BE902150A - Derives de la 1h, 7h-pyrazolo (1,5-a) pyrimidine-7-one et procede pour leur preparation. - Google Patents
Derives de la 1h, 7h-pyrazolo (1,5-a) pyrimidine-7-one et procede pour leur preparation.Info
- Publication number
- BE902150A BE902150A BE0/214812A BE214812A BE902150A BE 902150 A BE902150 A BE 902150A BE 0/214812 A BE0/214812 A BE 0/214812A BE 214812 A BE214812 A BE 214812A BE 902150 A BE902150 A BE 902150A
- Authority
- BE
- Belgium
- Prior art keywords
- compounds
- optionally substituted
- pyrazolo
- pyrimidine
- derivatives
- Prior art date
Links
- BUEFDJQUUGMUJO-UHFFFAOYSA-N 1h-pyrazolo[1,5-a]pyrimidin-7-one Chemical class O=C1C=CN=C2C=CNN12 BUEFDJQUUGMUJO-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 C1-C6 alkyl radical Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composés de la formule (I) ou R1 est un groupe alkyle en C1-C6, benzyle, pyridyle où phényle, ces deux derniers éventuellement substitués, R2 représente un radical pyridyle ou phényle éventuellement substitué, R3 représente un atome d'hydrogène ou radical alkyle en C1-C6 éventuellement substitué, R4 représente un hydrogène, un halogène, un radical alkyle en C1-C6, hydroxyle, alcoxy en C1-C6, alcényloxy en C3-C4, formyloxy ou alcanoyloxy en C2-C6, ainsi que les sels pharmaceutiquement acceptables de ces composés. Ces composés sont destinés à etre utilisés en tant que dépresseurs du système nerveux central.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08409424A GB2157285B (en) | 1984-04-11 | 1984-04-11 | 1h, 7h-pyrazolo1, 5-a pyrimidine-7-one derivatives and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE902150A true BE902150A (fr) | 1985-07-31 |
Family
ID=10559537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/214812A BE902150A (fr) | 1984-04-11 | 1985-04-10 | Derives de la 1h, 7h-pyrazolo (1,5-a) pyrimidine-7-one et procede pour leur preparation. |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS60228483A (fr) |
| BE (1) | BE902150A (fr) |
| DE (1) | DE3510134A1 (fr) |
| GB (1) | GB2157285B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2812636A1 (fr) * | 2000-08-02 | 2002-02-08 | Novapharme | Nouveaux derives 2-phenyl imidazo[1.2-a]pyrimidin-5-ones et 2-phenyl 2,3-dihydro imidazo[1,2-a]pyrimidin-5-ones |
| WO2002076987A1 (fr) * | 2001-03-27 | 2002-10-03 | Neurogen Corporation | (oxo-pyrazolo[1,5a]pyrimidin-2-yl)alkyl-carboxamides |
| PT1732926E (pt) | 2004-04-06 | 2009-04-03 | Novartis Vaccines & Diagnostic | Inibidores de cinesinas mitóticas |
| JP2010515687A (ja) | 2007-01-05 | 2010-05-13 | ノバルティス アーゲー | キネシンスピンドルタンパク質阻害剤（ｅｇ−５）としてのイミダゾール誘導体 |
-
1984
- 1984-04-11 GB GB08409424A patent/GB2157285B/en not_active Expired
-
1985
- 1985-03-20 DE DE19853510134 patent/DE3510134A1/de not_active Withdrawn
- 1985-04-10 JP JP60074527A patent/JPS60228483A/ja active Pending
- 1985-04-10 BE BE0/214812A patent/BE902150A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB2157285A (en) | 1985-10-23 |
| GB8409424D0 (en) | 1984-05-23 |
| JPS60228483A (ja) | 1985-11-13 |
| GB2157285B (en) | 1987-10-28 |
| DE3510134A1 (de) | 1985-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: FARMITALIA CARLO ERBA S.P.A. Effective date: 19880430 |