BE2025C539I2 - - Google Patents
Info
- Publication number
- BE2025C539I2 BE2025C539I2 BE2025C539C BE2025C539C BE2025C539I2 BE 2025C539 I2 BE2025C539 I2 BE 2025C539I2 BE 2025C539 C BE2025C539 C BE 2025C539C BE 2025C539 C BE2025C539 C BE 2025C539C BE 2025C539 I2 BE2025C539 I2 BE 2025C539I2
- Authority
- BE
- Belgium
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
- C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/385—Congenital anomalies
- G01N2800/387—Down syndrome; Trisomy 18; Trisomy 13
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0600662 | 2006-03-23 | ||
| SE0602591 | 2006-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE2025C539I2 true BE2025C539I2 (fr) | 2026-04-24 |
Family
ID=38522718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE2025C539C BE2025C539I2 (fr) | 2006-03-23 | 2025-09-15 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US8025878B2 (fr) |
| EP (2) | EP2325209A3 (fr) |
| JP (1) | JP5033868B2 (fr) |
| KR (1) | KR101413615B1 (fr) |
| CN (1) | CN101421303B (fr) |
| AT (1) | ATE492561T1 (fr) |
| AU (1) | AU2007227813B9 (fr) |
| BE (1) | BE2025C539I2 (fr) |
| BR (1) | BRPI0709050B1 (fr) |
| CA (1) | CA2630344C (fr) |
| CY (2) | CY1111337T1 (fr) |
| DE (1) | DE602007011415D1 (fr) |
| DK (1) | DK2004688T4 (fr) |
| FI (1) | FIC20250030I1 (fr) |
| FR (1) | FR25C1034I1 (fr) |
| HR (1) | HRP20110203T4 (fr) |
| HU (1) | HUS2500037I1 (fr) |
| IL (1) | IL191331A (fr) |
| MX (1) | MX2008012223A (fr) |
| MY (1) | MY169492A (fr) |
| NL (1) | NL301343I2 (fr) |
| NO (2) | NO347079B1 (fr) |
| NZ (1) | NZ567888A (fr) |
| PL (1) | PL2004688T5 (fr) |
| RS (1) | RS51723B2 (fr) |
| RU (1) | RU2429244C2 (fr) |
| SI (1) | SI2004688T2 (fr) |
| WO (1) | WO2007108756A1 (fr) |
| ZA (1) | ZA200805805B (fr) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2414772C (fr) | 2000-07-07 | 2011-06-28 | Jan Naslund | Prevention et traitement de la maladie d'alzheimer |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| HRP20140240T4 (hr) | 2005-11-30 | 2017-02-24 | Abbvie Inc. | Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba |
| US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
| RU2429244C2 (ru) | 2006-03-23 | 2011-09-20 | Байоарктик Ньюросайенс Аб | Улучшенные селективные в отношении протофибрилл антитела и их применение |
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| ES2429407T3 (es) | 2006-06-08 | 2013-11-14 | Chugai Seiyaku Kabushiki Kaisha | Agente preventivo o remedio para enfermedades inflamatorias |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| TW200844110A (en) | 2007-01-11 | 2008-11-16 | Univ Marburg Philipps | Diagnosis and treatment of alzheimer's disease and other neurodementing diseases |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| KR101680906B1 (ko) | 2007-09-26 | 2016-11-30 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
| ES2595638T3 (es) | 2007-09-26 | 2017-01-02 | Chugai Seiyaku Kabushiki Kaisha | Método para modificar el punto isoeléctrico de un anticuerpo mediante la sustitución de aminoácidos en una CDR |
| AU2008311367B2 (en) | 2007-10-05 | 2014-11-13 | Ac Immune S.A. | Use of anti-amyloid beta antibody in ocular diseases |
| EP2207568B1 (fr) * | 2007-11-16 | 2017-05-31 | The Rockefeller University | Anticorps spécifiques de la forme de protofibrille de protéine bêta-amyloïde |
