BE1003314A3 - Procede de dedoublement d'intermediaires interessants dans la preparation de diltiazem. - Google Patents
Procede de dedoublement d'intermediaires interessants dans la preparation de diltiazem. Download PDFInfo
- Publication number
- BE1003314A3 BE1003314A3 BE9000745A BE9000745A BE1003314A3 BE 1003314 A3 BE1003314 A3 BE 1003314A3 BE 9000745 A BE9000745 A BE 9000745A BE 9000745 A BE9000745 A BE 9000745A BE 1003314 A3 BE1003314 A3 BE 1003314A3
- Authority
- BE
- Belgium
- Prior art keywords
- diltiazem
- preparation
- interesting
- intermediates
- splitting
- Prior art date
Links
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 title abstract 2
- 229960004166 diltiazem Drugs 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000002269 spontaneous effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Procédé de dédoublement spontané de composés de la formule : dans laquelle R représente un alkyle inférieur et les astérisques indiquent les atomes de carbone asymétriques, les composés de formule III étant des intermédiaires intéressants pour la préparation de Diltiazem.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8921338A IT1232306B (it) | 1989-07-27 | 1989-07-27 | Processo di risoluzione di intermedi utili per la preparazione del diltiazem |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE1003314A3 true BE1003314A3 (fr) | 1992-02-25 |
Family
ID=11180324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE9000745A BE1003314A3 (fr) | 1989-07-27 | 1990-07-26 | Procede de dedoublement d'intermediaires interessants dans la preparation de diltiazem. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5097059A (fr) |
| JP (1) | JP2873609B2 (fr) |
| AT (1) | AT400143B (fr) |
| BE (1) | BE1003314A3 (fr) |
| CA (1) | CA2021342C (fr) |
| CH (1) | CH680855A5 (fr) |
| DE (1) | DE4023773B4 (fr) |
| ES (1) | ES2020789A6 (fr) |
| FR (1) | FR2650272B1 (fr) |
| GB (1) | GB2234243B (fr) |
| IT (1) | IT1232306B (fr) |
| NL (1) | NL194371C (fr) |
| SE (1) | SE509635C2 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL102592A (en) * | 1992-07-21 | 1996-09-12 | Teva Pharma | Optical resolution of threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)-propionic acid |
| FI93741C (fi) * | 1993-03-24 | 1995-05-26 | Orion Yhtymae Oy | Menetelmä optisesti puhtaitten (2S,3S)- ja (2R,3R)-threo-alkyyli-2-hydroksi-3-(4-metoksifenyyli)-3-(2-X-fenyylitio)propionaattien tai vastaavien asyloitujen yhdisteiden valmistamiseksi |
| IT1295376B1 (it) * | 1997-10-22 | 1999-05-12 | Zambon Spa | Processo per il riciclo di un sottoprodotto della sintesi del diltiazem |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0098892A1 (fr) * | 1982-07-09 | 1984-01-25 | Tanabe Seiyaku Co., Ltd. | Procédé pour la préparation de dérivés de 1,5-benzothiazépine |
| FR2534579A1 (fr) * | 1982-10-15 | 1984-04-20 | Luso Farmaco Inst | Procede pour la resolution optique de l'acide a-2-hydroxy-3(4-methoxyphenyl)-3-(2-aminophenylthio) propionique dl |
| EP0320532A1 (fr) * | 1986-07-15 | 1989-06-21 | Nihon Iyakuhin Kogyo Co., Ltd. | Dérivé optiquement actif d'un sel de l-lysine d'un acide carboxylique et son procédé de préparation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59110668A (ja) * | 1982-12-17 | 1984-06-26 | Tokawa Tetsuo | 2−置換−3−(p−メトキシフエニル)−3−〔(2−置換)フエニルチオ〕プロピオン酸の光学分割法 |
