|
US8097648B2
(en)
*
|
1998-06-17 |
2012-01-17 |
Eisai R&D Management Co., Ltd. |
Methods and compositions for use in treating cancer
|
|
HU227912B1
(en)
*
|
1998-06-17 |
2012-05-29 |
Eisai R & D Man Co |
Halichondrin analogs and methods of their use and preparation
|
|
US6653341B1
(en)
*
|
1998-06-17 |
2003-11-25 |
Eisai Co., Ltd. |
Methods and compositions for use in treating cancer
|
|
DE10037310A1
(de)
|
2000-07-28 |
2002-02-07 |
Asta Medica Ag |
Neue Indolderivate und deren Verwendung als Arzneimittel
|
|
AU2003224644A1
(en)
*
|
2002-02-27 |
2003-09-09 |
The Government Of The United States Of America, Represented By The Secretary, Department Of Healtan |
Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
|
|
CA2479764C
(en)
|
2002-03-22 |
2013-07-30 |
Eisai Co., Ltd. |
Hemiasterlin derivatives and uses thereof
|
|
US20050075395A1
(en)
*
|
2003-05-28 |
2005-04-07 |
Gary Gordon |
Continuous dosing regimen
|
|
EP1644008B1
(en)
*
|
2003-05-29 |
2011-12-21 |
Abbott Laboratories |
Continuous dosing regimen with abt-751
|
|
EP1653953A4
(en)
*
|
2003-07-29 |
2010-05-05 |
Eisai R&D Man Co Ltd |
METHOD AND DEVICES FOR THE MEDICINAL PRODUCTION
|
|
PL2522663T3
(pl)
|
2004-06-03 |
2015-08-31 |
Eisai R&D Man Co Ltd |
Produkty pośrednie do otrzymywania halichondryny B
|
|
CN109180615A
(zh)
*
|
2004-06-03 |
2019-01-11 |
卫材R&D管理有限公司 |
用于制备软海绵素b的类似物的中间体
|
|
US20060045846A1
(en)
*
|
2004-08-30 |
2006-03-02 |
Horstmann Thomas E |
Reagents and methods for labeling terminal olefins
|
|
EP1831697A4
(en)
*
|
2004-12-09 |
2011-01-26 |
Eisai R&D Man Co Ltd |
SEARCH FOR TUBULINISOTYPES IN CANCER THERAPY USING HALICHONDRIN B ANALOG
|
|
CN108948039B
(zh)
|
2007-10-03 |
2021-12-31 |
卫材R&D管理有限公司 |
用于合成软海绵素b类似物的中间体和方法
|
|
CN105801599A
(zh)
*
|
2008-04-04 |
2016-07-27 |
卫材R&D管理有限公司 |
软海绵素b类似物
|
|
HRP20161157T1
(hr)
|
2009-03-30 |
2016-11-18 |
Eisai R&D Management Co., Ltd. |
Liposomski pripravak
|
|
RU2476216C1
(ru)
*
|
2009-03-30 |
2013-02-27 |
Эйсай Ар Энд Ди Менеджмент Ко., Лтд. |
Липосомальная композиция
|
|
EP2415464B1
(en)
|
2009-03-30 |
2017-05-10 |
Eisai R&D Management Co., Ltd. |
Method for producing liposome composition
|
|
JP5556811B2
(ja)
*
|
2009-04-14 |
2014-07-23 |
日産化学工業株式会社 |
テトラヒドロピラン化合物の製造方法
|
|
BR112012003592B8
(pt)
|
2009-08-19 |
2021-05-25 |
Eisai R&D Man Co Ltd |
composição farmacêutica contendo derivado de quinolina
|
|
CN102803254B
(zh)
|
2010-01-26 |
2016-09-14 |
卫材R&D管理有限公司 |
用于软海绵素b类似物合成的呋喃并[3,2-b]吡喃衍生物
|
|
WO2012129100A1
(en)
|
2011-03-18 |
2012-09-27 |
Eisai R&D Management Co., Ltd. |
Methods and compositions for predicting response to eribulin
|
|
WO2012147900A1
(en)
|
2011-04-28 |
2012-11-01 |
Eisai R&D Management Co., Ltd. |
Microreactor process for halichondrin b analog synthesis
|
|
WO2012166899A2
(en)
|
2011-06-03 |
2012-12-06 |
Eisai R&D Management Co., Ltd. |
Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
|
|
CA2857385A1
(en)
|
2011-11-30 |
2013-06-06 |
Alphora Research Inc. |
Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene
|
|
US9174956B2
(en)
|
2011-12-16 |
2015-11-03 |
Alphora Research Inc. |
Process for preparation of 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives and intermediates useful thereof
|
|
JP6300030B2
(ja)
*
|
2011-12-29 |
2018-03-28 |
サンド アクツィエンゲゼルシャフト |
２−（（２ｓ，３ｓ，４ｒ，５ｒ）−５−（（ｓ）−３−アミノ−２−ヒドロキシプロプ−１−イル）−４−メトキシ−３−（フェニルスルホニルメチル）テトラヒドロフラン−２−イル）アセトアルデヒド誘導体およびこれらを調製するためのプロセス
|
|
US9278979B2
(en)
|
2012-03-30 |
2016-03-08 |
Alphora Research Inc. |
Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein
|
|
MX2015007185A
(es)
|
2012-12-04 |
2017-09-05 |
Eisai R&D Man Co Ltd |
Uso de eribulina en el tratamiento de cancer de pecho.
