BE900997A - Derives de fluorene. - Google Patents

Derives de fluorene.

Info

Publication number
BE900997A
BE900997A BE0/213963A BE213963A BE900997A BE 900997 A BE900997 A BE 900997A BE 0/213963 A BE0/213963 A BE 0/213963A BE 213963 A BE213963 A BE 213963A BE 900997 A BE900997 A BE 900997A
Authority
BE
Belgium
Prior art keywords
hydrogen
fluorene derivatives
alkyl
choh
analgesic
Prior art date
Application number
BE0/213963A
Other languages
English (en)
Inventor
Yoshihisa Shibata
Yoshikhiko Yoshimoto
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of BE900997A publication Critical patent/BE900997A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/37—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with a hydroxy group on a condensed system having three rings
    • C07C35/38—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with a hydroxy group on a condensed system having three rings derived from the fluorene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/19—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/225—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/227—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C07C49/237—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/252—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
    • C07C49/675—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Des composés à activité anti-inflammatoire, analgésique et anti-pyrétique sont représentés par la formule générale I où R1 est un substituant éventuel; R2 est l'hydrogène ou alkyle; R3 est l'hydrogène ou un groupe alcoxy; A est notamment CO ou CHOH; B est un groupe alkyle; X3 est H2 ou O, à l'exclusion du cas où tous les R1, R2 et R3 sont les hydrogènes, A est CO, B est le groupe méthyle et représente une liaison insaturée.
BE0/213963A 1983-11-09 1984-11-07 Derives de fluorene. BE900997A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58211373A JPS60104027A (ja) 1983-11-09 1983-11-09 フルオレン誘導体

Publications (1)

Publication Number Publication Date
BE900997A true BE900997A (fr) 1985-05-07

Family

ID=16604883

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/213963A BE900997A (fr) 1983-11-09 1984-11-07 Derives de fluorene.

Country Status (15)

Country Link
US (1) US4581377A (fr)
JP (1) JPS60104027A (fr)
KR (1) KR850004086A (fr)
AU (1) AU574110B2 (fr)
BE (1) BE900997A (fr)
CA (1) CA1234836A (fr)
CH (1) CH662345A5 (fr)
DE (1) DE3440503A1 (fr)
ES (1) ES8607894A1 (fr)
FR (1) FR2554441B1 (fr)
GB (1) GB2157680B (fr)
IT (1) IT1178218B (fr)
NL (1) NL8403276A (fr)
SE (1) SE459734B (fr)
ZA (1) ZA848357B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0655992T3 (da) * 1993-06-18 1999-07-19 Otsuka Pharma Co Ltd Fluorenonderivater, fremgangsmåde til deres fremstilling samt regenererings- og beskyttelsesmiddel mod central eller perife

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB760986A (en) * 1953-06-06 1956-11-07 Ruetgerswerke Ag Aromatic condensation products
US3903145A (en) * 1971-06-18 1975-09-02 Squibb & Sons Inc 9-Substituted fluorene-2-acetic acid derivatives
US4011266A (en) * 1973-10-31 1977-03-08 Xerox Corporation 2-vinyl-fluorenone and derivatives thereof
GB1479297A (en) * 1974-07-04 1977-07-13 Beecham Group Ltd 4-substituted butan-2-ones but-3-en-2-ones butan-2-ols and but-3-en-2-ols and pharmaceutical compositions containing them
US3975540A (en) * 1975-04-28 1976-08-17 Syntex (U.S.A.) Inc. 2-Substituted-5-oxo-5H-dibenzo(a,d)cycloheptenes, and derivatives thereof, and methods and compositions for the use thereof
DE3439484A1 (de) * 1984-10-27 1986-05-07 Röhm GmbH, 6100 Darmstadt Verfahren zur herstellung von 9,9-bis-(4-hydroxyphenyl)-fluoren

Also Published As

Publication number Publication date
NL8403276A (nl) 1985-06-03
ZA848357B (en) 1985-06-26
GB2157680B (en) 1988-03-16
GB2157680A (en) 1985-10-30
IT8449140A1 (it) 1986-05-08
CA1234836A (fr) 1988-04-05
AU574110B2 (en) 1988-06-30
CH662345A5 (fr) 1987-09-30
JPS60104027A (ja) 1985-06-08
DE3440503A1 (de) 1985-06-05
GB8426337D0 (en) 1984-11-21
US4581377A (en) 1986-04-08
SE8405592L (sv) 1985-05-10
JPH0460095B2 (fr) 1992-09-25
IT8449140A0 (it) 1984-11-08
AU3519284A (en) 1985-05-16
FR2554441B1 (fr) 1989-01-06
ES8607894A1 (es) 1986-06-01
SE8405592D0 (sv) 1984-11-08
KR850004086A (ko) 1985-07-01
IT1178218B (it) 1987-09-09
SE459734B (sv) 1989-07-31
FR2554441A1 (fr) 1985-05-10
ES537402A0 (es) 1986-06-01

Similar Documents

Publication Publication Date Title
FR2592048A1 (fr) Inhibiteurs d'ureido-renine, a action therapeutique
CA2092990A1 (fr) Dispersions cationiques a base de ceramides et/ou de glycoceramides
ATE81858T1 (de) 6-thioxanthinderivate.
FI88717C (fi) Foerfarande foer framstaellning av som laekemedel anvaendbara cyklopenta/d/pyrimidinderivat
CA2023645A1 (fr) Procede pour la preparation enantioselective de derives de la phenylisoserine
NO172094C (no) Insekt- og middbeskyttende middel inneholdende substituerte alfa,omega-aminoalkoholderivater, disses anvendelse i slike midler samt nye alfa,omega-aminoalkoholderivater
BE902611A (fr) Derives de 4, 5, 6, 7-tetrahydroimidazo 4, 5-c pyridine.
GR3001441T3 (en) Pyrrolidinylamide ester derivative having anti-prolyl endopeptidase activity, its synthesis and use and a pharmaceutical composition containing it
BE904587A (fr) Intermediaires intervenant dans la production d'epipodophyllotoxine et composes apparentes : procedes de preparation et emploi.
GB1527783A (en) Butyrophenone derivatives
GB1531946A (en) Cyclopentane derivatives useful as perfuming agents
FR2368277A1 (fr) Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique
ES480827A1 (es) Procedimiento para la preparacion de acidos fenilaminotiofe-noaceticos.
BE902147A (fr) Pesticides.
FI860074A0 (fi) Oktahydroindolizinfoereningar anvaendbara som smaertstillande medel.
NZ219052A (en) Octahydroindolizine derivatives and pharmaceutical compositions
BE905535A (fr) Aryloxy-phenoxy-acyl-malonates, leur preparation et les compositions herbicides les contenant.
BE900607A (fr) Agents prophylactiques et medicaments anti-adhesifs contenant un derive de benzylamine ayant une action secretolytique.
FR2637500A1 (fr) Medicaments a base de nouveaux derives de la carbonyl-2 n, n'-di-(trimethoxybenzoyle) piperazine
ATE18993T1 (de) Dibenzocycloheptenyliden-verbindungen zur verwendung bei der modulation der immunreaktion.
ES8400384A1 (es) Procedimiento para la preparacion de derivados de carbaciclina.
DE3679224D1 (de) Carbacyclin-derivate.
DE3561512D1 (de) Diphenylmethylimine derivatives
EP0196330A1 (fr) Utilisation des derives de la pyrrothine.
FR2434136A1 (fr) Nouvelles cetones ethyleniques, leur preparation et leur emploi

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: NIPPON SHINYAKU CO. LTD

Effective date: 19911130