CN1314913A - 有针对性的组合化合物库及其进行筛选所用的高效测定方法 - Google Patents

有针对性的组合化合物库及其进行筛选所用的高效测定方法 Download PDF

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Publication number
CN1314913A
CN1314913A CN 99809486 CN99809486A CN1314913A CN 1314913 A CN1314913 A CN 1314913A CN 99809486 CN99809486 CN 99809486 CN 99809486 A CN99809486 A CN 99809486A CN 1314913 A CN1314913 A CN 1314913A
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CN
China
Prior art keywords
acid
nucleoside
representative
carbohydrate
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN 99809486
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English (en)
Chinese (zh)
Inventor
J·卡弗
J·登尼斯
F·D·特罗佩尔
U·萨哈
L·兹瑟尔
A·达蒂
R·多诺范
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glycodesign Inc
Original Assignee
Glycodesign Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycodesign Inc filed Critical Glycodesign Inc
Publication of CN1314913A publication Critical patent/CN1314913A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN 99809486 1998-06-10 1999-06-10 有针对性的组合化合物库及其进行筛选所用的高效测定方法 Pending CN1314913A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8882898P 1998-06-10 1998-06-10
US60/088,828 1998-06-10
US12056299P 1999-02-17 1999-02-17
US60/120,562 1999-02-17

Publications (1)

Publication Number Publication Date
CN1314913A true CN1314913A (zh) 2001-09-26

Family

ID=26779099

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 99809486 Pending CN1314913A (zh) 1998-06-10 1999-06-10 有针对性的组合化合物库及其进行筛选所用的高效测定方法

Country Status (8)

Country Link
EP (1) EP1086064A2 (de)
JP (1) JP2002517474A (de)
CN (1) CN1314913A (de)
AU (1) AU4493099A (de)
CA (1) CA2334338A1 (de)
MX (1) MXPA00012237A (de)
NO (1) NO20006244L (de)
WO (1) WO1999064378A2 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101278079B (zh) * 2005-10-04 2012-09-19 阿尔卡米亚有限公司 药物设计方法
CN102917733A (zh) * 2010-04-07 2013-02-06 动量制药公司 用于产生糖蛋白的宿主细胞的选择和用途

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60022762T2 (de) 1999-07-29 2006-07-13 National Institute Of Advanced Industrial Science And Technology Polymerisierbare biotinderivate, bioptinpolymer und polymer, das auf stimulierung durch avidin reagiert
CA2390441A1 (en) * 1999-11-08 2001-05-17 Origenix Technologies, Inc. Combinatorial library synthesis and pharmaceutically active compounds produced thereby
US20020127598A1 (en) * 2000-03-27 2002-09-12 Wenqiang Zhou Solution-phase combinatorial library synthesis and pharmaceutically active compounds produced thereby
US7338932B2 (en) 2000-05-11 2008-03-04 Glycozym Aps Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
WO2001085215A2 (en) * 2000-05-11 2001-11-15 Glycozym Aps METHODS OF MODULATING FUNCTIONS OF POLYPEPTIDE GalNAc TRANSFERASES AND OF SCREENING SUBSTANCES THEREFOR, PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH AGENTS
CN101113160A (zh) 2001-05-16 2008-01-30 米珍尼克斯公司 基于核酸的化合物及其使用方法
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
EP1487978B1 (de) 2002-03-15 2008-11-19 Nuevolution A/S Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
WO2004013070A2 (en) 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
US8791053B2 (en) 2002-09-27 2014-07-29 Mpm-Holding Aps Spatially encoded polymer matrix
PT2348125T (pt) 2002-10-30 2017-08-29 Nuevolution As Método para a síntese de um complexo bifuncional
AU2003291964A1 (en) 2002-12-19 2004-07-14 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
ATE346078T1 (de) * 2003-06-19 2006-12-15 Hoffmann La Roche Verfahren zur herstellung von 4'- azidonukleosidderivaten
EP1670939B1 (de) 2003-09-18 2009-11-04 Nuevolution A/S Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
HUE056836T2 (hu) 2005-12-01 2022-03-28 Nuevolution As Enzimatikus kódolási eljárások nagy könyvtárak hatékony szintéziséhez
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2173990A1 (en) * 1993-10-12 1995-04-20 Narasinga Rao A library of glyco-peptides useful for identification of cell adhesion inhibitors
IL110024A (en) * 1994-06-15 1998-04-05 Yissum Res Dev Co Controlled release oral drug delivery system containing hydrogel- forming polymer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101278079B (zh) * 2005-10-04 2012-09-19 阿尔卡米亚有限公司 药物设计方法
CN102917733A (zh) * 2010-04-07 2013-02-06 动量制药公司 用于产生糖蛋白的宿主细胞的选择和用途

Also Published As

Publication number Publication date
MXPA00012237A (es) 2002-11-15
WO1999064378A3 (en) 2000-09-21
WO1999064378A2 (en) 1999-12-16
JP2002517474A (ja) 2002-06-18
NO20006244D0 (no) 2000-12-08
AU4493099A (en) 1999-12-30
NO20006244L (no) 2001-02-08
CA2334338A1 (en) 1999-12-16
EP1086064A2 (de) 2001-03-28

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C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication