ATE99695T1 - N-6-thienyl-substituierte adenosinderivate als herzgefaesserweiternde mittel. - Google Patents

N-6-thienyl-substituierte adenosinderivate als herzgefaesserweiternde mittel.

Info

Publication number: ATE99695T1
Authority: AT; Austria
Prior art keywords: phenyl; lower alkyl; substituted; thienyl; ribofuranosyl
Prior art date: 1984-04-18

Application number

AT88106818T

Other languages

English (en)

Inventor

Ray A Olsson

Robert D Thompson

Original Assignee

Whitby Research Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-04-18

Filing date

1988-04-28

Publication date

1994-01-15

1988-04-28 Application filed by Whitby Research Inc filed Critical Whitby Research Inc

1994-01-15 Application granted granted Critical

1994-01-15 Publication of ATE99695T1 publication Critical patent/ATE99695T1/de

Links

OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical class C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
MRWXACSTFXYYMV-UHFFFAOYSA-N Nebularine Natural products OC1C(O)C(CO)OC1N1C2=NC=NC=C2N=C1 MRWXACSTFXYYMV-UHFFFAOYSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
-1 monosubstituted adenosine Chemical class 0.000 abstract 3
230000000747 cardiac effect Effects 0.000 abstract 2
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000001769 aryl amino group Chemical group 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
230000000304 vasodilatating effect Effects 0.000 abstract 1
229940124549 vasodilator Drugs 0.000 abstract 1
239000003071 vasodilator agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Biotechnology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT88106818T 1984-04-18 1988-04-28 N-6-thienyl-substituierte adenosinderivate als herzgefaesserweiternde mittel. ATE99695T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US60143584A	1984-04-18	1984-04-18
EP88106818A EP0305643B1 (de)	1984-04-18	1985-04-11	N-6-thienyl-substituierte Adenosinderivate als herzgefässerweiternde Mittel

Publications (1)

Publication Number	Publication Date
ATE99695T1 true ATE99695T1 (de)	1994-01-15

Family

ID=24407470

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT85902253T ATE50777T1 (de)	1984-04-18	1985-04-11	Cardio-vasodilatatore n-6-substituierte adenosine.
AT88106818T ATE99695T1 (de)	1984-04-18	1988-04-28	N-6-thienyl-substituierte adenosinderivate als herzgefaesserweiternde mittel.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT85902253T ATE50777T1 (de)	1984-04-18	1985-04-11	Cardio-vasodilatatore n-6-substituierte adenosine.

Country Status (11)

