CA2020663A1 - Analogues de substitution de magainin peptides - Google Patents

Analogues de substitution de magainin peptides

Info

Publication number: CA2020663A1
Authority: CA; Canada
Prior art keywords: analogues; magainin; substitution; amino acid; acid residues
Prior art date: 1989-07-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2020663A

Other languages

English (en)

Other versions

CA2020663C (fr

Inventor

Richard A. Houghten

Julio H. Cuervo

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Scripps Research Institute

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-07

Filing date

1990-07-06

Publication date

1991-01-08

1990-07-06 Application filed by Individual filed Critical Individual

1991-01-08 Publication of CA2020663A1 publication Critical patent/CA2020663A1/fr

1999-12-07 Application granted granted Critical

1999-12-07 Publication of CA2020663C publication Critical patent/CA2020663C/fr

2010-07-06 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000006467 substitution reaction Methods 0.000 title abstract 5
108060003100 Magainin Proteins 0.000 title 1
125000000539 amino acid group Chemical group 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
101500009721 Xenopus laevis Magainin-2 Proteins 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
108091005128 magainin I Proteins 0.000 abstract 1
OFIZOVDANLLTQD-ZVNXOKPXSA-N magainin i Chemical compound C([C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O)C1=CC=CC=C1 OFIZOVDANLLTQD-ZVNXOKPXSA-N 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Reproductive Health (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Urology & Nephrology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

CA002020663A 1989-07-07 1990-07-06 Analogues de substitution de magainin peptides Expired - Lifetime CA2020663C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US37675489A	1989-07-07	1989-07-07
US376,754		1989-07-07

Publications (2)

Publication Number	Publication Date
CA2020663A1 true CA2020663A1 (fr)	1991-01-08
CA2020663C CA2020663C (fr)	1999-12-07

Family

ID=23486335

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002020663A Expired - Lifetime CA2020663C (fr)	1989-07-07	1990-07-06	Analogues de substitution de magainin peptides

Country Status (16)

Country	Link
EP (4)	EP0761684A3 (fr)
JP (1)	JP2854970B2 (fr)
CN (1)	CN1055480C (fr)
AT (1)	ATE146188T1 (fr)
AU (1)	AU650236B2 (fr)
CA (1)	CA2020663C (fr)
DE (1)	DE69029377T2 (fr)
DK (1)	DK0437556T3 (fr)
ES (1)	ES2095255T3 (fr)
IE (1)	IE63842B1 (fr)
IL (1)	IL94939A (fr)
PH (4)	PH30054A (fr)
PT (1)	PT94625B (fr)
SG (1)	SG47913A1 (fr)
WO (1)	WO1991000869A1 (fr)
ZA (1)	ZA905203B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN114634553A (zh) *	2022-04-27	2022-06-17	贵州医科大学	阳离子肽c9及其应用

