AU631693B2 - A83543 recovery process - Google Patents

A83543 recovery process

Info

Publication number: AU631693B2
Authority: AU; Australia
Prior art keywords: medium; phase; solvent; culture; methanol
Prior art date: 1989-10-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU66414/90A

Other languages

English (en)

Other versions

AU6641490A (en

Inventor

Patrick James Baker

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-30

Filing date

1990-10-26

Publication date

1992-12-03

1990-10-26 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1991-05-31 Publication of AU6641490A publication Critical patent/AU6641490A/en

1992-12-03 Application granted granted Critical

1992-12-03 Publication of AU631693B2 publication Critical patent/AU631693B2/en

2010-10-26 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Links

238000011084 recovery Methods 0.000 title description 8
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 54
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 33
238000000034 method Methods 0.000 claims description 30
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 28
239000002904 solvent Substances 0.000 claims description 21
238000000855 fermentation Methods 0.000 claims description 19
230000004151 fermentation Effects 0.000 claims description 19
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
229910001868 water Inorganic materials 0.000 claims description 16
239000012071 phase Substances 0.000 claims description 13
239000008346 aqueous phase Substances 0.000 claims description 10
239000012074 organic phase Substances 0.000 claims description 10
239000002028 Biomass Substances 0.000 claims description 7
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 7
238000001914 filtration Methods 0.000 claims description 7
235000002906 tartaric acid Nutrition 0.000 claims description 7
239000011975 tartaric acid Substances 0.000 claims description 7
239000002253 acid Substances 0.000 claims description 6
239000007791 liquid phase Substances 0.000 claims description 6
238000001223 reverse osmosis Methods 0.000 claims description 5
239000003960 organic solvent Substances 0.000 claims description 4
230000002378 acidificating effect Effects 0.000 claims description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 36
239000002609 medium Substances 0.000 description 31
239000013587 production medium Substances 0.000 description 18
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 17
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
239000000047 product Substances 0.000 description 12
239000000203 mixture Substances 0.000 description 10
241000868102 Saccharopolyspora spinosa Species 0.000 description 8
239000002054 inoculum Substances 0.000 description 8
239000003921 oil Substances 0.000 description 8
235000019198 oils Nutrition 0.000 description 8
238000004519 manufacturing process Methods 0.000 description 7
229910052757 nitrogen Inorganic materials 0.000 description 7
238000000926 separation method Methods 0.000 description 7
239000000243 solution Substances 0.000 description 7
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
239000007788 liquid Substances 0.000 description 6
238000005187 foaming Methods 0.000 description 5
239000001963 growth medium Substances 0.000 description 5
238000004128 high performance liquid chromatography Methods 0.000 description 5
239000011347 resin Substances 0.000 description 5
229920005989 resin Polymers 0.000 description 5
235000012424 soybean oil Nutrition 0.000 description 5
239000003549 soybean oil Substances 0.000 description 5
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 4
239000003708 ampul Substances 0.000 description 4
239000000284 extract Substances 0.000 description 4
239000000706 filtrate Substances 0.000 description 4
235000013336 milk Nutrition 0.000 description 4
239000008267 milk Substances 0.000 description 4
210000004080 milk Anatomy 0.000 description 4
239000002244 precipitate Substances 0.000 description 4
238000002360 preparation method Methods 0.000 description 4
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
229920005654 Sephadex Polymers 0.000 description 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
239000012141 concentrate Substances 0.000 description 3
235000012343 cottonseed oil Nutrition 0.000 description 3
235000013312 flour Nutrition 0.000 description 3
239000008103 glucose Substances 0.000 description 3
238000011534 incubation Methods 0.000 description 3
239000000463 material Substances 0.000 description 3
235000015097 nutrients Nutrition 0.000 description 3
229910052760 oxygen Inorganic materials 0.000 description 3
239000001301 oxygen Substances 0.000 description 3
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
241000255925 Diptera Species 0.000 description 2
239000012507 Sephadex™ Substances 0.000 description 2
240000008042 Zea mays Species 0.000 description 2
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
235000002017 Zea mays subsp mays Nutrition 0.000 description 2
239000002518 antifoaming agent Substances 0.000 description 2
