BE901224A - Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation. - Google Patents

Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation.

Info

Publication number
BE901224A
BE901224A BE0/214125A BE214125A BE901224A BE 901224 A BE901224 A BE 901224A BE 0/214125 A BE0/214125 A BE 0/214125A BE 214125 A BE214125 A BE 214125A BE 901224 A BE901224 A BE 901224A
Authority
BE
Belgium
Prior art keywords
intermediates
preparation
indole derivatives
medicaments
methods
Prior art date
Application number
BE0/214125A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BE901224A publication Critical patent/BE901224A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Nouveaux dérivés de l'indole de la formule générale (I), dans laquelle les substituants possèdent des significations définies, procédés pour leur préparation tels qu'une cyclisation d'un composé de la formule générale (II) et utilisation de ces composés de leurs sels physiologiquement acceptables et de produits de solvatation, qui possèdent une action vasoconstrictrice, pour le traitement de douleurs comme la migraine; composés intermédiaires et compositions pharmaceutique contenant ces substances.
BE0/214125A 1983-12-06 1984-12-06 Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation. BE901224A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838332435A GB8332435D0 (en) 1983-12-06 1983-12-06 Chemical compounds

Publications (1)

Publication Number Publication Date
BE901224A true BE901224A (fr) 1985-06-06

Family

ID=10552845

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214125A BE901224A (fr) 1983-12-06 1984-12-06 Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation.

Country Status (27)

Country Link
US (1) US4994483A (fr)
JP (2) JPH062733B2 (fr)
KR (1) KR850004459A (fr)
CN (2) CN85104233A (fr)
AT (1) AT381934B (fr)
AU (1) AU575365B2 (fr)
BE (1) BE901224A (fr)
CA (1) CA1233183A (fr)
CH (1) CH663411A5 (fr)
CY (1) CY1562A (fr)
DE (1) DE3444572C2 (fr)
DK (2) DK583684A (fr)
ES (2) ES8607234A1 (fr)
FI (1) FI80260C (fr)
FR (1) FR2555987B1 (fr)
GB (2) GB8332435D0 (fr)
HK (1) HK85690A (fr)
HU (2) HU196752B (fr)
IL (1) IL73756A (fr)
IT (1) IT1178268B (fr)
NL (1) NL8403719A (fr)
NO (1) NO162764C (fr)
NZ (1) NZ210469A (fr)
PT (1) PT80572B (fr)
SE (1) SE458446B (fr)
SG (1) SG65790G (fr)
ZA (1) ZA849498B (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
GB8430624D0 (en) * 1984-12-04 1985-01-09 Glaxo Group Ltd Chemical compounds
IT1181741B (it) * 1984-12-04 1987-09-30 Glaxo Group Ltd Derivati di indolo,procedimento per prepararli e composizioni farmaceutiche che li contengono
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8601959D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Indole derivatives
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
AU611469B2 (en) * 1987-08-13 1991-06-13 Glaxo Group Limited Indole derivatives
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
JPH01312506A (ja) * 1988-06-13 1989-12-18 Mitsui Petrochem Ind Ltd カラーフィルター
PT97888B (pt) * 1990-06-07 1998-12-31 Zeneca Ltd Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
RU2108326C1 (ru) * 1993-02-26 1998-04-10 Вита-Инвест С.А. Способ получения 2-карбокси-3-[2-(диметиламино)этил]-n-метил-1h-индол-5-метансульфонамида или его сложных эфиров
IT1264813B1 (it) * 1993-07-28 1996-10-10 Oxon Italia Spa Procedimento per la preparazione di alcansolfonammidi
EP0875513A1 (fr) * 1997-04-14 1998-11-04 Eli Lilly And Company Composés hétéroaromatiques substitués agonistes du récepteur 5-HT1F
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US7645886B2 (en) * 2002-12-20 2010-01-12 Ciba Specialty Corporation Synthesis of amines and intermediates for the synthesis thereof
AU2003242987A1 (en) * 2003-05-12 2004-11-26 Ramesh Babu Potluri A novel process for preparation of indole derivatives
US20060002989A1 (en) * 2004-06-10 2006-01-05 Ahmed Salah U Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
ZA200709038B (en) * 2005-04-13 2009-01-28 Neuraxon Inc Substituted indole compounds having nos inhibitory activity
CN101466709B (zh) * 2006-04-13 2013-03-20 轴突公司 具有nos抑制活性的1,5和3,6-取代的吲哚化合物
WO2008056378A2 (fr) * 2006-11-09 2008-05-15 Natco Pharma Limited Nouveau procédé destiné à la préparation de naratriptan
WO2008097664A1 (fr) * 2007-02-11 2008-08-14 Map Pharmaceuticals, Inc. Procédé d'administration thérapeutique de dhe pour procurer un soulagement rapide de la migraine tout en minimisant le profil des effets secondaires
EP2219449A4 (fr) * 2007-11-16 2010-10-27 Univ Arizona State Procédés de traitement de la douleur viscérale
EA201000808A1 (ru) 2007-11-16 2011-04-29 Ньюраксон, Инк. Индольные соединения и способы лечения висцеральной боли
WO2009062318A1 (fr) * 2007-11-16 2009-05-22 Neuraxon, Inc. Composés d'indole 3,5-substitués ayant une activité d'inhibition de la réabsorption de la nos et de la noradrénaline
WO2010151804A1 (fr) * 2009-06-26 2010-12-29 Map Pharmaceuticals, Inc. Administration de particules de dihydro-ergotamine mésylate au moyen d'un inhalateur-doseur
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
DK2480197T3 (en) 2009-09-25 2016-01-25 Reddys Lab Ltd Dr Compositions containing triptanforbindelser
CN103619805A (zh) * 2011-05-27 2014-03-05 国立大学法人德岛大学 苄胺衍生物
WO2013016223A2 (fr) 2011-07-22 2013-01-31 The University Of Chicago Traitements de la migraine et de troubles apparentés
CN102827062A (zh) * 2012-09-17 2012-12-19 扬子江药业集团四川海蓉药业有限公司 苹果酸阿莫曲坦的制备方法
AU2013361337A1 (en) 2012-12-21 2015-07-09 Map Pharmaceuticals, Inc. 8'-Hydroxy-Dihydroergotamine compounds and compositions

