BE2011C028I2 - Macrocyclic analogs and methods of their use and preparation - Google Patents

Macrocyclic analogs and methods of their use and preparation

Info

Publication number
BE2011C028I2
BE2011C028I2 BE2011C028C BE2011C028C BE2011C028I2 BE 2011C028 I2 BE2011C028 I2 BE 2011C028I2 BE 2011C028 C BE2011C028 C BE 2011C028C BE 2011C028 C BE2011C028 C BE 2011C028C BE 2011C028 I2 BE2011C028 I2 BE 2011C028I2
Authority
BE
Belgium
Prior art keywords
preparation
methods
macrocyclic analogs
analogs
macrocyclic
Prior art date
Application number
BE2011C028C
Other languages
English (en)
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22219026&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2011C028(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of BE2011C028I2 publication Critical patent/BE2011C028I2/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
BE2011C028C 1998-06-17 2011-09-02 Macrocyclic analogs and methods of their use and preparation BE2011C028I2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8968298P 1998-06-17 1998-06-17
PCT/US1999/013677 WO1999065894A1 (fr) 1998-06-17 1999-06-16 Analogues macrocycliques, leurs procedes d'utilisation et de preparation
EP99928746A EP1087960B1 (fr) 1998-06-17 1999-06-16 Analogues macrocycliques, leurs procedes d'utilisation et de preparation

Publications (1)

Publication Number Publication Date
BE2011C028I2 true BE2011C028I2 (en) 2018-08-24

Family

ID=22219026

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2011C028C BE2011C028I2 (en) 1998-06-17 2011-09-02 Macrocyclic analogs and methods of their use and preparation

Country Status (22)

