BE891585A - 5 alpha-androstane-17 beta-carboxylates et 5 beta-androstane-17 beta-carboxylates, leur preparation et leur utilisation - Google Patents

5 alpha-androstane-17 beta-carboxylates et 5 beta-androstane-17 beta-carboxylates, leur preparation et leur utilisation

Info

Publication number
BE891585A
BE891585A BE0/206909A BE206909A BE891585A BE 891585 A BE891585 A BE 891585A BE 0/206909 A BE0/206909 A BE 0/206909A BE 206909 A BE206909 A BE 206909A BE 891585 A BE891585 A BE 891585A
Authority
BE
Belgium
Prior art keywords
beta
androstane
carboxylates
alpha
preparation
Prior art date
Application number
BE0/206909A
Other languages
English (en)
Inventor
D Ayer
C Schlagel
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BE891585A publication Critical patent/BE891585A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE0/206909A 1980-12-22 1981-12-22 5 alpha-androstane-17 beta-carboxylates et 5 beta-androstane-17 beta-carboxylates, leur preparation et leur utilisation BE891585A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21929380A 1980-12-22 1980-12-22

Publications (1)

Publication Number Publication Date
BE891585A true BE891585A (fr) 1982-06-22

Family

ID=22818692

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/206909A BE891585A (fr) 1980-12-22 1981-12-22 5 alpha-androstane-17 beta-carboxylates et 5 beta-androstane-17 beta-carboxylates, leur preparation et leur utilisation

Country Status (8)

Country Link
JP (1) JPS57131000A (fr)
BE (1) BE891585A (fr)
DE (1) DE3149475A1 (fr)
FR (1) FR2496668A1 (fr)
GB (1) GB2089808A (fr)
IT (1) IT1142142B (fr)
NL (1) NL8105455A (fr)
ZA (1) ZA817929B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
SE8501693D0 (sv) * 1985-04-04 1985-04-04 Draco Ab Novel 16,17-acetalsubstituted androstane-17beta-carboxylic acid esters
ES2041245T3 (es) * 1985-10-23 1993-11-16 The Upjohn Company Esteroides angioestaticos.
JP5780521B2 (ja) 2008-05-28 2015-09-16 リベラジェン・バイオファーマ・インコーポレイテッドＲｅｖｅｒａＧｅｎ ＢｉｏＰｈａｒｍａ，Ｉｎｃ． 疾患を治療するための、ＮＦ−κＢの非ホルモン性ステロイド調節因子
WO2011127048A2 (fr) 2010-04-05 2011-10-13 Validus Biopharma MODULATEURS STÉROÏDES NON HORMONAUX DE NF-ĸB POUR LE TRAITEMENT DE MALADIES
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3828080A (en) * 1972-01-20 1974-08-06 Glaxo Lab Ltd Androstane-17beta-carboxylic acids and processes for the preparation thereof
DE3105307A1 (de) * 1980-02-15 1981-12-10 Glaxo Group Ltd., London "androstan-carbothioate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen"

Also Published As

Publication number Publication date
IT8125692A0 (it) 1981-12-18
DE3149475A1 (de) 1982-07-15
ZA817929B (en) 1982-10-27
GB2089808A (en) 1982-06-30
IT1142142B (it) 1986-10-08
NL8105455A (nl) 1982-07-16
JPS57131000A (en) 1982-08-13
FR2496668A1 (fr) 1982-06-25

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: THE UPJOHN CY

Effective date: 19861231