BE899739A - Werkwijze voor het controleren van de substitutie op aromatische kern,en, werkwijze en apparatuur ter bereiding van samenstelling voor scintigrafisch onderzoek. - Google Patents

Werkwijze voor het controleren van de substitutie op aromatische kern,en, werkwijze en apparatuur ter bereiding van samenstelling voor scintigrafisch onderzoek. Download PDF

Info

Publication number
BE899739A
BE899739A BE0/212997A BE212997A BE899739A BE 899739 A BE899739 A BE 899739A BE 0/212997 A BE0/212997 A BE 0/212997A BE 212997 A BE212997 A BE 212997A BE 899739 A BE899739 A BE 899739A
Authority
BE
Belgium
Prior art keywords
substitution
cylinder
reaction mixture
acid
piston
Prior art date
Application number
BE0/212997A
Other languages
English (en)
Dutch (nl)
Inventor
J Mertens
Original Assignee
Univ Bruxelles
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bruxelles filed Critical Univ Bruxelles
Priority to BE0/212997A priority Critical patent/BE899739A/nl
Publication of BE899739A publication Critical patent/BE899739A/nl
Priority to US06/735,037 priority patent/US4942231A/en
Priority to EP85200798A priority patent/EP0165630B1/de
Priority to AT85200798T priority patent/ATE47315T1/de
Priority to DE8585200798T priority patent/DE3573725D1/de
Priority to AU42727/85A priority patent/AU576861B2/en
Priority to JP60107078A priority patent/JPS6124A/ja
Priority to JP5-154585A priority patent/JPH06102079B2/ja
Priority to US07/569,058 priority patent/US5021220A/en
Priority to JP5154583A priority patent/JPH06211698A/ja
Priority to JP5154586A priority patent/JPH06237999A/ja
Priority to JP5154588A priority patent/JPH06199704A/ja
Priority to JP5154587A priority patent/JPH06211700A/ja
Priority to JP5154584A priority patent/JP2513573B2/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BE0/212997A 1984-05-24 1984-05-24 Werkwijze voor het controleren van de substitutie op aromatische kern,en, werkwijze en apparatuur ter bereiding van samenstelling voor scintigrafisch onderzoek. BE899739A (nl)

Priority Applications (14)

Application Number Priority Date Filing Date Title
BE0/212997A BE899739A (nl) 1984-05-24 1984-05-24 Werkwijze voor het controleren van de substitutie op aromatische kern,en, werkwijze en apparatuur ter bereiding van samenstelling voor scintigrafisch onderzoek.
US06/735,037 US4942231A (en) 1984-05-24 1985-05-17 Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound
EP85200798A EP0165630B1 (de) 1984-05-24 1985-05-20 Verfahren zur Herstellung einer chlorierten, bromierten, radiobromierten, jodierten und/oder radiojodierten aromatischen oder heteroaromatischen Verbindung, sowie ein Kit zur Herstellung einer auf diese Verbindung gegründete diagnostische Zusammensetzung
AT85200798T ATE47315T1 (de) 1984-05-24 1985-05-20 Verfahren zur herstellung einer chlorierten, bromierten, radiobromierten, jodierten und/oder radiojodierten aromatischen oder heteroaromatischen verbindung, sowie ein kit zur herstellung einer auf diese verbindung gegruendete diagnostische zusammensetzung.
DE8585200798T DE3573725D1 (en) 1984-05-24 1985-05-20 Method of preparing a chlorinated, brominated, radiobrominated, iodinated and/or radioiodinated, aromatic or heteroaromatic compound, as well as a kit for preparing a diagnostic composition on the basis of this compound
JP5-154585A JPH06102079B2 (ja) 1984-05-24 1985-05-21 注射可能な組成物の製造方法
JP60107078A JPS6124A (ja) 1984-05-24 1985-05-21 塩素化、臭素化、放射性臭素化、ヨウ素化および／または放射性ヨウ素化芳香族またはヘテロ芳香族化合物およびその製造方法
AU42727/85A AU576861B2 (en) 1984-05-24 1985-05-21 Halogenation of aromatic compounds
US07/569,058 US5021220A (en) 1984-05-24 1990-08-17 Kit for preparing radiodiagnostic examination compositions
JP5154583A JPH06211698A (ja) 1984-05-24 1993-06-02 造影剤組成物
JP5154586A JPH06237999A (ja) 1984-05-24 1993-06-02 器 具
JP5154588A JPH06199704A (ja) 1984-05-24 1993-06-02 放射性診断剤製造キット
JP5154587A JPH06211700A (ja) 1984-05-24 1993-06-02 温血動物の放射検定法
JP5154584A JP2513573B2 (ja) 1984-05-24 1993-06-02 診断剤組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE0/212997A BE899739A (nl) 1984-05-24 1984-05-24 Werkwijze voor het controleren van de substitutie op aromatische kern,en, werkwijze en apparatuur ter bereiding van samenstelling voor scintigrafisch onderzoek.

Publications (1)

Publication Number Publication Date
BE899739A true BE899739A (nl) 1984-11-26

Family

ID=3843761

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/212997A BE899739A (nl) 1984-05-24 1984-05-24 Werkwijze voor het controleren van de substitutie op aromatische kern,en, werkwijze en apparatuur ter bereiding van samenstelling voor scintigrafisch onderzoek.

