AU753206B2 - Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions - Google Patents

Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions Download PDF

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Publication number
AU753206B2
AU753206B2 AU55335/98A AU5533598A AU753206B2 AU 753206 B2 AU753206 B2 AU 753206B2 AU 55335/98 A AU55335/98 A AU 55335/98A AU 5533598 A AU5533598 A AU 5533598A AU 753206 B2 AU753206 B2 AU 753206B2
Authority
AU
Australia
Prior art keywords
composition
agents
polymer
sodium
gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
AU55335/98A
Other languages
English (en)
Other versions
AU5533598A (en
Inventor
Luis A. Dellamary
Stephen G. Flore
Lorraine E. Reeve
Jeffry G. Weers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alliance Pharmaceutical Corp
Original Assignee
Alliance Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alliance Pharmaceutical Corp filed Critical Alliance Pharmaceutical Corp
Publication of AU5533598A publication Critical patent/AU5533598A/en
Application granted granted Critical
Publication of AU753206B2 publication Critical patent/AU753206B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
AU55335/98A 1997-12-23 1997-12-23 Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions Expired - Fee Related AU753206B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1997/023865 WO1999032151A1 (fr) 1997-12-23 1997-12-23 Methodes et compositions pour l'apport d'agents pharmaceutiques et/ou la prevention d'adherences

Publications (2)

Publication Number Publication Date
AU5533598A AU5533598A (en) 1999-07-12
AU753206B2 true AU753206B2 (en) 2002-10-10

Family

ID=22262364

Family Applications (2)

Application Number Title Priority Date Filing Date
AU55335/98A Expired - Fee Related AU753206B2 (en) 1997-12-23 1997-12-23 Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions
AU19438/99A Abandoned AU1943899A (en) 1997-12-23 1998-12-23 Methods for delivering pharmaceutical agents to mucosal surfaces

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU19438/99A Abandoned AU1943899A (en) 1997-12-23 1998-12-23 Methods for delivering pharmaceutical agents to mucosal surfaces

Country Status (5)

Country Link
EP (1) EP1039932A1 (fr)
JP (1) JP2001526246A (fr)
AU (2) AU753206B2 (fr)
CA (1) CA2316248A1 (fr)
WO (2) WO1999032151A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0887076A3 (fr) * 1997-05-07 1999-03-31 Saturnus A.G. Prévention d'ahérences et un systeme d'insufflation endoscopique
US6881420B2 (en) 2000-06-23 2005-04-19 Teva Pharmaceutical Industries Ltd. Compositions and dosage forms for gastric delivery of irinotecan and methods of treatment that use it to inhibit cancer cell proliferation
US7674480B2 (en) * 2000-06-23 2010-03-09 Teva Pharmaceutical Industries Ltd. Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition
JP2004532847A (ja) 2001-04-20 2004-10-28 ザ ユニヴァーシティ オヴ ブリティッシュ コロンビア 疎水性薬物のためのミセル薬物送達システム
EP1414497A4 (fr) * 2001-08-08 2007-11-21 Univ Florida Nouveaux systemes de micelles et de micro-emulsions pour la solubilisation de medicaments
US7138133B2 (en) 2001-10-10 2006-11-21 The Procter & Gamble Company Orally administered liquid compositions
US20040191225A1 (en) * 2002-08-06 2004-09-30 Dinsmore Jonathan H. Injection system
US20040151691A1 (en) 2003-01-30 2004-08-05 Oxman Joel D. Hardenable thermally responsive compositions
US7223826B2 (en) 2003-01-30 2007-05-29 3M Innovative Properties Company Amide-functional polymers, compositions, and methods
US8802116B2 (en) 2003-02-27 2014-08-12 Novasel Australia Pty. Ltd. Poloxamer emulsion preparations
JP4473539B2 (ja) * 2003-08-12 2010-06-02 エスエス製薬株式会社 医薬組成物
WO2005079856A1 (fr) * 2004-02-23 2005-09-01 The University Of British Columbia Compositions de medicaments contenant des polymeres hydrophobes et des molecules amphipathiques
CN101378766B (zh) 2006-02-01 2013-05-01 株式会社三养生物制药 用于抑制粘连的组合物
US8062282B2 (en) 2006-02-13 2011-11-22 Fossa Medical, Inc. Methods and apparatus for temporarily occluding body openings
MY161021A (en) 2008-05-14 2017-03-31 Otonomy Inc Controlled release corticosteroid and methods for the treatment of otic disorders
WO2010011466A2 (fr) 2008-06-27 2010-01-28 Otonomy, Inc. Compositions de modulation du snc à libération contrôlée et procédés de traitement des troubles otiques
US8496957B2 (en) 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
MX2011000862A (es) * 2008-07-21 2011-03-15 Otonomy Inc Composiciones antimicrobianas de liberacion controlada y metodos para el tratamiento de trastornos oticos.
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
JP2013508381A (ja) * 2009-10-21 2013-03-07 オトノミ―，インク． ポロクサマーを包含する製剤のゲル化温度の調節
WO2011049958A2 (fr) * 2009-10-21 2011-04-28 Otonomy, Inc. Modulation de la température de gélification de formulations contenant des poloxamères
JP6143286B2 (ja) * 2013-05-13 2017-06-07 学校法人 関西大学 癒着防止材及びその製造方法
CN105682742A (zh) 2013-08-27 2016-06-15 奥德纳米有限公司 小儿耳部病症的治疗
US20170080120A1 (en) * 2014-05-16 2017-03-23 Ulstrast, Inc. Phase-shifting formulations
KR101627787B1 (ko) * 2014-07-24 2016-06-07 주식회사 메디톡스 열감응성 유착 방지용 조성물 및 그의 용도
EP3512513A4 (fr) 2016-09-16 2020-04-15 Otonomy, Inc. Formulations de gel otique pour le traitement de l'otite externe
JP6403297B2 (ja) * 2017-05-02 2018-10-10 川澄化学工業株式会社 癒着防止材の製造方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0470251A1 (fr) * 1989-04-25 1992-02-12 The Green Cross Corporation Composition liquide de prostaglandine
EP0551626A1 (fr) * 1991-12-19 1993-07-21 LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. Gel thermoréversible utile comme excipient pharmaceutique pour une formation galénique
US5366735A (en) * 1988-11-16 1994-11-22 Mediventures, Inc. Method and composition for post-surgical adhesion reduction

