BE900883A - Derives de (1,3)oxazino(4,3-a) isoquinoleine, procede pour les preparer et compositions pharmaceutiques les contenant. - Google Patents

Derives de (1,3)oxazino(4,3-a) isoquinoleine, procede pour les preparer et compositions pharmaceutiques les contenant.

Info

Publication number
BE900883A
BE900883A BE0/213876A BE213876A BE900883A BE 900883 A BE900883 A BE 900883A BE 0/213876 A BE0/213876 A BE 0/213876A BE 213876 A BE213876 A BE 213876A BE 900883 A BE900883 A BE 900883A
Authority
BE
Belgium
Prior art keywords
group
oxazino
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
BE0/213876A
Other languages
English (en)
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of BE900883A publication Critical patent/BE900883A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Ces dérivés correspondent à la formule générale (I) dans laquelle : R1 et R2 sont un radical hydroxy ou alcoxy, R3 est un atome d'hydrogène, un radical alcoyle ayant de cycloalcoyle ou cyclo-alcényle un groupe phényle éventuellement substitué, aralcoyle ou bien hétéroaryle, R4 est un atome d'hydrogène ou un groupe alcoyle ou R3 et R4 forment ensemble un groupe -(CH2)n-, dans lequel n est un entier de 3 à 7, R5 est un groupe hydroxy un atome d'halogène ou un groupe -O-C-(X)-R6 dans lequel R6 est un groupe phényle éventuellement substitué, X est un atome d'oxygène ou de soufre et sels de ceux-ci. Les composés de formule (I) présentent une activité immunosuppressive, antidépressive, analgésique, antipyrétique ou inhibitrice de la sécrétion d'acide gastrique.
BE0/213876A 1983-10-25 1984-10-24 Derives de (1,3)oxazino(4,3-a) isoquinoleine, procede pour les preparer et compositions pharmaceutiques les contenant. BE900883A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU833654A HU190458B (en) 1983-10-25 1983-10-25 Process for preparing /1,3/ oxazino /4,3-a/ isoquinoline-derivatives

Publications (1)

Publication Number Publication Date
BE900883A true BE900883A (fr) 1985-04-24

Family

ID=10964931

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/213876A BE900883A (fr) 1983-10-25 1984-10-24 Derives de (1,3)oxazino(4,3-a) isoquinoleine, procede pour les preparer et compositions pharmaceutiques les contenant.

Country Status (15)

Country Link
US (1) US4623647A (fr)
JP (1) JPS60115589A (fr)
AT (1) AT387576B (fr)
BE (1) BE900883A (fr)
CA (1) CA1238905A (fr)
CH (1) CH664570A5 (fr)
DE (1) DE3439131A1 (fr)
DK (1) DK508684A (fr)
FI (1) FI76806C (fr)
FR (1) FR2553776B1 (fr)
GB (1) GB2148887B (fr)
HU (1) HU190458B (fr)
IT (1) IT1213235B (fr)
NL (1) NL8403251A (fr)
SE (1) SE462043B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU191301B (en) * 1984-03-23 1987-02-27 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing 1-/hydroxy-methyl/-1,6,7,11b-tetrahydro-2h,4h-/1,3/-oxazino- or -thiazino/4,3-a/isoquinoline -derivatives
KR100429356B1 (ko) * 2001-04-23 2004-05-31 조수동 다약제 내성 극복 이소퀴놀린계 화합물 및 그 제조방법
US7264709B2 (en) * 2004-09-21 2007-09-04 Siemens Water Technologies Holding Corp. Method and apparatus for conditioning a sensor for measuring oxidation reduction potential

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1094470A (en) * 1965-08-19 1967-12-13 Merck Ag E Isoquinoline derivatives and preparation thereof
US3389141A (en) * 1966-05-16 1968-06-18 Bristol Myers Co 1-beta-aryloxyethyltetrahydro-isoquinolines
IE37234B1 (en) * 1972-02-14 1977-06-08 Ayerst Mckenna & Harrison Fused-ring indole derivatives

Also Published As

Publication number Publication date
SE462043B (sv) 1990-04-30
ATA339884A (de) 1988-07-15
FR2553776A1 (fr) 1985-04-26
DK508684A (da) 1985-04-26
AT387576B (de) 1989-02-10
GB2148887B (en) 1987-02-25
CH664570A5 (de) 1988-03-15
DE3439131A1 (de) 1985-05-02
NL8403251A (nl) 1985-05-17
SE8405338D0 (sv) 1984-10-25
HU190458B (en) 1986-09-29
US4623647A (en) 1986-11-18
FR2553776B1 (fr) 1987-04-24
FI844187A0 (fi) 1984-10-25
FI844187L (fi) 1985-04-26
DK508684D0 (da) 1984-10-25
CA1238905A (fr) 1988-07-05
FI76806C (fi) 1988-12-12
IT1213235B (it) 1989-12-14
GB8425250D0 (en) 1984-11-14
FI76806B (fi) 1988-08-31
JPS60115589A (ja) 1985-06-22
IT8423305A0 (it) 1984-10-25
GB2148887A (en) 1985-06-05

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: RICHTER GEDEON VEGYESZETI GYAR R.T.

Effective date: 19911031