BE885633A - Derives de 1,2,4-oxadiazolin-5-one, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Derives de 1,2,4-oxadiazolin-5-one, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
BE885633A
BE885633A BE0/202406A BE202406A BE885633A BE 885633 A BE885633 A BE 885633A BE 0/202406 A BE0/202406 A BE 0/202406A BE 202406 A BE202406 A BE 202406A BE 885633 A BE885633 A BE 885633A
Authority
BE
Belgium
Prior art keywords
oxadiazolin
derivatives
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
BE0/202406A
Other languages
English (en)
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of BE885633A publication Critical patent/BE885633A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
BE0/202406A 1979-10-11 1980-10-10 Derives de 1,2,4-oxadiazolin-5-one, procede pour leur preparation et compositions pharmaceutiques les contenant BE885633A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU79CI1973A HU179951B (en) 1979-10-11 1979-10-11 Process for preparing 1,2,4-oxadiazolin-5-one derivatives and pharmaceutical compositions containing thereof

Publications (1)

Publication Number Publication Date
BE885633A true BE885633A (fr) 1981-02-02

Family

ID=10994764

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/202406A BE885633A (fr) 1979-10-11 1980-10-10 Derives de 1,2,4-oxadiazolin-5-one, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (23)

Country Link
US (1) US4365064A (fr)
JP (1) JPS5661375A (fr)
AT (1) AT375369B (fr)
BE (1) BE885633A (fr)
CA (1) CA1154019A (fr)
CH (1) CH649547A5 (fr)
CS (1) CS241032B2 (fr)
DD (1) DD153550A5 (fr)
DE (1) DE3037432A1 (fr)
DK (1) DK149854C (fr)
ES (1) ES8106725A1 (fr)
FI (2) FI71932C (fr)
FR (1) FR2467203A1 (fr)
GB (1) GB2059967B (fr)
HU (1) HU179951B (fr)
IL (1) IL61175A (fr)
IT (1) IT1129305B (fr)
NL (1) NL8005586A (fr)
NO (1) NO154795C (fr)
PL (3) PL132131B1 (fr)
SE (1) SE452158B (fr)
SU (1) SU1087519A1 (fr)
YU (1) YU41738B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU180708B (en) * 1979-10-11 1983-04-29 Chinoin Gyogyszer Es Vegyeszet Process for preparing new 1,2,4-oxadiazine derivatives
JP2003528073A (ja) * 2000-03-20 2003-09-24 エヌ・ジーン リサーチ ラボラトリーズ インコーポレイテッド プロペンカルボン酸アミドキシム誘導体、その製法、及びこの誘導体を含有する医薬組成物
US9604930B2 (en) 2012-12-21 2017-03-28 Epizyme, Inc. Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof
US10118918B2 (en) 2012-12-21 2018-11-06 Epizyme, Inc. PRMT5 inhibitors and uses thereof
US9365555B2 (en) * 2012-12-21 2016-06-14 Epizyme, Inc. PRMT5 inhibitors and uses thereof
US9908887B2 (en) 2012-12-21 2018-03-06 Epizyme, Inc. PRMT5 inhibitors and uses thereof
JP2016505002A (ja) 2012-12-21 2016-02-18 エピザイム，インコーポレイティド ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するｐｒｍｔ５阻害剤およびその使用
AU2015301196A1 (en) 2014-08-04 2017-01-12 Epizyme, Inc. PRMT5 inhibitors and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1529700A (fr) * 1967-04-11 1968-06-21 Dausse Sa Lab Tertioaminoalcoyl oxadiazolinones et leur procédé de préparation
FR1575552A (fr) * 1967-12-07 1969-07-25
US4038279A (en) * 1972-12-23 1977-07-26 Boehringer Ingelheim Gmbh N-aryl-n'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof
US3994891A (en) * 1974-12-20 1976-11-30 Armour Pharmaceutical Company Tetrahydroisoquinoline compounds
US4187220A (en) * 1977-08-30 1980-02-05 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
HU180708B (en) * 1979-10-11 1983-04-29 Chinoin Gyogyszer Es Vegyeszet Process for preparing new 1,2,4-oxadiazine derivatives

Also Published As

Publication number Publication date
PL131375B1 (en) 1984-11-30
CS241032B2 (en) 1986-03-13
DK429780A (da) 1981-04-12
IT8068555A0 (it) 1980-10-09
AT375369B (de) 1984-07-25
NL8005586A (nl) 1981-04-14
FR2467203B1 (fr) 1985-03-22
YU41738B (en) 1987-12-31
IL61175A (en) 1984-08-31
PL132131B1 (en) 1985-02-28
FI71318C (fi) 1986-12-19
PL232292A1 (fr) 1982-04-26
DK149854B (da) 1986-10-13
GB2059967A (en) 1981-04-29
NO803044L (no) 1981-04-13
CA1154019A (fr) 1983-09-20
FI71932C (fi) 1987-03-09
ES495819A0 (es) 1981-09-16
JPS5661375A (en) 1981-05-26
DK149854C (da) 1987-04-21
FR2467203A1 (fr) 1981-04-17
PL232293A1 (fr) 1982-04-26
DD153550A5 (de) 1982-01-13
SU1087519A1 (ru) 1984-04-23
CH649547A5 (de) 1985-05-31
FI71318B (fi) 1986-09-09
IL61175A0 (en) 1980-11-30
FI803219L (fi) 1981-04-12
US4365064A (en) 1982-12-21
ES8106725A1 (es) 1981-09-16
PL227209A1 (fr) 1981-12-11
GB2059967B (en) 1983-06-02
HU179951B (en) 1983-01-28
CS673780A2 (en) 1985-06-13
FI803220L (fi) 1981-04-12
PL131451B1 (en) 1984-11-30
NO154795C (no) 1986-12-29
SE8007025L (sv) 1981-04-12
YU259480A (en) 1984-02-29
IT1129305B (it) 1986-06-04
NO154795B (no) 1986-09-15
ATA501380A (de) 1983-12-15
FI71932B (fi) 1986-11-28
SE452158B (sv) 1987-11-16
DE3037432A1 (de) 1981-05-27

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT

Effective date: 19931031