AU625018B2 - Variants of pai-2 - Google Patents

Variants of pai-2

Info

Publication number: AU625018B2
Authority: AU; Australia
Prior art keywords: pai; variant; dna molecule; ala; leu
Prior art date: 1989-12-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU69671/91A

Other languages

English (en)

Other versions

AU6967191A (en

Inventor

Neil Howard Goss

Michael Andrew Richardson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Biotech Australia Pty Ltd

Original Assignee

Biotech Australia Pty Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-20

Filing date

1990-12-20

Publication date

1992-06-25

1990-12-20 Application filed by Biotech Australia Pty Ltd filed Critical Biotech Australia Pty Ltd

1991-07-18 Publication of AU6967191A publication Critical patent/AU6967191A/en

1992-06-25 Application granted granted Critical

1992-06-25 Publication of AU625018B2 publication Critical patent/AU625018B2/en

2010-12-20 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8132—Plasminogen activator inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Rheumatology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AU69671/91A 1989-12-20 1990-12-20 Variants of pai-2 Ceased AU625018B2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPJ792489		1989-12-20
AUPJ7924		1989-12-20

Publications (2)

Publication Number	Publication Date
AU6967191A AU6967191A (en)	1991-07-18
AU625018B2 true AU625018B2 (en)	1992-06-25

Family

ID=3774424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU69671/91A Ceased AU625018B2 (en)	1989-12-20	1990-12-20	Variants of pai-2

Country Status (10)

Country	Link
US (1)	US5444153A (fr)
EP (1)	EP0458937B1 (fr)
JP (1)	JP2567536B2 (fr)
AT (1)	ATE156859T1 (fr)
AU (1)	AU625018B2 (fr)
DE (1)	DE69031271T2 (fr)
DK (1)	DK0458937T3 (fr)
ES (1)	ES2106772T3 (fr)
GR (1)	GR3025330T3 (fr)
WO (1)	WO1991009124A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5827727A (en)	1990-02-01	1998-10-27	Emory University	Method of resolution of 1,3-oxathiolane nucleoside enantiomers
DE4214215A1 (de) *	1992-04-30	1993-11-04	Behringwerke Ag	Verwendung von inhibitoren von plasminogenaktivatoren zur behandlung von entzuendungen
DE4214999C2 (de) *	1992-05-06	1994-07-14	Behringwerke Ag	Reinigung von Plasminogen-Aktivator-Inhibitor 2 durch Immunaffinitätschromatographie
US6391859B1 (en)	1995-01-27	2002-05-21	Emory University	[5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en)	1995-01-27	1997-12-30	Emory University	Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
ATE267198T1 (de) *	1997-03-19	2004-06-15	Univ Emory	Synthese und anti-hiv und anti-hepatitis virus aktivität von 1,3-oxaselenolan nucleosiden
US5994309A (en) *	1997-07-25	1999-11-30	Angstrom Pharmaceuticals, Inc.	Anti-invasive and anti-angiogenic compositions and methods
CN1299286A (zh)	1998-04-01	2001-06-13	澳洲生物科技公司	应用蛋白酶抑制剂治疗皮肤伤口
AUPP508798A0 (en) *	1998-08-05	1998-08-27	Biotech Australia Pty Limited	Method of treating psoriasis
EP1066834A3 (fr) *	1999-07-08	2004-06-02	Thomas Dr. Stief	Compositions pharmaceutiques comprenant un agent modulateur des phagocytes
AUPQ380699A0 (en) *	1999-11-02	1999-11-25	Biotech Australia Pty Limited	Protease inhibitors as modulators of periodontal wound healing
AUPQ582400A0 (en) *	2000-02-24	2000-03-16	Biotech Australia Pty Limited	A method of treatment and agents for use therein
US7455836B2 (en) *	2000-05-08	2008-11-25	The University Of Melbourne	Method of treatment and agents useful for same
US8062637B2 (en) *	2000-05-08	2011-11-22	Morphosys Ag	Methods of ameliorating inflammatory disease using an uPA antagonist
US6562572B1 (en) *	2000-09-27	2003-05-13	Mayo Foundation For Medical Education And Research	Methods for amplifying nucleic acid sequences
US20110028397A1 (en) *	2007-11-30	2011-02-03	Toezser Jozsef	Use of Urokinase Type Plasminogen Activator Inhibitors for the Treatment of Corneal Disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7165587A (en) *	1986-03-13	1987-10-09	Australian National University, The	Minactivin produced by recombinant dna technology
DE3722673A1 (de) *	1987-04-18	1989-01-19	Behringwerke Ag	Fuer plasminogenaktivator-inhibitor, typ 2 (pai-2) codierende dna