| US4552695A (en) * | 1983-04-21 | 1985-11-12 | Shionogi & Co., Ltd. | Process for production of diltiazem hydrochloride |
| IT1217988B (it) * | 1988-01-28 | 1990-03-30 | Ind Chimica Profarmaco Spa | Procedimento per la risoluzione ottica di un pacemo |
| US4908469A (en) * | 1988-05-18 | 1990-03-13 | Marion Laboratories, Inc. | 2-Hydroxy-propanoic acid acyclic alkyl esters for benzothiazepines |
| IT1226300B (it) * | 1988-07-26 | 1990-12-27 | Zambon Spa | Processo per la preparazione di intermedi per la sintesi del diltiazem. |
-
1989
- 1989-07-27 IT IT8921338A patent/IT1232306B/it active
-
1990
- 1990-07-05 CH CH2245/90A patent/CH680855A5/it not_active IP Right Cessation
- 1990-07-12 GB GB9015302A patent/GB2234243B/en not_active Expired - Fee Related
- 1990-07-16 JP JP2189251A patent/JP2873609B2/ja not_active Expired - Lifetime
- 1990-07-17 CA CA002021342A patent/CA2021342C/fr not_active Expired - Lifetime
- 1990-07-25 FR FR909009492A patent/FR2650272B1/fr not_active Expired - Fee Related
- 1990-07-26 SE SE9002499A patent/SE509635C2/sv not_active IP Right Cessation
- 1990-07-26 ES ES909002010A patent/ES2020789A6/es not_active Expired - Fee Related
- 1990-07-26 US US07/557,808 patent/US5097059A/en not_active Expired - Lifetime
- 1990-07-26 AT AT0156790A patent/AT400143B/de not_active IP Right Cessation
- 1990-07-26 BE BE9000745A patent/BE1003314A3/fr not_active IP Right Cessation
- 1990-07-26 DE DE4023773A patent/DE4023773B4/de not_active Expired - Fee Related
- 1990-07-27 NL NL9001710A patent/NL194371C/nl not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0098892A1 (fr) * | 1982-07-09 | 1984-01-25 | Tanabe Seiyaku Co., Ltd. | Procédé pour la préparation de dérivés de 1,5-benzothiazépine |
| FR2534579A1 (fr) * | 1982-10-15 | 1984-04-20 | Luso Farmaco Inst | Procede pour la resolution optique de l'acide a-2-hydroxy-3(4-methoxyphenyl)-3-(2-aminophenylthio) propionique dl |
| EP0320532A1 (fr) * | 1986-07-15 | 1989-06-21 | Nihon Iyakuhin Kogyo Co., Ltd. | Dérivé optiquement actif d'un sel de l-lysine d'un acide carboxylique et son procédé de préparation |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2873609B2 (ja) | 1999-03-24 |
| CH680855A5 (fr) | 1992-11-30 |
| GB9015302D0 (en) | 1990-08-29 |
| SE9002499L (sv) | 1991-01-28 |
| DE4023773A1 (de) | 1991-01-31 |
| SE9002499D0 (sv) | 1990-07-26 |
| NL194371B (nl) | 2001-10-01 |
| US5097059A (en) | 1992-03-17 |
| ATA156790A (de) | 1995-02-15 |
| SE509635C2 (sv) | 1999-02-15 |
| CA2021342C (fr) | 2002-01-29 |
| NL9001710A (nl) | 1991-02-18 |
| CA2021342A1 (fr) | 1991-01-28 |
| JPH03188059A (ja) | 1991-08-16 |
| IT8921338A0 (it) | 1989-07-27 |
| FR2650272A1 (fr) | 1991-02-01 |
| ES2020789A6 (es) | 1991-09-16 |
| GB2234243B (en) | 1992-11-25 |
| NL194371C (nl) | 2002-02-04 |
| IT1232306B (it) | 1992-01-28 |
| DE4023773B4 (de) | 2004-01-08 |
| AT400143B (de) | 1995-10-25 |
| FR2650272B1 (fr) | 1992-08-28 |
| GB2234243A (en) | 1991-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Effective date: 20050731 |