Country Status (2)

Country Link
JP (1) JPS6124A (de)
BE (1) BE899739A (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0165630A3 (en) * 1984-05-24 1986-01-08 Mallinckrodt, Inc. Method of preparing a chlorinated, brominated, radiobrominated, iodinated and/or radioiodinated, aromatic or heteroaromatic compound, as well as diagnostic composition on the basis of this compound, kit for preparing said composition, and method and equipment for the preparation of this composition
CN111499513A (zh) * 2020-04-24 2020-08-07 上海毕得医药科技有限公司 一种2,3,4,5-四溴苯甲酸酯的合成方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62278838A (ja) * 1986-05-28 1987-12-03 Sharp Corp クロツク信号再生回路
JPH0780858B2 (ja) * 1987-10-19 1995-08-30 住友化学工業株式会社 放射性ベンゾジアゼピン誘導体およびその製造法
JP2546697B2 (ja) * 1987-12-16 1996-10-23 株式会社第一ラジオアイソトープ研究所 放射性ヨウ素化芳香族化合物の製造法
GB0514087D0 (en) * 2005-07-11 2005-08-17 Ge Healthcare Ltd Stabilised radiopharmaceutical compositions
KR101254636B1 (ko) * 2011-02-14 2013-04-15 한국수력원자력 주식회사 방사성 메틸요오드 추적자 제조방법 및 그 장치

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0165630A3 (en) * 1984-05-24 1986-01-08 Mallinckrodt, Inc. Method of preparing a chlorinated, brominated, radiobrominated, iodinated and/or radioiodinated, aromatic or heteroaromatic compound, as well as diagnostic composition on the basis of this compound, kit for preparing said composition, and method and equipment for the preparation of this composition
CN111499513A (zh) * 2020-04-24 2020-08-07 上海毕得医药科技有限公司 一种2,3,4,5-四溴苯甲酸酯的合成方法
CN111499513B (zh) * 2020-04-24 2023-03-14 上海毕得医药科技股份有限公司 一种2,3,4,5-四溴苯甲酸酯的合成方法

Also Published As

Publication number Publication date
JPH0584290B2 (de) 1993-12-01
JPS6124A (ja) 1986-01-06

Similar Documents

Publication Publication Date Title
US4452774A (en) Isonitrile radionuclide complexes for labelling and imaging agents
EP0165630B1 (de) Verfahren zur Herstellung einer chlorierten, bromierten, radiobromierten, jodierten und/oder radiojodierten aromatischen oder heteroaromatischen Verbindung, sowie ein Kit zur Herstellung einer auf diese Verbindung gegründete diagnostische Zusammensetzung
DE69803205T2 (de) Verfahren zur herstellung von facial metall tricarbonyl verbindungen und ihre anwendung zur markierung von biosubstraten
EP0183555B1 (de) Metall-Isonitril-Additionsprodukte für die Herstellung radioaktiver Komplexe für Markierungs- und Abbildungsmittel
JPWO2019027059A1 (ja) 放射標識されたアリール化合物の製造方法
DE3424525A1 (de) Verfahren zur herstellung von (pfeil hoch)1(pfeil hoch)(pfeil hoch)8(pfeil hoch)f-alkyl- und arylverbindungen durch halogenaustausch
BE899739A (nl) Werkwijze voor het controleren van de substitutie op aromatische kern,en, werkwijze en apparatuur ter bereiding van samenstelling voor scintigrafisch onderzoek.
CA1081122A (en) Radioactive composition for hepatobiliary system scintigraphy
JP2690142B2 (ja) テクネチウム−９９ｍの陽イオン錯体を製造するためのリガンド
Goulding et al. The preparation of fluorine-18 labelled p-fluorophenylalanine for clinical use
US3859429A (en) M-iodohippuric acid labelled with radioactive iodine and process for its preparation
DE3852828T2 (de) Tris(isonitrile)kupfer(i)-addukte zur herstellung von radionuklid-komplexen.
US4826961A (en) Method for preparing radiopharmaceutical complexes
US3814769A (en) Catalyzed radioiodine exchange
IE58717B1 (en) Metal-isonitrile adducts for preparing radionuclide complexes
JP2025521871A (ja) 化合物ｉの液体組成物、調製方法及びその使用
Venkatachalam et al. Synthesis of 18F‐radiolabeled diphenyl gallium dithiosemicarbazone using a novel halogen exchange method and in vivo biodistribution
SK277878B6 (en) Admission-cement non-radioactive amlifier for making of stable enantiometric form of diagnostic of kidneys function
JPH0339515B2 (de)
HK40111817A (en) Production method for radiolabeled aryl compound
Farah Evaluation of the reaction parameters and thermodynamics of the iodide‐exchange preparation of radioiodinated 15‐(p‐iodophenyl) pentadecanoic acid by both solid phase and solution methods
Cox The Chemistry and Pharmacy of Ida-Derivatives
Barton et al. Ligand exchange kinetics by the radioactive tracer technique: An inorganic or radiochemistry experiment
IE55024B1 (en) Isonitrile radionuclide complexes for labelling and imaging agents
CS201754B1 (cs) Způsob výroby injekčního roztoku bengálské'červeně značené radioaktivním izotopem jódu

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: VRIJE UNIVERSITEIT BRUSSEL

Effective date: 19910531