AU2014361798B2 - Methods to treat lymphoplasmacytic lymphoma - Google Patents
Methods to treat lymphoplasmacytic lymphoma Download PDFInfo
- Publication number
- AU2014361798B2 AU2014361798B2 AU2014361798A AU2014361798A AU2014361798B2 AU 2014361798 B2 AU2014361798 B2 AU 2014361798B2 AU 2014361798 A AU2014361798 A AU 2014361798A AU 2014361798 A AU2014361798 A AU 2014361798A AU 2014361798 B2 AU2014361798 B2 AU 2014361798B2
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- certain embodiments
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- 0 CCN1CC*(Cc(c(C(F)(F)F)c2)ccc2NC(c2cc(OC3=CC(NC4CNC4)NC=N3)c(C)cc2)=O)CC1 Chemical compound CCN1CC*(Cc(c(C(F)(F)F)c2)ccc2NC(c2cc(OC3=CC(NC4CNC4)NC=N3)c(C)cc2)=O)CC1 0.000 description 18
- QWQFGTOJXBOYJO-HYXAFXHYSA-N C/C=C(/C(N1)=O)\SC1=C Chemical compound C/C=C(/C(N1)=O)\SC1=C QWQFGTOJXBOYJO-HYXAFXHYSA-N 0.000 description 1
- YRNYCYKPEAJOBQ-HYXAFXHYSA-N CC(C)/C=C(/C(N1)=O)\SC1=N Chemical compound CC(C)/C=C(/C(N1)=O)\SC1=N YRNYCYKPEAJOBQ-HYXAFXHYSA-N 0.000 description 1
- BDRXIHMSZOYUAN-UHFFFAOYSA-N CC(C)C(N1CCN(C)CC1)=O Chemical compound CC(C)C(N1CCN(C)CC1)=O BDRXIHMSZOYUAN-UHFFFAOYSA-N 0.000 description 1
- UJTKZASSWFSFJS-UHFFFAOYSA-N CC(C)NC(CCN(CC1)CCN1C(OC(C)(C)C)=O)=O Chemical compound CC(C)NC(CCN(CC1)CCN1C(OC(C)(C)C)=O)=O UJTKZASSWFSFJS-UHFFFAOYSA-N 0.000 description 1
- BUCKQURJUDIRKS-UHFFFAOYSA-N CC(C)Nc1ncnc(NCCN2CCCC2)c1 Chemical compound CC(C)Nc1ncnc(NCCN2CCCC2)c1 BUCKQURJUDIRKS-UHFFFAOYSA-N 0.000 description 1
- NOVYSIQVVWXHGB-UHFFFAOYSA-N CCC(Nc1cc(Oc2c(C)ccc(C(Nc3ccc(CN4CCN(CC)CC4)c(C(F)(F)F)c3)=O)c2)ncn1)=O Chemical compound CCC(Nc1cc(Oc2c(C)ccc(C(Nc3ccc(CN4CCN(CC)CC4)c(C(F)(F)F)c3)=O)c2)ncn1)=O NOVYSIQVVWXHGB-UHFFFAOYSA-N 0.000 description 1
- FIBFTUNTEWACAK-UHFFFAOYSA-N CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2NC(c2cc(Oc3cc(NC4CNC4)ncn3)c(C)cc2)=O)CC1 Chemical compound CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2NC(c2cc(Oc3cc(NC4CNC4)ncn3)c(C)cc2)=O)CC1 FIBFTUNTEWACAK-UHFFFAOYSA-N 0.000 description 1
- IKQXHPDWGQELDU-UHFFFAOYSA-N CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2NC(c2cc(Oc3cc(NN(C)C)ncn3)c(C)cc2)=O)CC1 Chemical compound CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2NC(c2cc(Oc3cc(NN(C)C)ncn3)c(C)cc2)=O)CC1 IKQXHPDWGQELDU-UHFFFAOYSA-N 0.000 description 1
- KBCFGUGFJSFWKD-UHFFFAOYSA-N CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2NC(c2cc(Oc3cc(Nc4cncnc4)ncn3)c(C)cc2)=O)CC1 Chemical compound CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2NC(c2cc(Oc3cc(Nc4cncnc4)ncn3)c(C)cc2)=O)CC1 KBCFGUGFJSFWKD-UHFFFAOYSA-N 0.000 description 1
- BMPXPANSAQOTAY-UHFFFAOYSA-N CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2NC(c2cc(Oc3nc(Nc4c[o]nc4)ncc3)c(C)cc2)=O)CC1 Chemical compound CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2NC(c2cc(Oc3nc(Nc4c[o]nc4)ncc3)c(C)cc2)=O)CC1 BMPXPANSAQOTAY-UHFFFAOYSA-N 0.000 description 1
- GJAQIFQPFSPOOM-UHFFFAOYSA-N CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2NC(c2cc(Oc3ncnc(NC(C4CC4)=O)c3)c(C)cc2)=O)CC1 Chemical compound CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2NC(c2cc(Oc3ncnc(NC(C4CC4)=O)c3)c(C)cc2)=O)CC1 GJAQIFQPFSPOOM-UHFFFAOYSA-N 0.000 description 1
- FCNPQYHKUYSELK-UHFFFAOYSA-N CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2NC(c2cc(Oc3ncnc(NC)c3)c(C)cc2)=O)CC1 Chemical compound CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2NC(c2cc(Oc3ncnc(NC)c3)c(C)cc2)=O)CC1 FCNPQYHKUYSELK-UHFFFAOYSA-N 0.000 description 1
