AU628026B2 - New acyllabdane derivatives, a process for their preparation,and their use as medicaments - Google Patents

New acyllabdane derivatives, a process for their preparation,and their use as medicaments Download PDF

Info

Publication number
AU628026B2
AU628026B2 AU24649/88A AU2464988A AU628026B2 AU 628026 B2 AU628026 B2 AU 628026B2 AU 24649/88 A AU24649/88 A AU 24649/88A AU 2464988 A AU2464988 A AU 2464988A AU 628026 B2 AU628026 B2 AU 628026B2
Authority
AU
Australia
Prior art keywords
formula
group
alkyl
compound
hereinbefore defined
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU24649/88A
Other languages
English (en)
Other versions
AU2464988A (en
Inventor
Alihussein Nomanbhai Dohadwalla
Rajeshwari Kannan
Yatendra Khandelwal
Bansi Lal
Ramanujam Rajgopalan
Richard Helmut Rupp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU2464988A publication Critical patent/AU2464988A/en
Application granted granted Critical
Publication of AU628026B2 publication Critical patent/AU628026B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
AU24649/88A 1987-11-04 1988-11-03 New acyllabdane derivatives, a process for their preparation,and their use as medicaments Ceased AU628026B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3737353 1987-11-04
DE19873737353 DE3737353A1 (de) 1987-11-04 1987-11-04 Neue acyllabdan-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
AU2464988A AU2464988A (en) 1989-05-25
AU628026B2 true AU628026B2 (en) 1992-09-10

Family

ID=6339720

Family Applications (1)

Application Number Title Priority Date Filing Date
AU24649/88A Ceased AU628026B2 (en) 1987-11-04 1988-11-03 New acyllabdane derivatives, a process for their preparation,and their use as medicaments

Country Status (10)

Country Link
EP (1) EP0315097A3 (2)
JP (1) JPH01151572A (2)
KR (1) KR890008132A (2)
AU (1) AU628026B2 (2)
DE (1) DE3737353A1 (2)
DK (1) DK613888A (2)
HU (1) HUT50805A (2)
IN (1) IN170600B (2)
PT (1) PT88923B (2)
ZA (1) ZA888194B (2)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4999351A (en) * 1989-01-11 1991-03-12 Hoechst-Roussel Pharmaceuticals, Inc. 7-aryl and heteroaryl ethers of desacetylforskolin
US5177207A (en) * 1989-01-11 1993-01-05 Hoechst-Roussel Pharmaceuticals, Inc. 7-aryl and heteroaryl ethers of desacetylforskolin
CN121698841A (zh) * 2026-02-13 2026-03-20 云南省药物研究所 一种1-乙酰基异佛司可林的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5423686A (en) * 1985-03-01 1986-09-04 Hoechst-Roussel Pharmaceuticals Incorporated Labd-14-en-11-one derivatives
AU1741288A (en) * 1987-06-06 1988-12-08 Hoechst Aktiengesellschaft New polyoxygenated labdane derivatives, a process for their preparation, and their use as medicaments
AU3452189A (en) * 1988-05-09 1989-11-09 Hoechst-Roussel Pharmaceuticals Incorporated Hydrazinocarbonyloxylabdanes, a process for their preparation and their use as medicaments

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1594115A (en) * 1976-10-21 1981-07-30 Hoechst Ag Polyoxygenated labdane derivatives
AU591196B2 (en) * 1985-11-15 1989-11-30 Nippon Kayaku Kabushiki Kaisha Novel forskolin derivatives
DE3623300A1 (de) * 1986-07-11 1988-01-21 Hoechst Ag 7-acyloxy-6-aminoacyloxypolyoxylabdane, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FI875699A7 (fi) * 1986-12-29 1988-06-30 Hoechst Roussel Pharma Nya karbamoyloxilabdaner, mellanprodukter och foerfaranden foer deras framstaellning samt deras anvaendning saosom laekemedel.
HU201921B (en) * 1987-06-29 1991-01-28 Nippon Kayaku Kk New process for producing 6-acylforscholine derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5423686A (en) * 1985-03-01 1986-09-04 Hoechst-Roussel Pharmaceuticals Incorporated Labd-14-en-11-one derivatives
AU1741288A (en) * 1987-06-06 1988-12-08 Hoechst Aktiengesellschaft New polyoxygenated labdane derivatives, a process for their preparation, and their use as medicaments
AU3452189A (en) * 1988-05-09 1989-11-09 Hoechst-Roussel Pharmaceuticals Incorporated Hydrazinocarbonyloxylabdanes, a process for their preparation and their use as medicaments

