PT92080A - Processo para a preparacao de novos glicosidos antraciclinicos e de antraciclinonas 4-substituidas intermedias com accao anti-tumoral - Google Patents

Processo para a preparacao de novos glicosidos antraciclinicos e de antraciclinonas 4-substituidas intermedias com accao anti-tumoral

Info

Publication number: PT92080A
Authority: PT; Portugal
Prior art keywords: group; substituted; preparation; antimacyclinic; ancercyclines
Prior art date: 1988-10-25

Application number

PT92080A

Other languages

English (en)

Other versions

PT92080B (pt

Inventor

Walter Cabri

Silvia De Bernardinis

Franco Francalanci

Sergio Penco

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-25

Filing date

1989-10-23

Publication date

1990-04-30

1989-10-23 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1990-04-30 Publication of PT92080A publication Critical patent/PT92080A/pt

1995-06-30 Publication of PT92080B publication Critical patent/PT92080B/pt

Links

230000000259 anti-tumor effect Effects 0.000 title abstract 2
239000002253 acid Substances 0.000 title 1
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
229940045799 anthracyclines and related substance Drugs 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000004185 ester group Chemical group 0.000 abstract 1
229930182470 glycoside Natural products 0.000 abstract 1
150000002338 glycosides Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004665 trialkylsilyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT92080A 1988-10-25 1989-10-23 Processo para a preparacao de novos glicosidos antraciclinicos e de antraciclinonas 4-substituidas intermedias com accao anti-tumoral PT92080B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888824947A GB8824947D0 (en)	1988-10-25	1988-10-25	New 4-substituted anthracyclinones & process for preparing them

Publications (2)

Publication Number	Publication Date
PT92080A true PT92080A (pt)	1990-04-30
PT92080B PT92080B (pt)	1995-06-30

Family

ID=10645743

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT92080A PT92080B (pt)	1988-10-25	1989-10-23	Processo para a preparacao de novos glicosidos antraciclinicos e de antraciclinonas 4-substituidas intermedias com accao anti-tumoral

Country Status (18)

Country	Link
US (1)	US5587495A (pt)
EP (1)	EP0366973B1 (pt)
JP (1)	JPH04501414A (pt)
KR (1)	KR900701812A (pt)
AT (1)	ATE99318T1 (pt)
AU (1)	AU624444B2 (pt)
DE (1)	DE68911855T2 (pt)
DK (1)	DK168597B1 (pt)
ES (1)	ES2061871T3 (pt)
FI (1)	FI93364C (pt)
GB (1)	GB8824947D0 (pt)
HU (1)	HU207733B (pt)
IE (1)	IE64161B1 (pt)
IL (1)	IL92052A (pt)
NZ (1)	NZ231052A (pt)
PT (1)	PT92080B (pt)
WO (1)	WO1990004601A1 (pt)
ZA (1)	ZA898052B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8803301D0 (en) *	1988-02-12	1988-03-09	Erba Carlo Spa	Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) *	1988-04-11	1988-05-11	Erba Carlo Spa	Process for preparing 4-demethoxydauno-mycinone
NL9001834A (nl) *	1990-08-16	1992-03-16	Pharmachemie Bv	Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten.
US7053191B2 (en) *	2003-05-21	2006-05-30	Solux Corporation	Method of preparing 4-R-substituted 4-demethoxydaunorubicin
CN100379749C (zh) *	2003-05-21	2008-04-09	獀洛克斯股份有限公司	4-r-取代的4-去甲氧基柔红霉素的制备方法
US8802830B2 (en) *	2005-12-20	2014-08-12	Solux Corporation	Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) *	2008-01-08	2013-01-22	Solux Corporation	Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en)	2011-04-29	2014-09-30	Synbias Pharma Ag	Method of producing 4-demethoxydaunorubicin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1500421A (en) *	1975-01-22	1978-02-08	Farmaceutici Italia	Optically active anthracyclinones
US4116981A (en) *	1977-05-02	1978-09-26	Yuh-Geng Tsay	5,12-epoxy-naphthacene-6,11-dione derivatives
AU567978B2 (en) *	1983-10-19	1987-12-10	Anti-Cancer Council Of Victoria	Carminomycinone precursors and analogues and derivatives thereof.
EP0159357B1 (en) *	1983-10-19	1992-09-09	The University Of Melbourne	Carminomycinone precursors and analogues and derivatives thereof

1988
- 1988-10-25 GB GB888824947A patent/GB8824947D0/en active Pending
1989
- 1989-10-06 ES ES89118648T patent/ES2061871T3/es not_active Expired - Lifetime
- 1989-10-06 DE DE89118648T patent/DE68911855T2/de not_active Expired - Fee Related
- 1989-10-06 AT AT89118648T patent/ATE99318T1/de not_active IP Right Cessation
- 1989-10-06 EP EP89118648A patent/EP0366973B1/en not_active Expired - Lifetime
- 1989-10-18 NZ NZ231052A patent/NZ231052A/xx unknown
- 1989-10-19 IL IL9205289A patent/IL92052A/en not_active IP Right Cessation
- 1989-10-23 PT PT92080A patent/PT92080B/pt not_active IP Right Cessation
- 1989-10-23 IE IE340789A patent/IE64161B1/en not_active IP Right Cessation
- 1989-10-24 US US07/678,352 patent/US5587495A/en not_active Expired - Fee Related
- 1989-10-24 ZA ZA898052A patent/ZA898052B/xx unknown
- 1989-10-24 KR KR1019900701338A patent/KR900701812A/ko not_active Abandoned
- 1989-10-24 WO PCT/EP1989/001266 patent/WO1990004601A1/en not_active Ceased
- 1989-10-24 JP JP1511359A patent/JPH04501414A/ja active Pending
- 1989-10-24 HU HU896397A patent/HU207733B/hu not_active IP Right Cessation
- 1989-10-24 AU AU44962/89A patent/AU624444B2/en not_active Ceased
1991
- 1991-04-22 FI FI911952A patent/FI93364C/fi not_active IP Right Cessation
- 1991-04-24 DK DK075291A patent/DK168597B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU207733B (en)	1993-05-28
FI93364C (fi)	1995-03-27
FI93364B (fi)	1994-12-15
IL92052A0 (en)	1990-07-12
DK168597B1 (da)	1994-05-02
DK75291A (da)	1991-06-20
DE68911855D1 (de)	1994-02-10
HU896397D0 (en)	1991-07-29
JPH04501414A (ja)	1992-03-12
IL92052A (en)	1994-06-24
ZA898052B (en)	1990-08-29
IE893407L (en)	1990-04-25
KR900701812A (ko)	1990-12-04
GB8824947D0 (en)	1988-11-30
DE68911855T2 (de)	1994-04-21
EP0366973A1 (en)	1990-05-09
FI911952A0 (fi)	1991-04-22
AU624444B2 (en)	1992-06-11
ATE99318T1 (de)	1994-01-15
HUT57228A (en)	1991-11-28
EP0366973B1 (en)	1993-12-29
AU4496289A (en)	1990-05-14
DK75291D0 (da)	1991-04-24
NZ231052A (en)	1991-04-26
PT92080B (pt)	1995-06-30
ES2061871T3 (es)	1994-12-16
IE64161B1 (en)	1995-07-12
US5587495A (en)	1996-12-24
WO1990004601A1 (en)	1990-05-03

Legal Events

Date

Code

Title

Description

1998-10-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19980630

Publication	Publication Date	Title
PT83843B (pt)	1989-01-17	Processo para a preparacao de promedicamentos de rapamicina
ZA878714B (pt)	1988-05-20
PT81855B (pt)	1987-11-30	Processo de preparacao de arilciclobutilalquilaminas e de composicoes farmaceuticas que as contem
ES2112870T3 (es)	1998-04-16	Derivados de acido glicirretico.
DK0488513T3 (da)	1996-06-17	Anvendelse af dioxabicyclo(3.3.0)octanderivater til fremstilling af et medikament til inhibering af cholesterolmetabolismen
EP1437359A3 (en)	2005-03-30	Novel 3,6-Hemiketals from the Class of 9a-Azalides
HU896397D0 (en)	1991-07-29	Process for the preparation of new 4-substituted anthracyclinones and anthracyclin-glycosides
PL306849A1 (en)	1995-07-24	Compounds belonging to the d-vitamins group and method of obtaining them
FI911016A0 (fi)	1991-02-28	Menetelmä farmakologisesti aktiivisten substituoitujen -diketonien valmistamiseksi
GR3005961T3 (pt)	1993-06-07
PT91323A (pt)	1990-02-08	Processo para a preparacao de glicosidos antraciclinicos, de antraciclinonas 4-substituidas intermedias e de composicoes farmaceuticas que os contem
PT88568A (pt)	1988-10-01	Process for the preparation of saccharides derivatives
ES2115816T3 (es)	1998-07-01	Derivados macrolidas de 16-eslabones y su procedimiento de preparacion.
PT90291A (pt)	1989-11-10	Processo para a preparacao de compostos afins das avermectinas uteis como agentes antiparasiticos
ES510828A0 (es)	1983-03-16	"un procedimiento para la preparacion de un derivado de morfolina".