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963367A (en) * 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US4810503A (en) * 1987-03-31 1989-03-07 Basf Corporation Polymers which form gels at low concentrations in water
US4983585A (en) * 1987-05-04 1991-01-08 Mdr Group, Inc. Viscoelastic fluid for use in surgery and other therapies and method of using same
US5126141A (en) * 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
EP0598116B1 (fr) * 1989-11-27 1996-07-24 Nippon Shinyaku Company, Limited Emulsion grasse
CA2040460C (fr) * 1990-05-01 1997-06-10 Tacey X. Viegas Distribution de medicaments au moyen de gels thermoreversibles
US5252318A (en) * 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
US5484610A (en) * 1991-01-02 1996-01-16 Macromed, Inc. pH and temperature sensitive terpolymers for oral drug delivery
IT1247529B (it) * 1991-04-24 1994-12-17 Poli Ind Chimica Spa Composizioni farmaceutiche in forma di schiuma per somministrazione intravaginale, cutanea e orale
US5264047A (en) * 1991-07-17 1993-11-23 Church & Dwight Co., Inc. Low foaming effective hydrotrope
IT1255460B (it) * 1992-07-28 1995-11-02 Poli Ind Chimica Spa Composizioni farmaceutiche in forma di microemulsioni o di dispersioni liposomiali bioadesive per la somministrazione transmucosale di sostanze peptidiche e di proteine farmacologicamente attive
AU5539294A (en) * 1992-12-24 1994-07-19 Hemagen/Pfc Fluorocarbon emulsions
US5624962A (en) * 1993-04-16 1997-04-29 Wakamoto Pharmaceutical Co., Ltd. Aqueous drug composition having property of reversible thermosetting gelation
PL177323B1 (pl) * 1993-10-01 1999-10-29 Syntex Inc Kompozycja farmaceutyczna zawierająca mykofenolan mofetylu lub kwas mykofenolowy i sposób wytwarzania kompozycji farmaceutycznej zawierającej mykofenolan mofetylu lub kwas mykofenolowy
EP0748342B1 (fr) * 1994-03-04 2001-10-04 University of Washington Copolymeres en blocs et greffes, et procedes les concernant
US5585108A (en) * 1994-12-30 1996-12-17 Nanosystems L.L.C. Formulations of oral gastrointestinal therapeutic agents in combination with pharmaceutically acceptable clays

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366735A (en) * 1988-11-16 1994-11-22 Mediventures, Inc. Method and composition for post-surgical adhesion reduction
EP0470251A1 (fr) * 1989-04-25 1992-02-12 The Green Cross Corporation Composition liquide de prostaglandine
EP0551626A1 (fr) * 1991-12-19 1993-07-21 LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. Gel thermoréversible utile comme excipient pharmaceutique pour une formation galénique

Also Published As

Publication number Publication date
WO1999032152A2 (fr) 1999-07-01
WO1999032152A3 (fr) 1999-12-09
WO1999032151A1 (fr) 1999-07-01
AU1943899A (en) 1999-07-12
EP1039932A1 (fr) 2000-10-04
JP2001526246A (ja) 2001-12-18
CA2316248A1 (fr) 1999-07-01
AU5533598A (en) 1999-07-12

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Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE APPLICANT TO READ ALLIANCE PHARMACEUTICAL CORP.

MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application