- IVMXZQAMEUPQFS-UHFFFAOYSA-N CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2NC(c2ccc(C)c(Oc3cc(Nc4n[n](C)cc4)ncn3)c2)=O)CC1 Chemical compound CCN1CCN(Cc(c(C(F)(F)F)c2)ccc2NC(c2ccc(C)c(Oc3cc(Nc4n[n](C)cc4)ncn3)c2)=O)CC1 IVMXZQAMEUPQFS-UHFFFAOYSA-N 0.000 description 1
- INGLCIWCZSLENQ-UHFFFAOYSA-N CCN1CCN(Cc(cc2)c(C(F)(F)F)cc2NC(c2cc(Oc3cc(Nc4c[nH]nc4)ncn3)c(C)cc2)=O)CC1 Chemical compound CCN1CCN(Cc(cc2)c(C(F)(F)F)cc2NC(c2cc(Oc3cc(Nc4c[nH]nc4)ncn3)c(C)cc2)=O)CC1 INGLCIWCZSLENQ-UHFFFAOYSA-N 0.000 description 1
- WGCYRFWNGRMRJA-UHFFFAOYSA-N CCN1CCNCC1 Chemical compound CCN1CCNCC1 WGCYRFWNGRMRJA-UHFFFAOYSA-N 0.000 description 1
- HVPWCXPBVJEMKK-UHFFFAOYSA-N CNNC(C=C)=O Chemical compound CNNC(C=C)=O HVPWCXPBVJEMKK-UHFFFAOYSA-N 0.000 description 1
- BLHTXORQJNCSII-UHFFFAOYSA-N Cc1c[n](C)cn1 Chemical compound Cc1c[n](C)cn1 BLHTXORQJNCSII-UHFFFAOYSA-N 0.000 description 1
- BSKHPKMHTQYZBB-UHFFFAOYSA-N Cc1ccccn1 Chemical compound Cc1ccccn1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 description 1
- QMNUDYFKZYBWQX-UHFFFAOYSA-N O=C1NC=Nc2c1cccc2 Chemical compound O=C1NC=Nc2c1cccc2 QMNUDYFKZYBWQX-UHFFFAOYSA-N 0.000 description 1
- UFWIBTONFRDIAS-UHFFFAOYSA-N c1cc2ccccc2cc1 Chemical compound c1cc2ccccc2cc1 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N c1ccc2ncncc2c1 Chemical compound c1ccc2ncncc2c1 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361915684P | 2013-12-13 | 2013-12-13 | |
| US61/915,684 | 2013-12-13 | ||
| US201462036934P | 2014-08-13 | 2014-08-13 | |
| US62/036,934 | 2014-08-13 | ||
| PCT/US2014/070162 WO2015089479A1 (en) | 2013-12-13 | 2014-12-12 | Methods to treat lymphoplasmacytic lymphoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014361798A1 AU2014361798A1 (en) | 2016-06-09 |
| AU2014361798B2 true AU2014361798B2 (en) | 2020-06-11 |
Family
ID=53371894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014361798A Ceased AU2014361798B2 (en) | 2013-12-13 | 2014-12-12 | Methods to treat lymphoplasmacytic lymphoma |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9856223B2 (2) |
| EP (1) | EP3079683A4 (2) |
| JP (1) | JP6879740B2 (2) |
| AU (1) | AU2014361798B2 (2) |
| CA (1) | CA2932351A1 (2) |
| WO (1) | WO2015089479A1 (2) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2932353A1 (en) | 2013-12-13 | 2015-06-18 | Steven P. Treon | Methods to treat lymphoplasmacytic lymphoma |
| EP3079683A4 (en) | 2013-12-13 | 2017-12-20 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| EP3715346B1 (en) | 2014-10-22 | 2024-01-03 | Dana-Farber Cancer Institute, Inc. | Thiazolyl-containing compounds for treating proliferative diseases |
| JP6854762B2 (ja) | 2014-12-23 | 2021-04-07 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤 |
| USRE50776E1 (en) | 2015-03-27 | 2026-02-03 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
| JP6947651B2 (ja) * | 2015-06-26 | 2021-10-13 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | ４，６−ピリミジニレン誘導体およびこれらの使用 |
| JP2019507179A (ja) | 2016-03-01 | 2019-03-14 | プロペロン セラピューティックス インコーポレイテッド | Ｗｄｒ５タンパク質−タンパク質結合の阻害剤 |
| US11319299B2 (en) | 2016-03-01 | 2022-05-03 | Propellon Therapeutics Inc. | Substituted carboxamides as inhibitors of WDR5 protein-protein binding |
| WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| CN115819417A (zh) | 2016-09-09 | 2023-03-21 | 因赛特公司 | 作为hpk1调节剂的吡唑并吡啶衍生物及其用于治疗癌症的用途 |
| US10280164B2 (en) | 2016-09-09 | 2019-05-07 | Incyte Corporation | Pyrazolopyridone compounds and uses thereof |
| US20180072741A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyrimidine compounds and uses thereof |
