BE858949A - Nouvelles phenyl-6 1,2,4-triazolo (4,3-b) pyridazines substituees, leurs utilisations comme anxiolytiques et hypotenseurs et leurs procedes de preparation - Google Patents
Nouvelles phenyl-6 1,2,4-triazolo (4,3-b) pyridazines substituees, leurs utilisations comme anxiolytiques et hypotenseurs et leurs procedes de preparationInfo
- Publication number
- BE858949A BE858949A BE181116A BE181116A BE858949A BE 858949 A BE858949 A BE 858949A BE 181116 A BE181116 A BE 181116A BE 181116 A BE181116 A BE 181116A BE 858949 A BE858949 A BE 858949A
- Authority
- BE
- Belgium
- Prior art keywords
- hypotensors
- anxiolytics
- triazolo
- preparation methods
- new phenyl
- Prior art date
Links
- 239000002249 anxiolytic agent Substances 0.000 title 1
- 229940005530 anxiolytics Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000004892 pyridazines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/12—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/725,597 US4230705A (en) | 1976-09-22 | 1976-09-22 | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE858949A true BE858949A (fr) | 1978-03-22 |
Family
ID=24915205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE181116A BE858949A (fr) | 1976-09-22 | 1977-09-22 | Nouvelles phenyl-6 1,2,4-triazolo (4,3-b) pyridazines substituees, leurs utilisations comme anxiolytiques et hypotenseurs et leurs procedes de preparation |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4230705A (fr) |
| BE (1) | BE858949A (fr) |
| IS (1) | IS2407A7 (fr) |
| MC (1) | MC1168A1 (fr) |
| MW (1) | MW2177A1 (fr) |
| PH (1) | PH13960A (fr) |
| SE (1) | SE7710595L (fr) |
| SU (1) | SU793399A3 (fr) |
| ZA (1) | ZA775110B (fr) |
| ZM (1) | ZM6677A1 (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2562071B1 (fr) * | 1984-03-30 | 1986-12-19 | Sanofi Sa | Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| US4569934A (en) * | 1984-10-09 | 1986-02-11 | American Cyanamid Company | Imidazo[1,2-b]pyridazines |
| US4591589A (en) * | 1985-01-16 | 1986-05-27 | Roussel Uclaf | 2-aryl pyrazolo[4,3-c]cinnolin-3-ones |
| US4654343A (en) * | 1985-10-31 | 1987-03-31 | American Cyanamid Company | N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas |
| CA2198019A1 (fr) * | 1994-09-16 | 1996-03-21 | Takeda Chemical Industries, Ltd. | Methode et intermediaires pour la preparation de triazolopyridines; utilisation comme medicaments |
| GB9726701D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
| GB9726699D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
| GB9726702D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
| GB9723999D0 (en) | 1997-11-13 | 1998-01-14 | Merck Sharp & Dohme | Therapeutic use |
| US6110915A (en) * | 1997-12-18 | 2000-08-29 | Merck & Co., Inc. | Antiemetic use of triazolo-pyridazine derivatives |
| AU746866B2 (en) | 1998-01-14 | 2002-05-02 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for GABA receptors |
| GB9801208D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801202D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801210D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| MXPA00007135A (es) * | 1998-01-21 | 2002-11-07 | Merck Sharp & Dohme | Derivados de triazolo-piridazina como ligandos para receptores gaba. |
| GB9801234D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801397D0 (en) | 1998-01-22 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801538D0 (en) | 1998-01-23 | 1998-03-25 | Merck Sharp & Dohme | Pharmaceutical product |
| HUE034911T2 (hu) * | 2009-07-27 | 2018-03-28 | Gilead Sciences Inc | Fúzionált heterociklusos vegyületek mint ioncsatorna modulátorok |
| EP2588197B1 (fr) | 2010-07-02 | 2014-11-05 | Gilead Sciences, Inc. | Composés hétérocycliques condensés en tant que modulateurs des canaux ioniques |
| WO2012154760A1 (fr) | 2011-05-10 | 2012-11-15 | Gilead Sciences, Inc. | Composés hétérocycliques condensés utilisés comme modulateurs des canaux sodiques |
| UY34171A (es) | 2011-07-01 | 2013-01-31 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como moduladores del canal iónico |
| NO3175985T3 (fr) | 2011-07-01 | 2018-04-28 | ||
| CA3281817A1 (en) * | 2016-11-28 | 2026-03-02 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018098491A1 (fr) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Composés et procédés d'utilisation desdits composés |
| US11492345B2 (en) | 2017-02-13 | 2022-11-08 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018187480A1 (fr) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Composés et leurs méthodes d'utilisation |
| US11278535B2 (en) | 2017-08-15 | 2022-03-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| IL309843B2 (en) | 2018-05-30 | 2026-05-01 | Praxis Prec Medicines Inc | History of [4,2,1]triazolo[3,4-a]pyridines and their use as sodium ion channel modulators |
| EA202092908A1 (ru) | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| PE20221280A1 (es) | 2019-11-27 | 2022-09-05 | Praxis Prec Medicines Inc | Formulaciones de moduladores de canales ionicos y metodos de preparacion y uso de moduladores de canales ionicos |
| KR20250005348A (ko) | 2022-04-26 | 2025-01-09 | 프락시스 프리시젼 메디신즈, 인크. | 신경 장애의 치료 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1187281A (en) * | 1967-04-10 | 1970-04-08 | Leuna Werke Veb | Process for the Production of Pyridazine Derivatives |
-
1976
- 1976-09-22 US US05/725,597 patent/US4230705A/en not_active Expired - Lifetime
-
1977
- 1977-08-23 ZA ZA00775110A patent/ZA775110B/xx unknown
- 1977-08-23 MW MW21/77A patent/MW2177A1/xx unknown
- 1977-08-30 ZM ZM66/77A patent/ZM6677A1/xx unknown
- 1977-09-01 IS IS2407A patent/IS2407A7/is unknown
- 1977-09-16 PH PH20235A patent/PH13960A/en unknown
- 1977-09-19 MC MC771259A patent/MC1168A1/fr unknown
- 1977-09-21 SE SE7710595A patent/SE7710595L/xx not_active Application Discontinuation
- 1977-09-21 SU SU772523706A patent/SU793399A3/ru active
- 1977-09-22 BE BE181116A patent/BE858949A/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IS2407A7 (is) | 1977-10-05 |
| ZA775110B (en) | 1979-03-28 |
| PH13960A (en) | 1980-11-12 |
| US4230705A (en) | 1980-10-28 |
| MW2177A1 (en) | 1979-06-13 |
| SU793399A3 (ru) | 1980-12-30 |
| ZM6677A1 (en) | 1979-07-19 |
| MC1168A1 (fr) | 1978-06-02 |
| SE7710595L (sv) | 1978-05-25 |
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