AU4493099A - Directed combinatorial compound library and high throughput assays for screening same - Google Patents

Directed combinatorial compound library and high throughput assays for screening same Download PDF

Info

Publication number: AU4493099A
Authority: AU; Australia
Prior art keywords: nucleoside; monomer; halogen; compound; spacer
Prior art date: 1998-06-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU44930/99A

Other languages

English (en)

Inventor

Jeremy Carver

Alessandro Datti

James Dennis

Rob Donovan

Uttam Saha

Francois D. Tropper

Lothar Ziser

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Glycodesign Inc

Original Assignee

Glycodesign Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-10

Filing date

1999-06-10

Publication date

1999-12-30

1999-06-10 Application filed by Glycodesign Inc filed Critical Glycodesign Inc

1999-12-30 Publication of AU4493099A publication Critical patent/AU4493099A/en

Status Abandoned legal-status Critical Current

Links

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229940081066 picolinic acid Drugs 0.000 description 1
239000006187 pill Substances 0.000 description 1
HXEACLLIILLPRG-UHFFFAOYSA-N pipecolic acid Chemical compound OC(=O)C1CCCCN1 HXEACLLIILLPRG-UHFFFAOYSA-N 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
229920005990 polystyrene resin Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
229960002429 proline Drugs 0.000 description 1
AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
230000000644 propagated effect Effects 0.000 description 1
125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
230000004224 protection Effects 0.000 description 1
238000010791 quenching Methods 0.000 description 1
239000012857 radioactive material Substances 0.000 description 1
230000004223 radioprotective effect Effects 0.000 description 1
238000013102 re-test Methods 0.000 description 1
239000000376 reactant Substances 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
210000000664 rectum Anatomy 0.000 description 1
238000006268 reductive amination reaction Methods 0.000 description 1
101150103562 rfaG gene Proteins 0.000 description 1
101150066981 rfbF gene Proteins 0.000 description 1
PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
101150009419 ribF gene Proteins 0.000 description 1
125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
210000003935 rough endoplasmic reticulum Anatomy 0.000 description 1
210000003079 salivary gland Anatomy 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
229940043230 sarcosine Drugs 0.000 description 1
230000007017 scission Effects 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
230000028327 secretion Effects 0.000 description 1
229960001153 serine Drugs 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
238000010008 shearing Methods 0.000 description 1
125000005630 sialyl group Chemical group 0.000 description 1
230000019491 signal transduction Effects 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
238000001542 size-exclusion chromatography Methods 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
230000010473 stable expression Effects 0.000 description 1
238000012289 standard assay Methods 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
210000000130 stem cell Anatomy 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical compound NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 description 1
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
BUXTXUBQAKIQKS-UHFFFAOYSA-N sulfuryl diisocyanate Chemical compound O=C=NS(=O)(=O)N=C=O BUXTXUBQAKIQKS-UHFFFAOYSA-N 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
239000000829 suppository Substances 0.000 description 1
238000003239 susceptibility assay Methods 0.000 description 1
HKYHBMLIEAMWRO-UHFFFAOYSA-N sy002454 Chemical compound OC(=O)C1=CC([N+]([O-])=O)=NN1 HKYHBMLIEAMWRO-UHFFFAOYSA-N 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000008685 targeting Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
QIQITDHWZYEEPA-UHFFFAOYSA-N thiophene-2-carbonyl chloride Chemical compound ClC(=O)C1=CC=CS1 QIQITDHWZYEEPA-UHFFFAOYSA-N 0.000 description 1
QERYCTSHXKAMIS-UHFFFAOYSA-N thiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC=CS1 QERYCTSHXKAMIS-UHFFFAOYSA-N 0.000 description 1
150000003585 thioureas Chemical class 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
230000036962 time dependent Effects 0.000 description 1
238000004448 titration Methods 0.000 description 1
238000000954 titration curve Methods 0.000 description 1
210000002105 tongue Anatomy 0.000 description 1
238000007070 tosylation reaction Methods 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
238000009901 transfer hydrogenation reaction Methods 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
150000004043 trisaccharides Chemical class 0.000 description 1
229910052722 tritium Inorganic materials 0.000 description 1
229960004799 tryptophan Drugs 0.000 description 1
230000005740 tumor formation Effects 0.000 description 1
230000005751 tumor progression Effects 0.000 description 1
208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
230000002476 tumorcidal effect Effects 0.000 description 1
241001529453 unidentified herpesvirus Species 0.000 description 1
241000712461 unidentified influenza virus Species 0.000 description 1
241001430294 unidentified retrovirus Species 0.000 description 1
150000003672 ureas Chemical class 0.000 description 1
210000003708 urethra Anatomy 0.000 description 1
210000003932 urinary bladder Anatomy 0.000 description 1
206010046766 uterine cancer Diseases 0.000 description 1
238000010200 validation analysis Methods 0.000 description 1
229960004295 valine Drugs 0.000 description 1
239000013598 vector Substances 0.000 description 1
230000001018 virulence Effects 0.000 description 1
238000010626 work up procedure Methods 0.000 description 1
FBZONXHGGPHHIY-UHFFFAOYSA-N xanthurenic acid Chemical compound C1=CC=C(O)C2=NC(C(=O)O)=CC(O)=C21 FBZONXHGGPHHIY-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Immunology (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Saccharide Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AU44930/99A 1998-06-10 1999-06-10 Directed combinatorial compound library and high throughput assays for screening same Abandoned AU4493099A (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US8882898P	1998-06-10	1998-06-10
US60088828		1998-06-10
US12056299P	1999-02-17	1999-02-17
US60120562		1999-02-17
PCT/CA1999/000550 WO1999064378A2 (en)	1998-06-10	1999-06-10	Directed combinatorial compound library and high throughput assays for screening same