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4923807A (en) *	1984-05-18	1990-05-08	New England Medical Center Hospitals Inc.	Arg-Serpin human plasminogen activator inhibitor designated PAI-2
DE3587711T2 (de) *	1984-08-13	1994-04-28	Biotech Australia Pty Ltd	Minaktivin.
IL81879A (en) *	1986-03-13	1994-07-31	Biotech Australia Pty Ltd	Purification of minactivin for homogeneity, production of minactivin as recombinant techniques, and uses of homogeneous or recombinant minactivin
CA2041638C (fr) *	1989-09-05	2001-05-15	Peter L. Whitfeld	Produits de polynucleotide recombinants servant a fournir des secretions de pai-2

1990
- 1990-12-20 AU AU69671/91A patent/AU625018B2/en not_active Ceased
- 1990-12-20 JP JP3501647A patent/JP2567536B2/ja not_active Expired - Fee Related
- 1990-12-20 DE DE69031271T patent/DE69031271T2/de not_active Expired - Fee Related
- 1990-12-20 ES ES91901253T patent/ES2106772T3/es not_active Expired - Lifetime
- 1990-12-20 AT AT91901253T patent/ATE156859T1/de not_active IP Right Cessation
- 1990-12-20 DK DK91901253.4T patent/DK0458937T3/da active
- 1990-12-20 WO PCT/AU1990/000603 patent/WO1991009124A1/fr not_active Ceased
- 1990-12-20 US US07/768,286 patent/US5444153A/en not_active Expired - Fee Related
- 1990-12-20 EP EP91901253A patent/EP0458937B1/fr not_active Expired - Lifetime
1997
- 1997-11-11 GR GR970402972T patent/GR3025330T3/el unknown

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7165587A (en) *	1986-03-13	1987-10-09	Australian National University, The	Minactivin produced by recombinant dna technology
DE3722673A1 (de) *	1987-04-18	1989-01-19	Behringwerke Ag	Fuer plasminogenaktivator-inhibitor, typ 2 (pai-2) codierende dna

Also Published As

Publication number	Publication date
EP0458937A1 (fr)	1991-12-04
ES2106772T3 (es)	1997-11-16
AU6967191A (en)	1991-07-18
ATE156859T1 (de)	1997-08-15
US5444153A (en)	1995-08-22
DE69031271T2 (de)	1998-02-26
DE69031271D1 (de)	1997-09-18
JPH04503761A (ja)	1992-07-09
DK0458937T3 (da)	1998-02-23
EP0458937B1 (fr)	1997-08-13
WO1991009124A1 (fr)	1991-06-27
EP0458937A4 (en)	1992-04-01
JP2567536B2 (ja)	1996-12-25
GR3025330T3 (en)	1998-02-27

Publication	Publication Date	Title
AU625018B2 (en)	1992-06-25	Variants of pai-2
AU735015B2 (en)	2001-06-28	Use of substrate subtraction libraries to distinguish enzyme specificities
ES2067486T5 (es)	2005-04-16	Proteina inhibidora de factor de necrosis tumoral (tnf) y su purificacion.
Antalis et al.	1988	Cloning and expression of a cDNA coding for a human monocyte-derived plasminogen activator inhibitor.
JPH05502375A (ja)	1993-04-28	活性化可能なフィブリン溶解および抗血栓症タンパク質
EP0277212B1 (fr)	1995-04-05	Essai de depistage d'inhibiteurs d'activateurs de plasminogene de type tissulaire et de type urokinase, genes de codage de l'inhibiteur
JP2533869B2 (ja)	1996-09-11	Ｈｕｓｉ―ｉ型インヒビタ―の生物学的活性を有するタンパク質をコ―ドするｄｎａ配列、前記ｄｎａ配列を含む組換え体クロ―ニングベクタ―及び前記ベクタ―により形質転換された細菌
Egelund et al.	1997	Type‐1 plasminogen‐activator inhibitor: conformational differences between latent, active, reactive‐centre‐cleaved and plasminogen‐activator‐complexed forms, as probed by proteolytic susceptibility
EP0446315B1 (fr)	1997-06-11	Procede de preparation de pai-2
US20030186329A1 (en)	2003-10-02	Use of substrate subtraction libraries to distinguish enzyme specificities
US8975370B2 (en)	2015-03-10	Inhibitor proteins of a protease and use thereof
CA1338381C (fr)	1996-06-11	Minactivine (inhibiteur-2 de l'activateur du plasminogene)
US5412073A (en)	1995-05-02	Polypeptides and DNA coding therefor
US5422090A (en)	1995-06-06	Human PAI-2
AU608752B2 (en)	1991-04-18	Minactivin produced by recombinant dna technology
AU629980C (en)	1994-02-03	Recombinant product
EP0471759A1 (fr)	1992-02-26	EXPRESSION DE HAUT NIVEAU DE L'INHIBITEUR D'ACTIVATEUR DE PLASMINOGENE HUMAIN FONCTIONNEL (PAI-1) DANS $i(E. COLI)