Country	Link
US (1)	US5043325A (de)
EP (4)	EP0180614B1 (de)
JP (1)	JPH0655756B2 (de)
AT (2)	ATE50777T1 (de)
AU (1)	AU582359B2 (de)
CA (4)	CA1279063C (de)
DE (2)	DE3576344D1 (de)
ES (1)	ES8707544A1 (de)
IE (3)	IE930270L (de)
WO (1)	WO1985004882A1 (de)
ZA (1)	ZA852746B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5310731A (en) *	1984-06-28	1994-05-10	Whitby Research, Inc.	N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents
AU575438B2 (en) *	1984-10-26	1988-07-28	Warner-Lambert Company	N6 - substituted deoxyribose analogues of adenosines
WO1988003148A2 (en) *	1986-10-31	1988-05-05	Warner-Lambert Company	Heteroaromatic derivatives of adenoside
US5063233A (en) *	1986-11-14	1991-11-05	Ciba-Geigy Corporation	N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists
US4954504A (en) *	1986-11-14	1990-09-04	Ciba-Geigy Corporation	N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity
US4968697A (en) *	1987-02-04	1990-11-06	Ciba-Geigy Corporation	2-substituted adenosine 5'-carboxamides as antihypertensive agents
US5034381A (en) *	1988-01-07	1991-07-23	Ciba-Geigy Corporation	2-(substituted amino) adenosines as antihypertensives
US5256650A (en) *	1989-03-29	1993-10-26	Merrell Dow Pharmaceuticals Inc.	Selective adenosine receptor agents
ZA902280B (en) *	1989-03-29	1990-12-28	Merrell Dow Pharma	Selective adenosine receptor agents
US5391739A (en) *	1989-03-29	1995-02-21	Merrell Dow Pharmaceuticals Inc.	Selective adenosine receptor agents
US5155098A (en) *	1989-06-09	1992-10-13	Hoechst-Roussel Pharmaceuticals Inc.	N-heteroaryl-purin-6-amines, and pharmaceutical compositions and methods employing them
US5017578A (en) *	1989-06-09	1991-05-21	Hoechst-Roussel Pharmaceuticals Inc.	N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents
GB9011623D0 (en) *	1990-05-24	1990-07-11	Efamol Holdings	Synthesis of nucleotide and nucleoside derivatives
US5430138A (en) *	1990-07-27	1995-07-04	Chiron Corporation	Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable
DK0550631T3 (da) *	1990-09-25	1997-01-20	Rhone Poulenc Rorer Int	Forbindelser med blodtrykssænkende virkning og virkning mod iskæmi
US5561134A (en) *	1990-09-25	1996-10-01	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
DK62592D0 (de) *	1992-05-14	1992-05-14	Novo Nordisk As
DK62692D0 (de) *	1992-05-14	1992-05-14	Novo Nordisk As
DK155292D0 (da) *	1992-12-23	1992-12-23	Novo Nordisk As	Kemiske forbindelser, deres fremstilling og anvendelse
GB9301000D0 (en) *	1993-01-20	1993-03-10	Glaxo Group Ltd	Chemical compounds
US5589467A (en) *	1993-09-17	1996-12-31	Novo Nordisk A/S	2,5',N6-trisubstituted adenosine derivatives
US5683989A (en) *	1993-12-17	1997-11-04	Novo Nordisk A/S	Treatment of ischemias by administration of 2,N6 -substituted adenosines
US6376472B1 (en)	1996-07-08	2002-04-23	Aventis Pharmaceuticals, Inc.	Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
TW528755B (en)	1996-12-24	2003-04-21	Glaxo Group Ltd	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
YU44900A (sh)	1998-01-31	2003-01-31	Glaxo Group Limited	Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
US6495528B1 (en)	1998-06-23	2002-12-17	Smithkline Beecham Corporation	2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives
PE20060272A1 (es) *	2004-05-24	2006-05-22	Glaxo Group Ltd	(2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
GB0514809D0 (en)	2005-07-19	2005-08-24	Glaxo Group Ltd	Compounds