Country Link
US (4) US6214865B1 (fr)
EP (4) EP2272839B1 (fr)
JP (1) JP4454151B2 (fr)
KR (1) KR100798600B1 (fr)
CN (1) CN1216051C (fr)
AT (1) ATE502932T1 (fr)
AU (1) AU762998B2 (fr)
BE (1) BE2011C028I2 (fr)
BR (1) BRPI9911326B8 (fr)
CA (3) CA2335300C (fr)
CY (2) CY1111516T1 (fr)
DE (2) DE69943296D1 (fr)
DK (1) DK1087960T3 (fr)
FR (1) FR11C0038I2 (fr)
HU (1) HU227912B1 (fr)
IL (1) IL139960A0 (fr)
LU (1) LU91854I2 (fr)
NO (5) NO328280B1 (fr)
NZ (1) NZ508597A (fr)
PT (1) PT1087960E (fr)
WO (1) WO1999065894A1 (fr)
ZA (1) ZA200007159B (fr)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8097648B2 (en) * 1998-06-17 2012-01-17 Eisai R&D Management Co., Ltd. Methods and compositions for use in treating cancer
US6653341B1 (en) 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
JP4454151B2 (ja) * 1998-06-17 2010-04-21 エーザイ・アール・アンド・ディー・マネジメント株式会社 大環状類似体及びそれらの使用並びに調製方法
DE10037310A1 (de) 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
EP1531846A4 (fr) * 2002-02-27 2006-04-19 Us Gov Health & Human Serv Conjugues de ligand, adaptateur et agent cytotoxique, compositions associees et procedes d'utilisation relatifs
KR101208266B1 (ko) 2002-03-22 2012-12-05 에자이 알앤드디 매니지먼트 가부시키가이샤 헤미아스텔린 유도체 및 이의 용도
US20050075395A1 (en) * 2003-05-28 2005-04-07 Gary Gordon Continuous dosing regimen
CA2526385C (fr) * 2003-05-29 2008-07-22 Abbott Laboratories Schema posologique d'administration en continu
WO2005011589A2 (fr) * 2003-07-29 2005-02-10 Eisai Co., Ltd. Procedes et dispositifs pour la delivrance de medicaments
CA2822994C (fr) * 2004-06-03 2016-09-27 Eisai R&D Management Co., Ltd. Intermediaires pour la preparation d'analogues d'halichondrine b
SI2522663T1 (sl) 2004-06-03 2015-08-31 Eisai R&D Management Co., Ltd. Vmesne spojine za pripravo halihondrina B
US20060045846A1 (en) * 2004-08-30 2006-03-02 Horstmann Thomas E Reagents and methods for labeling terminal olefins
US20060154312A1 (en) * 2004-12-09 2006-07-13 Sergei Agoulnik Tubulin isotype screening in cancer therapy using halichondrin B analogs
BRPI0817909B1 (pt) * 2007-10-03 2022-06-21 Eisai R&D Management Co., Ltd Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos
CA2720632C (fr) * 2008-04-04 2016-12-20 Eisai R&D Management Co., Ltd. Analogues b de l'halichondrine
WO2010113983A1 (fr) 2009-03-30 2010-10-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 Procédé de mise au point d'une composition liposomique
RU2476216C1 (ru) * 2009-03-30 2013-02-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Липосомальная композиция
CN102369008B (zh) 2009-03-30 2014-10-29 卫材R&D管理有限公司 脂质体组合物
US8765974B2 (en) * 2009-04-14 2014-07-01 Nissan Chemical Industries, Ltd. Method for producing tetrahydropyran compound and intermediate thereof
MY162940A (en) 2009-08-19 2017-07-31 Eisai R&D Man Co Ltd Quinoline derivative-containing pharmaceutical composition
RU2579511C2 (ru) 2010-01-26 2016-04-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Производные фуро[3,2-в]пирана, применимые в синтезе аналогов
EP2686441B1 (fr) 2011-03-18 2019-05-08 Eisai R&D Management Co., Ltd. Procédé et utilisation pour prédire la réponse à l'éribuline
WO2012147900A1 (fr) 2011-04-28 2012-11-01 Eisai R&D Management Co., Ltd. Procédé en microréacteurs pour synthèse d'analogue d'halichondrine b
JP6038128B2 (ja) 2011-06-03 2016-12-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
WO2013078559A1 (fr) 2011-11-30 2013-06-06 Alphora Research Inc. Procédé de préparation de (3r)-2,4-di-groupe partant-3-méthylbut-1-ène
JP2015501818A (ja) 2011-12-16 2015-01-19 アルフォラ リサーチ インコーポレイテッドAlphora Research Inc. 3−((2s,5s)−4−メチレン−5−(3−オキソプロピル)テトラヒドロフラン−2−イル)プロパノール誘導体およびそれらの有用な中間体を調製する方法
CA2860446C (fr) * 2011-12-29 2017-01-10 Alphora Research Inc. Derives de 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofurane-2-yl)acetaldehyde et procede pour leur preparation
US9278979B2 (en) 2012-03-30 2016-03-08 Alphora Research Inc. Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein
RU2689977C2 (ru) 2012-12-04 2019-05-30 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Применение эрибулина для лечения рака молочной железы
CA2909209A1 (fr) 2013-05-15 2014-11-20 Alphora Research Inc. Derives de 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol, leur preparation et intermediaires utiles correspondants
BR112015029386B1 (pt) 2013-06-26 2023-11-14 Eisai R&D Management Co., Ltd. Uso de eribulina e lenvatinibe como terapia de combinação e kit
EP3016957A4 (fr) * 2013-07-03 2016-11-30 Alphora Res Inc Procédé de synthèse pour la préparation d'analogues c1-céto macrocycliques de l'halichondrine b et intermédiaires utiles dans la synthèse, notamment des intermédiaires contenant des groupes -so2-(p-tolyle)
CN103483352A (zh) * 2013-10-18 2014-01-01 李友香 抗肿瘤的药用原料药
BR112016009452B1 (pt) 2013-11-04 2022-06-07 Eisai R&D Management Co., Ltd Métodos de preparar intermediários na síntese de eribulina, métodos de preparar eribulina e mesilato de eribulina, e compostos intermediários
EP3077399B1 (fr) 2013-12-06 2019-02-20 Eisai R&D Management Co., Ltd. Procédés utiles pour la synthèse d'analogues d'halichondrine b
CN104860978A (zh) * 2014-02-20 2015-08-26 正大天晴药业集团股份有限公司 软海绵素b类似物的合成中间体
TW201617326A (zh) 2014-03-06 2016-05-16 Alphora研發股份有限公司 (s)-1-((2r,3r,4s,5s)-5-烯丙-3-甲氧-4-(對甲苯磺醯甲基)四氫呋喃-2-基)-3-氨基丙-2-醇之結晶衍生物
US20170100367A1 (en) 2014-05-28 2017-04-13 Eisai R&D Management Co., Ltd. Use of eribulin in the treatment of cancer
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
PT3524595T (pt) 2014-08-28 2022-09-19 Eisai R&D Man Co Ltd Derivado de quinolina altamente puro e método para produção do mesmo
US10208058B2 (en) * 2014-09-09 2019-02-19 Cipla Limited Process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts and intermediates thereof
CN105713031B (zh) * 2014-12-05 2021-05-07 正大天晴药业集团股份有限公司 一种用于制备艾日布林的中间体及其制备方法
LT3263106T (lt) 2015-02-25 2024-01-10 Eisai R&D Management Co., Ltd. Chinolino darinių kartumo sumažinimo būdas
AU2016226157B2 (en) 2015-03-04 2022-01-27 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and eribulin for treating cancer
KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
MX392296B (es) * 2015-05-07 2025-03-24 Eisai R&D Man Co Ltd Reacciones de macrociclizacion e intermediarios y otros fragmentos utiles en la sintesis de macrolidos de halicondrina.
WO2016182850A1 (fr) 2015-05-08 2016-11-17 Albany Molecular Research, Inc. Méthodes et intermédiaires pour la préparation d'omacétaxine et de dérivés de céphalotaxine associés
MX373231B (es) 2015-06-16 2020-05-08 Eisai R&D Man Co Ltd Agente anticancerigeno.
US12220398B2 (en) 2015-08-20 2025-02-11 Eisai R&D Management Co., Ltd. Tumor therapeutic agent
CN108601760A (zh) * 2016-02-12 2018-09-28 卫材R&D管理有限公司 艾日布林的合成中的中间体及相关的合成方法
WO2017188350A1 (fr) 2016-04-28 2017-11-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 Procédé d'inhibition de croissance tumorale
WO2017203459A1 (fr) 2016-05-26 2017-11-30 Dr. Reddy's Laboratories Limited Procédé de préparation d'éribuline et de ses intermédiaires
KR102404629B1 (ko) 2016-06-30 2022-06-02 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 중간체
WO2018071792A1 (fr) 2016-10-14 2018-04-19 Merck Sharp & Dohme Corp. Combinaison d'un antagoniste de pd-1 et d'éribuline dans le traitement du cancer urothélial
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
WO2018096478A2 (fr) 2016-11-23 2018-05-31 Dr. Reddy’S Laboratories Limited Procédé de préparation d'éribuline et de ses intermédiaires
KR101880939B1 (ko) 2017-01-02 2018-08-17 연성정밀화학(주) 에리불린 메실산염의 제조 중간체 및 그의 제조방법
US10865212B2 (en) 2017-01-02 2020-12-15 Yonsung Fine Chemical Co.. Ltd. Intermediate for preparing eribulin mesylate and process for preparing the same
KR101991710B1 (ko) 2017-12-14 2019-06-21 연성정밀화학(주) 에리불린 메실산염의 제조 중간체 및 그의 제조방법
CN108341738B (zh) * 2017-01-24 2022-10-21 江苏恒瑞医药股份有限公司 用于制备艾日布林的方法及其中间体
CN108341828B (zh) * 2017-01-24 2021-04-06 江苏恒瑞医药股份有限公司 用于制备艾日布林的方法及其中间体
US12303505B2 (en) 2017-02-08 2025-05-20 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition
SMT202200455T1 (it) 2017-04-05 2023-01-13 Harvard College Composto macrociclico e relativi usi
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
RU2019134940A (ru) 2017-05-16 2021-06-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Лечение гепатоцеллюлярной карциномы
WO2019010363A1 (fr) 2017-07-06 2019-01-10 President And Fellows Of Harvard College Synthèse d'halichondrines
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
US20190046513A1 (en) 2017-08-10 2019-02-14 Huya Bioscience International, Llc Combination therapies of hdac inhibitors and tubulin inhibitors
CN109694379B (zh) * 2017-10-24 2020-09-11 江苏恒瑞医药股份有限公司 用于制备艾日布林的中间体及其制备方法
US11142509B2 (en) 2017-11-09 2021-10-12 Yonsung Fine Chemical Co., Ltd. Intermediate for preparing eribulin mesylate and process for preparing the same
WO2019099646A1 (fr) 2017-11-15 2019-05-23 President And Fellows Of Harvard College Composés macrocycliques et utilisations de ces composés
WO2019097073A1 (fr) 2017-11-20 2019-05-23 Basilea Pharmaceutica International AG Associations pharmaceutiques destinées à être utilisées dans le traitement du cancer
WO2019102490A1 (fr) 2017-11-21 2019-05-31 Natco Pharma Limited Préparation d'intermédiaires d'éribuline
IL275729B2 (en) 2018-01-03 2023-09-01 Eisai R&D Man Co Ltd Prins reaction and compounds useful in the synthesis of helicondrin macrolides and their analogs
WO2019211877A1 (fr) 2018-05-03 2019-11-07 Cipla Limited Procédé de préparation d'analogues cétoniques macrocycliques de halichondrine b
WO2020008382A1 (fr) * 2018-07-04 2020-01-09 Dr. Reddy’S Laboratories Limited Procédé de préparation d'éribuline et de ses intermédiaires
WO2020016847A2 (fr) * 2018-07-20 2020-01-23 Dr. Reddy’S Laboratories Limited Procédé de purification pour la préparation d'éribuline et de ses intermédiaires
CN113166096A (zh) * 2018-10-09 2021-07-23 雷迪博士实验室有限公司 制备艾立布林的方法及其中间体
US12522611B2 (en) * 2018-11-28 2026-01-13 Natco Pharma Limited Process for the preparation of high pure Eribulin and its Mesylate salt
US12398105B2 (en) 2018-12-20 2025-08-26 Auransa Inc. Analogues of pentamidine and uses therefor
US11447499B2 (en) 2019-06-14 2022-09-20 Rk Pharma Inc. Process for the preparation of eribulin mesylate intermediate
US12247239B2 (en) 2019-06-21 2025-03-11 Council Of Scientific & Industrial Research Chemo-enzymatic process for the preparation of homopropargylic alcohol
US11083705B2 (en) 2019-07-26 2021-08-10 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
US12036204B2 (en) 2019-07-26 2024-07-16 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
WO2021090062A1 (fr) 2019-11-07 2021-05-14 Eisai R&D Management Co., Ltd. Conjugués anticorps-médicament d'éribuline dirigés contre la mésothéline et procédés d'utilisation
CN113135876B (zh) * 2020-01-16 2024-05-17 南通诺泰生物医药技术有限公司 艾日布林及其中间体的制备方法
JP7821733B2 (ja) * 2020-01-22 2026-02-27 上海森輝医薬有限公司 エリブリン誘導体の薬物複合体、その調製方法及びその医薬的応用
KR102377262B1 (ko) 2020-05-11 2022-03-22 연성정밀화학(주) 결정성 에리불린 염
IL279168B (en) * 2020-12-02 2022-04-01 Finetech Pharmaceutical Ltd A process for the preparation of eribulin
CN113354659B (zh) 2021-06-08 2022-04-08 江苏慧聚药业股份有限公司 甲磺酸艾日布林的合成
CA3225975A1 (fr) * 2021-07-22 2023-01-26 Shanghai Senhui Medicine Co., Ltd. Conjugue de medicament de derive d'eribuline
WO2023212746A2 (fr) * 2022-04-30 2023-11-02 William Marsh Rice University Stratégie unifiée pour la synthèse totale d'un analogue d'éribuline et de macrolactame d'halichondrine b
CN118356507A (zh) * 2023-01-17 2024-07-19 成都百利多特生物药业有限责任公司 一种艾日布林类药物的偶联物
EP4725969A1 (fr) 2023-06-09 2026-04-15 Latticon (Suzhou) Biopharmaceuticals Co., Ltd. Conjugué anticorps-médicament bispécifique complémentaire anti-her2, son procédé de préparation et son utilisation
CN118834221B (zh) * 2023-08-08 2025-10-21 浙江星月药物科技有限公司 一种软海绵素b类似物
TW202518024A (zh) 2023-10-13 2025-05-01 日商衛材R&D企管股份有限公司 抗體-藥物軛合物代謝物
WO2025106586A1 (fr) * 2023-11-13 2025-05-22 Luxvitae Therapeutics Inc. Composés cétoniques macrocycliques et leurs applications
WO2025228172A1 (fr) * 2024-04-28 2025-11-06 上海拓济医药有限责任公司 Dérivé d'éribuline, conjugué anticorps-médicament de celui-ci et utilisation médicale associée

