ATE99934T1 - Heteroaryl-3-oxo-propannitril-derivate, nuetzlich zur behandlung von rheumatoider arthritis und anderen autoimmunkrankheiten. - Google Patents

Heteroaryl-3-oxo-propannitril-derivate, nuetzlich zur behandlung von rheumatoider arthritis und anderen autoimmunkrankheiten.

Info

Publication number: ATE99934T1
Authority: AT; Austria
Prior art keywords: rheumatoid arthritis; propannitrile; heteroaryl; oxo; treatment
Prior art date: 1989-04-06

Application number

AT90905498T

Other languages

English (en)

Inventor

Gianfederico Doria

Anna Maria Isetta

Rinaldo Ferreccio

Mario Ferrari

Maria Chiara Fornasiero

Domenico Trizio

Original Assignee

Erba Carlo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-06

Filing date

1990-04-04

Publication date

1994-01-15

1990-04-04 Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa

1994-01-15 Application granted granted Critical

1994-01-15 Publication of ATE99934T1 publication Critical patent/ATE99934T1/de

Links

206010039073 rheumatoid arthritis Diseases 0.000 title abstract 2
208000023275 Autoimmune disease Diseases 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001064 morpholinomethyl group Chemical group [H]C([H])(*)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT90905498T 1989-04-06 1990-04-04 Heteroaryl-3-oxo-propannitril-derivate, nuetzlich zur behandlung von rheumatoider arthritis und anderen autoimmunkrankheiten. ATE99934T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB898907799A GB8907799D0 (en)	1989-04-06	1989-04-06	Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases
PCT/EP1990/000527 WO1990011760A1 (en)	1989-04-06	1990-04-04	Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases

Publications (1)

Publication Number	Publication Date
ATE99934T1 true ATE99934T1 (de)	1994-01-15

Family

ID=10654581

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90905498T ATE99934T1 (de)	1989-04-06	1990-04-04	Heteroaryl-3-oxo-propannitril-derivate, nuetzlich zur behandlung von rheumatoider arthritis und anderen autoimmunkrankheiten.

Country Status (15)

Country	Link
US (2)	US5196445A (de)
EP (1)	EP0423269B1 (de)
JP (1)	JPH03505332A (de)
KR (1)	KR920700031A (de)
AT (1)	ATE99934T1 (de)
AU (1)	AU5416990A (de)
CA (1)	CA2030530A1 (de)
DD (1)	DD298478A5 (de)
DE (1)	DE69005974T2 (de)
GB (1)	GB8907799D0 (de)
HU (1)	HUT58518A (de)
IL (1)	IL93989A0 (de)
PT (1)	PT93680A (de)
WO (1)	WO1990011760A1 (de)
ZA (1)	ZA902649B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5922755A (en) *	1993-04-09	1999-07-13	Toyama Chemical Co., Ltd.	Immunomodulator, cell adhesion inhibtor, and agent for treating, and preventing autoimmune diseases
WO1994024095A1 (en) *	1993-04-16	1994-10-27	Abbott Laboratories	Immunosuppressive agents
ES2187667T3 (es)	1995-08-15	2003-06-16	Connetics Corp	Uso de relaxina para estimular angiogenesis.
US7285422B1 (en) *	1997-01-23	2007-10-23	Sequenom, Inc.	Systems and methods for preparing and analyzing low volume analyte array elements
US5902825A (en) *	1997-01-07	1999-05-11	Mitreoak, Ltd.	Composition and method for the palliation of pain associated with diseases of the bone and bone joints
GB9720901D0 (en) *	1997-10-01	1997-12-03	Pharmacia & Upjohn Spa	Condensed benzothiopyranic compounds
US20030224071A1 (en) *	1999-08-20	2003-12-04	Howard Murad	Pharmaceutical compositions and methods for managing connective tissue ailments
WO2002100334A2 (en) *	2001-06-11	2002-12-19	University Of Miami	Use of radiopharmaceutical complexes in achieving transplantation tolerance
CA2460939C (en) *	2001-09-19	2008-07-29	Pharmacia Corporation	Substituted pyrazolyl compounds for the treatment of inflammation
EP1444207A2 (de) *	2001-09-19	2004-08-11	Pharmacia Corporation	Substituierte pyrazolylverbindungen zur behandlung von entzündungen
US20050116027A1 (en) *	2003-06-12	2005-06-02	First Data Corp.	Personalized presentation instrument production systems and methods
MX2012005518A (es) *	2009-11-13	2012-06-19	Merck Serono Sa	Derivados de pirazol amina triciclica.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4268516A (en) *	1978-10-11	1981-05-19	Pfizer Inc.	[1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents
US4173634A (en) *	1979-02-23	1979-11-06	E. R. Squibb & Sons, Inc.	Basically-substituted tricyclic pyrazoles useful as antiinflammatory agents
JPS57109787A (en) *	1980-12-26	1982-07-08	Chugai Pharmaceut Co Ltd	Pyrazoloindazole derivative
US4816467A (en) *	1987-01-09	1989-03-28	Farmitalia Carlo Erba S.R.L	Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions and use
NZ223204A (en) *	1987-01-21	1989-12-21	Erba Farmitalia	Pyrazole derivatives and pharmaceutical compositions
GB8814587D0 (en) *	1988-06-20	1988-07-27	Erba Carlo Spa	Condensed pyrazole 3-oxo-propanenitrile derivatives & process for their preparation
GB8814586D0 (en) *	1988-06-20	1988-07-27	Erba Carlo Spa	Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation
PH26314A (en) *	1988-08-09	1994-04-29	Boots Co Plc	Benzopyrano [4,3-c] pyrazoles derivatives
GB2227741B (en) *	1989-02-06	1992-08-05	Erba Carlo Spa	Condensed 3-oxo-propanenitrile derivatives and process for their preparation