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2881164A (en) *	1955-07-18	1959-04-07	American Cyanamid Co	Ribofuranosyl derivatives of 6-aralkylamino and 6-heterocyclicalkylaminopurines
NL128629C (de) *	1966-05-07
DE1670077C3 (de) *	1966-05-07	1975-04-24	Boehringer Mannheim Gmbh, 6800 Mannheim	Adenosin-Derivate und Verfahren zu ihrer Herstellung
DE1670235A1 (de) *	1967-06-08	1971-01-28	Boehringer Mannheim Gmbh	Verfahren zur Herstellung von Adenosin-Derivaten
SE329623B (de) *	1967-06-08	1970-10-19	C F Boehringer Soehne Gmbh
DE1670265A1 (de) *	1967-08-25	1971-01-28	Boehringer Mannheim Gmbh	2-Amino-Adenosinderivate und Verfahren zu deren Herstellung
DE1913816A1 (de) *	1969-03-19	1971-01-14	Boehringer Mannheim Gmbh	N(6)-Alkyl-adenosinderivate und Verfahren zu ihrer Herstellung
DE2007273A1 (de) *	1970-02-18	1971-08-26	Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof	N(6) Aralkyl adenosin Derivate und Verfahren zur Herstellung derselben
US4224438A (en) *	1970-07-14	1980-09-23	Boehringer Mannheim Gmbh	Adenosine-5'-carboxylic acid amides
DE2052596A1 (de) *	1970-10-27	1972-05-04	Boehringer Mannheim Gmbh, 6800 Mannheim	Neuartige Verwendung von N(6)-substituierten Adenosin-Derivaten
US4029884A (en) *	1971-03-18	1977-06-14	Abbott Laboratories	Adenosine-5'-carboxylic acid amides
DE2139107A1 (de) *	1971-08-04	1973-02-15	Merck Patent Gmbh	Heterocyclisch substituierte adenosinverbindungen
BE788958A (fr) *	1971-09-18	1973-03-19	Schering Ag	Derives d'adenosine et leur procede de preparation
US4090021A (en) *	1971-10-08	1978-05-16	Schering Aktiengesellschaft	Process for the production of N6 -substituted adenosine nucleotides and products resulting therefrom
JPS4926295A (de) *	1972-07-06	1974-03-08
DE2238923A1 (de) *	1972-08-08	1974-02-14	Boehringer Mannheim Gmbh	Acylierte n(6)-aralkyl-adenosinderivate und verfahren zur herstellung derselben
US3966916A (en) *	1972-09-09	1976-06-29	Boehringer Mannheim G.M.B.H.	N(6)-disubstituted adenoisine compounds and therapeutic compositions
JPS5022040A (de) *	1973-06-27	1975-03-08
US4081534A (en) *	1973-09-11	1978-03-28	Burroughs Wellcome Co.	Amino purine nucleosides as autoimmune suppressant agents
DE2426682A1 (de) *	1974-06-01	1975-12-11	Boehringer Mannheim Gmbh	Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
US4167565A (en) *	1976-11-08	1979-09-11	Abbott Laboratories	Adenosine-5'-carboxamides and method of use
US4189485A (en) *	1977-08-23	1980-02-19	Takeda Chemical Industries, Ltd.	Purine derivatives
JPS57130997A (en) *	1981-01-30	1982-08-13	Searle & Co	N6-substituted adenosine
JPS57140716A (en) *	1981-02-24	1982-08-31	Yamasa Shoyu Co Ltd	Antiallergic agent
US4514405A (en) *	1981-09-17	1985-04-30	Merck Patent Gesellschaft Mit Beschrankter Haftung	Use of adenosine derivatives as anticonvulsants
US4495180A (en) *	1982-06-21	1985-01-22	Merck & Co., Inc.	Prodrugs of Ara-A an antiviral agent
CA1239397A (en) *	1983-08-01	1988-07-19	James A. Bristol	N.sup.6-substituted adenosines
DE3406533A1 (de) *	1984-02-23	1985-08-29	Boehringer Mannheim Gmbh, 6800 Mannheim	Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
AU579412B2 (en) *	1984-10-26	1988-11-24	Warner-Lambert Company	N` - substituted adenosines

1985
- 1985-04-11 AT AT85902253T patent/ATE50777T1/de active
- 1985-04-11 EP EP85902253A patent/EP0180614B1/de not_active Expired - Lifetime
- 1985-04-11 JP JP60501780A patent/JPH0655756B2/ja not_active Expired - Lifetime
- 1985-04-11 EP EP88106817A patent/EP0300145A3/de not_active Withdrawn
- 1985-04-11 DE DE8585902253T patent/DE3576344D1/de not_active Expired - Fee Related
- 1985-04-11 DE DE88106818T patent/DE3587717T2/de not_active Expired - Fee Related
- 1985-04-11 AU AU42195/85A patent/AU582359B2/en not_active Ceased
- 1985-04-11 EP EP88106818A patent/EP0305643B1/de not_active Expired - Lifetime
- 1985-04-11 EP EP88106816A patent/EP0300144A3/de not_active Withdrawn
- 1985-04-11 WO PCT/US1985/000633 patent/WO1985004882A1/en not_active Ceased
- 1985-04-12 ZA ZA852746A patent/ZA852746B/xx unknown
- 1985-04-16 IE IE930270A patent/IE930270L/xx unknown
- 1985-04-16 ES ES542290A patent/ES8707544A1/es not_active Expired
- 1985-04-16 IE IE96585A patent/IE60213B1/en not_active IP Right Cessation
- 1985-04-16 IE IE930269A patent/IE930269L/xx unknown
- 1985-12-04 CA CA000479012A patent/CA1279063C/en not_active Expired - Fee Related
1986
- 1986-02-13 US US06/829,285 patent/US5043325A/en not_active Expired - Fee Related
1988
- 1988-04-28 AT AT88106818T patent/ATE99695T1/de active
1990
- 1990-09-28 CA CA000615876A patent/CA1293721C/en not_active Expired - Fee Related
- 1990-09-28 CA CA000615878A patent/CA1305135C/en not_active Expired - Fee Related
- 1990-09-28 CA CA000615877A patent/CA1293722C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPH0655756B2 (ja)	1994-07-27
DE3587717T2 (de)	1994-04-28
EP0180614B1 (de)	1990-03-07
EP0300144A3 (de)	1989-09-27
CA1279063C (en)	1991-01-15
IE930270L (en)	1985-10-18
CA1305135C (en)	1992-07-14
EP0300144A2 (de)	1989-01-25
ES8707544A1 (es)	1987-08-01
IE930269L (en)	1985-10-18
EP0305643A2 (de)	1989-03-08
IE850965L (en)	1985-10-17
ES542290A0 (es)	1987-08-01
EP0180614A1 (de)	1986-05-14
DE3587717D1 (de)	1994-02-17
EP0305643B1 (de)	1994-01-05
EP0305643A3 (en)	1989-08-30
AU582359B2 (en)	1989-03-23
DE3576344D1 (de)	1990-04-12
JPS61501914A (ja)	1986-09-04
IE60213B1 (en)	1994-06-15
US5043325A (en)	1991-08-27
CA1293721C (en)	1991-12-31
EP0300145A3 (de)	1989-08-30
AU4219585A (en)	1985-11-15
EP0300145A2 (de)	1989-01-25
WO1985004882A1 (en)	1985-11-07
CA1293722C (en)	1991-12-31
ATE50777T1 (de)	1990-03-15
ZA852746B (en)	1985-12-24

Publication	Publication Date	Title
ATE99695T1 (de)	1994-01-15	N-6-thienyl-substituierte adenosinderivate als herzgefaesserweiternde mittel.
RU92004381A (ru)	1995-05-20	Производные 2-замещенного сахарина как ингибиторы протеолитических ферментов
MY118612A (en)	2004-12-31	Pyrazine compounds
NO933069L (no)	1993-11-01	1-substituert,2-substituert 1H-imidazo (4,5-c)-kinolin-4-aminer
ATE79380T1 (de)	1992-08-15	2-substituierte-e-kondensierte(1,2,4>triazolo(1,5-c>pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
DE68903474D1 (de)	1992-12-17	Topische zusammensetzung.
FI873726A0 (fi)	1987-08-27	Dihydropyridinfoereningar, foerfaranden foer deras framstaellning och deras anvaendning.
EP0202654A3 (de)	1987-12-16	5-Carboxy-1,4-dihydropyrimidinderivate
DE3685823D1 (de)	1992-07-30	Sulfamoyl-harnstoff-derivate.
FI882358A0 (fi)	1988-05-19	Cykliska antikoagulationspeptider.
DK415789A (da)	1990-02-27	Tetracykliske antidepressive midler
DE68911371D1 (de)	1994-01-27	2,2-Disubstituierte Benzopyran-Leukotrien-D4-Antagonisten.
IT8120322A0 (it)	1981-03-13	Derivati fosfonici di 7-[(2-ammino-4-tiazolil)ossimmino]cefalosporine
AU556932B2 (en)	1986-11-27	Dipetide with heterocyclic groiup
ES2046181T3 (es)	1994-02-01	Procedimiento de preparacion de derivados de cianoacetamida con actividad fungicida.
ES8403921A1 (es)	1984-05-01	Procedimiento para preparar fosfatos de oximas aciclicos y heterociclicos con actividad insecticida, acaricida y nematocida.
DK105185D0 (da)	1985-03-07	Fungicide midler og deres anvendelse, deri anvendte 3-hydrazino-1,2-benzisothiazol-1,1-dioxidderivater samt disses fremstilling
JO1274B1 (en)	1985-04-20	Pyridine derivatives
DK565787A (da)	1988-05-01	1-carbamoyl-2-pyrazolinderivater med herbicid virkning
ATE216393T1 (de)	2002-05-15	Salze von glukopyranosederivate und ihre zwischenprodukte
EP0418655A3 (en)	1991-12-18	Conjugated gamma-hydroxybutenolide compounds and antiulcer agents containing the same as an effective ingredient
PT80161A (en)	1985-04-01	A n-(6-substituted pyridine-2-carbonyl)-3-substituted histidine derivative a method of preparing the same and its use as an anti-tumor agent
ATE71378T1 (de)	1992-01-15	Purin-histamin-h1-antagonisten, ihre herstellung und sie enthaltende pharmazeutische praeparate.
JPS5334724A (en)	1978-03-31	Phosphoryl thiourea derivatives and coccidiostatic agents containing the same