BE902012A - 1, NOR-2-HYDROXYMETHYLIC DERIVATIVES OF 13, 14-DIDEHYDROCARBOPROSTACYCLINES AND PREPARATION METHOD. - Google Patents
1, NOR-2-HYDROXYMETHYLIC DERIVATIVES OF 13, 14-DIDEHYDROCARBOPROSTACYCLINES AND PREPARATION METHOD.Info
- Publication number
- BE902012A BE902012A BE0/214700A BE214700A BE902012A BE 902012 A BE902012 A BE 902012A BE 0/214700 A BE0/214700 A BE 0/214700A BE 214700 A BE214700 A BE 214700A BE 902012 A BE902012 A BE 902012A
- Authority
- BE
- Belgium
- Prior art keywords
- alkyl
- agents
- hydroxymethylic
- didehydrocarboprostacyclines
- derivatives
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 239000002220 antihypertensive agent Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002496 gastric effect Effects 0.000 abstract 2
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 206010022714 Intestinal ulcer Diseases 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Composés de formule (I) dans laquelle m varie de 1 à 4, l'un des symboles R1 et R2 est H ou alkyle en C1-C4, cependant que l'autre représente OH, l'un des symboles R3 et R4 est H ou alkyle en C1-C4, cependant que l'autre est indépendamment H, F ou alkyle en C1-C4, n égal O ou 1, p égal O ou varie de 1 à 5 et B représente un radical alkyle en C1-C4 ou monocycloaliphatique en C4-C7 à substitution alkylique en C1-C4 éventuelle. Ces composés servent au traitement d'ulcères gastriques et intestinaux, à l'inhibition de la sécrétion gastrique, comme agents d'antithromboagglutination et de thrombodésagglutination, d'agents vasodilatateurs ou hypotenseurs ou antihypertension et d'agents permettant de traiter les maladies pulmonaires d'obstruction.Compounds of formula (I) in which m varies from 1 to 4, one of the symbols R1 and R2 is H or C1-C4 alkyl, while the other represents OH, one of the symbols R3 and R4 is H or C1-C4 alkyl, while the other is independently H, F or C1-C4 alkyl, n equals O or 1, p equals O or ranges from 1 to 5 and B represents a C1-C4 alkyl radical or C4-C7 monocycloaliphatic with possible C1-C4 alkyl substitution. These compounds are used for the treatment of gastric and intestinal ulcers, for the inhibition of gastric secretion, as antithromboagglutination and thrombodeagglutination agents, vasodilator or hypotensive or antihypertension agents and agents used to treat pulmonary diseases. obstruction.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08407791A GB2156340A (en) | 1984-03-26 | 1984-03-26 | 1-Nor-2-hydroxymethyl-derivatives of carboprostacyclins and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE902012A true BE902012A (en) | 1985-07-16 |
Family
ID=10558688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/214700A BE902012A (en) | 1984-03-26 | 1985-03-25 | 1, NOR-2-HYDROXYMETHYLIC DERIVATIVES OF 13, 14-DIDEHYDROCARBOPROSTACYCLINES AND PREPARATION METHOD. |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS60209538A (en) |
| BE (1) | BE902012A (en) |
| DE (1) | DE3507943A1 (en) |
| GB (1) | GB2156340A (en) |
| IT (1) | IT1200399B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3812533A1 (en) * | 1988-04-15 | 1989-10-26 | Josef Seelen | SEAL FOR BLOW TUBE OR SHAFT |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2038333B (en) * | 1978-01-26 | 1982-10-06 | Erba Farmitalia | 12 -formyl- (20 12)octanor-9-deoxy-9 -methylene pgi derivatives |
| US4705806A (en) * | 1978-02-13 | 1987-11-10 | Morton Jr Douglas R | Prostacyclin analogs |
-
1984
- 1984-03-26 GB GB08407791A patent/GB2156340A/en not_active Withdrawn
-
1985
- 1985-03-05 IT IT19766/85A patent/IT1200399B/en active
- 1985-03-06 DE DE19853507943 patent/DE3507943A1/en not_active Withdrawn
- 1985-03-22 JP JP60055775A patent/JPS60209538A/en active Pending
- 1985-03-25 BE BE0/214700A patent/BE902012A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60209538A (en) | 1985-10-22 |
| IT1200399B (en) | 1989-01-18 |
| IT8519766A0 (en) | 1985-03-05 |
| GB2156340A (en) | 1985-10-09 |
| DE3507943A1 (en) | 1985-09-26 |
| GB8407791D0 (en) | 1984-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: FARMITALIA CARLO ERBA S.P.A. Effective date: 19910331 |