|
|
AU2014268086A1
(en)
|
2013-05-15 |
2015-11-05 |
Alphora Research Inc. |
3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof
|
|
AU2014299699B2
(en)
|
2013-06-26 |
2019-10-10 |
Eisai R&D Management Co., Ltd. |
Use of eribulin and lenvatinib as combination therapy for treatment of cancer
|
|
US9850254B2
(en)
|
2013-07-03 |
2017-12-26 |
Sandoz Ag |
Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing-SO2-(p-tolyl) groups
|
|
CN103483352A
(zh)
*
|
2013-10-18 |
2014-01-01 |
李友香 |
抗肿瘤的药用原料药
|
|
CN105683198B
(zh)
|
2013-11-04 |
2019-03-12 |
卫材R&D管理有限公司 |
软海绵素b的类似物合成中有用的大环化反应和中间体
|
|
HUE043088T2
(hu)
*
|
2013-12-06 |
2019-08-28 |
Eisai R&D Man Co Ltd |
Halikondrin B analógok szintézisében alkalmazható eljárások
|
|
CN104860978A
(zh)
*
|
2014-02-20 |
2015-08-26 |
正大天晴药业集团股份有限公司 |
软海绵素b类似物的合成中间体
|
|
TW201617326A
(zh)
|
2014-03-06 |
2016-05-16 |
Ａｌｐｈｏｒａ研發股份有限公司 |
（ｓ）－１－（（２ｒ，３ｒ，４ｓ，５ｓ）－５－烯丙－３－甲氧－４－（對甲苯磺醯甲基）四氫呋喃－２－基）－３－氨基丙－２－醇之結晶衍生物
|
|
JP2017516802A
(ja)
|
2014-05-28 |
2017-06-22 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
がんの治療におけるエリブリンの使用
|
|
EP3160970A4
(en)
|
2014-06-30 |
2017-12-27 |
President and Fellows of Harvard College |
Synthesis of halichondrin analogs and uses thereof
|
|
CA2957005C
(en)
|
2014-08-28 |
2021-10-12 |
Eisai R&D Management Co., Ltd. |
High-purity quinoline derivative and method for manufacturing same
|
|
EP3191479B1
(en)
*
|
2014-09-09 |
2020-04-08 |
Cipla Limited |
"process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof"
|
|
CN105713031B
(zh)
*
|
2014-12-05 |
2021-05-07 |
正大天晴药业集团股份有限公司 |
一种用于制备艾日布林的中间体及其制备方法
|
|
SG11201706630UA
(en)
|
2015-02-25 |
2017-09-28 |
Eisai R&D Man Co Ltd |
Method for suppressing bitterness of quinoline derivative
|
|
WO2016140717A1
(en)
|
2015-03-04 |
2016-09-09 |
Merck Sharp & Dohme Corp. |
Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
|
|
KR20170122810A
(ko)
|
2015-03-04 |
2017-11-06 |
머크 샤프 앤드 돔 코포레이션 |
암을 치료하기 위한 pd-1 길항제 및 에리불린의 조합
|
|
WO2016176560A1
(en)
|
2015-04-30 |
2016-11-03 |
President And Fellows Of Harvard College |
Chromium-mediated coupling and application to the synthesis of halichondrins
|
|
RU2020141025A
(ru)
*
|
2015-05-07 |
2020-12-28 |
Эйсай Ар Энд Ди Менеджмент Ко., Лтд. |
Реакции макроциклизации и промежуточные соединения и другие фрагменты, полезные в синтезе макролидов галихондринов
|
|
US10597401B2
(en)
|
2015-05-08 |
2020-03-24 |
Albany Molecular Research, Inc. |
Methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof
|
|
BR112017027227B1
(pt)
|
2015-06-16 |
2023-12-12 |
Eisai R&D Management Co., Ltd |
Agente anti-câncer
|
|
JP6553726B2
(ja)
|
2015-08-20 |
2019-07-31 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
腫瘍治療剤
|
|
US10676481B2
(en)
|
2016-02-12 |
2020-06-09 |
Eisai R&D Management Co., Ltd. |
Intermediates in the synthesis of eribulin and related methods of synthesis