238000013459 approach Methods 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
229910000019 calcium carbonate Inorganic materials 0.000 description 2
230000001143 conditioned effect Effects 0.000 description 2
235000005822 corn Nutrition 0.000 description 2
230000000694 effects Effects 0.000 description 2
QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 description 2
239000002024 ethyl acetate extract Substances 0.000 description 2
239000012535 impurity Substances 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
239000000401 methanolic extract Substances 0.000 description 2
QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 2
229940073769 methyl oleate Drugs 0.000 description 2
238000000746 purification Methods 0.000 description 2
230000001105 regulatory effect Effects 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
239000000741 silica gel Substances 0.000 description 2
229910002027 silica gel Inorganic materials 0.000 description 2
229960001866 silicon dioxide Drugs 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
239000008399 tap water Substances 0.000 description 2
235000020679 tap water Nutrition 0.000 description 2
235000013619 trace mineral Nutrition 0.000 description 2
239000011573 trace mineral Substances 0.000 description 2
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
239000005695 Ammonium acetate Substances 0.000 description 1
241001600408 Aphis gossypii Species 0.000 description 1
101100313763 Arabidopsis thaliana TIM22-2 gene Proteins 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
241001414720 Cicadellidae Species 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
108010082495 Dietary Plant Proteins Proteins 0.000 description 1
235000019733 Fish meal Nutrition 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
238000010268 HPLC based assay Methods 0.000 description 1
241000258937 Hemiptera Species 0.000 description 1
241000238631 Hexapoda Species 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241000920471 Lucilia caesar Species 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 description 1
229910017974 NH40H Inorganic materials 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
241000364057 Peoria Species 0.000 description 1
241000305186 Persectania ewingii Species 0.000 description 1
RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
241000212342 Sium Species 0.000 description 1
235000019764 Soybean Meal Nutrition 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
241001494115 Stomoxys calcitrans Species 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
239000003929 acidic solution Substances 0.000 description 1
238000005273 aeration Methods 0.000 description 1
238000010564 aerobic fermentation Methods 0.000 description 1
239000008272 agar Substances 0.000 description 1
238000013019 agitation Methods 0.000 description 1
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
235000019257 ammonium acetate Nutrition 0.000 description 1
229940043376 ammonium acetate Drugs 0.000 description 1
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
238000003556 assay Methods 0.000 description 1
235000015278 beef Nutrition 0.000 description 1
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
BJDCWCLMFKKGEE-CMDXXVQNSA-N chembl252518 Chemical compound C([C@@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2O[C@H](O)[C@@H]4C BJDCWCLMFKKGEE-CMDXXVQNSA-N 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000010779 crude oil Substances 0.000 description 1
238000012258 culturing Methods 0.000 description 1
238000010908 decantation Methods 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
238000001514 detection method Methods 0.000 description 1
238000011161 development Methods 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
239000004467 fishmeal Substances 0.000 description 1
239000012634 fragment Substances 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
239000011521 glass Substances 0.000 description 1
150000002337 glycosamines Chemical class 0.000 description 1
239000002917 insecticide Substances 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
150000005605 isobutyric acids Chemical class 0.000 description 1
239000008101 lactose Substances 0.000 description 1
238000011031 large-scale manufacturing process Methods 0.000 description 1
238000011068 loading method Methods 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
150000004672 propanoic acids Chemical class 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
238000011160 research Methods 0.000 description 1
238000012807 shake-flask culturing Methods 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000004455 soybean meal Substances 0.000 description 1
241000894007 species Species 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
239000004474 valine Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000003643 water by type Substances 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Cephalosporin Compounds (AREA)
Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Processing Of Solid Wastes (AREA)