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436238A (en) 1992-03-12 1995-07-25 President And Fellows Of Harvard College Halichondrins and related compounds
US5338865A (en) * 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
GB9206244D0 (en) * 1992-03-23 1992-05-06 Pharma Mar Sa Cytotoxic compound from a marine sponge
US5426194A (en) * 1993-01-19 1995-06-20 Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University Isolation and structure of Halistatin 1
US6653341B1 (en) * 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
JP4454151B2 (ja) * 1998-06-17 2010-04-21 エーザイ・アール・アンド・ディー・マネジメント株式会社 大環状類似体及びそれらの使用並びに調製方法
SI2522663T1 (sl) 2004-06-03 2015-08-31 Eisai R&D Management Co., Ltd. Vmesne spojine za pripravo halihondrina B
BRPI0817909B1 (pt) 2007-10-03 2022-06-21 Eisai R&D Management Co., Ltd Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos
CN101910180A (zh) 2007-11-16 2010-12-08 卫材R&D管理有限公司 用于软海绵素b类似物合成的新颖中间体和用于该中间体的新颖脱磺酰化反应
CA2720632C (fr) 2008-04-04 2016-12-20 Eisai R&D Management Co., Ltd. Analogues b de l'halichondrine
RU2579511C2 (ru) 2010-01-26 2016-04-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Производные фуро[3,2-в]пирана, применимые в синтезе аналогов