| TW201634479A (zh) * | 2007-12-05 | 2016-10-01 | 中外製藥股份有限公司 | 抗nr10抗體及其應用 |
| CN102936287B (zh) * | 2008-02-08 | 2015-09-09 | 伊缪纳斯制药株式会社 | 能够特异性结合Aβ寡聚体的抗体及其应用 |
| PT2282758T (pt) | 2008-04-29 | 2019-02-12 | Bioarctic Ab | Anticorpos e vacinas para uso em métodos terapêuticos e diagnósticos para perturbações relacionadas com a alfa-sinucleína |
| US9085614B2 (en) * | 2008-08-01 | 2015-07-21 | Immunas Pharma, Inc. | Antibodies that specifically bind to Aβ oligomers and uses thereof |
| EP2328930B1 (fr) * | 2008-08-20 | 2014-12-24 | Probiodrug AG | Anticorps dirigés contre une protéine-1 chimiotactique des monocytes a terminal pyroglutamate (mcp-1 n1pe) |
| JP5717624B2 (ja) | 2009-03-19 | 2015-05-13 | 中外製薬株式会社 | 抗体定常領域改変体 |
| EP2826789A1 (fr) | 2009-03-19 | 2015-01-21 | Chugai Seiyaku Kabushiki Kaisha | Variant d'une région constante d'anticorps |
| CN102459335B (zh) | 2009-04-17 | 2015-11-25 | 伊缪纳斯制药株式会社 | 特异性结合Aβ寡聚体的抗体及其用途 |
| FR2945538B1 (fr) * | 2009-05-12 | 2014-12-26 | Sanofi Aventis | Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide. |
| LT2448968T (lt) * | 2009-06-29 | 2021-05-10 | Bioarctic Ab | Antikūnai, atpažįstantys n gale sutrumpintas amiloido protofibriles/oligomerus |
| EP2273273A1 (fr) * | 2009-07-11 | 2011-01-12 | Rheinische Friedrich-Wilhelms-Universität Bonn | Inhibiteurs de la nitration de peptides ß amyloïdes et leurs utilisations pour le diagnostic et le traitement de la maladie d'Alzheimer |
| JP5599454B2 (ja) * | 2009-08-06 | 2014-10-01 | イムナス・ファーマ株式会社 | Aβオリゴマーに特異的に結合する抗体およびその利用 |
| WO2011016238A1 (fr) | 2009-08-06 | 2011-02-10 | Immunas Pharma, Inc. | Anticorps qui se lient spécifiquement à des bêta-oligomères et utilisation de ceux-ci |
| US10266585B2 (en) | 2009-08-28 | 2019-04-23 | The Board Of Regents Of The Univerity Of Texas System | Methods of treating brain injury |
| EA034462B1 (ru) * | 2009-11-24 | 2020-02-11 | Алетиа Байотерапьютикс Инк. | Антикластериновые антитела и антигенсвязывающие фрагменты и их использование для уменьшения объема новообразований |
| JP5894939B2 (ja) | 2010-02-26 | 2016-03-30 | バイオアークティック ニューロサイエンス アーベー | プロトフィブリル結合抗体ならびにパーキンソン病、レビー小体型認知症および他のα−シヌクレイノパチーの治療および診断方法におけるこれらの使用 |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| WO2011151076A2 (fr) | 2010-06-04 | 2011-12-08 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Anticorps monoclonaux ciblant des oligomères aβ |
| EP2598882B1 (fr) | 2010-07-30 | 2017-07-26 | AC Immune S.A. | Anticorps humanisés sûrs et fonctionnels pour utilisation dans le traitement de l'amyloïdose |
| EP3533803B1 (fr) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anticorps anti-bêta-amyloïde |
| AU2011315920B2 (en) | 2010-10-15 | 2016-04-28 | The Board Of Regents Of The University Of Texas System | Antibodies that bind amyloid oligomers |
| EP3604339B1 (fr) | 2011-01-14 | 2021-03-10 | The Regents Of The University Of California | Anticorps thérapeutiques contre la protéine ror-1 et leurs procédés d'utilisation |
| EP2497782A1 (fr) | 2011-03-08 | 2012-09-12 | Alzinova AB | Anticorps anti-oligomère et leurs utilisations |
| CN107233569B (zh) | 2011-10-25 | 2021-08-31 | 普罗西纳生物科学有限公司 | 抗体制剂和方法 |
| JP2013159596A (ja) * | 2012-02-08 | 2013-08-19 | Nihon Univ | β−アミロイド前駆体タンパク質のマイクロ凝集体に特異的なモノクローナル抗体 |