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2095255T3 (es) *	1989-07-07	1997-02-16	Scripps Research Inst	Analogos de sustitucion de peptidos magainina.
US5221664A (en) *	1990-04-23	1993-06-22	Magainin Pharmaaceuticals Inc.	Composition and treatment with biologically active peptides and toxic cations
AU648140B2 (en) *	1991-02-01	1994-04-14	Virtual Drug Development, Inc.	Reverse antimicrobial peptides and antimicrobial compositions
WO1992022317A1 (fr) *	1991-06-12	1992-12-23	Magainin Pharmaceuticals, Inc.	Composition de peptides biologiquement actifs presentant des substitutions au niveau de leur terminaison c et traitement a l'aide de ces peptides
US5424290A (en) *	1992-10-26	1995-06-13	Magainin Pharmaceuticals Inc.	Biologically active peptides and uses therefor
US5561107A (en) *	1993-06-04	1996-10-01	Demeter Biotechnologies, Ltd.	Method of enhancing wound healing by stimulating fibroblast and keratinocyte growth in vivo, utilizing amphipathic peptides
US5773413A (en) *	1993-06-04	1998-06-30	Demeter Biotechnologies, Ltd.	Method of combating mammalian neoplasias, and lytic peptides therefor
CN101928340A (zh) *	2009-12-24	2010-12-29	深圳市圣西马生物技术有限公司	一组抗菌肽衍生物及其应用
CN104710523B (zh) *	2013-12-11	2017-12-29	华东理工大学	对铜绿假单胞菌具有抗菌性能的Magainin肽修饰物及其制备方法
CA2989311A1 (fr) *	2015-07-02	2017-01-05	Dana-Farber Cancer Institute, Inc.	Peptides stabilises anti-microbiens
CN109069578A (zh)	2016-02-29	2018-12-21	达纳-法伯癌症研究所股份有限公司	用于治疗感染的钉合的细胞内靶向抗微生物肽
JP7305614B2 (ja) *	2017-07-19	2023-07-10	デイナファーバーキャンサーインスティチュート，インコーポレイテッド	抗生物質耐性細菌感染症の処置のための安定化抗菌ペプチド
CN111892646B (zh) *	2020-08-13	2023-05-02	中国人民解放军军事科学院军事医学研究院	抗菌肽衍生物及其在制备抗细菌感染药物中的应用
CN112625092B (zh) *	2021-01-13	2023-03-28	兰州大学	一种基于polybia-MPI的抗菌多肽化合物及其合成与应用
CN120081951B (zh) *	2025-03-06	2025-09-30	辽宁波尔莱特农牧实业集团有限公司	一种抗菌肽Magainin 2-hEGF融合蛋白及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4810777A (en) *	1987-03-04	1989-03-07	The United States Of America As Represented By The Department Of Health And Human Services	Antimicrobial compounds
EP0362209B1 (fr) *	1987-03-04	1994-06-08	THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce	Composes bioactifs synthetiques nouveaux et procede d'obtention d'effets bioactifs
ES2095255T3 (es) *	1989-07-07	1997-02-16	Scripps Research Inst	Analogos de sustitucion de peptidos magainina.

1990
- 1990-06-28 ES ES90909538T patent/ES2095255T3/es not_active Expired - Lifetime
- 1990-06-28 EP EP96201383A patent/EP0761684A3/fr not_active Ceased
- 1990-06-28 EP EP90909538A patent/EP0437556B1/fr not_active Expired - Lifetime
- 1990-06-28 AT AT90909538T patent/ATE146188T1/de not_active IP Right Cessation
- 1990-06-28 WO PCT/US1990/003675 patent/WO1991000869A1/fr not_active Ceased
- 1990-06-28 EP EP96201385A patent/EP0751149A3/fr not_active Ceased
- 1990-06-28 EP EP96201384A patent/EP0751148A3/fr not_active Ceased
- 1990-06-28 AU AU59454/90A patent/AU650236B2/en not_active Ceased
- 1990-06-28 SG SG1996005217A patent/SG47913A1/en unknown
- 1990-06-28 DK DK90909538.2T patent/DK0437556T3/da active
- 1990-06-28 DE DE69029377T patent/DE69029377T2/de not_active Expired - Fee Related
- 1990-06-28 JP JP2509660A patent/JP2854970B2/ja not_active Expired - Fee Related
- 1990-07-02 IL IL9493990A patent/IL94939A/en active IP Right Grant
- 1990-07-03 ZA ZA905203A patent/ZA905203B/xx unknown
- 1990-07-06 PH PH40802A patent/PH30054A/en unknown
- 1990-07-06 PT PT94625A patent/PT94625B/pt not_active IP Right Cessation
- 1990-07-06 CA CA002020663A patent/CA2020663C/fr not_active Expired - Lifetime
- 1990-07-06 IE IE247690A patent/IE63842B1/en not_active IP Right Cessation
- 1990-07-06 CN CN90106803A patent/CN1055480C/zh not_active Expired - Fee Related
1992
- 1992-12-21 PH PH45486A patent/PH30219A/en unknown
- 1992-12-21 PH PH45488A patent/PH30218A/en unknown
- 1992-12-21 PH PH45487A patent/PH30410A/en unknown

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN114634553A (zh) *	2022-04-27	2022-06-17	贵州医科大学	阳离子肽c9及其应用
CN114634553B (zh) *	2022-04-27	2024-03-08	贵州医科大学	阳离子肽c9及其应用

