BE1022355B1 - Nouvelles méthodes d'induction d'une réponse immunitaire - Google Patents

Nouvelles méthodes d'induction d'une réponse immunitaire Download PDF

Info

Publication number
BE1022355B1
BE1022355B1 BE2015/5209A BE201505209A BE1022355B1 BE 1022355 B1 BE1022355 B1 BE 1022355B1 BE 2015/5209 A BE2015/5209 A BE 2015/5209A BE 201505209 A BE201505209 A BE 201505209A BE 1022355 B1 BE1022355 B1 BE 1022355B1
Authority
BE
Belgium
Prior art keywords
adjuvant
composition
rts
times lower
antigen
Prior art date
Application number
BE2015/5209A
Other languages
English (en)
French (fr)
Other versions
BE1022355A1 (fr
Inventor
William Ripley Ballou Jr
Arnaud Michel Didierlaurent
Der Most Robbert Gerrit Van
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of BE1022355A1 publication Critical patent/BE1022355A1/fr
Application granted granted Critical
Publication of BE1022355B1 publication Critical patent/BE1022355B1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/002Protozoa antigens
    • A61K39/015Hemosporidia antigens, e.g. Plasmodium antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/04Mycobacterium, e.g. Mycobacterium tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/29Hepatitis virus
    • A61K39/292Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55572Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55577Saponins; Quil A; QS21; ISCOMS
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588Adjuvants of undefined constitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00Reverse transcribing DNA viruses
    • C12N2730/00011Details
    • C12N2730/10011Hepadnaviridae
    • C12N2730/10111Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BE2015/5209A 2014-04-02 2015-04-02 Nouvelles méthodes d'induction d'une réponse immunitaire BE1022355B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1405921.6 2014-04-02
GBGB1405921.6A GB201405921D0 (en) 2014-04-02 2014-04-02 Novel methods for inducing an immune response

Publications (2)

Publication Number Publication Date
BE1022355A1 BE1022355A1 (fr) 2016-02-16
BE1022355B1 true BE1022355B1 (fr) 2016-03-26

Family

ID=50737873

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2015/5209A BE1022355B1 (fr) 2014-04-02 2015-04-02 Nouvelles méthodes d'induction d'une réponse immunitaire

Country Status (18)