| US9822170B2 (en) | 2012-02-22 | 2017-11-21 | Alethia Biotherapeutics Inc. | Co-use of a clusterin inhibitor with an EGFR inhibitor to treat cancer |
| DK3019240T3 (da) | 2013-07-09 | 2024-06-03 | Annexon Inc | Anti-komplementfaktor C1Q antistoffer og anvendelser deraf |
| CN112552401B (zh) | 2013-09-13 | 2023-08-25 | 广州百济神州生物制药有限公司 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
| LT3071597T (lt) * | 2013-11-21 | 2020-10-12 | F. Hoffmann-La Roche Ag | Antikūnai prieš alfa-sunukleiną ir jų naudojimo būdai |
| CN106604742B (zh) | 2014-07-03 | 2019-01-11 | 百济神州有限公司 | 抗pd-l1抗体及其作为治疗剂及诊断剂的用途 |
| WO2016005466A2 (fr) * | 2014-07-10 | 2016-01-14 | Bioarctic Neuroscience Ab | Anticorps se liant aux protofibrilles ass améliorés |
| BR112017001385B1 (pt) | 2014-07-22 | 2023-12-05 | Cb Therapeutics, Inc. | Anticorpo isolado ou fragmento do mesmo que liga a pd-1, uso deste, composição, polinucleotídeo isolado e vetor de expressão |
| KR102476226B1 (ko) | 2014-08-05 | 2022-12-12 | 아폴로믹스 인코포레이티드 | 항-pd-l1 항체 |
| SI3215527T1 (sl) | 2014-11-05 | 2025-04-30 | Annexon, Inc. | Humanizirana protitelesa proti komplementnemu faktorju C1q in njihova uporaba |
| WO2016100615A2 (fr) * | 2014-12-18 | 2016-06-23 | The University Of Chicago | Procédés et composition pour la neutralisation de la grippe |
| JP5954916B1 (ja) | 2015-04-14 | 2016-07-20 | 中外製薬株式会社 | Il−31アンタゴニストを有効成分として含有する、アトピー性皮膚炎の予防用及び/又は治療用医薬組成物 |
| WO2017013599A1 (fr) | 2015-07-21 | 2017-01-26 | Bioarctic Neuroscience Ab | Procédé de traitement d'une lésion cérébrale traumatique ciblant des peptides agrégés |
| EP3380518B1 (fr) | 2015-11-24 | 2026-03-25 | Annexon, Inc. | Fragments fab anti-complément de facteur c1q et leurs utilisations |
| JP2017132742A (ja) * | 2016-01-29 | 2017-08-03 | 国立大学法人 大分大学 | Aβオリゴマー特異的抗体の新規薬理用途 |
| TWI798751B (zh) | 2016-07-01 | 2023-04-11 | 美商美國禮來大藥廠 | 抗-N3pGlu類澱粉β肽抗體及其用途 |
| US10864203B2 (en) | 2016-07-05 | 2020-12-15 | Beigene, Ltd. | Combination of a PD-1 antagonist and a RAF inhibitor for treating cancer |
| BR112019000098A2 (pt) | 2016-07-14 | 2019-04-09 | Bioarctic Ab | proteína de fornecimento ao cérebro, método de tratamento e/ou profilaxia de distúrbios cerebrais em mamíferos que possuem ou encontram-se em risco de desenvolver o mencionado distúrbio e método de diagnóstico e/ou detecção de distúrbios cerebrais em mamíferos suspeitos de possuir ou que se encontram em risco de desenvolver o mencionado distúrbio |
| WO2018033135A1 (fr) | 2016-08-19 | 2018-02-22 | Beigene, Ltd. | Utilisation d'une combinaison comprenant un inhibiteur de btk pour le traitement de cancers |
| AU2017335634A1 (en) | 2016-09-27 | 2019-03-14 | Cero Therapeutics, Inc. | Chimeric engulfment receptor molecules |
| BR112019008359A2 (pt) | 2016-10-27 | 2019-10-01 | Eisai R&D Man Co Ltd | método para tratamento da doença de alzheimer, e, composição farmacêutica. |
| US11555038B2 (en) | 2017-01-25 | 2023-01-17 | Beigene, Ltd. | Crystalline forms of (S)-7-(1-(but-2-ynoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof |
| EP3645569A4 (fr) | 2017-06-26 | 2021-03-24 | BeiGene, Ltd. | Immunothérapie pour carcinome hépatocellulaire |
| US11530257B2 (en) | 2017-06-29 | 2022-12-20 | The Trustees Of Columbia University In The City Of New York | Chimeric antibodies for treatment of amyloid deposition diseases |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| US11382974B2 (en) | 2017-08-01 | 2022-07-12 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for treatment of amyloid deposition diseases |