Also Published As

Publication number	Publication date
EP0437556B1 (fr)	1996-12-11
WO1991000869A1 (fr)	1991-01-24
CN1049166A (zh)	1991-02-13
PH30054A (en)	1996-11-08
DE69029377T2 (de)	1997-06-19
SG47913A1 (en)	1998-04-17
DK0437556T3 (da)	1996-12-30
PH30219A (en)	1997-02-05
PT94625A (pt)	1991-03-20
EP0761684A3 (fr)	1997-07-02
JPH04506801A (ja)	1992-11-26
AU650236B2 (en)	1994-06-16
EP0751149A3 (fr)	1997-07-02
IE63842B1 (en)	1995-06-14
ES2095255T3 (es)	1997-02-16
EP0751148A2 (fr)	1997-01-02
EP0751149A2 (fr)	1997-01-02
IL94939A0 (en)	1991-06-10
PT94625B (pt)	1997-03-31
CA2020663C (fr)	1999-12-07
PH30218A (en)	1997-02-05
ATE146188T1 (de)	1996-12-15
EP0761684A2 (fr)	1997-03-12
EP0751148A3 (fr)	1997-07-02
AU5945490A (en)	1991-02-06
EP0437556A1 (fr)	1991-07-24
IL94939A (en)	1996-12-05
PH30410A (en)	1997-05-09
CN1055480C (zh)	2000-08-16
EP0437556A4 (en)	1992-05-20
JP2854970B2 (ja)	1999-02-10
ZA905203B (en)	1991-05-29
IE902476A1 (en)	1991-02-13
DE69029377D1 (de)	1997-01-23

Legal Events

Date	Code	Title	Description
1995-07-07	EEER	Examination request
2010-07-06	MKEX	Expiry

Publication	Publication Date	Title
CA2016521A1 (fr)	1990-11-11	Proteine de liaison de la fibronectine et sa preparation
AUPP051497A0 (en)	1997-12-18	Antimicrobial peptides
CA2100745A1 (fr)	1993-05-20	Peptides agonistes de l'amyline et leur utilisation
EP1440980A3 (fr)	2005-01-19	Analogues peptidiques de la protéine basique de la myéline humaine
EP0906919A3 (fr)	1999-04-21	Nouveaux peptides liant les intégrines
IL205233A0 (en)	2011-01-31	A polypeptide comprising the amino acid sequence of osteoprotegerin from residues 22 to 401 inclusive, or a fragment or trunaction thereof
DE68905387D1 (de)	1993-04-22	Aminosaeure-nahrungsmittelzusammensetzungen.
EP1939293A3 (fr)	2008-07-09	Protéine ZCYTO21 d'interféron
CA2318398A1 (fr)	1999-07-29	Nouveaux peptides doues d'une action biologique
KR0180256B1 (en)	1999-04-01	Bpc peptides, their preparation and use
WO1996028470A3 (fr)	1996-11-14	Analogues peptidiques de proteine de base de myeline utile dans le traitement de la sclerose en plaques
CA2208274A1 (fr)	1996-06-27	Analogues de peptide p227 et compositions pharmaceutiques comprenant ces analogues utilisees dans le traitement ou le diagnostic du diabete
PH30054A (en)	1996-11-08	Substitution analogues of magainin peptides
AU1691588A (en)	1988-12-01	A fibronectin binding protein as well as its preparation
EP0161007A3 (fr)	1988-09-14	Analogues de l'hexapeptide rétro-inverso C-terminal de la substance P
EP1006126A3 (fr)	2000-10-25	Peptide possedant une activité ostéogénique
CA2071950A1 (fr)	1992-04-23	Proteine fixatrice du collagene et sa preparation
CA2004885A1 (fr)	1990-06-07	Peptides anticoagulant
CA2171953A1 (fr)	1995-03-30	Analogues de regulateurs de proteines du complement d'activation
CA2078000A1 (fr)	1991-09-13	Peptides stimulateurs de neutrophile
GB2283974A (en)	1995-05-24	Allatostatins and their use
HU9303247D0 (en)	1994-03-28	Processfor producing 5-thia-1,4-diazabicyclo(4.2.0)octene-3,8-dioxo analogues of beta-lactame
EP1295943A4 (fr)	2005-11-16	Polypeptides capables le pouvoir de stimuler les neutrophiles
EP0290029A3 (fr)	1990-07-18	(19-Alanine) calcitonine
WO1999060117A3 (fr)	2000-01-20	Polypeptide prax-1