Country Link
US (3) US10688168B2 (2)
EP (2) EP3125929B8 (2)
JP (2) JP6645982B2 (2)
KR (2) KR20160132115A (2)
CN (2) CN106456739A (2)
AR (1) AR099960A1 (2)
AU (1) AU2015239025B2 (2)
BE (1) BE1022355B1 (2)
BR (2) BR112016022463A2 (2)
CA (2) CA2943007C (2)
EA (1) EA037405B1 (2)
ES (2) ES2853773T3 (2)
GB (1) GB201405921D0 (2)
IL (1) IL247493B (2)
MX (3) MX2016012982A (2)
SG (1) SG11201607086QA (2)
WO (2) WO2015150567A1 (2)
ZA (1) ZA201605955B (2)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201405921D0 (en) * 2014-04-02 2014-05-14 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
GB201621686D0 (en) * 2016-12-20 2017-02-01 Glaxosmithkline Biologicals Sa Novel methods for inducing an immune response
CA3063954A1 (en) 2017-05-30 2018-12-06 Glaxosmithline Biologicals S.A. Methods for manufacturing an adjuvant
BR112020010790A2 (pt) 2017-12-01 2020-11-10 Glaxosmithkline Biologicals S.A. purificação da saponina
JP7640473B2 (ja) 2019-06-05 2025-03-05 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム サポニン精製
KR20230013237A (ko) 2020-03-09 2023-01-26 다이나박스 테크놀로지 코퍼레이션 Tlr9 효능제를 포함하는 대상포진 백신
CN113125756B (zh) * 2020-07-15 2022-10-25 南京岚煜生物科技有限公司 抗体标准品赋值和抗原中和当量确定的方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US152200A (en) * 1874-06-16 Improvement in garters
US1002607A (en) * 1905-08-28 1911-09-05 John Willard Taylor Paper pulley.
UA56132C2 (uk) * 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
CA2502268A1 (en) 2002-10-23 2004-05-06 Glaxosmithkline Biologicals S.A. Methods for vaccinating against malaria
ES2371175T3 (es) 2004-10-14 2011-12-28 Crucell Holland B.V. Vacunas de sensibilización/refuerzo de malaria.
EP2426141B1 (en) * 2005-04-29 2014-10-01 GlaxoSmithKline Biologicals S.A. Method for preventing or treating M tuberculosis infection
TWI457133B (zh) * 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
CA2668100C (en) * 2006-11-01 2014-12-23 Immport Therapeutics, Inc. Compositions and methods for immunodominant antigens
HRP20161606T1 (hr) * 2007-03-02 2017-01-13 Glaxosmithkline Biologicals Sa Novi postupak i pripravci
US9452209B2 (en) * 2007-04-20 2016-09-27 Glaxosmithkline Biologicals Sa Influenza vaccine
MX2011000982A (es) * 2008-07-25 2011-03-02 Glaxosmithkline Biolog Sa La proteina de tuberculosis rv2386c, composiciones y usos de la misma.
PT2315773T (pt) * 2008-07-25 2016-11-23 Glaxosmithkline Biologicals Sa Polipéptidos, polinucleótidos e composições para utilização no tratamento de tuberculose latente
HUE037121T2 (hu) * 2008-07-25 2018-08-28 Glaxosmithkline Biologicals Sa Új készítmények és eljárások
SI2528621T1 (sl) * 2010-01-27 2017-01-31 Glaxosmithkline Biologicals S.A., Modificirani tuberkolozni antigeni
PL2651436T3 (pl) * 2010-12-14 2016-10-31 Kompozycja antygenów mykobakteryjnych
US20170056345A1 (en) * 2014-02-18 2017-03-02 Stc.Unm Booster drug therapy for mycobacterium infections
GB201405921D0 (en) * 2014-04-02 2014-05-14 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
WO2015161853A1 (en) * 2014-04-24 2015-10-29 Statens Serum Institut New m.tuberculosis vaccines
GB201513176D0 (en) * 2015-07-27 2015-09-09 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ELENA MATA ET AL: "Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research", BIOMED RESEARCH INTERNATIONAL, vol. 6, no. 5, 1 January 2013 (2013-01-01), pages 599 - 19, XP055208483, ISSN: 2314-6133, DOI: 10.1016/j.ijpharm.2008.08.039 *
GIOVANNI GABUTTI ET AL: "Booster Vaccination: The Role of Reduced Antigen Content Vaccines as a Preschool Booster", BIOMED RESEARCH INTERNATIONAL, vol. 60, no. 1, 1 January 2014 (2014-01-01), pages 13 - 10, XP055192849, ISSN: 2314-6133, DOI: 10.4103/0974-777X.77298 *
HILL ADRIAN V S: "Vaccines against malaria", PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON. SERIES B: BIOLOGICAL SCIENCES, ROYAL SOCIETY OF LONDON, LONDON, GB, vol. 366, no. 1579, 12 October 2011 (2011-10-12), pages 2806 - 2814, XP002700406, ISSN: 0080-4622, DOI: 10.1098/RSTB.2011.0091 *
L. C. PAOLETTI ET AL: "Effects of Alum Adjuvant or a Booster Dose on Immunogenicity during Clinical Trials of Group B Streptococcal Type III Conjugate Vaccines", INFECTION AND IMMUNITY, vol. 69, no. 11, 1 November 2001 (2001-11-01), pages 6696 - 6701, XP055208551, ISSN: 0019-9567, DOI: 10.1128/IAI.69.11.6696-6701.2001 *
STOUTE J A ET AL: "A PRELIMINARY EVALUATION OF A RECOMBINANT CIRCUMSPOROZOITE PROTEIN VACCINE AGAINST PLASMODIUM FALCIPARUM MALARIA", NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 336, no. 2, 9 January 1997 (1997-01-09), pages 86 - 91, XP000990284, ISSN: 0028-4793, DOI: 10.1056/NEJM199701093360202 *
STOUTE J A ET AL: "LONG-TERM EFFICACY AND IMMUNE RESPONSES FOLLOWING IMMUNIZATION WITH THE RTS,S MALARIA VACCINE", JOURNAL OF INFECTIOUS DISEASES. JID, UNIVERSITY OF CHICAGO PRESS, CHICAGO, IL, vol. 178, no. 4, 1 October 1998 (1998-10-01), pages 1139 - 1144, XP008046110, ISSN: 0022-1899, DOI: 10.1086/515657 *
W. R. BALLOU: "The development of the RTS,S malaria vaccine candidate: challenges and lessons", PARASITE IMMUNOLOGY, vol. 31, no. 9, 1 September 2009 (2009-09-01), pages 492 - 500, XP055208451, ISSN: 0141-9838, DOI: 10.1111/j.1365-3024.2009.01143.x *