| EP4714966A2 (fr) | 2017-09-26 | 2026-03-25 | Cero Therapeutics Holdings, Inc. | Molécules de récepteur d'engulment chimérique et procédés d'utilisation |
| WO2019108795A1 (fr) | 2017-11-29 | 2019-06-06 | Beigene Switzerland Gmbh | Traitement de lymphomes à cellules b indolentes ou agressives au moyen d'une combinaison comprenant des inhibiteurs de btk |
| EP3753952A4 (fr) * | 2017-12-13 | 2022-04-13 | XDCExplorer (Shanghai) Co., Ltd. | Anticorps egfrviii et conjugué, procédé de préparation associé et utilisation correspondante |
| MX2020010241A (es) | 2018-03-28 | 2020-10-16 | Cero Therapeutics Inc | Composiciones de inmunoterapia celular y usos de las mismas. |
| WO2019191332A1 (fr) | 2018-03-28 | 2019-10-03 | Cero Therapeutics, Inc. | Récepteurs d'engloutissement chimériques et leurs utilisations pour des maladies neurodégénératives |
| US12018069B2 (en) | 2018-06-28 | 2024-06-25 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for imaging amyloid deposits |
| CN111094340B (zh) | 2018-07-17 | 2022-11-22 | 江苏恒瑞医药股份有限公司 | 抗Abeta抗体、其抗原结合片段及应用 |
| US20210324056A1 (en) | 2018-07-24 | 2021-10-21 | Eisai R&D Management Co., Ltd. | Methods of treatment and prevention of alzheimer's disease |
| WO2020160156A2 (fr) | 2019-01-30 | 2020-08-06 | Immutics, Inc. | Anticorps anti-gal3 et leurs utilisations |
| MX2022005654A (es) | 2019-11-20 | 2022-06-22 | Chugai Pharmaceutical Co Ltd | Preparacion que contiene anticuerpo. |
| US20230108300A1 (en) * | 2020-01-29 | 2023-04-06 | The Trustees Of The University Of Pennsylvania | Compositions and methods of t cell receptor vb family member targeting for the treatment of t cell associated disease |
| EP4157338A4 (fr) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | Méthodes de traitement de maladies inflammatoires par blocage de la galectine-3 |
| DK4172199T3 (da) | 2020-06-26 | 2025-08-18 | Bioarctic Ab | Alfa-synuklein-protofibril-bindende antistoffer |
| US12480961B2 (en) | 2020-12-16 | 2025-11-25 | Cognext Diagnostics LLC | Methods for diagnosing alzheimer's disease and other neurological disorders |
| TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
| WO2022251048A1 (fr) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anticorps anti-amyloïde bêta et leurs utilisations |
| CA3220572A1 (fr) | 2021-06-11 | 2022-12-15 | Bioarctic Ab | Molecule de liaison bispecifique |
| AU2022307687A1 (en) | 2021-07-09 | 2024-01-04 | Eisai R&D Management Co., Ltd. | Biomarkers for alzheimer's disease treatment |
| US20240352109A1 (en) | 2021-08-30 | 2024-10-24 | Eisai R&D Management Co., Ltd. | Subcutaneous formulations of anti-abeta protofibril antibody and methods of use thereof |
| KR102753583B1 (ko) * | 2021-11-11 | 2025-01-10 | 의료법인 명지의료재단 | Kras 특이적 활성화 t 세포 유도용 항원 조성물 |
| WO2023099788A1 (fr) | 2021-12-03 | 2023-06-08 | Neurimmune Ag | Nouveau dosage de puissance pour des médicaments à base d'anticorps et moyens utiles associés |
| US12486322B2 (en) | 2021-12-13 | 2025-12-02 | Annexon, Inc. | Anti-complement factor C1q antibodies with single binding arms and uses thereof |
| WO2023111618A1 (fr) | 2021-12-17 | 2023-06-22 | Eisai R&D Management Co., Ltd. | Méthodes d'utilisation d'un anticorps anti-amyloïde à protofibrille bêta et d'un anticorps anti-tau |