| WO2018140934A1 (en) | 2017-01-30 | 2018-08-02 | The Children's Hospital Of Philadelphia | Compositions and methods for hemoglobin production |
| WO2018152220A1 (en) | 2017-02-15 | 2018-08-23 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| EP3638670B1 (en) | 2017-06-13 | 2021-07-21 | Bayer Pharma Aktiengesellschaft | Substituted pyrrolopyridine-derivatives as map4k1 modulators for the treatment of cancer diseases |
| EP3638669A1 (en) | 2017-06-13 | 2020-04-22 | Bayer Pharma Aktiengesellschaft | Substituted pyrrolopyridine-derivatives |
| WO2018228925A1 (en) | 2017-06-13 | 2018-12-20 | Bayer Pharma Aktiengesellschaft | Substituted pyrrolopyridine-derivatives |
| CN109180677A (zh) | 2017-06-30 | 2019-01-11 | 厦门大学 | 取代芳基醚类化合物、其制备方法、药用组合物及其应用 |
| CA3070013A1 (en) | 2017-07-18 | 2019-01-24 | Bayer Pharma Aktiengesellschaft | Substituted pyrrolopyridine-derivatives |
| US10722495B2 (en) | 2017-09-08 | 2020-07-28 | Incyte Corporation | Cyanoindazole compounds and uses thereof |
| US11542251B2 (en) | 2018-02-14 | 2023-01-03 | Dana-Farber Cancer Institute, Inc. | IRAK degraders and uses thereof |
| EP3755703B1 (en) | 2018-02-20 | 2022-05-04 | Incyte Corporation | N-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide derivatives and related compounds as hpk1 inhibitors for treating cancer |
| US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
| US10752635B2 (en) | 2018-02-20 | 2020-08-25 | Incyte Corporation | Indazole compounds and uses thereof |
| US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
| EP3810132A4 (en) | 2018-06-25 | 2022-06-22 | Dana-Farber Cancer Institute, Inc. | TAIRE FAMILY KINASE INHIBITORS AND RELATED USES |
| CN117285467A (zh) | 2018-07-31 | 2023-12-26 | 罗索肿瘤学公司 | 喷雾干燥的分散体和制剂 |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
| WO2020068729A1 (en) | 2018-09-25 | 2020-04-02 | Incyte Corporation | Pyrazolo[4,3-d]pyrimidine compounds as alk2 abd/or fgfr modulators |
| WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| US11203591B2 (en) | 2018-10-31 | 2021-12-21 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| WO2020120257A1 (en) | 2018-12-11 | 2020-06-18 | Bayer Aktiengesellschaft | Substituted pyrrolopyridine-derivatives |
| US12281126B2 (en) | 2018-12-28 | 2025-04-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 and uses thereof |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| BR112022002059A2 (pt) | 2019-08-06 | 2022-06-07 | Incyte Corp | Formas sólidas de um inibidor de hpk1 |
| WO2021249913A1 (en) | 2020-06-09 | 2021-12-16 | Bayer Aktiengesellschaft | 2'-(quinolin-3-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxylate derivatives and related compounds as map4k1 (hpk1) inhibitors for the treatment of cancer |
| US20240174683A1 (en) | 2021-02-05 | 2024-05-30 | Bayer Aktiengesellschaft | Map4k1 inhibitors |
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| ATE254105T1 (de) | 1998-09-25 | 2003-11-15 | Astrazeneca Ab | Benzamid-derivate und ihre verwendung als cytokine inhibitoren |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2017502006A (ja) | 2017-01-19 |
| US10633348B2 (en) | 2020-04-28 |
| AU2014361798A1 (en) | 2016-06-09 |
| EP3079683A1 (en) | 2016-10-19 |
| EP3079683A4 (en) | 2017-12-20 |
| US20180194739A1 (en) | 2018-07-12 |
| US20160318878A1 (en) | 2016-11-03 |
| WO2015089479A1 (en) | 2015-06-18 |
| CA2932351A1 (en) | 2015-06-18 |
| USRE50030E1 (en) | 2024-07-02 |
| US9856223B2 (en) | 2018-01-02 |
| JP6879740B2 (ja) | 2021-06-02 |
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