Also Published As

Publication number Publication date
JP6655549B2 (ja) 2020-02-26
EA037405B1 (ru) 2021-03-25
EP3125930A1 (en) 2017-02-08
SG11201607086QA (en) 2016-09-29
EP3125929B8 (en) 2023-12-27
US10624961B2 (en) 2020-04-21
CN106456738B (zh) 2021-06-29
MX2016012982A (es) 2016-12-07
JP2017511327A (ja) 2017-04-20
EP3125929C0 (en) 2023-11-01
AU2015239025B2 (en) 2018-01-25
BE1022355A1 (fr) 2016-02-16
CA2943007C (en) 2024-01-09
KR20230075525A (ko) 2023-05-31
KR102762440B1 (ko) 2025-02-03
MX2022013912A (es) 2022-12-13
AU2015239025A1 (en) 2016-09-22
MX2016012932A (es) 2016-12-07
CA2943007A1 (en) 2015-10-08
AR099960A1 (es) 2016-08-31
CN106456738A (zh) 2017-02-22
US11951161B2 (en) 2024-04-09
ES2961840T3 (es) 2024-03-14
CN106456739A (zh) 2017-02-22
JP2017511324A (ja) 2017-04-20
ZA201605955B (en) 2019-04-24
JP6645982B2 (ja) 2020-02-14
WO2015150568A1 (en) 2015-10-08
US20200306353A1 (en) 2020-10-01
KR20160132115A (ko) 2016-11-16
US20170112914A1 (en) 2017-04-27
EP3125929A1 (en) 2017-02-08
IL247493B (en) 2022-08-01
EP3125930B1 (en) 2020-12-02
GB201405921D0 (en) 2014-05-14
EA201691638A1 (ru) 2017-04-28
EP3125929B1 (en) 2023-11-01
US20170136110A1 (en) 2017-05-18
BR112016022787A2 (pt) 2018-03-27
ES2853773T3 (es) 2021-09-17
CA2943711A1 (en) 2015-10-08
WO2015150567A1 (en) 2015-10-08
US10688168B2 (en) 2020-06-23
BR112016022463A2 (pt) 2017-10-10
IL247493A0 (en) 2016-11-30

Similar Documents

Publication Publication Date Title
BE1022355B1 (fr) Nouvelles méthodes d'induction d'une réponse immunitaire
JP5486802B2 (ja) 抗マラリアワクチン
AP1166A (en) Vaccine composition against malaria.
CN110290806A (zh) 用于诱导免疫应答的新型方法
BE1024188B1 (fr) Composition séchée
BE1022373B1 (fr) Nouveaux vaccins antipaludeens
BE1021315B1 (fr) Nouvelles compositions
BE1022950B1 (fr) Procedes d'induction d'une reponse immunitaire
WO2019243018A1 (fr) Composes peptidiques multiepitopiques et vaccins contre la leishmaniose
BE1022523B1 (fr) Vaccination
FR3014103B1 (fr) Composition vaccinale pour la prevention et/ou le traitement de leishmanioses, peptides immunogenes et procede d'obtention

Legal Events

Date Code Title Description
MM Lapsed because of non-payment of the annual fee

Effective date: 20190430