BE611392A - - Google Patents
Info
- Publication number
- BE611392A BE611392A BE611392DA BE611392A BE 611392 A BE611392 A BE 611392A BE 611392D A BE611392D A BE 611392DA BE 611392 A BE611392 A BE 611392A
- Authority
- BE
- Belgium
- Prior art keywords
- emi
- antirheumatic drug
- cortisonic
- nique
- nonsolvent
- Prior art date
Links
- 239000003435 antirheumatic agent Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 claims 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 claims 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- 229960004544 cortisone Drugs 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003873 salicylate salts Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16D—COUPLINGS FOR TRANSMITTING ROTATION; CLUTCHES; BRAKES
- F16D3/00—Yielding couplings, i.e. with means permitting movement between the connected parts during the drive
- F16D3/50—Yielding couplings, i.e. with means permitting movement between the connected parts during the drive with the coupling parts connected by one or more intermediate members
- F16D3/78—Yielding couplings, i.e. with means permitting movement between the connected parts during the drive with the coupling parts connected by one or more intermediate members shaped as an elastic disc or flat ring, arranged perpendicular to the axis of the coupling parts, different sets of spots of the disc or ring being attached to each coupling part, e.g. Hardy couplings
Landscapes
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
<EMI ID=1.1> <EMI ID=2.1> <EMI ID=3.1> <EMI ID=4.1> <EMI ID=5.1> ,.1,.",p, <EMI ID=6.1> <EMI ID=7.1> <EMI ID=8.1> molécules de bicarbonate de sodium et d'une molécule diacide acé- <EMI ID=9.1> <EMI ID=10.1> <EMI ID=11.1> La mise en contact intime et progressive des deux réac- <EMI ID=12.1> <EMI ID=13.1> <EMI ID=14.1> <EMI ID=15.1> <EMI ID=16.1> <EMI ID=17.1> <EMI ID=18.1> <EMI ID=19.1> <EMI ID=20.1> <EMI ID=21.1> <EMI ID=22.1> <EMI ID=23.1> <EMI ID=24.1> <EMI ID=25.1> la première Dortion de bicarbonate de sodium). La masse se ramollit. La température remonte lentement et sa valeur initiale est <EMI ID=26.1> Laisser reposer le mélange pendant deux heures. La masse, de <EMI ID=27.1> A l'aide d'un bain-marie ou d'un dispositif à circulation d'eau chaude, élever la température du mélange vers 28-30[deg.]C. La réaction reprend et la masse se fluidifie à. nouveau. <EMI ID=28.1> 168 g de bicarbonate de sodium suivant la technique décrite pour la première partie. Laisser reposer une heure. Agiter pendant une demi-heure (vitesse 2). <EMI ID=29.1> ture du laboratoire (20[deg.] environ), puis séché sous vide (15 à <EMI ID=30.1> (2 à 3 jours) . <EMI ID=31.1> La purification du produit est ensuite réalisée de la manière f <EMI ID=32.1> <EMI ID=33.1> d'acétone, puis 1 fois avec 500 ml d'éther éthylique. Faire suivre chaque lavage d'un essorage. Sécher sous vide <EMI ID=34.1> (2 .leurs). <EMI ID=35.1> <EMI ID=36.1> <EMI ID=37.1> <EMI ID=38.1> s'apparentant à celles des salicylates classiques, tel le
Claims (1)
- <EMI ID=39.1>a mis en évidence, outre sa parfaite tolérance (aucun cas d'intolérance gastrique n'a été observé), son action cortisonique marquée et son efficacité comme antirhumatismal susceptible de relayer la cortisone, sinon de la remplacer.Il- s'est montré particulièrement intéressant dans les indications suivantes :<EMI ID=40.1><EMI ID=41.1><EMI ID=42.1><EMI ID=43.1>pur sans excipient, et des comprimés, dont un exemple est donné<EMI ID=44.1><EMI ID=45.1><EMI ID=46.1><EMI ID=47.1><EMI ID=48.1><EMI ID=49.1> î la proportion de 1 molécule d'acide acétylsalicylique pour 2<EMI ID=50.1><EMI ID=51.1><EMI ID=52.1>! nique non solvant du complexe obtenu.3.- Médicament antirhumatismal constitué par le produit selon la) éventuellement associé aux excipients habituelle- ment utilisés dans les préparations pharmaceutiques..
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE846892X | 1937-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE611392A true BE611392A (fr) |
Family
ID=6775173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE611392D BE611392A (fr) | 1937-12-02 |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE611392A (fr) |
| FR (1) | FR846892A (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1363513A (en) * | 1971-04-06 | 1974-08-14 | Norton Villiers Ltd | Vehicles |
-
0
- BE BE611392D patent/BE611392A/fr unknown
-
1938
- 1938-12-01 FR FR846892D patent/FR846892A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR846892A (fr) | 1939-09-27 |
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