AU2010286704B2 - Methods for the prevention and treatment of cerebral ischemia - Google Patents

Methods for the prevention and treatment of cerebral ischemia Download PDF

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Publication number
AU2010286704B2
AU2010286704B2 AU2010286704A AU2010286704A AU2010286704B2 AU 2010286704 B2 AU2010286704 B2 AU 2010286704B2 AU 2010286704 A AU2010286704 A AU 2010286704A AU 2010286704 A AU2010286704 A AU 2010286704A AU 2010286704 B2 AU2010286704 B2 AU 2010286704B2
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AU
Australia
Prior art keywords
alpha
tocotrienol quinone
subject
effective amount
stereoisomers
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Ceased
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AU2010286704A
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English (en)
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AU2010286704A1 (en
Inventor
Viktoria Kheifets
Guy M. Miller
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PTC Therapeutics Inc
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PTC Therapeutics Inc
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Assigned to BIOELECTRON TECHNOLOGY CORPORATION reassignment BIOELECTRON TECHNOLOGY CORPORATION Request to Amend Deed and Register Assignors: EDISON PHARMACEUTICALS, INC.
Assigned to PTC THERAPEUTICS, INC. reassignment PTC THERAPEUTICS, INC. Request for Assignment Assignors: BIOELECTRON TECHNOLOGY CORPORATION
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2010286704A 2009-08-26 2010-08-24 Methods for the prevention and treatment of cerebral ischemia Ceased AU2010286704B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27526909P 2009-08-26 2009-08-26
US61/275,269 2009-08-26
PCT/US2010/046503 WO2011025785A1 (en) 2009-08-26 2010-08-24 Methods for the prevention and treatment of cerebral ischemia

Publications (2)

Publication Number Publication Date
AU2010286704A1 AU2010286704A1 (en) 2012-03-22
AU2010286704B2 true AU2010286704B2 (en) 2016-10-20

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AU2010286704A Ceased AU2010286704B2 (en) 2009-08-26 2010-08-24 Methods for the prevention and treatment of cerebral ischemia

Country Status (17)

Country Link
US (3) US20110207828A1 (2)
EP (1) EP2470168B1 (2)
JP (2) JP5785546B2 (2)
CN (1) CN102647981B (2)
AU (1) AU2010286704B2 (2)
BR (1) BR112012004167A2 (2)
CA (1) CA2772294C (2)
DK (1) DK2470168T3 (2)
EA (1) EA028677B1 (2)
ES (1) ES2663709T3 (2)
HU (1) HUE037592T2 (2)
MX (1) MX337990B (2)
NO (1) NO2470168T3 (2)
PL (1) PL2470168T3 (2)
PT (1) PT2470168T (2)
SI (1) SI2470168T1 (2)
WO (1) WO2011025785A1 (2)

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WO2007100652A2 (en) 2006-02-22 2007-09-07 Edison Pharmaceuticals, Inc. Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
EA038941B1 (ru) 2007-11-06 2021-11-12 ПиТиСи ТЕРАПЬЮТИКС, ИНК. ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ
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EP2362726B1 (en) 2008-10-14 2018-08-08 Bioelectron Technology Corporation Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells
ES2553557T3 (es) 2008-10-28 2015-12-10 Edison Pharmaceuticals, Inc. Proceso para la producción de alfa-tocotrienol y derivados
CA2777479C (en) 2009-04-28 2017-10-17 Ptc Therapeutics, Inc. Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones
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US10707531B1 (en) 2016-09-27 2020-07-07 New Dominion Enterprises Inc. All-inorganic solvents for electrolytes
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JP2021529835A (ja) * 2018-07-03 2021-11-04 ベンチュリス セラピューティクス， インク．Ｖｅｎｔｕｒｉｓ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 脳卒中を治療するための組成物及び方法
KR102337954B1 (ko) * 2018-08-16 2021-12-10 차의과학대학교 산학협력단 뇌졸중 치료용 조성물 및 이를 스크리닝하는 방법
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CN121949079A (zh) 2019-10-04 2026-05-01 康德生物医疗有限公司 治疗线粒体异常疾病的伐替苯醌的醌、氢醌和萘醌类似物
AU2020366448A1 (en) * 2019-10-17 2022-05-12 The Penn State Research Foundation Regenerating functional neurons for treatment of hemorrhagic stroke
CN115996916B (zh) 2020-04-03 2025-09-23 康德生物医疗有限公司 用于预防和/或治疗包括弗里德赖希共济失调的线粒体疾病的组合物和方法
JP2023553728A (ja) * 2020-12-22 2023-12-25 コーニンクレッカ フィリップス エヌ ヴェ 血管狭窄の位置特定
CN113066113B (zh) * 2021-04-27 2022-01-11 河北医科大学第二医院 自发性高血压大鼠脑模板和地图集的构建方法及设备
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Also Published As

Publication number Publication date
JP5785546B2 (ja) 2015-09-30
WO2011025785A1 (en) 2011-03-03
AU2010286704A1 (en) 2012-03-22
PT2470168T (pt) 2018-03-28
CN102647981B (zh) 2016-09-28
HUE037592T2 (hu) 2018-09-28
CA2772294C (en) 2018-08-21
ES2663709T3 (es) 2018-04-16
EA028677B1 (ru) 2017-12-29
MX2012002374A (es) 2012-04-10
DK2470168T3 (en) 2018-05-07
JP2013503168A (ja) 2013-01-31
PL2470168T3 (pl) 2018-06-29
US20170007553A1 (en) 2017-01-12
CA2772294A1 (en) 2011-03-03
BR112012004167A2 (pt) 2016-03-29
EA201200355A1 (ru) 2012-07-30
JP2015091899A (ja) 2015-05-14
NO2470168T3 (2) 2018-06-30
US20110207828A1 (en) 2011-08-25
EP2470168A1 (en) 2012-07-04
US20180344667A1 (en) 2018-12-06
CN102647981A (zh) 2012-08-22
EP2470168B1 (en) 2018-01-31
MX337990B (es) 2016-03-30
SI2470168T1 (en) 2018-05-31

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