BE1000318A4 - Nouvelles compositions pharmaceutiques a base d'un derive de la benzodiazepine. - Google Patents

Nouvelles compositions pharmaceutiques a base d'un derive de la benzodiazepine. Download PDF

Info

Publication number: BE1000318A4
Authority: BE; Belgium
Prior art keywords: temazepam; treatment; insomnia; gelatin capsules; sep
Prior art date: 1986-09-23

Application number

BE8701058A

Other languages

English (en)

French (fr)

Original Assignee

Sandoz Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-09-23

Filing date

1987-09-21

Publication date

1988-10-18

1987-09-21 Application filed by Sandoz Sa filed Critical Sandoz Sa

1988-10-18 Application granted granted Critical

1988-10-18 Publication of BE1000318A4 publication Critical patent/BE1000318A4/fr

Links

125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
SEQDDYPDSLOBDC-UHFFFAOYSA-N Temazepam Chemical compound N=1C(O)C(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 SEQDDYPDSLOBDC-UHFFFAOYSA-N 0.000 claims abstract description 51
229960003188 temazepam Drugs 0.000 claims abstract description 50
208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims abstract description 16
206010022437 insomnia Diseases 0.000 claims abstract description 16
239000007903 gelatin capsule Substances 0.000 claims description 25
239000002775 capsule Substances 0.000 claims description 13
239000002245 particle Substances 0.000 claims description 13
239000003814 drug Substances 0.000 claims 1
230000001684 chronic effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 description 5
239000000203 mixture Substances 0.000 description 5
239000000902 placebo Substances 0.000 description 4
229940068196 placebo Drugs 0.000 description 4
230000000694 effects Effects 0.000 description 3
230000004622 sleep time Effects 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
239000003326 hypnotic agent Substances 0.000 description 2
239000008101 lactose Substances 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
230000004617 sleep duration Effects 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
230000002745 absorbent Effects 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
150000001557 benzodiazepines Chemical class 0.000 description 1
239000012159 carrier gas Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000000428 dust Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000007789 gas Substances 0.000 description 1
239000001307 helium Substances 0.000 description 1
229910052734 helium Inorganic materials 0.000 description 1
SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
230000000147 hypnotic effect Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
229910052743 krypton Inorganic materials 0.000 description 1
DNNSSWSSYDEUBZ-UHFFFAOYSA-N krypton atom Chemical compound [Kr] DNNSSWSSYDEUBZ-UHFFFAOYSA-N 0.000 description 1
239000007788 liquid Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
229940068918 polyethylene glycol 400 Drugs 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BE8701058A 1986-09-23 1987-09-21 Nouvelles compositions pharmaceutiques a base d'un derive de la benzodiazepine. BE1000318A4 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US91057186A	1986-09-23	1986-09-23

Publications (1)

Publication Number	Publication Date
BE1000318A4 true BE1000318A4 (fr)	1988-10-18

Family

ID=25429005

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE8701058A BE1000318A4 (fr)	1986-09-23	1987-09-21	Nouvelles compositions pharmaceutiques a base d'un derive de la benzodiazepine.

Country Status (8)

Country	Link
JP (1)	JPS63101325A (2)
BE (1)	BE1000318A4 (2)
CA (1)	CA1302886C (2)
CH (1)	CH673947A5 (2)
DE (1)	DE3731840A1 (2)
FR (1)	FR2604091B1 (2)
GB (1)	GB2195242A (2)
IT (1)	IT1221509B (2)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9307833D0 (en) *	1993-04-15	1993-06-02	Glaxo Inc	Modulators of cholecystokinin and gastrin
DE19603402A1 (de) *	1995-02-24	1996-08-29	Basf Ag	Weichgelatinekapseln

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0025546A2 (de) *	1979-09-14	1981-03-25	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Therapeutische Verwendung tranquillisierend wirksamer Benzodiazepinderivate und diese enthaltende Kombinationspräparate
EP0047899A1 (de) *	1980-09-09	1982-03-24	Bayer Ag	Feste Arzneizubereitungen enthaltend Nifedipin und Verfahren zu ihrer Herstellung
WO1984003416A1 (en) *	1983-03-02	1984-09-13	Scherer Corp R P	Soft gelatin capsules having improved stability by incorporation of embrittlement inhibiting substances
WO1984003417A1 (en) *	1983-03-02	1984-09-13	Scherer Corp R P	Soft gelatin capsules and fill achieving optimum hardness and flexibility during storage
WO1987000428A1 (en) *	1985-07-24	1987-01-29	Pyare Seth	Oxazepam containing pharmaceutical composition

1987
- 1987-09-18 CH CH3616/87A patent/CH673947A5/de not_active IP Right Cessation
- 1987-09-21 FR FR878713108A patent/FR2604091B1/fr not_active Expired
- 1987-09-21 BE BE8701058A patent/BE1000318A4/fr not_active IP Right Cessation
- 1987-09-21 GB GB08722205A patent/GB2195242A/en not_active Withdrawn
- 1987-09-22 DE DE19873731840 patent/DE3731840A1/de not_active Withdrawn
- 1987-09-22 JP JP62236428A patent/JPS63101325A/ja active Pending
- 1987-09-22 IT IT48408/87A patent/IT1221509B/it active
- 1987-09-22 CA CA000547518A patent/CA1302886C/en not_active Expired - Lifetime

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0025546A2 (de) *	1979-09-14	1981-03-25	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Therapeutische Verwendung tranquillisierend wirksamer Benzodiazepinderivate und diese enthaltende Kombinationspräparate
EP0047899A1 (de) *	1980-09-09	1982-03-24	Bayer Ag	Feste Arzneizubereitungen enthaltend Nifedipin und Verfahren zu ihrer Herstellung
WO1984003416A1 (en) *	1983-03-02	1984-09-13	Scherer Corp R P	Soft gelatin capsules having improved stability by incorporation of embrittlement inhibiting substances
WO1984003417A1 (en) *	1983-03-02	1984-09-13	Scherer Corp R P	Soft gelatin capsules and fill achieving optimum hardness and flexibility during storage
WO1987000428A1 (en) *	1985-07-24	1987-01-29	Pyare Seth	Oxazepam containing pharmaceutical composition

Also Published As

Publication number	Publication date
IT8748408A0 (it)	1987-09-22
FR2604091B1 (fr)	1989-05-05
GB8722205D0 (en)	1987-10-28
GB2195242A (en)	1988-04-07
DE3731840A1 (de)	1988-03-31
IT1221509B (it)	1990-07-06
FR2604091A1 (fr)	1988-03-25
JPS63101325A (ja)	1988-05-06
CA1302886C (en)	1992-06-09
CH673947A5 (2)	1990-04-30

Legal Events

Date

Code

Title

Description

1992-03-31

RE

Patent lapsed

Owner name: S.A. SANDOZ

Effective date: 19910930

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