BE1002693A5 - Sequence nucleotidique codant pour le precurseur du facteur de croissance transformant beta 2, precurseur du facteur de croissance transformant beta 2 et facteur de croissance transformant beta 2. - Google Patents

Sequence nucleotidique codant pour le precurseur du facteur de croissance transformant beta 2, precurseur du facteur de croissance transformant beta 2 et facteur de croissance transformant beta 2. Download PDF

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Publication number
BE1002693A5
BE1002693A5 BE8801141A BE8801141A BE1002693A5 BE 1002693 A5 BE1002693 A5 BE 1002693A5 BE 8801141 A BE8801141 A BE 8801141A BE 8801141 A BE8801141 A BE 8801141A BE 1002693 A5 BE1002693 A5 BE 1002693A5
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BE
Belgium
Prior art keywords
beta
growth factor
transforming growth
precursor
nucleotide sequence
Prior art date
Application number
BE8801141A
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English (en)
Original Assignee
Oncogen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of BE1002693A5 publication Critical patent/BE1002693A5/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne essentiellement une séquence nucléotidique codant pour le précurseur du facteur de croissance transformant beta 2. Selon l'invention, cette séquence nucléotidique comprend la séquence codante de nucléotides sensiblement telle que représentée à la figure 1a depuis environ le résidu de nucléotide numméro 1 jusqu'à environ le résidu de nucléotide numéro 1326. L'invention trouve application notamment dans la production en grande quantité du facteur de croissance transformant beta 2.
BE8801141A 1987-10-06 1988-10-05 Sequence nucleotidique codant pour le precurseur du facteur de croissance transformant beta 2, precurseur du facteur de croissance transformant beta 2 et facteur de croissance transformant beta 2. BE1002693A5 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10675287A 1987-10-06 1987-10-06
US14826788A 1988-01-25 1988-01-25
US23406588A 1988-08-18 1988-08-18

Publications (1)

Publication Number Publication Date
BE1002693A5 true BE1002693A5 (fr) 1991-05-07

Family

ID=27380183

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8801141A BE1002693A5 (fr) 1987-10-06 1988-10-05 Sequence nucleotidique codant pour le precurseur du facteur de croissance transformant beta 2, precurseur du facteur de croissance transformant beta 2 et facteur de croissance transformant beta 2.

Country Status (22)

Country Link
JP (1) JPH02444A (fr)
KR (1) KR970001236B1 (fr)
CN (1) CN1035845A (fr)
AT (1) AT398433B (fr)
BE (1) BE1002693A5 (fr)
CH (1) CH680002A5 (fr)
DE (1) DE3833897C2 (fr)
DK (1) DK556388A (fr)
ES (1) ES2012556A6 (fr)
FI (1) FI884546A7 (fr)
FR (1) FR2621324B1 (fr)
GB (1) GB2210620B8 (fr)
GR (1) GR1000492B (fr)
IE (1) IE60918B1 (fr)
IL (1) IL87877A0 (fr)
IT (1) IT1227957B (fr)
MY (1) MY103779A (fr)
NL (1) NL8802442A (fr)
NO (1) NO884429L (fr)
NZ (1) NZ226486A (fr)
PT (1) PT88670B (fr)
SE (1) SE8803528L (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221620A (en) * 1987-10-06 1993-06-22 Oncogen Cloning and expression of transforming growth factor β2
US5445941A (en) * 1993-06-21 1995-08-29 Eli Lilly And Company Method for screening anti-osteoporosis agents
CN100389120C (zh) * 2005-04-12 2008-05-21 中国人民解放军第三军医大学野战外科研究所 封闭TGF－β1的反义寡核苷酸及其在制备治疗纤维化相关疾病药物中的用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0169016A2 (fr) * 1984-07-16 1986-01-22 Celtrix Pharmaceuticals, Inc. Facteur induisant le polypeptide cartilage dans les os
EP0200341A1 (fr) * 1985-03-22 1986-11-05 Genentech, Inc. Acide nucléique codant de TGF-bêta et ses utilisations
EP0268561A2 (fr) * 1986-11-17 1988-05-25 Sandoz Ag Préparation et utilisation d'un facteur suppresseur de cellules T
WO1988005787A1 (fr) * 1987-01-30 1988-08-11 Techne Corporation Facteur beta de croissance de transformation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931548A (en) * 1987-01-30 1990-06-05 Techne Corporation Heterodimer form of transforming growth factor-beta
AU1539188A (en) * 1987-05-04 1988-11-10 Bristol-Myers Squibb Company TGF-B2 and novel compositions having anti-neoplastic activity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0169016A2 (fr) * 1984-07-16 1986-01-22 Celtrix Pharmaceuticals, Inc. Facteur induisant le polypeptide cartilage dans les os
EP0200341A1 (fr) * 1985-03-22 1986-11-05 Genentech, Inc. Acide nucléique codant de TGF-bêta et ses utilisations
EP0268561A2 (fr) * 1986-11-17 1988-05-25 Sandoz Ag Préparation et utilisation d'un facteur suppresseur de cellules T
WO1988005787A1 (fr) * 1987-01-30 1988-08-11 Techne Corporation Facteur beta de croissance de transformation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIOCHEMISTRY *
CHEMICAL ABSTRACTS *
J. CELLULAR BIOCHEMISTRY SUPPLEMENT *
NATURE *
THE JOURNAL OF BIOLOGICAL CHEMISTRY *

Also Published As

Publication number Publication date
SE8803528L (sv) 1989-04-07
IT1227957B (it) 1991-05-20
FR2621324A1 (fr) 1989-04-07
DK556388A (da) 1989-04-07
PT88670B (pt) 1992-12-31
CH680002A5 (fr) 1992-05-29
IE60918B1 (en) 1994-08-24
AT398433B (de) 1994-12-27
DE3833897C2 (de) 1997-03-20
FR2621324B1 (fr) 1994-02-18
DK556388D0 (da) 1988-10-05
NL8802442A (nl) 1989-05-01
JPH02444A (ja) 1990-01-05
GB2210620B (en) 1992-07-08
ATA245488A (de) 1994-04-15
KR970001236B1 (ko) 1997-02-04
CN1035845A (zh) 1989-09-27
KR890006814A (ko) 1989-06-16
NO884429D0 (no) 1988-10-05
ES2012556A6 (es) 1990-04-01
GR1000492B (el) 1992-07-30
NO884429L (no) 1989-04-07
GB2210620A (en) 1989-06-14
SE8803528D0 (sv) 1988-10-05
GB8823448D0 (en) 1988-11-16
DE3833897A1 (de) 1989-05-03
NZ226486A (en) 1991-08-27
FI884546A7 (fi) 1989-04-07
IE883018L (en) 1989-04-06
IT8822213A0 (it) 1988-10-06
GB2210620B8 (en) 1995-07-17
IL87877A0 (en) 1989-03-31
MY103779A (en) 1993-09-30
FI884546A0 (fi) 1988-10-03

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: ONCOGEN

Effective date: 19971031