Publications (1)

Publication Number	Publication Date
AU4493099A true AU4493099A (en)	1999-12-30

Family

ID=26779099

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU44930/99A Abandoned AU4493099A (en)	1998-06-10	1999-06-10	Directed combinatorial compound library and high throughput assays for screening same

Country Status (8)

Country	Link
EP (1)	EP1086064A2 (de)
JP (1)	JP2002517474A (de)
CN (1)	CN1314913A (de)
AU (1)	AU4493099A (de)
CA (1)	CA2334338A1 (de)
MX (1)	MXPA00012237A (de)
NO (1)	NO20006244L (de)
WO (1)	WO1999064378A2 (de)

Families Citing this family (19)

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DE60022762T2 (de)	1999-07-29	2006-07-13	National Institute Of Advanced Industrial Science And Technology	Polymerisierbare biotinderivate, bioptinpolymer und polymer, das auf stimulierung durch avidin reagiert
CA2390441A1 (en) *	1999-11-08	2001-05-17	Origenix Technologies, Inc.	Combinatorial library synthesis and pharmaceutically active compounds produced thereby
US20020127598A1 (en) *	2000-03-27	2002-09-12	Wenqiang Zhou	Solution-phase combinatorial library synthesis and pharmaceutically active compounds produced thereby
US7338932B2 (en)	2000-05-11	2008-03-04	Glycozym Aps	Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
WO2001085215A2 (en) *	2000-05-11	2001-11-15	Glycozym Aps	METHODS OF MODULATING FUNCTIONS OF POLYPEPTIDE GalNAc TRANSFERASES AND OF SCREENING SUBSTANCES THEREFOR, PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH AGENTS
CN101113160A (zh)	2001-05-16	2008-01-30	米珍尼克斯公司	基于核酸的化合物及其使用方法
EP1401850A1 (de)	2001-06-20	2004-03-31	Nuevolution A/S	Nukleosidderivate zur herstellung einer verbindungsbibliothek
EP1487978B1 (de)	2002-03-15	2008-11-19	Nuevolution A/S	Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
WO2004013070A2 (en)	2002-08-01	2004-02-12	Nuevolution A/S	Multi-step synthesis of templated molecules
US8791053B2 (en)	2002-09-27	2014-07-29	Mpm-Holding Aps	Spatially encoded polymer matrix
PT2348125T (pt)	2002-10-30	2017-08-29	Nuevolution As	Método para a síntese de um complexo bifuncional
AU2003291964A1 (en)	2002-12-19	2004-07-14	Nuevolution A/S	Quasirandom structure and function guided synthesis methods
US20070026397A1 (en)	2003-02-21	2007-02-01	Nuevolution A/S	Method for producing second-generation library
ATE346078T1 (de) *	2003-06-19	2006-12-15	Hoffmann La Roche	Verfahren zur herstellung von 4'- azidonukleosidderivaten
EP1670939B1 (de)	2003-09-18	2009-11-04	Nuevolution A/S	Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