| MX2024007288A (es) | 2021-12-17 | 2024-06-28 | Eisai R&D Man Co Ltd | Metodos de uso de un anticuerpo anti protofibrilla beta amiloide y anticuerpo anti tau. |
| AU2022439338A1 (en) | 2022-02-02 | 2024-08-15 | Eisai R&D Management Co., Ltd. | Methods of treatment using p-tau181 level |
| JP2025539394A (ja) | 2022-11-28 | 2025-12-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | タウpetレベルを使用する治療の方法 |
| EP4602067A1 (fr) | 2023-01-20 | 2025-08-20 | Mabwell Therapeutics Inc. | Anticorps anti-protofibrille/oligomère beta amyloïde et leurs utilisations |
| KR20260022396A (ko) | 2023-06-09 | 2026-02-19 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 항-Aβ 프로토피브릴 항체를 사용한 치료 방법 |
| WO2025122968A1 (fr) | 2023-12-06 | 2025-06-12 | Eisai R&D Management Co., Ltd. | Prédiction d'un trouble cognitif léger sur la base de comorbidités de patient |
| WO2025137532A1 (fr) * | 2023-12-21 | 2025-06-26 | Eisai R&D Management Co., Ltd. | Méthode de quantification de protofibrilles bêta-amyloïdes |
| WO2025260029A1 (fr) * | 2024-06-14 | 2025-12-18 | Eisai R&D Management Co., Ltd. | Procédé de quantification de protofibrille bêta-amyloïde |
| WO2026015877A1 (fr) | 2024-07-12 | 2026-01-15 | Eisai R&D Management Co., Ltd. | Biomarqueur fluide |
| WO2026060081A1 (fr) * | 2024-09-12 | 2026-03-19 | Denali Therapeutics Inc. | Anticorps anti-amyloïde bêta et procédés d'utilisation |
| WO2026068532A1 (fr) | 2024-09-24 | 2026-04-02 | Bioarctic Ab | Molécule de liaison bispécifique |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5231000A (en) | 1987-10-08 | 1993-07-27 | The Mclean Hospital | Antibodies to A4 amyloid peptide |
| US5753624A (en) * | 1990-04-27 | 1998-05-19 | Milkhaus Laboratory, Inc. | Materials and methods for treatment of plaquing disease |
| DE69126304T2 (de) | 1990-04-27 | 1997-09-04 | Mcmichael, John, Delanson, N.Y. | Verfahren und zusammensetzung zur behandlung von erkrankungen des zns hervorgerufen durch abnormales beta-amyloid-protein |
| US6174916B1 (en) * | 1990-04-27 | 2001-01-16 | Milkhaus Laboratory, Ltd. | Methods for treating herpes virus infections |
| US5604102A (en) | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
| AU702293B2 (en) * | 1993-10-27 | 1999-02-18 | Athena Neurosciences, Inc. | Transgenic animals harboring APP allele having Swedish mutation |
| WO1995031996A1 (fr) | 1994-05-25 | 1995-11-30 | Milkhaus Lab | Compositions et procedes de traitement de maladies a formation de plaque |
| US7427392B1 (en) | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
| US6114133A (en) * | 1994-11-14 | 2000-09-05 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-β peptide (x-≧41) |
| US5786180A (en) * | 1995-02-14 | 1998-07-28 | Bayer Corporation | Monoclonal antibody 369.2B specific for β A4 peptide |
| US5854215A (en) * | 1995-03-14 | 1998-12-29 | Praecis Pharmaceuticals Incorporated | Modulators of β-amyloid peptide aggregation |
| US5854204A (en) * | 1995-03-14 | 1998-12-29 | Praecis Pharmaceuticals, Inc. | Aβ peptides that modulate β-amyloid aggregation |
| US5817626A (en) * | 1995-03-14 | 1998-10-06 | Praecis Pharmaceuticals Incorporated | Modulators of beta-amyloid peptide aggregation |
| US6303567B1 (en) * | 1995-03-14 | 2001-10-16 | Praecis Pharmaceuticals, Inc . | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
