ZA852746B - N-6 substituted adenosine derivatives as cardiac vasodilators - Google Patents

N-6 substituted adenosine derivatives as cardiac vasodilators

Info

Publication number
ZA852746B
ZA852746B ZA852746A ZA852746A ZA852746B ZA 852746 B ZA852746 B ZA 852746B ZA 852746 A ZA852746 A ZA 852746A ZA 852746 A ZA852746 A ZA 852746A ZA 852746 B ZA852746 B ZA 852746B
Authority
ZA
South Africa
Prior art keywords
phenyl
lower alkyl
ribofuranosyl
purine
beta
Prior art date
Application number
ZA852746A
Other languages
English (en)
Inventor
Ray A Olsson
Robert D Thompson
Original Assignee
Nelson Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nelson Res & Dev filed Critical Nelson Res & Dev
Publication of ZA852746B publication Critical patent/ZA852746B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ZA852746A 1984-04-18 1985-04-12 N-6 substituted adenosine derivatives as cardiac vasodilators ZA852746B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60143584A 1984-04-18 1984-04-18

Publications (1)

Publication Number Publication Date
ZA852746B true ZA852746B (en) 1985-12-24

Family

ID=24407470

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA852746A ZA852746B (en) 1984-04-18 1985-04-12 N-6 substituted adenosine derivatives as cardiac vasodilators

Country Status (11)

Country Link
US (1) US5043325A (de)
EP (4) EP0180614B1 (de)
JP (1) JPH0655756B2 (de)
AT (2) ATE50777T1 (de)
AU (1) AU582359B2 (de)
CA (4) CA1279063C (de)
DE (2) DE3576344D1 (de)
ES (1) ES8707544A1 (de)
IE (3) IE930270L (de)
WO (1) WO1985004882A1 (de)
ZA (1) ZA852746B (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310731A (en) * 1984-06-28 1994-05-10 Whitby Research, Inc. N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents
AU575438B2 (en) * 1984-10-26 1988-07-28 Warner-Lambert Company N6 - substituted deoxyribose analogues of adenosines
WO1988003148A2 (en) * 1986-10-31 1988-05-05 Warner-Lambert Company Heteroaromatic derivatives of adenoside
US5063233A (en) * 1986-11-14 1991-11-05 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists
US4954504A (en) * 1986-11-14 1990-09-04 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity
US4968697A (en) * 1987-02-04 1990-11-06 Ciba-Geigy Corporation 2-substituted adenosine 5'-carboxamides as antihypertensive agents
US5034381A (en) * 1988-01-07 1991-07-23 Ciba-Geigy Corporation 2-(substituted amino) adenosines as antihypertensives
US5256650A (en) * 1989-03-29 1993-10-26 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
ZA902280B (en) * 1989-03-29 1990-12-28 Merrell Dow Pharma Selective adenosine receptor agents
US5391739A (en) * 1989-03-29 1995-02-21 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
US5155098A (en) * 1989-06-09 1992-10-13 Hoechst-Roussel Pharmaceuticals Inc. N-heteroaryl-purin-6-amines, and pharmaceutical compositions and methods employing them
US5017578A (en) * 1989-06-09 1991-05-21 Hoechst-Roussel Pharmaceuticals Inc. N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents
GB9011623D0 (en) * 1990-05-24 1990-07-11 Efamol Holdings Synthesis of nucleotide and nucleoside derivatives
US5430138A (en) * 1990-07-27 1995-07-04 Chiron Corporation Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable
DK0550631T3 (da) * 1990-09-25 1997-01-20 Rhone Poulenc Rorer Int Forbindelser med blodtrykssænkende virkning og virkning mod iskæmi
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
DK62592D0 (de) * 1992-05-14 1992-05-14 Novo Nordisk As
DK62692D0 (de) * 1992-05-14 1992-05-14 Novo Nordisk As
DK155292D0 (da) * 1992-12-23 1992-12-23 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
GB9301000D0 (en) * 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
US5589467A (en) * 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
US5683989A (en) * 1993-12-17 1997-11-04 Novo Nordisk A/S Treatment of ischemias by administration of 2,N6 -substituted adenosines
US6376472B1 (en) 1996-07-08 2002-04-23 Aventis Pharmaceuticals, Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
YU44900A (sh) 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
US6495528B1 (en) 1998-06-23 2002-12-17 Smithkline Beecham Corporation 2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives
PE20060272A1 (es) * 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds

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Publication number Priority date Publication date Assignee Title
US2881164A (en) * 1955-07-18 1959-04-07 American Cyanamid Co Ribofuranosyl derivatives of 6-aralkylamino and 6-heterocyclicalkylaminopurines
NL128629C (de) * 1966-05-07
DE1670077C3 (de) * 1966-05-07 1975-04-24 Boehringer Mannheim Gmbh, 6800 Mannheim Adenosin-Derivate und Verfahren zu ihrer Herstellung
DE1670235A1 (de) * 1967-06-08 1971-01-28 Boehringer Mannheim Gmbh Verfahren zur Herstellung von Adenosin-Derivaten
SE329623B (de) * 1967-06-08 1970-10-19 C F Boehringer Soehne Gmbh
DE1670265A1 (de) * 1967-08-25 1971-01-28 Boehringer Mannheim Gmbh 2-Amino-Adenosinderivate und Verfahren zu deren Herstellung
DE1913816A1 (de) * 1969-03-19 1971-01-14 Boehringer Mannheim Gmbh N(6)-Alkyl-adenosinderivate und Verfahren zu ihrer Herstellung
DE2007273A1 (de) * 1970-02-18 1971-08-26 Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof N(6) Aralkyl adenosin Derivate und Verfahren zur Herstellung derselben
US4224438A (en) * 1970-07-14 1980-09-23 Boehringer Mannheim Gmbh Adenosine-5'-carboxylic acid amides
DE2052596A1 (de) * 1970-10-27 1972-05-04 Boehringer Mannheim Gmbh, 6800 Mannheim Neuartige Verwendung von N(6)-substituierten Adenosin-Derivaten
US4029884A (en) * 1971-03-18 1977-06-14 Abbott Laboratories Adenosine-5'-carboxylic acid amides
DE2139107A1 (de) * 1971-08-04 1973-02-15 Merck Patent Gmbh Heterocyclisch substituierte adenosinverbindungen
BE788958A (fr) * 1971-09-18 1973-03-19 Schering Ag Derives d'adenosine et leur procede de preparation
US4090021A (en) * 1971-10-08 1978-05-16 Schering Aktiengesellschaft Process for the production of N6 -substituted adenosine nucleotides and products resulting therefrom
JPS4926295A (de) * 1972-07-06 1974-03-08
DE2238923A1 (de) * 1972-08-08 1974-02-14 Boehringer Mannheim Gmbh Acylierte n(6)-aralkyl-adenosinderivate und verfahren zur herstellung derselben
US3966916A (en) * 1972-09-09 1976-06-29 Boehringer Mannheim G.M.B.H. N(6)-disubstituted adenoisine compounds and therapeutic compositions
JPS5022040A (de) * 1973-06-27 1975-03-08
US4081534A (en) * 1973-09-11 1978-03-28 Burroughs Wellcome Co. Amino purine nucleosides as autoimmune suppressant agents
DE2426682A1 (de) * 1974-06-01 1975-12-11 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
US4167565A (en) * 1976-11-08 1979-09-11 Abbott Laboratories Adenosine-5'-carboxamides and method of use
US4189485A (en) * 1977-08-23 1980-02-19 Takeda Chemical Industries, Ltd. Purine derivatives
JPS57130997A (en) * 1981-01-30 1982-08-13 Searle & Co N6-substituted adenosine
JPS57140716A (en) * 1981-02-24 1982-08-31 Yamasa Shoyu Co Ltd Antiallergic agent
US4514405A (en) * 1981-09-17 1985-04-30 Merck Patent Gesellschaft Mit Beschrankter Haftung Use of adenosine derivatives as anticonvulsants
US4495180A (en) * 1982-06-21 1985-01-22 Merck & Co., Inc. Prodrugs of Ara-A an antiviral agent
CA1239397A (en) * 1983-08-01 1988-07-19 James A. Bristol N.sup.6-substituted adenosines
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
AU579412B2 (en) * 1984-10-26 1988-11-24 Warner-Lambert Company N` - substituted adenosines

Also Published As

Publication number Publication date
JPH0655756B2 (ja) 1994-07-27
DE3587717T2 (de) 1994-04-28
EP0180614B1 (de) 1990-03-07
EP0300144A3 (de) 1989-09-27
CA1279063C (en) 1991-01-15
IE930270L (en) 1985-10-18
CA1305135C (en) 1992-07-14
EP0300144A2 (de) 1989-01-25
ES8707544A1 (es) 1987-08-01
IE930269L (en) 1985-10-18
EP0305643A2 (de) 1989-03-08
IE850965L (en) 1985-10-17
ATE99695T1 (de) 1994-01-15
ES542290A0 (es) 1987-08-01
EP0180614A1 (de) 1986-05-14
DE3587717D1 (de) 1994-02-17
EP0305643B1 (de) 1994-01-05
EP0305643A3 (en) 1989-08-30
AU582359B2 (en) 1989-03-23
DE3576344D1 (de) 1990-04-12
JPS61501914A (ja) 1986-09-04
IE60213B1 (en) 1994-06-15
US5043325A (en) 1991-08-27
CA1293721C (en) 1991-12-31
EP0300145A3 (de) 1989-08-30
AU4219585A (en) 1985-11-15
EP0300145A2 (de) 1989-01-25
WO1985004882A1 (en) 1985-11-07
CA1293722C (en) 1991-12-31
ATE50777T1 (de) 1990-03-15

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