JP5174672B2 (ja) *	2005-10-04	2013-04-03	アルケミアリミティッド	薬物設計の方法
HUE056836T2 (hu)	2005-12-01	2022-03-28	Nuevolution As	Enzimatikus kódolási eljárások nagy könyvtárak hatékony szintéziséhez
CN102917733A (zh) *	2010-04-07	2013-02-06	动量制药公司	用于产生糖蛋白的宿主细胞的选择和用途
WO2011127933A1 (en)	2010-04-16	2011-10-20	Nuevolution A/S	Bi-functional complexes and methods for making and using such complexes

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CA2173990A1 (en) *	1993-10-12	1995-04-20	Narasinga Rao	A library of glyco-peptides useful for identification of cell adhesion inhibitors
IL110024A (en) *	1994-06-15	1998-04-05	Yissum Res Dev Co	Controlled release oral drug delivery system containing hydrogel- forming polymer

1999
- 1999-06-10 CA CA002334338A patent/CA2334338A1/en not_active Abandoned
- 1999-06-10 JP JP2000553388A patent/JP2002517474A/ja active Pending
- 1999-06-10 EP EP99927613A patent/EP1086064A2/de not_active Withdrawn
- 1999-06-10 AU AU44930/99A patent/AU4493099A/en not_active Abandoned
- 1999-06-10 WO PCT/CA1999/000550 patent/WO1999064378A2/en not_active Ceased
- 1999-06-10 MX MXPA00012237A patent/MXPA00012237A/es not_active Application Discontinuation
- 1999-06-10 CN CN 99809486 patent/CN1314913A/zh active Pending
2000
- 2000-12-08 NO NO20006244A patent/NO20006244L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1314913A (zh)	2001-09-26
MXPA00012237A (es)	2002-11-15
WO1999064378A3 (en)	2000-09-21
WO1999064378A2 (en)	1999-12-16
JP2002517474A (ja)	2002-06-18
NO20006244D0 (no)	2000-12-08
NO20006244L (no)	2001-02-08
CA2334338A1 (en)	1999-12-16
EP1086064A2 (de)	2001-03-28

Legal Events

Date	Code	Title	Description
2004-04-08	MK5	Application lapsed section 142(2)(e) - patent request and compl. specification not accepted

Publication	Publication Date	Title
AU4493099A (en)	1999-12-30	Directed combinatorial compound library and high throughput assays for screening same
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Gimisis	2010	Synthesis of N-glucopyranosidic derivatives as potential inhibitors that bind at the catalytic site of glycogen phosphorylase
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Lioux et al.	2005	Synthesis of peptidoglycan units with UDP at the anomeric position
EP1417223B1 (de)	2007-09-26	Verfahren zur herstellung von lipid ii
Bosco et al.	2008	6-Azido d-galactose transfer to N-acetyl-d-glucosamine derivative using commercially available β-1, 4-galactosyltransferase
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