1989
- 1989-04-06 GB GB898907799A patent/GB8907799D0/en active Pending
1990
- 1990-04-03 IL IL93989A patent/IL93989A0/xx unknown
- 1990-04-04 AU AU54169/90A patent/AU5416990A/en not_active Abandoned
- 1990-04-04 DE DE90905498T patent/DE69005974T2/de not_active Expired - Fee Related
- 1990-04-04 CA CA002030530A patent/CA2030530A1/en not_active Abandoned
- 1990-04-04 HU HU9036A patent/HUT58518A/hu unknown
- 1990-04-04 WO PCT/EP1990/000527 patent/WO1990011760A1/en not_active Ceased
- 1990-04-04 EP EP90905498A patent/EP0423269B1/de not_active Expired - Lifetime
- 1990-04-04 AT AT90905498T patent/ATE99934T1/de not_active IP Right Cessation
- 1990-04-04 JP JP2505759A patent/JPH03505332A/ja active Pending
- 1990-04-04 KR KR1019900702560A patent/KR920700031A/ko not_active Withdrawn
- 1990-04-05 PT PT93680A patent/PT93680A/pt not_active Application Discontinuation
- 1990-04-05 ZA ZA902649A patent/ZA902649B/xx unknown
- 1990-10-02 DD DD90344383A patent/DD298478A5/de not_active IP Right Cessation
- 1990-10-31 US US07/613,482 patent/US5196445A/en not_active Expired - Fee Related
1993
- 1993-07-01 US US08/084,470 patent/US5352676A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HUT58518A (en)	1992-03-30
US5352676A (en)	1994-10-04
GB8907799D0 (en)	1989-05-17
CA2030530A1 (en)	1990-10-07
US5196445A (en)	1993-03-23
KR920700031A (ko)	1992-02-19
DD298478A5 (de)	1992-02-27
HU903690D0 (en)	1991-03-28
JPH03505332A (ja)	1991-11-21
WO1990011760A1 (en)	1990-10-18
ZA902649B (en)	1991-01-30
IL93989A0 (en)	1991-01-31
PT93680A (pt)	1990-11-20
EP0423269B1 (de)	1994-01-12
DE69005974T2 (de)	1994-05-05
EP0423269A1 (de)	1991-04-24
AU5416990A (en)	1990-11-05
DE69005974D1 (de)	1994-02-24

Legal Events

Date	Code	Title	Description
1994-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
NO843836L (no)	1985-03-27	Terapeutisk aktive sulfamatderivater
PT74356B (en)	1984-05-30	Process for the preparation of 2-penem
DK0874812T3 (da)	2000-09-11	Hidtil ukendte 2,3,5-trimethyl-4-hydroxyanilidderivater, fremstilling deraf og terapeutisk anvendelse deraf
ES2172525T3 (es)	2002-10-01	Inhibicion de la fibrosis uterina.
DE69005974D1 (de)	1994-02-24	Heteroaryl-3-oxo-propannitril-derivate, nützlich zur behandlung von rheumatoider arthritis und anderen autoimmunkrankheiten.
DK0652002T3 (da)	2001-04-17	Anvendelse af 2-phenyl-3-aroylebenzothiophener til fremstilling af et medikament til hæmning af brusknedbrydning
EP0831813A4 (de)	2001-09-19	Verfahren zur behandlung durch pneumocytis carini verursachten lungenentzündung und dafür geeignete verbindung
DK562488A (da)	1989-04-09	Farmaceutisk praeparat indeholdende polyminderivater, samt nogle af disse polyaminderivater
ATE26273T1 (de)	1987-04-15	3-indolcarboxamid-verbindungen.
ATE169217T1 (de)	1998-08-15	Verwendung von furanonderivaten zur vorbeugung oder behandlung von autoimmunkrankheiten
ATE5961T1 (de)	1984-02-15	N-acylpeptid-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
DE3676378D1 (de)	1991-02-07	Isoxazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutischen praeparate.
EA200001157A3 (ru)	2001-08-27	Новые замещенные производные (дигидро)бензоксазина и (дигидро)бензотиазина, способ их получения и содержащие их фармацевтические композиции
PT87310A (pt)	1988-05-01	Process for the preparation of thiadiazole guanidines
ATE81465T1 (de)	1992-10-15	Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten.
ES2009283A6 (es)	1989-09-16	Procedimiento para preparar nuevos aminoacilatos de glicerol-acetal.
FR2729665B1 (fr)	1997-04-18	Nouveaux derives de glycylanilides, leur preparation et leur application en therapeutique
ES2005778A6 (es)	1989-03-16	Procedimiento para la obtencion de derivados de diisobutilxantina.