AU2012252437B2 - Molecular markers in prostate cancer - Google Patents

Molecular markers in prostate cancer Download PDF

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Publication number: AU2012252437B2
Authority: AU; Australia
Prior art keywords: prostate cancer; expression; prca; prostate; patients
Prior art date: 2011-05-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU2012252437A

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English (en)

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AU2012252437A1 (en

Inventor

Franciscus Petrus Smit

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

MDxHealth Research BV

Original Assignee

Noviogendix Research BV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-05-12

Filing date

2012-05-09

Publication date

2017-05-18

2012-05-09 Application filed by Noviogendix Research BV filed Critical Noviogendix Research BV

2013-11-28 Publication of AU2012252437A1 publication Critical patent/AU2012252437A1/en

2017-05-18 Application granted granted Critical

2017-05-18 Publication of AU2012252437B2 publication Critical patent/AU2012252437B2/en

Status Ceased legal-status Critical Current

2032-05-09 Anticipated expiration legal-status Critical

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN108220443A (zh) *	2018-01-31	2018-06-29	北京泱深生物信息技术有限公司	Cgref1作为标志物在肾透明细胞癌诊疗中的应用

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20120041274A1 (en)	2010-01-07	2012-02-16	Myriad Genetics, Incorporated	Cancer biomarkers
EP3812469A1 (fr)	2010-07-07	2021-04-28	Myriad Genetics, Inc.	Signatures géniques pour le pronostic du cancer
US9605319B2 (en)	2010-08-30	2017-03-28	Myriad Genetics, Inc.	Gene signatures for cancer diagnosis and prognosis
WO2013064636A1 (fr) *	2011-11-04	2013-05-10	Noviogendix Research B.V.	Combinaisons de marqueurs moléculaires dans le cancer de la prostate fournissant un outil de diagnostic ayant une sensibilité/spécificité améliorée
EP2920322B1 (fr)	2012-11-16	2023-01-11	Myriad Genetics, Inc.	Signatures génétiques utilisées en vue du pronostic d'un cancer
CN105861692A (zh) *	2013-06-24	2016-08-17	复旦大学附属肿瘤医院	研究前列腺癌复发和转移的方法
AU2014308050A1 (en) *	2013-08-13	2016-03-03	Noviogendix Research B.V.	Combinations of molecular markers in prostate cancer providing a diagnostic tool with improved sensitivity/specificity
WO2015070045A1 (fr) *	2013-11-08	2015-05-14	Baylor College Of Medicine	Nouveaux marqueurs diagnostiques/pronostiques et cible thérapeutique pour le cancer
US20150252425A1 (en) *	2014-03-05	2015-09-10	Caldera Health Ltd.	Gene expression profiling for the diagnosis of prostate cancer
WO2015175692A1 (fr)	2014-05-13	2015-11-19	Myriad Genetics, Inc.	Signatures génétiques utilisées en vue du pronostic d'un cancer
US10329625B2 (en)	2015-11-20	2019-06-25	Mdxhealth Research B.V.	Method for detecting DLX1 mRNA, HOXC6 mRNA, and KLK3 mRNA in a urine sample and predicting and treating clinically significant prostate cancer
SG10202006117QA (en) *	2016-04-21	2020-08-28	Immatics Biotechnologies Gmbh	Immunotherapy against melanoma and other cancers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009042742A1 (fr) *	2007-09-25	2009-04-02	The Regents Of The University Of Michigan	Marqueurs cancéreux dlx1

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060040262A1 (en) *	2002-12-27	2006-02-23	Morris David W	Novel compositions and methods in cancer
US20080182865A1 (en) *	2005-03-11	2008-07-31	Witta Samir E	Histone deacetylase inhibitors sensitize cancer cells to epidermal growth factor inhibitors
ES2300176B1 (es) *	2006-02-15	2009-05-01	Consejo Superior Investig. Cientificas	Metodo para el diagnostico molecular de cancer de prostata, kit para implementar el metodo.
JP2012504397A (ja) *	2008-10-01	2012-02-23	ノヴィオジェンディクス・リサーチ・ベスローテン・フェンノートシャップ	前立腺がんにおける分子マーカー

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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009042742A1 (fr) *	2007-09-25	2009-04-02	The Regents Of The University Of Michigan	Marqueurs cancéreux dlx1

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN108220443A (zh) *	2018-01-31	2018-06-29	北京泱深生物信息技术有限公司	Cgref1作为标志物在肾透明细胞癌诊疗中的应用

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CA2835730A1 (fr)	2012-11-15
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US20200165684A1 (en)	2020-05-28
ES2663069T3 (es)	2018-04-11
CA3115945A1 (fr)	2012-11-15
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US20140073535A1 (en)	2014-03-13

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US20210246515A1 (en)	2021-08-12	COMBINATION OF mRNA EXPRESSION LEVELS OF DLX1 AND HOXC6 IN URINE AS MOLECULAR MARKERS IN PROSTATE CANCER
AU2009299862B2 (en)	2016-02-04	Molecular markers in prostate cancer
EP3080293B1 (fr)	2019-03-13	Classification du cancer de la prostate
EP2971177B1 (fr)	2019-09-11	Compositions et procédés pour détecter et déterminer un pronostic de cancer de la prostate
WO2012152800A1 (fr)	2012-11-15	Marqueurs moléculaires dans le cancer de la prostate
EP3237640B1 (fr)	2020-07-08	Test de méthylation d'adn pour le cancer de la prostate
O'DRISCOLL et al.	2008	Feasibility and relevance of global expression profiling of gene transcripts in serum from breast cancer patients using whole genome microarrays and quantitative RT-PCR
AU2012331104B2 (en)	2018-03-15	Combinations of molecular markers in prostate cancer providing a diagnostic tool with improved sensitivity/specificity
JP5865241B2 (ja)	2016-02-17	肉腫の予後分子署名およびその使用
US20140106363A1 (en)	2014-04-17	Molecular markers in prostate cancer
CA3115945C (fr)	2025-08-12	Marqueurs moleculaires du cancer de la prostate
EP3348652B1 (fr)	2023-07-26	Marqueurs moléculaires du cancer de la prostate
EP2334809B1 (fr)	2014-11-05	Marqueurs moléculaires pour le cancer de la prostate
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Saramäki	2006	Gene copy number alterations in prostate cancer
Wu	2020	Circulating cell-free DNA methylation analysis of metastatic prostate cancer
KR20250086607A (ko)	2025-06-13	전립선암의 진단을 위한 신규 rna 바이오마커
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AU2014224523A1 (en)	2015-09-24	Molecular markers in bladder cancer
Gabril et al.	2014	Molecular Testing in Prostate Cancer

AU2012252437B2 - Molecular markers in prostate cancer - Google Patents

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