BE902014A - NEWS 13,14,19,20-TETRADEHYDRO-CARBOPROSTACYCLINES AND PREPARATION METHOD. - Google Patents

NEWS 13,14,19,20-TETRADEHYDRO-CARBOPROSTACYCLINES AND PREPARATION METHOD.

Info

Publication number
BE902014A
BE902014A BE0/214702A BE214702A BE902014A BE 902014 A BE902014 A BE 902014A BE 0/214702 A BE0/214702 A BE 0/214702A BE 214702 A BE214702 A BE 214702A BE 902014 A BE902014 A BE 902014A
Authority
BE
Belgium
Prior art keywords
hydrogen atom
symbols
alkyl radical
compounds
agents
Prior art date
Application number
BE0/214702A
Other languages
French (fr)
Inventor
N Mongelli
R Ceserani
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE902014A publication Critical patent/BE902014A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composés de formule (I) dans laquelle R représente un atome d'hydrogène ou un radical alkyle en C1-C6; m représente un nombre entier dont la valeur varie de 1 à 5; l'un des symboles R1 et R2 représente un atome d'hydrogène ou un radical alkyle en C1-C6, cependant que l'autre de ces symboles représente le radical hydroxyle; l'un des symboles R3 et R4 représente un atome d'hydrogène, cependant que l'autre de ces symboles représente un atome d'hydrogène ou un radical alkyle en C1-C4, et R5 représente un radical alkyle en C1-C6 ainsi que les sels acceptables en pharmacie humaine ou en pharmacie vétérinaire de ces composés. Les composés de formule (I) possèdent une utilité particulière à titre d'agents d'antithromboagglutination et/ou de thrombodésagglutination, et de plus à titre d'agents vasodilatateurs.Compounds of formula (I) in which R represents a hydrogen atom or a C1-C6 alkyl radical; m represents an integer whose value varies from 1 to 5; one of the symbols R1 and R2 represents a hydrogen atom or a C1-C6 alkyl radical, while the other of these symbols represents the hydroxyl radical; one of the symbols R3 and R4 represents a hydrogen atom, while the other of these symbols represents a hydrogen atom or a C1-C4 alkyl radical, and R5 represents a C1-C6 alkyl radical as well as the salts acceptable in human pharmacy or in veterinary pharmacy of these compounds. The compounds of formula (I) have particular utility as antithromboagglutination agents and / or thrombodeagglutination agents, and moreover as vasodilator agents.

BE0/214702A 1984-03-26 1985-03-25 NEWS 13,14,19,20-TETRADEHYDRO-CARBOPROSTACYCLINES AND PREPARATION METHOD. BE902014A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08407793A GB2156342B (en) 1984-03-26 1984-03-26 13,14,19,20-tetradehydro derivatives of carboprostacyclins and process for their preparation

Publications (1)

Publication Number Publication Date
BE902014A true BE902014A (en) 1985-07-16

Family

ID=10558690

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214702A BE902014A (en) 1984-03-26 1985-03-25 NEWS 13,14,19,20-TETRADEHYDRO-CARBOPROSTACYCLINES AND PREPARATION METHOD.

Country Status (5)

Country Link
JP (1) JPS60209545A (en)
BE (1) BE902014A (en)
DE (1) DE3507942A1 (en)
GB (1) GB2156342B (en)
IT (1) IT1183478B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2013661B (en) * 1978-01-26 1982-11-10 Erba Farmitalia 9-deoxy-9 -methylene isosteres of pgi2

Also Published As

Publication number Publication date
IT1183478B (en) 1987-10-22
IT8519767A0 (en) 1985-03-05
JPS60209545A (en) 1985-10-22
GB2156342B (en) 1987-12-23
GB2156342A (en) 1985-10-09
GB8407793D0 (en) 1984-05-02
DE3507942A1 (en) 1985-09-26

Similar Documents

Publication Publication Date Title
BE902213A (en) PHENETHANOLAMINE COMPOUNDS.
TNSN86111A1 (en) PROCESS FOR THE PREPARATION OF TERTIARY HYDROXYALKYLXANTHINES
FR2451913A1 (en) GLYCINAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF VARIOUS FORMS OF EPLEPSY, DYSKINESIA AND MEMORY DISORDERS
TNSN87033A1 (en) TOLUNITRILES SUBSTITUTED BY DESα - HETEROCYCLES
EP1245249A3 (en) Use of a cationic amphipathic compound as a transfection agent, vaccine additive or drug
CA2203618A1 (en) New metalloprotease inhibitors, their preparation process and the pharmaceutical compounds that contain them
BE900345A (en) OPHTHALMIC PHARMACEUTICAL COMPOSITION BASED ON A PHENYLACETIC ACID DERIVATIVE.
BE903334A (en) NOVEL RETINOICALLY ACTIVE NAPHTHALENIC DERIVATIVES, PREPARATION METHODS THEREOF, AND MEDICINAL AND COSMETIC COMPOSITIONS CONTAINING THEM
PT81855B (en) PREPARATION PROCESS OF ARILCYCLOBUTILALQUILAMINS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
BE902876A (en) AMINOPHENOL DERIVATIVES
FR2637183A1 (en) NOVEL CHOLESTEROL BIOSYNTHESIS INHIBITORS AND THEIR PREPARATION
BE905110A (en) POLY-4-AMINOPYRROLE-2-CARBOXAMIDES AND DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC USES.
CA2143252A1 (en) Benzodioxanes derivatives; process for preparing the same and pharmaceutical compositions containing them
FR2637286A1 (en) NOVEL BENZOXAZOLINON DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
BE904641A (en) 5-PYRIMIDINE-CARBOXAMIDES AND TREATMENT OF LEUKEMIA AND TUMORS WITH THE SAME.
KR860700250A (en) New amidine compounds
FR2452483A1 (en) ALCENYLPHENYLMALEIMIDES DERIVATIVES, THEIR LINEAR DIMERES AND THEIR PREPARATION PROCESS
BE904587A (en) INTERMEDIATES INVOLVED IN THE PRODUCTION OF EPIPODOPHYLLOTOXIN AND RELATED COMPOUNDS: METHODS OF PREPARATION AND USE.
ATE50773T1 (en) ALKYLRESORCINOPHOSPHITES.
KR900016178A (en) 2-substituted N, N'-ditrimethoxybenzoyl piperazine, preparation method thereof and therapeutic composition containing the same
BE904983A (en) 3-SUBSTITUTED PROPENYLAMINOTHIAZOLYLCEPHALOSPORANIC ACIDS AND THEIR ESTERS.
BE902014A (en) NEWS 13,14,19,20-TETRADEHYDRO-CARBOPROSTACYCLINES AND PREPARATION METHOD.
FR2397425A1 (en) NEW DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
BE902015A (en) NEWS 13,14,19,19,20-HEXADEHYDRO-CARBOPROSTACYCLINES AND METHOD OF PREPARATION.
PT91323A (en) METHOD FOR THE PREPARATION OF ANCERICYCLIC GLYCOSIDES, INTERMEDIATE 4-SUBSTITUTED ANTHRACICLINONES AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FARMITALIA CARLO ERBA S.P.A.

Effective date: 19910331