|
|
WO2017188350A1
(ja)
|
2016-04-28 |
2017-11-02 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
腫瘍の成長を抑制する方法
|
|
WO2017203459A1
(en)
|
2016-05-26 |
2017-11-30 |
Dr. Reddy's Laboratories Limited |
Process for preparation of eribulin and intermediates thereof
|
|
SG11201811671XA
(en)
|
2016-06-30 |
2019-01-30 |
Eisai R&D Man Co Ltd |
Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
|
|
EP3525818A1
(en)
|
2016-10-14 |
2019-08-21 |
Merck Sharp & Dohme Corp. |
Combination of a pd-1 antagonist and eribulin for treating urothelial cancer
|
|
JP6978758B2
(ja)
|
2016-11-11 |
2021-12-08 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
パラジウム媒介ケトール化
|
|
WO2018096478A2
(en)
|
2016-11-23 |
2018-05-31 |
Dr. Reddy’S Laboratories Limited |
Process for preparation of eribulin and intermediates thereof
|
|
KR101880939B1
(ko)
|
2017-01-02 |
2018-08-17 |
연성정밀화학(주) |
에리불린 메실산염의 제조 중간체 및 그의 제조방법
|
|
JP6920699B2
(ja)
*
|
2017-01-02 |
2021-08-18 |
ヨンスン ファイン ケミカル カンパニー，リミテッド |
エリブリンメシル酸塩の製造中間体及びその製造方法
|
|
KR101991710B1
(ko)
|
2017-12-14 |
2019-06-21 |
연성정밀화학(주) |
에리불린 메실산염의 제조 중간체 및 그의 제조방법
|
|
CN108341828B
(zh)
*
|
2017-01-24 |
2021-04-06 |
江苏恒瑞医药股份有限公司 |
用于制备艾日布林的方法及其中间体
|
|
CN108341738B
(zh)
*
|
2017-01-24 |
2022-10-21 |
江苏恒瑞医药股份有限公司 |
用于制备艾日布林的方法及其中间体
|
|
US12303505B2
(en)
|
2017-02-08 |
2025-05-20 |
Eisai R&D Management Co., Ltd. |
Tumor-treating pharmaceutical composition
|
|
KR102836514B1
(ko)
|
2017-04-05 |
2025-07-22 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
마크로시클릭 화합물 및 그의 용도
|
|
US9938288B1
(en)
|
2017-04-05 |
2018-04-10 |
President And Fellows Of Harvard College |
Macrocyclic compound and uses thereof
|
|
BR112019023064A2
(pt)
|
2017-05-16 |
2020-06-09 |
Eisai R&D Man Co Ltd |
tratamento de carcinoma hepatocelular
|
|
HUE061306T2
(hu)
|
2017-07-06 |
2023-06-28 |
Harvard College |
Halikondrinok szintézise
|
|
US11498892B2
(en)
|
2017-07-06 |
2022-11-15 |
President And Fellows Of Harvard College |
Fe/Cu-mediated ketone synthesis
|
|
US20190046513A1
(en)
|
2017-08-10 |
2019-02-14 |
Huya Bioscience International, Llc |
Combination therapies of hdac inhibitors and tubulin inhibitors
|
|
CN109694379B
(zh)
*
|
2017-10-24 |
2020-09-11 |
江苏恒瑞医药股份有限公司 |
用于制备艾日布林的中间体及其制备方法
|
|
US11142509B2
(en)
|
2017-11-09 |
2021-10-12 |
Yonsung Fine Chemical Co., Ltd. |
Intermediate for preparing eribulin mesylate and process for preparing the same
|
|
ES2974243T3
(es)
|
2017-11-15 |
2024-06-26 |
Harvard College |
Compuestos macrocíclicos y usos de los mismos
|
|
EP3713565A1
(en)
|
2017-11-20 |
2020-09-30 |
Basilea Pharmaceutica International AG |
Pharmaceutical combinations for use in the treatment of neoplastic diseases
|
|
US11008296B2
(en)
|
2017-11-21 |
2021-05-18 |
Natco Pharma Limited |
Intermediates for the preparation of eribulin thereof
|
|
KR20250057138A
(ko)
|
