cessation
- 1989-10-18 NZ NZ231052A patent/NZ231052A/xx unknown
- 1989-10-19 IL IL9205289A patent/IL92052A/en not_active IP Right Cessation
- 1989-10-23 IE IE340789A patent/IE64161B1/en not_active IP Right Cessation
- 1989-10-23 PT PT92080A patent/PT92080B/pt not_active IP Right Cessation
- 1989-10-24 WO PCT/EP1989/001266 patent/WO1990004601A1/en not_active Ceased
- 1989-10-24 JP JP1511359A patent/JPH04501414A/ja active Pending
- 1989-10-24 HU HU896397A patent/HU207733B/hu not_active IP Right Cessation
- 1989-10-24 US US07/678,352 patent/US5587495A/en not_active Expired - Fee Related
- 1989-10-24 AU AU44962/89A patent/AU624444B2/en not_active Ceased
- 1989-10-24 KR KR1019900701338A patent/KR900701812A/ko not_active Abandoned
- 1989-10-24 ZA ZA898052A patent/ZA898052B/xx unknown
1991
- 1991-04-22 FI FI911952A patent/FI93364C/fi not_active IP Right Cessation
- 1991-04-24 DK DK075291A patent/DK168597B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI93364C (fi)	1995-03-27
PT92080A (pt)	1990-04-30
EP0366973B1 (de)	1993-12-29
IL92052A (en)	1994-06-24
DK75291A (da)	1991-06-20
DK168597B1 (da)	1994-05-02
AU4496289A (en)	1990-05-14
PT92080B (pt)	1995-06-30
GB8824947D0 (en)	1988-11-30
US5587495A (en)	1996-12-24
IE64161B1 (en)	1995-07-12
HUT57228A (en)	1991-11-28
AU624444B2 (en)	1992-06-11
HU896397D0 (en)	1991-07-29
HU207733B (en)	1993-05-28
JPH04501414A (ja)	1992-03-12
WO1990004601A1 (en)	1990-05-03
ZA898052B (en)	1990-08-29
NZ231052A (en)	1991-04-26
ES2061871T3 (es)	1994-12-16
IL92052A0 (en)	1990-07-12
EP0366973A1 (de)	1990-05-09
DE68911855D1 (de)	1994-02-10
FI911952A0 (fi)	1991-04-22
KR900701812A (ko)	1990-12-04
DE68911855T2 (de)	1994-04-21
FI93364B (fi)	1994-12-15
DK75291D0 (da)	1991-04-24
IE893407L (en)	1990-04-25

Legal Events

Date	Code	Title	Description
1994-10-15	UEP	Publication of translation of european patent specification
1998-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ES2186672T3 (es)	2003-05-16	Procedimiento para la produccion de derivados 13-eter de milbemicinas, e intermedios de los mismos.
PT83843B (pt)	1989-01-17	Processo para a preparacao de promedicamentos de rapamicina
ES2112870T3 (es)	1998-04-16	Derivados de acido glicirretico.
DK0488513T3 (da)	1996-06-17	Anvendelse af dioxabicyclo(3.3.0)octanderivater til fremstilling af et medikament til inhibering af cholesterolmetabolismen
EP1437359A3 (de)	2005-03-30	Neue 3,6-Hemiketale der 9a-Azalidklasse
ATE99318T1 (de)	1994-01-15	4-substituierte-anthracyclinone und anthracyclin- glycoside und verfahren zu ihrer herstellung.
ATE168367T1 (de)	1998-08-15	Vitamin-d-derivate und verfahren zu deren herstellung
DE69029781D1 (de)	1997-03-06	Anthracyclinglycosid-Derivate und Verfahren zu ihrer Herstellung
DE68900638D1 (de)	1992-02-13	4-substituierte anthracyclinone und anthracyclinonglycoside und ihre herstellung.
PT88568A (pt)	1988-10-01	Process for the preparation of saccharides derivatives
DE69409874D1 (de)	1998-06-04	16-Gliederige Makrolid-Derivate und Verfahren zu deren Herstellung
PT90291A (pt)	1989-11-10	Processo para a preparacao de compostos afins das avermectinas uteis como agentes antiparasiticos
ATE36154T1 (de)	1988-08-15	4-phenylaminopyridin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.