| US5985242A (en) * | 1995-10-27 | 1999-11-16 | Praecis Pharmaceuticals, Inc. | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
| JPH09178743A (ja) | 1995-12-27 | 1997-07-11 | Oriental Yeast Co Ltd | 可溶性appの定量法 |
| US6054114A (en) * | 1996-05-08 | 2000-04-25 | Massachusetts Institute Of Technology | Organometallic ligands for the localization and quantification of amyloid in vivo and in vitro |
| US6218506B1 (en) | 1997-02-05 | 2001-04-17 | Northwestern University | Amyloid β protein (globular assembly and uses thereof) |
| US20060178302A1 (en) * | 1997-02-05 | 2006-08-10 | Northwestern University & The University Of Southern California | Amyloid beta protein (globular assembly and uses thereof) |
| US20030068316A1 (en) | 1997-02-05 | 2003-04-10 | Klein William L. | Anti-ADDL antibodies and uses thereof |
| TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| EP1033998B1 (fr) | 1997-12-03 | 2005-10-19 | Neuralab, Ltd. | Suppression des modifications liees aux beta-amyloides dans la maladie d'alzheimer |
| AU2486900A (en) | 1998-12-29 | 2000-07-31 | University Of Georgia Research Foundation, Inc., The | Rubredoxin fusion proteins, protein expression system and methods |
| US6670195B1 (en) | 1999-05-26 | 2003-12-30 | New York University | Mutant genes in Familial British Dementia and Familial Danish Dementia |
| UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
| PE20010212A1 (es) | 1999-06-01 | 2001-02-22 | Neuralab Ltd | Composiciones del peptido a-beta y procesos para producir las mismas |
| DE60043165D1 (de) | 1999-08-04 | 2009-11-26 | Univ Southern California | Globularer Aufbau vom Amyloid-beta- protein und deren Verwendungen |
| MXPA02005576A (es) | 1999-11-29 | 2002-12-13 | Neurochem Inc | Vacuna para la prevencion y tratamiento de la enfermedad de alzheimer y otras enfermedades relacionadas con amiloides. |
| AU2001274873B2 (en) | 2000-05-22 | 2006-10-05 | New York University | Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid beta for induction of an immune response to amyloid beta and amyloid deposits |
| CA2414772C (fr) | 2000-07-07 | 2011-06-28 | Jan Naslund | Prevention et traitement de la maladie d'alzheimer |
| US20030187011A1 (en) * | 2001-12-20 | 2003-10-02 | Lashuel Hilal A. | Apomorphine inhibitors of amyloid-beta (Abeta) fibril formation and their use in amyloidosis based disease |
| WO2003068801A2 (fr) * | 2002-02-11 | 2003-08-21 | Genentech, Inc. | Variantes d'anticorps a vitesses d'association d'antigene accelerees |
| ATE514707T1 (de) | 2002-04-19 | 2011-07-15 | Univ Toronto | Immunologisches verfahren und zusammensetzungen für die behandlung der krankheit von alzheimer |
| JP2003334075A (ja) * | 2002-05-21 | 2003-11-25 | Japan Tobacco Inc | 簡便な変異抗体の製造方法 |
| US20040049134A1 (en) * | 2002-07-02 | 2004-03-11 | Tosaya Carol A. | System and methods for treatment of alzheimer's and other deposition-related disorders of the brain |
| ATE506072T1 (de) * | 2002-09-12 | 2011-05-15 | Univ California | Immunogene und entsprechende antikörper, die spezifisch sind für häufige hochmolekulare aggregations-zwischenprodukte von amyloiden aus proteinen unterschiedlicher sequenz |