2018-01-03 |
2025-04-28 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 화합물
|
|
WO2019211877A1
(en)
|
2018-05-03 |
2019-11-07 |
Cipla Limited |
Process for the preparation of macrocyclic ketone analogs of halichondrin b
|
|
WO2020008382A1
(en)
*
|
2018-07-04 |
2020-01-09 |
Dr. Reddy’S Laboratories Limited |
Process for preparation of eribulin and intermediates thereof
|
|
JP2021532102A
(ja)
*
|
2018-07-20 |
2021-11-25 |
ドクター レディズ ラボラトリーズ リミテッド |
エリブリンおよびその中間体の調製のための精製プロセス
|
|
US20210340156A1
(en)
*
|
2018-10-09 |
2021-11-04 |
Dr. Reddy's Laboratories Limited |
Process for preparation of eribulin and intermediates thereof
|
|
WO2020110146A1
(en)
*
|
2018-11-28 |
2020-06-04 |
Natco Pharma Limited |
Process for the preparation of high pure eribulin and its mesylate salt
|
|
BR112021012138A2
(pt)
|
2018-12-20 |
2021-08-31 |
Auransa Inc. |
Análogos de pentamidina e seus usos
|
|
US11447499B2
(en)
|
2019-06-14 |
2022-09-20 |
Rk Pharma Inc. |
Process for the preparation of eribulin mesylate intermediate
|
|
WO2020255164A1
(en)
|
2019-06-21 |
2020-12-24 |
Council Of Scientific And Industrial Research |
A chemo-enzymatic process for the preparation of homopropargylic alcohol
|
|
US12036204B2
(en)
|
2019-07-26 |
2024-07-16 |
Eisai R&D Management Co., Ltd. |
Pharmaceutical composition for treating tumor
|
|
US11083705B2
(en)
|
2019-07-26 |
2021-08-10 |
Eisai R&D Management Co., Ltd. |
Pharmaceutical composition for treating tumor
|
|
CN114729042B
(zh)
|
2019-11-07 |
2026-03-03 |
卫材R&D管理有限公司 |
抗间皮素艾日布林抗体-药物缀合物及使用方法
|
|
CN113135876B
(zh)
*
|
2020-01-16 |
2024-05-17 |
南通诺泰生物医药技术有限公司 |
艾日布林及其中间体的制备方法
|
|
WO2021148003A1
(zh)
*
|
2020-01-22 |
2021-07-29 |
上海森辉医药有限公司 |
艾日布林衍生物的药物偶联物、其制备方法及其在医药上的应用
|
|
KR102377262B1
(ko)
|
2020-05-11 |
2022-03-22 |
연성정밀화학(주) |
결정성 에리불린 염
|
|
IL279168B
(en)
*
|
2020-12-02 |
2022-04-01 |
Finetech Pharmaceutical Ltd |
A process for the preparation of eribulin
|
|
CN113354659B
(zh)
|
2021-06-08 |
2022-04-08 |
江苏慧聚药业股份有限公司 |
甲磺酸艾日布林的合成
|
|
KR20240037267A
(ko)
*
|
2021-07-22 |
2024-03-21 |
상하이 센후이 메디슨 컴퍼니 리미티드 |
에리불린 유도체의 약물 접합체
|
|
WO2023212746A2
(en)
*
|
2022-04-30 |
2023-11-02 |
William Marsh Rice University |
A unified strategy for the total syntheses of eribulin and a macrolactam analogue of halichondrin b
|
|
KR20250133788A
(ko)
*
|
2023-01-17 |
2025-09-08 |
시스트이뮨, 인코포레이티드 |
에리불린 약물 접합체
|
|
WO2024251240A1
(zh)
|
2023-06-09 |
2024-12-12 |
徕特康(苏州)生物制药有限公司 |
抗her2互补性双特异抗体-药物偶联物及其制备方法和用途
|
|
CN118834221B
(zh)
*
|
2023-08-08 |
2025-10-21 |
浙江星月药物科技有限公司 |
一种软海绵素b类似物
|
|
TW202518024A
(zh)
|
2023-10-13 |
2025-05-01 |
日商衛材R&D企管股份有限公司 |
抗體－藥物軛合物代謝物
|
|
WO2025106586A1
(en)
*
|
2023-11-13 |
2025-05-22 |
Luxvitae Therapeutics Inc. |
Macrocyclic ketone compounds and applications thereof
|
|
WO2025228172A1
(zh)
*
|
2024-04-28 |
2025-11-06 |
上海拓济医药有限责任公司 |
艾日布林衍生物及其抗体药物偶联物和医药用途
|