Also Published As

Publication number Publication date
AU2464988A (en) 1989-05-25
PT88923B (pt) 1993-01-29
DK613888A (da) 1989-05-05
EP0315097A2 (de) 1989-05-10
IN170600B (2) 1992-04-18
KR890008132A (ko) 1989-07-08
JPH01151572A (ja) 1989-06-14
PT88923A (pt) 1988-12-01
ZA888194B (en) 1989-07-26
EP0315097A3 (de) 1990-07-04
HUT50805A (en) 1990-03-28
DK613888D0 (da) 1988-11-03
DE3737353A1 (de) 1989-05-18

Similar Documents

Publication Publication Date Title
CA2178161C (en) Indole derivatives
AU666927B2 (en) Indole derivatives
US5624947A (en) Phenyl derivatives useful as tachykinin antagonists
DE69716062T2 (de) Benzofuran-derivate und deren verwendung
US6716864B2 (en) Interheteroaryl 7-oxabicyclic [2.2.1]heptane oxazoles as prostaglandin F2α antagonists
AU606036B2 (en) Novel polyoxygenated labdane derivatives, processes for their preparation and their use as medicaments
KR19990063850A (ko) Nmda 길항제로서의 테트라히드로퀴놀린
JPH03505205A (ja) 縮合ピラゾル３―オキソ―プロパンニトリル誘導体及びその製造方法
EP0116360A1 (de) 1-Phenyl-2-aminocarbonylindol-Verbindungen sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE60311861T2 (de) Pyrazolochinoline mit immunmodulierender wirkung
US5206241A (en) Labdanes and process for their preparation
EP0019440B1 (en) Benzimidazolone derivatives, process for their preparation and pharmaceutical compositions containing them
US6369089B1 (en) Interheteroaryl 7-oxabicyclic [2.2.1]heptane oxazoles as prostaglandin F2α antagonists
DD299425A5 (de) Neue 4,4-disubstituierte piperidin-derivate und verfahren zu ihrer herstellung
JP2539118B2 (ja) 置換ピラジン及びその塩並びにそれらを含有する組成物
US20020165399A1 (en) Interphenylene 7-oxabicyclic [2.2.1] heptane oxazoles as prostaglandin F2a antagonists
EP0389425B1 (de) Neue Benzothiopyranylamine
DD285604A5 (de) Verfahren zur herstellung von enol-ethern und estern
EP0279948A1 (en) Novel carbamoyloxylabdanes, intermediates and a process for the preparation thereof and their use as medicaments
IE901063L (en) Polycyclic amines useful as cerebrovascular agents
KR100188902B1 (ko) [(1-아릴피롤리딘-2-일)메틸]피페라진 유도체, 그들의 제법 및 치료학적 용도
DE69113338T2 (de) Pyranobenzoxadiazolderivate.
US5916902A (en) Processes and intermediates for preparing 5, 7-dihydro-3- 2-(1-benzylpiperidin-4-yl)ethyl-!6H-pyrrolo- 4, 5-F!-1, 2-benzisoxazol-6-one
HUT50805A (en) Process for producing new acyl labdane derivatives and pharmaceutical compositions comprising such compounds
CH633290A5 (en) Process for preparing derivatives of 7-oxo-1,3-diazabicyclo[3.2.0]heptane-2-carboxylic acid