| WO2005025516A2 (fr) | 2003-09-12 | 2005-03-24 | The Regents Of The University Of California | Anticorps monoclonaux specifiques a des intermediaires d'agregation de poids moleculaire eleve communs a des amyloides formes a partir de proteines de sequence differente |
| EP1545582A4 (fr) | 2002-10-01 | 2008-09-17 | Univ Northwestern | Ligands diffusibles derives de l'amyloide beta (addl), substituts d'addl, molecules de liaison aux addl, et leurs utilisations |
| JP2006505272A (ja) * | 2002-11-04 | 2006-02-16 | バイオアークティック ニューロサイエンス アーベー | βアミロイド前駆体タンパク質の構造およびプロセシングを調節する薬剤の同定のための方法 |
| DE10303974A1 (de) * | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US20050124016A1 (en) * | 2003-08-01 | 2005-06-09 | Enh Research Institute | Antibodies specific for toxic amyloid beta protein oligomers |
| EP1668369B1 (fr) | 2003-08-20 | 2016-01-06 | ProMIS Neurosciences Inc. | Dosage de protection d'epitope et procede de detection de conformations proteiques |
| SE0400707D0 (sv) | 2004-03-22 | 2004-03-22 | Bioarctic Neuroscience Ab | Transgenic animal model |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| EP1769002A1 (fr) | 2004-07-02 | 2007-04-04 | Northwestern University | Anticorps monoclonaux ciblant des ensembles pathologiques de beta-amyloides (abeta) |
| US20060079447A1 (en) * | 2004-10-08 | 2006-04-13 | Wetzel Ronald B | Stabilized A-beta protofibrillar aggregates |
| US20080044356A1 (en) | 2004-10-22 | 2008-02-21 | Regents Of The University Of Minnesota | Assemblies of Oligomeric Amyloid Beta Protein and Uses Thereof |
| US7811563B2 (en) | 2004-10-25 | 2010-10-12 | Northwestern University | Anti-addl antibodies and uses thereof |
| WO2006066233A1 (fr) * | 2004-12-15 | 2006-06-22 | Neuralab Limited | Essai d'immunoprecipitation permettant de predire l'efficacite in vivo d'anticorps anti-proteine beta-amyloide |
| CA2593846A1 (fr) | 2005-01-14 | 2006-08-10 | The Regents Of The University Of California | Compositions et methodes d'inhibition de la formation de drusen et methodes de diagnostic ou de traitement de pathologies liees aux drusen |
| GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
| US7700099B2 (en) * | 2005-02-14 | 2010-04-20 | Merck & Co., Inc. | Non-immunostimulatory antibody and compositions containing the same |
| US7731962B2 (en) * | 2005-02-14 | 2010-06-08 | Merck & Co., Inc. | Anti-ADDL monoclonal antibody and use thereof |
| WO2006094724A2 (fr) | 2005-03-05 | 2006-09-14 | Abbott Gmbh & Co. Kg | Methode de criblage, procede servant a purifier des a$g(b) oligomeres non diffusibles, anticorps selectifs contre les dits a$g(b) oligomeres non diffusibles et procede servant a preparer ces anticorps |
| WO2006137354A1 (fr) | 2005-06-21 | 2006-12-28 | Medical & Biological Laboratories Co., Ltd. | Anticorps avec effet inhibiteur sur la formation de fibrilles amyloïdes |
| TW200726482A (en) | 2005-06-30 | 2007-07-16 | Merck & Co Inc | Method for preparing a covalently cross linked oligomer of amyloid beta peptides |
| TW200726774A (en) | 2005-06-30 | 2007-07-16 | Merck & Co Inc | Composition and method for producing stable amyloid beta oligomers |
| CN101291692A (zh) | 2005-10-21 | 2008-10-22 | 默克制药公司 | 抗addl单克隆抗体及其应用 |
| US9133267B2 (en) | 2005-11-22 | 2015-09-15 | The Trustees Of The University Of Pennsylvania | Antibody treatment of Alzheimer's and related diseases |
| RU2429244C2 (ru) | 2006-03-23 | 2011-09-20 | Байоарктик Ньюросайенс Аб | Улучшенные селективные в отношении протофибрилл антитела и их применение |