AU66414/90A 1989-10-30 1990-10-26 A83543 recovery process Ceased AU631693B2 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US42944189A	1989-10-30	1989-10-30
US429441		1989-10-30
US45139489A	1989-12-15	1989-12-15
US451394		1989-12-15

Publications (2)

Publication Number	Publication Date
AU6641490A AU6641490A (en)	1991-05-31
AU631693B2 true AU631693B2 (en)	1992-12-03

Family

ID=27028194

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU66414/90A Ceased AU631693B2 (en)	1989-10-30	1990-10-26	A83543 recovery process

Country Status (5)

Country	Link
EP (1)	EP0454820A4 (fr)
JP (1)	JPH05504469A (fr)
AU (1)	AU631693B2 (fr)
BR (1)	BR9006982A (fr)
WO (1)	WO1991006552A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
OA09249A (fr) *	1988-12-19	1992-06-30	Lilly Co Eli	Composés de macrolides.
US5227295A (en) *	1991-11-08	1993-07-13	Dowelanco	Process for isolating A83543 and its components
US5591606A (en) *	1992-11-06	1997-01-07	Dowelanco	Process for the production of A83543 compounds with Saccharopolyspora spinosa
WO1994020518A1 (fr) *	1993-03-12	1994-09-15	Dowelanco	Nouveaux composes a83543 et procede de production desdits composes
WO1995011295A1 (fr) *	1993-10-22	1995-04-27	Gist-Brocades N.V.	Procede ameliore de recuperation a partir d'un bouillon de fermentation aqueux
US6001981A (en) *	1996-06-13	1999-12-14	Dow Agrosciences Llc	Synthetic modification of Spinosyn compounds
GB2326020B (en) *	1997-06-06	2002-05-15	Ericsson Telefon Ab L M	Waveguide
DE102005018256B3 (de) *	2005-04-20	2006-08-31	Dechema Gesellschaft Für Chemische Technik Und Biotechnologie E.V.	Verfahren zur fermentativen Herstellung von Duft- und/oder Aromastoffen
CN119736216A (zh) *	2025-03-05	2025-04-01	深圳市新产业眼科新技术有限公司	培养基及其配置方法

Citations (3)

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Publication number	Priority date	Publication date	Assignee	Title
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- 1990-10-26 WO PCT/US1990/006187 patent/WO1991006552A1/fr not_active Ceased
- 1990-10-26 JP JP2515669A patent/JPH05504469A/ja active Pending
- 1990-10-26 EP EP19900916854 patent/EP0454820A4/en not_active Withdrawn
- 1990-10-26 AU AU66414/90A patent/AU631693B2/en not_active Ceased

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Also Published As

Publication number	Publication date
JPH05504469A (ja)	1993-07-15
AU6641490A (en)	1991-05-31
WO1991006552A1 (fr)	1991-05-16
BR9006982A (pt)	1991-12-24
EP0454820A4 (en)	1992-03-11
EP0454820A1 (fr)	1991-11-06

Publication	Publication Date	Title
EP0573628B1 (fr)	1999-01-20	Nouveaux composes a83543 et leur procede de production
US5227295A (en)	1993-07-13	Process for isolating A83543 and its components
AU624458B2 (en)	1992-06-11	Macrolide compounds
US4160861A (en)	1979-07-10	Method for the separation of antibiotic macrolides
EP0388152B1 (fr)	1994-10-12	Procédé de préparation d'un agent immunosuppressif (demethimmunomycine) mettant en oeuvre une souche mutante d'un microorganisme
AU631693B2 (en)	1992-12-03	A83543 recovery process
US5563054A (en)	1996-10-08	Process for preparation of benzo[B]thiophene glucuronides
US4252898A (en)	1981-02-24	Antibiotics A6888C and A6888X
US4161583A (en)	1979-07-17	Method for the separation and purification of antibiotic macrolides
EP0043280B1 (fr)	1984-03-14	Procédé pour la préparation d'un macrolide
US4172940A (en)	1979-10-30	Purification of C-076 compounds by single column chromatography
IE45888B1 (en)	1982-12-29	Method for producing maytansinol and its derivatives
US4440857A (en)	1984-04-03	Process for preparing mycarosyltylactone
CA1211731A (fr)	1986-09-23	Derives de de(mycinosyloxy)tylosine
JPH0737B2 (ja)	1995-01-11	スタウロスポリン発酵法
US4160083A (en)	1979-07-03	Process for the separation of antibiotic macrolides
EP0466365A2 (fr)	1992-01-15	Produits d'une fermentation d'un micro-organisme ayant une activité immunosupressante
US4358584A (en)	1982-11-09	Antibiotics A6888C and A6888X
EP0526906A1 (fr)	1993-02-10	Procédé de production de dérivés 3-déacylés d'antibiotique macrolide à 16 chaînons, microorganisme utilisé pour ce procédé et nouvel anti-biotique macrolide
CA1113874A (fr)	1981-12-08	Antibiotique bl580 zeta produit par le streptomyces hygroscopicus
US4296101A (en)	1981-10-20	Antibiotic kristenin
EP0045205B1 (fr)	1984-10-03	Macrolides
EP0037736A1 (fr)	1981-10-14	Dérivés de mycoplanécine, leur préparation et compositions pharmaceutiques les contenant
US2965547A (en)	1960-12-20	Process for the production of l-6-diazo-5-oxonorleucine
EP0442003A1 (fr)	1991-08-21	Antibiotique LL-E 19085 alpha