Also Published As

Publication number Publication date
CY1111516T1 (el) 2014-04-09
WO1999065894A1 (fr) 1999-12-23
US6469182B1 (en) 2002-10-22
CA2335300C (fr) 2008-10-07
JP4454151B2 (ja) 2010-04-21
NO2011026I2 (no) 2012-06-11
US6365759B1 (en) 2002-04-02
AU762998B2 (en) 2003-07-10
EP2277873A1 (fr) 2011-01-26
NO20006316L (no) 2001-02-15
BR9911326A (pt) 2001-04-03
CA2632433A1 (fr) 1999-12-23
HUP0103357A2 (hu) 2002-01-28
EP2277873B1 (fr) 2012-05-30
NO20006316D0 (no) 2000-12-12
CA2335300A1 (fr) 1999-12-23
BRPI9911326B8 (pt) 2021-05-25
KR100798600B1 (ko) 2008-01-28
EP1087960A1 (fr) 2001-04-04
AU4573999A (en) 2000-01-05
US20110172446A1 (en) 2011-07-14
DE69943296D1 (de) 2011-05-05
CN1216051C (zh) 2005-08-24
EP2272839B1 (fr) 2012-08-22
LU91854I2 (fr) 2011-10-17
ATE502932T1 (de) 2011-04-15
KR20010083050A (ko) 2001-08-31
NZ508597A (en) 2004-01-30
DK1087960T3 (da) 2011-06-14
CN1312804A (zh) 2001-09-12
DE122011100031I1 (de) 2011-12-15
NO2011018I1 (no) 2011-09-26
ZA200007159B (en) 2001-12-04
CY2011010I2 (el) 2014-04-09
RU2245335C2 (ru) 2005-01-27
CA2755266C (fr) 2014-08-12
BR9911326B1 (pt) 2015-01-06
CA2632433C (fr) 2012-02-07
HUP0103357A3 (en) 2002-10-28
EP1087960A4 (fr) 2004-12-01
EP1087960B1 (fr) 2011-03-23
NO20093217L (no) 2001-02-15
IL139960A0 (en) 2002-02-10
HK1035534A1 (en) 2001-11-30
CY2011010I1 (el) 2014-04-09
NO2022019I1 (no) 2022-06-03
EP2272840A1 (fr) 2011-01-12
HU227912B1 (en) 2012-05-29
NO328280B1 (no) 2010-01-25
JP2002518384A (ja) 2002-06-25
CA2755266A1 (fr) 1999-12-23
PT1087960E (pt) 2011-06-17
AU762998C (en) 2000-01-05
FR11C0038I1 (fr) 2011-10-14
NO2011026I1 (no) 2012-01-09
EP2272840B1 (fr) 2012-08-22
US6214865B1 (en) 2001-04-10
NO331183B1 (no) 2011-10-24
EP2272839A1 (fr) 2011-01-12
US8148554B2 (en) 2012-04-03
FR11C0038I2 (fr) 2013-01-11

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