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US3322787A (en) * 1964-09-25 1967-05-30 Merck & Co Inc Alpha-hydrazino-beta-(3-indolyl) alkanoic acid derivatives
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
US3468882A (en) * 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
IT1036004B (it) * 1968-05-21 1979-10-30 Abc Ist Biolog Chem Spa Acidt 3 indolil adetoidrossamici
US3730723A (en) * 1971-06-17 1973-05-01 Eastman Kodak Co Direct positive processes utilizing silver halide surface image emulsions containing desensitizers
US4283410A (en) * 1978-06-15 1981-08-11 Miles Laboratories, Inc. 3-Amino or amido-2-(1H-indol-3-yl) propanoic acid derivatives
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
SE454777B (sv) * 1980-08-12 1988-05-30 Glaxo Group Ltd 5-substituerade 3-aminoalkyl-1h-indoler, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
IT1171449B (it) * 1980-08-12 1987-06-10 Glaxo Group Ltd Composti eterociclici indolici procedimento per produrli e composizioni farmaceutiche che li contengono
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
IT1181741B (it) * 1984-12-04 1987-09-30 Glaxo Group Ltd Derivati di indolo,procedimento per prepararli e composizioni farmaceutiche che li contengono

Also Published As

Publication number Publication date
AU575365B2 (en) 1988-07-28
ES8800150A1 (es) 1987-10-16
KR850004459A (ko) 1985-07-15
CY1562A (en) 1991-05-17
HK85690A (en) 1990-10-25
CN1015055B (zh) 1991-12-11
IT8449265A0 (it) 1984-12-06
NO844879L (no) 1985-06-07
AU3636784A (en) 1985-06-13
DK583684D0 (da) 1984-12-06
PT80572B (en) 1986-12-22
CA1233183A (fr) 1988-02-23
NZ210469A (en) 1989-01-27
GB8430810D0 (en) 1985-01-16
ES538336A0 (es) 1986-06-01
NO162764C (no) 1990-02-14
ZA849498B (en) 1986-09-24
FR2555987A1 (fr) 1985-06-07
IT1178268B (it) 1987-09-09
GB8332435D0 (en) 1984-01-11
CN85106225A (zh) 1987-02-18
IL73756A (en) 1988-02-29
ES8607234A1 (es) 1986-06-01
DE3444572C2 (de) 1993-10-14
JPH062733B2 (ja) 1994-01-12
CN85104233A (zh) 1987-01-07
HUT36455A (en) 1985-09-30
FI844789L (fi) 1985-06-07
SE8406200D0 (sv) 1984-12-06
FI80260B (fi) 1990-01-31
SE458446B (sv) 1989-04-03
PT80572A (en) 1985-06-01
DK583684A (da) 1985-06-07
FR2555987B1 (fr) 1987-07-17
DE3444572A1 (de) 1985-06-20
IL73756A0 (en) 1985-03-31
GB2150932A (en) 1985-07-10
JPS60155156A (ja) 1985-08-15
HUT40624A (en) 1987-01-28
SG65790G (en) 1990-10-26
DK214090D0 (da) 1990-09-06
HU196752B (en) 1989-01-30
GB2150932B (en) 1987-10-28
SE8406200L (sv) 1985-06-07
NL8403719A (nl) 1985-07-01
DK214090A (da) 1990-09-06
JPH03184958A (ja) 1991-08-12
NO162764B (no) 1989-11-06
FI844789A0 (fi) 1984-12-05
CH663411A5 (fr) 1987-12-15
US4994483A (en) 1991-02-19
ATA387384A (de) 1986-05-15
ES546631A0 (es) 1987-10-16
AT381934B (de) 1986-12-10
FI80260C (fi) 1990-05-10

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: GLAXO GROUP LTD

Effective date: 19911231