| EP2207568B1 (fr) | 2007-11-16 | 2017-05-31 | The Rockefeller University | Anticorps spécifiques de la forme de protofibrille de protéine bêta-amyloïde |
| LT2448968T (lt) | 2009-06-29 | 2021-05-10 | Bioarctic Ab | Antikūnai, atpažįstantys n gale sutrumpintas amiloido protofibriles/oligomerus |
-
2007
- 2007-03-23 RU RU2008141905/10A patent/RU2429244C2/ru active
- 2007-03-23 NZ NZ567888A patent/NZ567888A/en unknown
- 2007-03-23 NO NO20084445A patent/NO347079B1/no unknown
- 2007-03-23 BR BRPI0709050A patent/BRPI0709050B1/pt not_active IP Right Cessation
- 2007-03-23 DE DE602007011415T patent/DE602007011415D1/de active Active
- 2007-03-23 RS RS20110122A patent/RS51723B2/sr unknown
- 2007-03-23 US US12/294,207 patent/US8025878B2/en active Active
- 2007-03-23 KR KR1020087023261A patent/KR101413615B1/ko active Active
- 2007-03-23 EP EP10195985A patent/EP2325209A3/fr not_active Withdrawn
- 2007-03-23 AU AU2007227813A patent/AU2007227813B9/en active Active
- 2007-03-23 MY MYPI20083703A patent/MY169492A/en unknown
- 2007-03-23 PL PL07747965T patent/PL2004688T5/pl unknown
- 2007-03-23 WO PCT/SE2007/000292 patent/WO2007108756A1/fr not_active Ceased
- 2007-03-23 EP EP07747965.7A patent/EP2004688B2/fr active Active
- 2007-03-23 MX MX2008012223A patent/MX2008012223A/es active IP Right Grant
- 2007-03-23 AT AT07747965T patent/ATE492561T1/de active
- 2007-03-23 SI SI200730510T patent/SI2004688T2/sl unknown
- 2007-03-23 HR HRP20110203TT patent/HRP20110203T4/hr unknown
- 2007-03-23 CA CA2630344A patent/CA2630344C/fr active Active
- 2007-03-23 JP JP2009501383A patent/JP5033868B2/ja active Active
- 2007-03-23 CN CN2007800098173A patent/CN101421303B/zh active Active
- 2007-03-23 DK DK07747965.7T patent/DK2004688T4/da active
-
2008
- 2008-05-11 IL IL191331A patent/IL191331A/en active IP Right Grant
- 2008-07-02 ZA ZA2008/05805A patent/ZA200805805B/en unknown
-
2011
- 2011-03-15 CY CY20111100288T patent/CY1111337T1/el unknown
- 2011-08-26 US US13/219,012 patent/US9034334B2/en active Active
-
2025
- 2025-08-28 CY CY2025024C patent/CY2025024I1/el unknown
- 2025-08-29 FI FIC20250030C patent/FIC20250030I1/fi unknown
- 2025-09-03 FR FR25C1034C patent/FR25C1034I1/fr active Active
- 2025-09-05 NO NO2025041C patent/NO2025041I1/no unknown
- 2025-09-09 HU HUS2500037C patent/HUS2500037I1/hu unknown
- 2025-09-12 NL NL301343C patent/NL301343I2/nl unknown
- 2025-09-15 BE BE2025C539C patent/BE2025C539I2/fr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BE2025C539I2 (fr) | ||
| BRPI0720064A2 (fr) | ||
| BRMU8603216U8 (fr) | ||
| BRPI0715824A8 (fr) | ||
| BRPI0713487A2 (fr) | ||
| BR122016023444A2 (fr) | ||
| BRPI0708307B8 (fr) | ||
| CH2121272H1 (fr) | ||
| BY9789C1 (fr) | ||
| CN300725913S (zh) | 童装(3712) | |
| CN300732020S (zh) | 酒包装盒(十年口都窖) | |
| CN300725925S (zh) | 童装(3791) | |
| CN300726119S (zh) | 牙刷板(p-134) | |
| CN300725923S (zh) | 童装(3775) | |
| CN300725922S (zh) | 童装(3773) | |
| CN300725921S (zh) | 童装(3771) | |
| CN300725920S (zh) | 童装(3754) | |
| CN300725919S (zh) | 童装(3752) | |
| CN300725918S (zh) | 童装(3748) | |
| CN300725917S (zh) | 童装(3734) | |
| CN300725916S (zh) | 童装(3732) | |
| CN300725915S (zh) | 童装(3728) | |
| CN300725914S (zh) | 童装(3714) | |
| CN300727330S (zh) | 摩托车 | |
| CN300725927S (zh) | 童装(3795) |